id	sid	tid	token	lemma	pos
44558c99h59	1	1	mycobacterium	mycobacterium	NOUN
44558c99h59	1	2	tuberculosis	tuberculosis	NOUN
44558c99h59	1	3	is	be	AUX
44558c99h59	1	4	the	the	DET
44558c99h59	1	5	etiological	etiological	ADJ
44558c99h59	1	6	agent	agent	NOUN
44558c99h59	1	7	of	of	ADP
44558c99h59	1	8	human	human	ADJ
44558c99h59	1	9	tuberculosis	tuberculosis	NOUN
44558c99h59	1	10	(	(	PUNCT
44558c99h59	1	11	tb	tb	PROPN
44558c99h59	1	12	)	)	PUNCT
44558c99h59	1	13	,	,	PUNCT
44558c99h59	1	14	a	a	DET
44558c99h59	1	15	disease	disease	NOUN
44558c99h59	1	16	responsible	responsible	ADJ
44558c99h59	1	17	for	for	ADP
44558c99h59	1	18	more	more	ADJ
44558c99h59	1	19	than	than	ADP
44558c99h59	1	20	one	one	NUM
44558c99h59	1	21	million	million	NUM
44558c99h59	1	22	deaths	death	NOUN
44558c99h59	1	23	in	in	ADP
44558c99h59	1	24	2013	2013	NUM
44558c99h59	1	25	.	.	PUNCT
44558c99h59	2	1	a	a	DET
44558c99h59	2	2	major	major	ADJ
44558c99h59	2	3	mechanism	mechanism	NOUN
44558c99h59	2	4	by	by	ADP
44558c99h59	2	5	which	which	PRON
44558c99h59	2	6	this	this	DET
44558c99h59	2	7	bacterial	bacterial	ADJ
44558c99h59	2	8	pathogen	pathogen	NOUN
44558c99h59	2	9	mediates	mediate	VERB
44558c99h59	2	10	infection	infection	NOUN
44558c99h59	2	11	is	be	AUX
44558c99h59	2	12	through	through	ADP
44558c99h59	2	13	the	the	DET
44558c99h59	2	14	export	export	NOUN
44558c99h59	2	15	of	of	ADP
44558c99h59	2	16	virulence	virulence	NOUN
44558c99h59	2	17	factors	factor	NOUN
44558c99h59	2	18	from	from	ADP
44558c99h59	2	19	the	the	DET
44558c99h59	2	20	esat-6	esat-6	NOUN
44558c99h59	2	21	system-1	system-1	PROPN
44558c99h59	2	22	(	(	PUNCT
44558c99h59	2	23	esx-1	esx-1	X
44558c99h59	2	24	)	)	PUNCT
44558c99h59	2	25	.	.	PUNCT
44558c99h59	3	1	to	to	PART
44558c99h59	3	2	better	well	ADV
44558c99h59	3	3	understand	understand	VERB
44558c99h59	3	4	mycobacterial	mycobacterial	ADJ
44558c99h59	3	5	pathogenicity	pathogenicity	NOUN
44558c99h59	3	6	,	,	PUNCT
44558c99h59	3	7	we	we	PRON
44558c99h59	3	8	studied	study	VERB
44558c99h59	3	9	the	the	DET
44558c99h59	3	10	basic	basic	ADJ
44558c99h59	3	11	genetic	genetic	ADJ
44558c99h59	3	12	and	and	CCONJ
44558c99h59	3	13	molecular	molecular	ADJ
44558c99h59	3	14	requirements	requirement	NOUN
44558c99h59	3	15	of	of	ADP
44558c99h59	3	16	esx-1	esx-1	ADP
44558c99h59	3	17	secretion	secretion	NOUN
44558c99h59	3	18	and	and	CCONJ
44558c99h59	3	19	virulence	virulence	NOUN
44558c99h59	3	20	in	in	ADP
44558c99h59	3	21	pathogenic	pathogenic	ADJ
44558c99h59	3	22	mycobacteria	mycobacteria	NOUN
44558c99h59	3	23	.	.	PUNCT
44558c99h59	4	1	using	use	VERB
44558c99h59	4	2	mycobacterium	mycobacterium	NOUN
44558c99h59	4	3	marinum	marinum	PROPN
44558c99h59	4	4	as	as	ADP
44558c99h59	4	5	a	a	DET
44558c99h59	4	6	model	model	NOUN
44558c99h59	4	7	species	specie	NOUN
44558c99h59	4	8	,	,	PUNCT
44558c99h59	4	9	we	we	PRON
44558c99h59	4	10	screened	screen	VERB
44558c99h59	4	11	a	a	DET
44558c99h59	4	12	near	near	ADV
44558c99h59	4	13	-	-	PUNCT
44558c99h59	4	14	saturating	saturate	VERB
44558c99h59	4	15	transposon	transposon	ADJ
44558c99h59	4	16	-	-	PUNCT
44558c99h59	4	17	insertion	insertion	NOUN
44558c99h59	4	18	library	library	NOUN
44558c99h59	4	19	for	for	ADP
44558c99h59	4	20	mutant	mutant	ADJ
44558c99h59	4	21	strains	strain	NOUN
44558c99h59	4	22	exhibiting	exhibit	VERB
44558c99h59	4	23	morphology	morphology	NOUN
44558c99h59	4	24	defects	defect	NOUN
44558c99h59	4	25	.	.	PUNCT
44558c99h59	5	1	we	we	PRON
44558c99h59	5	2	report	report	VERB
44558c99h59	5	3	here	here	ADV
44558c99h59	5	4	the	the	DET
44558c99h59	5	5	identification	identification	NOUN
44558c99h59	5	6	and	and	CCONJ
44558c99h59	5	7	characterization	characterization	NOUN
44558c99h59	5	8	of	of	ADP
44558c99h59	5	9	two	two	NUM
44558c99h59	5	10	mutant	mutant	ADJ
44558c99h59	5	11	m.	m.	NOUN
44558c99h59	5	12	marinum	marinum	ADJ
44558c99h59	5	13	strains	strain	NOUN
44558c99h59	5	14	that	that	PRON
44558c99h59	5	15	are	be	AUX
44558c99h59	5	16	deficient	deficient	ADJ
44558c99h59	5	17	for	for	ADP
44558c99h59	5	18	esx-1	esx-1	DET
44558c99h59	5	19	function	function	NOUN
44558c99h59	5	20	and	and	CCONJ
44558c99h59	5	21	attenuated	attenuate	VERB
44558c99h59	5	22	in	in	ADP
44558c99h59	5	23	infection	infection	NOUN
44558c99h59	5	24	models	model	NOUN
44558c99h59	5	25	.	.	PUNCT
44558c99h59	6	1	from	from	ADP
44558c99h59	6	2	these	these	DET
44558c99h59	6	3	analyses	analysis	NOUN
44558c99h59	6	4	we	we	PRON
44558c99h59	6	5	expanded	expand	VERB
44558c99h59	6	6	the	the	DET
44558c99h59	6	7	genetic	genetic	ADJ
44558c99h59	6	8	requirements	requirement	NOUN
44558c99h59	6	9	for	for	ADP
44558c99h59	6	10	esx-1	esx-1	DET
44558c99h59	6	11	secretion	secretion	NOUN
44558c99h59	6	12	in	in	ADP
44558c99h59	6	13	m.	m.	PROPN
44558c99h59	6	14	marinum	marinum	PROPN
44558c99h59	6	15	to	to	PART
44558c99h59	6	16	include	include	VERB
44558c99h59	6	17	mmar_4414	mmar_4414	NOUN
44558c99h59	6	18	and	and	CCONJ
44558c99h59	6	19	the	the	DET
44558c99h59	6	20	mmar_1663	mmar_1663	PROPN
44558c99h59	6	21	-	-	PUNCT
44558c99h59	6	22	mmar_1668	mmar_1668	NOUN
44558c99h59	6	23	locus	locus	NOUN
44558c99h59	6	24	.	.	PUNCT
44558c99h59	7	1	we	we	PRON
44558c99h59	7	2	also	also	ADV
44558c99h59	7	3	determined	determine	VERB
44558c99h59	7	4	that	that	SCONJ
44558c99h59	7	5	esx-1	esx-1	ADP
44558c99h59	7	6	-	-	PUNCT
44558c99h59	7	7	dependent	dependent	ADJ
44558c99h59	7	8	virulence	virulence	NOUN
44558c99h59	7	9	is	be	AUX
44558c99h59	7	10	mediated	mediate	VERB
44558c99h59	7	11	through	through	ADP
44558c99h59	7	12	the	the	DET
44558c99h59	7	13	proteins	protein	NOUN
44558c99h59	7	14	substrates	substrate	NOUN
44558c99h59	7	15	associated	associate	VERB
44558c99h59	7	16	with	with	ADP
44558c99h59	7	17	the	the	DET
44558c99h59	7	18	bacterial	bacterial	ADJ
44558c99h59	7	19	surface	surface	NOUN
44558c99h59	7	20	,	,	PUNCT
44558c99h59	7	21	contrary	contrary	ADJ
44558c99h59	7	22	to	to	ADP
44558c99h59	7	23	the	the	DET
44558c99h59	7	24	assumption	assumption	NOUN
44558c99h59	7	25	that	that	SCONJ
44558c99h59	7	26	true	true	ADJ
44558c99h59	7	27	exo	exo	NOUN
44558c99h59	7	28	-	-	PUNCT
44558c99h59	7	29	proteins	protein	NOUN
44558c99h59	7	30	facilitate	facilitate	NOUN
44558c99h59	7	31	virulence	virulence	NOUN
44558c99h59	7	32	.	.	PUNCT
44558c99h59	8	1	finally	finally	ADV
44558c99h59	8	2	,	,	PUNCT
44558c99h59	8	3	we	we	PRON
44558c99h59	8	4	determined	determine	VERB
44558c99h59	8	5	that	that	SCONJ
44558c99h59	8	6	the	the	DET
44558c99h59	8	7	protein	protein	NOUN
44558c99h59	8	8	product	product	NOUN
44558c99h59	8	9	of	of	ADP
44558c99h59	8	10	mmar_4414	mmar_4414	NOUN
44558c99h59	8	11	directly	directly	ADV
44558c99h59	8	12	interacts	interact	VERB
44558c99h59	8	13	with	with	ADP
44558c99h59	8	14	ecca	ecca	PROPN
44558c99h59	8	15	,	,	PUNCT
44558c99h59	8	16	an	an	DET
44558c99h59	8	17	established	established	ADJ
44558c99h59	8	18	component	component	NOUN
44558c99h59	8	19	of	of	ADP
44558c99h59	8	20	the	the	DET
44558c99h59	8	21	esx-1	esx-1	X
44558c99h59	8	22	system	system	NOUN
44558c99h59	8	23	.	.	PUNCT
44558c99h59	9	1	in	in	ADP
44558c99h59	9	2	summary	summary	NOUN
44558c99h59	9	3	,	,	PUNCT
44558c99h59	9	4	these	these	DET
44558c99h59	9	5	studies	study	NOUN
44558c99h59	9	6	identified	identify	VERB
44558c99h59	9	7	two	two	NUM
44558c99h59	9	8	major	major	ADJ
44558c99h59	9	9	genetic	genetic	ADJ
44558c99h59	9	10	loci	locus	NOUN
44558c99h59	9	11	required	require	VERB
44558c99h59	9	12	for	for	ADP
44558c99h59	9	13	esx-1	esx-1	DET
44558c99h59	9	14	function	function	NOUN
44558c99h59	9	15	and	and	CCONJ
44558c99h59	9	16	provide	provide	VERB
44558c99h59	9	17	novel	novel	ADJ
44558c99h59	9	18	insights	insight	NOUN
44558c99h59	9	19	into	into	ADP
44558c99h59	9	20	the	the	DET
44558c99h59	9	21	working	work	VERB
44558c99h59	9	22	model	model	NOUN
44558c99h59	9	23	of	of	ADP
44558c99h59	9	24	esx-1	esx-1	ADP
44558c99h59	9	25	secretion	secretion	NOUN
44558c99h59	9	26	in	in	ADP
44558c99h59	9	27	pathogenic	pathogenic	ADJ
44558c99h59	9	28	mycobacteria	mycobacteria	PROPN
44558c99h59	9	29	.	.	PUNCT
44558c99h59	10	1	the	the	DET
44558c99h59	10	2	continued	continue	VERB
44558c99h59	10	3	study	study	NOUN
44558c99h59	10	4	of	of	ADP
44558c99h59	10	5	these	these	PRON
44558c99h59	10	6	,	,	PUNCT
44558c99h59	10	7	and	and	CCONJ
44558c99h59	10	8	other	other	ADJ
44558c99h59	10	9	yet	yet	CCONJ
44558c99h59	10	10	still	still	ADV
44558c99h59	10	11	undiscovered	undiscovered	ADJ
44558c99h59	10	12	esx-1	esx-1	ADP
44558c99h59	10	13	components	component	NOUN
44558c99h59	10	14	,	,	PUNCT
44558c99h59	10	15	may	may	AUX
44558c99h59	10	16	contribute	contribute	VERB
44558c99h59	10	17	to	to	ADP
44558c99h59	10	18	the	the	DET
44558c99h59	10	19	future	future	ADJ
44558c99h59	10	20	control	control	NOUN
44558c99h59	10	21	and	and	CCONJ
44558c99h59	10	22	prevention	prevention	NOUN
44558c99h59	10	23	of	of	ADP
44558c99h59	10	24	m.	m.	NOUN
44558c99h59	10	25	tuberculosis	tuberculosis	NOUN
44558c99h59	10	26	infection	infection	NOUN
44558c99h59	10	27	.	.	PUNCT