id sid tid token lemma pos 44558c99g6b 1 1 given give VERB 44558c99g6b 1 2 the the DET 44558c99g6b 1 3 periodic periodic ADJ 44558c99g6b 1 4 shortages shortage NOUN 44558c99g6b 1 5 and and CCONJ 44558c99g6b 1 6 safety safety NOUN 44558c99g6b 1 7 concerns concern NOUN 44558c99g6b 1 8 of of ADP 44558c99g6b 1 9 blood blood NOUN 44558c99g6b 1 10 , , PUNCT 44558c99g6b 1 11 the the DET 44558c99g6b 1 12 development development NOUN 44558c99g6b 1 13 of of ADP 44558c99g6b 1 14 an an DET 44558c99g6b 1 15 artificial artificial ADJ 44558c99g6b 1 16 blood blood NOUN 44558c99g6b 1 17 substitute substitute NOUN 44558c99g6b 1 18 capable capable ADJ 44558c99g6b 1 19 of of ADP 44558c99g6b 1 20 adequately adequately ADV 44558c99g6b 1 21 transporting transport VERB 44558c99g6b 1 22 oxygen oxygen NOUN 44558c99g6b 1 23 without without ADP 44558c99g6b 1 24 eliciting elicit VERB 44558c99g6b 1 25 undue undue ADJ 44558c99g6b 1 26 side side NOUN 44558c99g6b 1 27 effects effect NOUN 44558c99g6b 1 28 would would AUX 44558c99g6b 1 29 be be AUX 44558c99g6b 1 30 quite quite ADV 44558c99g6b 1 31 beneficial beneficial ADJ 44558c99g6b 1 32 . . PUNCT 44558c99g6b 2 1 acellular acellular ADJ 44558c99g6b 2 2 modified modify VERB 44558c99g6b 2 3 hemoglobin hemoglobin NOUN 44558c99g6b 2 4 - - PUNCT 44558c99g6b 2 5 based base VERB 44558c99g6b 2 6 oxygen oxygen NOUN 44558c99g6b 2 7 carriers carrier NOUN 44558c99g6b 2 8 with with ADP 44558c99g6b 2 9 high high ADJ 44558c99g6b 2 10 oxygen oxygen NOUN 44558c99g6b 2 11 affinity affinity NOUN 44558c99g6b 2 12 ( ( PUNCT 44558c99g6b 2 13 p50 p50 NOUN 44558c99g6b 2 14 < < X 44558c99g6b 2 15 26 26 NUM 44558c99g6b 2 16 mmhg mmhg NOUN 44558c99g6b 2 17 ) ) PUNCT 44558c99g6b 2 18 are be AUX 44558c99g6b 2 19 a a DET 44558c99g6b 2 20 new new ADJ 44558c99g6b 2 21 class class NOUN 44558c99g6b 2 22 of of ADP 44558c99g6b 2 23 blood blood NOUN 44558c99g6b 2 24 substitutes substitute NOUN 44558c99g6b 2 25 being be AUX 44558c99g6b 2 26 explored explore VERB 44558c99g6b 2 27 . . PUNCT 44558c99g6b 3 1 it it PRON 44558c99g6b 3 2 has have AUX 44558c99g6b 3 3 been be AUX 44558c99g6b 3 4 theorized theorize VERB 44558c99g6b 3 5 that that SCONJ 44558c99g6b 3 6 these these DET 44558c99g6b 3 7 oxygen oxygen NOUN 44558c99g6b 3 8 carriers carrier NOUN 44558c99g6b 3 9 may may AUX 44558c99g6b 3 10 have have VERB 44558c99g6b 3 11 less less ADV 44558c99g6b 3 12 vasoactive vasoactive ADJ 44558c99g6b 3 13 side side NOUN 44558c99g6b 3 14 effects effect NOUN 44558c99g6b 3 15 compared compare VERB 44558c99g6b 3 16 to to ADP 44558c99g6b 3 17 their their PRON 44558c99g6b 3 18 low low ADJ 44558c99g6b 3 19 oxygen oxygen NOUN 44558c99g6b 3 20 affinity affinity NOUN 44558c99g6b 3 21 counterparts counterpart NOUN 44558c99g6b 3 22 and and CCONJ 44558c99g6b 3 23 may may AUX 44558c99g6b 3 24 transport transport VERB 44558c99g6b 3 25 oxygen oxygen NOUN 44558c99g6b 3 26 in in ADP 44558c99g6b 3 27 a a DET 44558c99g6b 3 28 more more ADV 44558c99g6b 3 29 physiological physiological ADJ 44558c99g6b 3 30 manner manner NOUN 44558c99g6b 3 31 . . PUNCT 44558c99g6b 4 1 in in ADP 44558c99g6b 4 2 this this DET 44558c99g6b 4 3 study study NOUN 44558c99g6b 4 4 , , PUNCT 44558c99g6b 4 5 a a DET 44558c99g6b 4 6 parallel parallel ADJ 44558c99g6b 4 7 synthetic synthetic ADJ 44558c99g6b 4 8 approach approach NOUN 44558c99g6b 4 9 was be AUX 44558c99g6b 4 10 used use VERB 44558c99g6b 4 11 to to PART 44558c99g6b 4 12 produce produce VERB 44558c99g6b 4 13 a a DET 44558c99g6b 4 14 small small ADJ 44558c99g6b 4 15 library library NOUN 44558c99g6b 4 16 of of ADP 44558c99g6b 4 17 oxygen oxygen NOUN 44558c99g6b 4 18 carriers carrier NOUN 44558c99g6b 4 19 by by ADP 44558c99g6b 4 20 cross cross ADJ 44558c99g6b 4 21 - - ADJ 44558c99g6b 4 22 linking link VERB 44558c99g6b 4 23 / / SYM 44558c99g6b 4 24 polymerizing polymerizing NOUN 44558c99g6b 4 25 bovine bovine NOUN 44558c99g6b 4 26 hemoglobin hemoglobin NOUN 44558c99g6b 4 27 ( ( PUNCT 44558c99g6b 4 28 hb hb PROPN 44558c99g6b 4 29 ) ) PUNCT 44558c99g6b 4 30 with with ADP 44558c99g6b 4 31 glutaraldehyde glutaraldehyde PROPN 44558c99g6b 4 32 and and CCONJ 44558c99g6b 4 33 ring ring NOUN 44558c99g6b 4 34 - - PUNCT 44558c99g6b 4 35 opened open VERB 44558c99g6b 4 36 saccharides saccharide NOUN 44558c99g6b 4 37 . . PUNCT 44558c99g6b 5 1 the the DET 44558c99g6b 5 2 type type NOUN 44558c99g6b 5 3 and and CCONJ 44558c99g6b 5 4 concentration concentration NOUN 44558c99g6b 5 5 of of ADP 44558c99g6b 5 6 cross cross ADJ 44558c99g6b 5 7 - - ADJ 44558c99g6b 5 8 linker linker ADJ 44558c99g6b 5 9 and and CCONJ 44558c99g6b 5 10 quenching quench VERB 44558c99g6b 5 11 agent agent NOUN 44558c99g6b 5 12 , , PUNCT 44558c99g6b 5 13 as as ADV 44558c99g6b 5 14 well well ADV 44558c99g6b 5 15 as as ADP 44558c99g6b 5 16 reaction reaction NOUN 44558c99g6b 5 17 time time NOUN 44558c99g6b 5 18 , , PUNCT 44558c99g6b 5 19 were be AUX 44558c99g6b 5 20 all all PRON 44558c99g6b 5 21 manipulated manipulate VERB 44558c99g6b 5 22 to to PART 44558c99g6b 5 23 yield yield VERB 44558c99g6b 5 24 oxygen oxygen NOUN 44558c99g6b 5 25 carriers carrier NOUN 44558c99g6b 5 26 with with ADP 44558c99g6b 5 27 various various ADJ 44558c99g6b 5 28 molecular molecular ADJ 44558c99g6b 5 29 weight weight NOUN 44558c99g6b 5 30 distributions distribution NOUN 44558c99g6b 5 31 and and CCONJ 44558c99g6b 5 32 oxygen oxygen NOUN 44558c99g6b 5 33 binding bind VERB 44558c99g6b 5 34 properties property NOUN 44558c99g6b 5 35 . . PUNCT 44558c99g6b 6 1 a a DET 44558c99g6b 6 2 high high ADJ 44558c99g6b 6 3 degree degree NOUN 44558c99g6b 6 4 of of ADP 44558c99g6b 6 5 hb hb PROPN 44558c99g6b 6 6 cross cross PROPN 44558c99g6b 6 7 - - ADJ 44558c99g6b 6 8 linking link VERB 44558c99g6b 6 9 with with ADP 44558c99g6b 6 10 glutaraldehyde glutaraldehyde PROPN 44558c99g6b 6 11 resulted result VERB 44558c99g6b 6 12 in in ADP 44558c99g6b 6 13 the the DET 44558c99g6b 6 14 synthesis synthesis NOUN 44558c99g6b 6 15 of of ADP 44558c99g6b 6 16 polymerized polymerized ADJ 44558c99g6b 6 17 hb hb PROPN 44558c99g6b 6 18 ( ( PUNCT 44558c99g6b 6 19 polyhb polyhb PROPN 44558c99g6b 6 20 ) ) PUNCT 44558c99g6b 6 21 dispersions dispersion NOUN 44558c99g6b 6 22 with with ADP 44558c99g6b 6 23 low low ADJ 44558c99g6b 6 24 p50s p50s PROPN 44558c99g6b 6 25 ( ( PUNCT 44558c99g6b 6 26 < < X 44558c99g6b 6 27 26 26 NUM 44558c99g6b 6 28 mmhg mmhg NOUN 44558c99g6b 6 29 ) ) PUNCT 44558c99g6b 6 30 , , PUNCT 44558c99g6b 6 31 low low PROPN 44558c99g6b 6 32 hill hill NOUN 44558c99g6b 6 33 coefficients coefficient NOUN 44558c99g6b 6 34 ( ( PUNCT 44558c99g6b 6 35 < < X 44558c99g6b 6 36 2.3 2.3 NUM 44558c99g6b 6 37 ) ) PUNCT 44558c99g6b 6 38 , , PUNCT 44558c99g6b 6 39 and and CCONJ 44558c99g6b 6 40 high high ADJ 44558c99g6b 6 41 methemoglobin methemoglobin ADJ 44558c99g6b 6 42 ( ( PUNCT 44558c99g6b 6 43 methb methb ADJ 44558c99g6b 6 44 ) ) PUNCT 44558c99g6b 6 45 levels level NOUN 44558c99g6b 6 46 ( ( PUNCT 44558c99g6b 6 47 > > X 44558c99g6b 6 48 10 10 NUM 44558c99g6b 6 49 % % NOUN 44558c99g6b 6 50 ) ) PUNCT 44558c99g6b 6 51 . . PUNCT 44558c99g6b 7 1 in in ADP 44558c99g6b 7 2 this this DET 44558c99g6b 7 3 work work NOUN 44558c99g6b 7 4 , , PUNCT 44558c99g6b 7 5 the the DET 44558c99g6b 7 6 high high ADJ 44558c99g6b 7 7 methb methb ADJ 44558c99g6b 7 8 level level NOUN 44558c99g6b 7 9 of of ADP 44558c99g6b 7 10 glutaraldehyde glutaraldehyde PROPN 44558c99g6b 7 11 polyhb polyhb PROPN 44558c99g6b 7 12 dispersions dispersion NOUN 44558c99g6b 7 13 was be AUX 44558c99g6b 7 14 countered counter VERB 44558c99g6b 7 15 by by ADP 44558c99g6b 7 16 reducing reduce VERB 44558c99g6b 7 17 the the DET 44558c99g6b 7 18 polyhb polyhb PROPN 44558c99g6b 7 19 dispersions dispersion NOUN 44558c99g6b 7 20 post post VERB 44558c99g6b 7 21 - - NOUN 44558c99g6b 7 22 reaction reaction NOUN 44558c99g6b 7 23 with with ADP 44558c99g6b 7 24 ascorbic ascorbic ADJ 44558c99g6b 7 25 acid acid NOUN 44558c99g6b 7 26 . . PUNCT 44558c99g6b 8 1 utilization utilization NOUN 44558c99g6b 8 2 of of ADP 44558c99g6b 8 3 ring ring NOUN 44558c99g6b 8 4 - - PUNCT 44558c99g6b 8 5 opened open VERB 44558c99g6b 8 6 saccharides saccharide NOUN 44558c99g6b 8 7 as as SCONJ 44558c99g6b 8 8 hb hb PROPN 44558c99g6b 8 9 cross cross ADJ 44558c99g6b 8 10 - - ADJ 44558c99g6b 8 11 linking linking ADJ 44558c99g6b 8 12 reagents reagent NOUN 44558c99g6b 8 13 resulted result VERB 44558c99g6b 8 14 in in ADP 44558c99g6b 8 15 polyhb polyhb PROPN 44558c99g6b 8 16 dispersions dispersion NOUN 44558c99g6b 8 17 with with ADP 44558c99g6b 8 18 even even ADV 44558c99g6b 8 19 lower low ADJ 44558c99g6b 8 20 p50s p50s PROPN 44558c99g6b 8 21 ( ( PUNCT 44558c99g6b 8 22 ~7 ~7 NUM 44558c99g6b 8 23 - - SYM 44558c99g6b 8 24 9 9 NUM 44558c99g6b 8 25 mmhg mmhg NOUN 44558c99g6b 8 26 ) ) PUNCT 44558c99g6b 8 27 compared compare VERB 44558c99g6b 8 28 to to ADP 44558c99g6b 8 29 glutaraldehyde glutaraldehyde PROPN 44558c99g6b 8 30 polyhb polyhb PROPN 44558c99g6b 8 31 dispersions dispersion NOUN 44558c99g6b 8 32 . . PUNCT 44558c99g6b 9 1 in in ADP 44558c99g6b 9 2 fact fact NOUN 44558c99g6b 9 3 , , PUNCT 44558c99g6b 9 4 o o X 44558c99g6b 9 5 - - X 44558c99g6b 9 6 methylglucopyranoside methylglucopyranoside PROPN 44558c99g6b 9 7 showed show VERB 44558c99g6b 9 8 the the DET 44558c99g6b 9 9 most most ADJ 44558c99g6b 9 10 promise promise NOUN 44558c99g6b 9 11 as as ADP 44558c99g6b 9 12 an an DET 44558c99g6b 9 13 hb hb PROPN 44558c99g6b 9 14 cross cross ADJ 44558c99g6b 9 15 - - ADJ 44558c99g6b 9 16 linking link VERB 44558c99g6b 9 17 reagent reagent NOUN 44558c99g6b 9 18 and and CCONJ 44558c99g6b 9 19 resulted result VERB 44558c99g6b 9 20 in in ADP 44558c99g6b 9 21 a a DET 44558c99g6b 9 22 higher high ADJ 44558c99g6b 9 23 degree degree NOUN 44558c99g6b 9 24 of of ADP 44558c99g6b 9 25 hb hb PROPN 44558c99g6b 9 26 cross cross PROPN 44558c99g6b 9 27 - - ADJ 44558c99g6b 9 28 linking linking ADJ 44558c99g6b 9 29 and and CCONJ 44558c99g6b 9 30 lower low ADJ 44558c99g6b 9 31 methb methb ADJ 44558c99g6b 9 32 levels level NOUN 44558c99g6b 9 33 compared compare VERB 44558c99g6b 9 34 to to ADP 44558c99g6b 9 35 other other ADJ 44558c99g6b 9 36 ring ring NOUN 44558c99g6b 9 37 - - PUNCT 44558c99g6b 9 38 opened open VERB 44558c99g6b 9 39 saccharides saccharide NOUN 44558c99g6b 9 40 . . PUNCT 44558c99g6b 10 1 polymerization polymerization NOUN 44558c99g6b 10 2 of of ADP 44558c99g6b 10 3 bovine bovine PROPN 44558c99g6b 10 4 hb hb PROPN 44558c99g6b 10 5 with with ADP 44558c99g6b 10 6 glutaraldehyde glutaraldehyde PROPN 44558c99g6b 10 7 resulted result VERB 44558c99g6b 10 8 in in ADP 44558c99g6b 10 9 decreased decrease VERB 44558c99g6b 10 10 allosteric allosteric NOUN 44558c99g6b 10 11 effects effect NOUN 44558c99g6b 10 12 of of ADP 44558c99g6b 10 13 ph ph NOUN 44558c99g6b 10 14 and and CCONJ 44558c99g6b 10 15 clon clon VERB 44558c99g6b 10 16 the the DET 44558c99g6b 10 17 oxygen oxygen NOUN 44558c99g6b 10 18 binding bind VERB 44558c99g6b 10 19 properties property NOUN 44558c99g6b 10 20 of of ADP 44558c99g6b 10 21 polyhb polyhb PROPN 44558c99g6b 10 22 dispersions dispersion NOUN 44558c99g6b 10 23 , , PUNCT 44558c99g6b 10 24 although although SCONJ 44558c99g6b 10 25 it it PRON 44558c99g6b 10 26 was be AUX 44558c99g6b 10 27 not not PART 44558c99g6b 10 28 completely completely ADV 44558c99g6b 10 29 abolished abolish VERB 44558c99g6b 10 30 . . PUNCT 44558c99g6b 11 1 modeling model VERB 44558c99g6b 11 2 the the DET 44558c99g6b 11 3 oxygen oxygen NOUN 44558c99g6b 11 4 transporting transport VERB 44558c99g6b 11 5 ability ability NOUN 44558c99g6b 11 6 of of ADP 44558c99g6b 11 7 these these DET 44558c99g6b 11 8 oxygen oxygen NOUN 44558c99g6b 11 9 carriers carrier NOUN 44558c99g6b 11 10 in in ADP 44558c99g6b 11 11 a a DET 44558c99g6b 11 12 human human ADJ 44558c99g6b 11 13 capillary capillary NOUN 44558c99g6b 11 14 showed show VERB 44558c99g6b 11 15 that that SCONJ 44558c99g6b 11 16 a a DET 44558c99g6b 11 17 moderately moderately ADV 44558c99g6b 11 18 low low ADJ 44558c99g6b 11 19 p50 p50 NOUN 44558c99g6b 11 20 ( ( PUNCT 44558c99g6b 11 21 such such ADJ 44558c99g6b 11 22 as as ADP 44558c99g6b 11 23 18 18 NUM 44558c99g6b 11 24 mmhg mmhg NOUN 44558c99g6b 11 25 ) ) PUNCT 44558c99g6b 11 26 oxygen oxygen NOUN 44558c99g6b 11 27 carrier carrier NOUN 44558c99g6b 11 28 delivered deliver VERB 44558c99g6b 11 29 oxygen oxygen NOUN 44558c99g6b 11 30 more more ADV 44558c99g6b 11 31 consistently consistently ADV 44558c99g6b 11 32 over over ADP 44558c99g6b 11 33 a a DET 44558c99g6b 11 34 wide wide ADJ 44558c99g6b 11 35 range range NOUN 44558c99g6b 11 36 of of ADP 44558c99g6b 11 37 hypoxic hypoxic NOUN 44558c99g6b 12 1 po2 po2 NOUN 44558c99g6b 12 2 levels level NOUN 44558c99g6b 12 3 . . PUNCT 44558c99g6b 13 1 in in ADP 44558c99g6b 13 2 contrast contrast NOUN 44558c99g6b 13 3 , , PUNCT 44558c99g6b 13 4 very very ADV 44558c99g6b 13 5 low low ADJ 44558c99g6b 13 6 p50 p50 NOUN 44558c99g6b 13 7 ( ( PUNCT 44558c99g6b 13 8 such such ADJ 44558c99g6b 13 9 as as ADP 44558c99g6b 13 10 6 6 NUM 44558c99g6b 13 11 or or CCONJ 44558c99g6b 13 12 13 13 NUM 44558c99g6b 13 13 mmhg mmhg NOUN 44558c99g6b 13 14 ) ) PUNCT 44558c99g6b 13 15 oxygen oxygen NOUN 44558c99g6b 13 16 carriers carrier NOUN 44558c99g6b 13 17 specifically specifically ADV 44558c99g6b 13 18 target target VERB 44558c99g6b 13 19 oxygen oxygen NOUN 44558c99g6b 13 20 delivery delivery NOUN 44558c99g6b 13 21 to to ADP 44558c99g6b 13 22 tissues tissue NOUN 44558c99g6b 13 23 with with ADP 44558c99g6b 13 24 low low ADJ 44558c99g6b 13 25 oxygen oxygen NOUN 44558c99g6b 13 26 tensions tension NOUN 44558c99g6b 13 27 , , PUNCT 44558c99g6b 13 28 which which PRON 44558c99g6b 13 29 are be AUX 44558c99g6b 13 30 observed observe VERB 44558c99g6b 13 31 clinically clinically ADV 44558c99g6b 13 32 in in ADP 44558c99g6b 13 33 cases case NOUN 44558c99g6b 13 34 of of ADP 44558c99g6b 13 35 severe severe ADJ 44558c99g6b 13 36 hypoxia hypoxia NOUN 44558c99g6b 13 37 . . PUNCT