id sid tid token lemma pos 3b59183384s 1 1 the the DET 3b59183384s 1 2 cytoskeleton cytoskeleton NOUN 3b59183384s 1 3 is be AUX 3b59183384s 1 4 a a DET 3b59183384s 1 5 dynamic dynamic ADJ 3b59183384s 1 6 cellular cellular ADJ 3b59183384s 1 7 " " PUNCT 3b59183384s 1 8 scaffold scaffold NOUN 3b59183384s 1 9 " " PUNCT 3b59183384s 1 10 that that PRON 3b59183384s 1 11 is be AUX 3b59183384s 1 12 present present ADJ 3b59183384s 1 13 in in ADP 3b59183384s 1 14 all all DET 3b59183384s 1 15 eukaryotic eukaryotic ADJ 3b59183384s 1 16 cells cell NOUN 3b59183384s 1 17 . . PUNCT 3b59183384s 2 1 interestingly interestingly ADV 3b59183384s 2 2 , , PUNCT 3b59183384s 2 3 two two NUM 3b59183384s 2 4 major major ADJ 3b59183384s 2 5 cytoskeletal cytoskeletal ADJ 3b59183384s 2 6 elements element NOUN 3b59183384s 2 7 ì¢ ì¢ VERB 3b59183384s 2 8 ââ ââ NOUN 3b59183384s 2 9 " " PUNCT 3b59183384s 2 10 microtubules microtubule NOUN 3b59183384s 2 11 ( ( PUNCT 3b59183384s 2 12 mts mts NOUN 3b59183384s 2 13 ) ) PUNCT 3b59183384s 2 14 and and CCONJ 3b59183384s 2 15 actin actin NOUN 3b59183384s 2 16 ì¢ ì¢ ADJ 3b59183384s 2 17 ââ ââ NOUN 3b59183384s 2 18 " " PUNCT 3b59183384s 2 19 are be AUX 3b59183384s 2 20 crucial crucial ADJ 3b59183384s 2 21 for for ADP 3b59183384s 2 22 the the DET 3b59183384s 2 23 cell cell NOUN 3b59183384s 2 24 survival survival NOUN 3b59183384s 2 25 : : PUNCT 3b59183384s 2 26 mts mts NOUN 3b59183384s 2 27 drive drive VERB 3b59183384s 2 28 essential essential ADJ 3b59183384s 2 29 cell cell NOUN 3b59183384s 2 30 activities activity NOUN 3b59183384s 2 31 ranging range VERB 3b59183384s 2 32 from from ADP 3b59183384s 2 33 separating separate VERB 3b59183384s 2 34 chromosomes chromosome NOUN 3b59183384s 2 35 to to ADP 3b59183384s 2 36 transporting transport VERB 3b59183384s 2 37 large large ADJ 3b59183384s 2 38 particles particle NOUN 3b59183384s 2 39 , , PUNCT 3b59183384s 2 40 while while SCONJ 3b59183384s 2 41 actin actin NOUN 3b59183384s 2 42 filaments filament NOUN 3b59183384s 2 43 provide provide VERB 3b59183384s 2 44 mechanical mechanical ADJ 3b59183384s 2 45 structure structure NOUN 3b59183384s 2 46 and and CCONJ 3b59183384s 2 47 motility motility NOUN 3b59183384s 2 48 . . PUNCT 3b59183384s 3 1 the the DET 3b59183384s 3 2 dynamic dynamic ADJ 3b59183384s 3 3 behavior behavior NOUN 3b59183384s 3 4 of of ADP 3b59183384s 3 5 mts mts NOUN 3b59183384s 3 6 and and CCONJ 3b59183384s 3 7 actin actin NOUN 3b59183384s 3 8 are be AUX 3b59183384s 3 9 separately separately ADV 3b59183384s 3 10 regulated regulate VERB 3b59183384s 3 11 by by ADP 3b59183384s 3 12 two two NUM 3b59183384s 3 13 groups group NOUN 3b59183384s 3 14 of of ADP 3b59183384s 3 15 proteins protein NOUN 3b59183384s 3 16 : : PUNCT 3b59183384s 3 17 mt mt PROPN 3b59183384s 3 18 binding bind VERB 3b59183384s 3 19 proteins protein NOUN 3b59183384s 3 20 ( ( PUNCT 3b59183384s 3 21 mtbps mtbps NOUN 3b59183384s 3 22 ) ) PUNCT 3b59183384s 3 23 and and CCONJ 3b59183384s 3 24 actin actin NOUN 3b59183384s 3 25 binding bind VERB 3b59183384s 3 26 proteins protein NOUN 3b59183384s 3 27 ( ( PUNCT 3b59183384s 3 28 abps abps X 3b59183384s 3 29 ) ) PUNCT 3b59183384s 3 30 . . PUNCT 3b59183384s 4 1 for for SCONJ 3b59183384s 4 2 cells cell NOUN 3b59183384s 4 3 to to PART 3b59183384s 4 4 function function VERB 3b59183384s 4 5 properly properly ADV 3b59183384s 4 6 , , PUNCT 3b59183384s 4 7 actin actin NOUN 3b59183384s 4 8 filaments filament NOUN 3b59183384s 4 9 and and CCONJ 3b59183384s 4 10 mt mt PROPN 3b59183384s 4 11 polymers polymer NOUN 3b59183384s 4 12 must must AUX 3b59183384s 4 13 cooperate cooperate VERB 3b59183384s 4 14 , , PUNCT 3b59183384s 4 15 but but CCONJ 3b59183384s 4 16 the the DET 3b59183384s 4 17 mechanism mechanism NOUN 3b59183384s 4 18 of of ADP 3b59183384s 4 19 " " PUNCT 3b59183384s 4 20 cross cross ADJ 3b59183384s 4 21 - - NOUN 3b59183384s 4 22 talk talk NOUN 3b59183384s 4 23 " " PUNCT 3b59183384s 4 24 between between ADP 3b59183384s 4 25 actin actin NOUN 3b59183384s 4 26 and and CCONJ 3b59183384s 4 27 mt mt PROPN 3b59183384s 4 28 are be AUX 3b59183384s 4 29 as as ADV 3b59183384s 4 30 yet yet ADV 3b59183384s 4 31 poorly poorly ADV 3b59183384s 4 32 understood understand VERB 3b59183384s 4 33 . . PUNCT 3b59183384s 5 1 this this DET 3b59183384s 5 2 thesis thesis NOUN 3b59183384s 5 3 focuses focus VERB 3b59183384s 5 4 on on ADP 3b59183384s 5 5 a a DET 3b59183384s 5 6 unique unique ADJ 3b59183384s 5 7 mt mt PROPN 3b59183384s 5 8 binding bind VERB 3b59183384s 5 9 protein protein NOUN 3b59183384s 5 10 called call VERB 3b59183384s 5 11 eb1 eb1 PROPN 3b59183384s 5 12 , , PUNCT 3b59183384s 5 13 how how SCONJ 3b59183384s 5 14 it it PRON 3b59183384s 5 15 interacts interact VERB 3b59183384s 5 16 with with ADP 3b59183384s 5 17 mts mts NOUN 3b59183384s 5 18 , , PUNCT 3b59183384s 5 19 and and CCONJ 3b59183384s 5 20 our our PRON 3b59183384s 5 21 evidence evidence NOUN 3b59183384s 5 22 demonstrates demonstrate VERB 3b59183384s 5 23 that that SCONJ 3b59183384s 5 24 it it PRON 3b59183384s 5 25 plays play VERB 3b59183384s 5 26 an an DET 3b59183384s 5 27 important important ADJ 3b59183384s 5 28 role role NOUN 3b59183384s 5 29 in in ADP 3b59183384s 5 30 actin actin NOUN 3b59183384s 5 31 - - PUNCT 3b59183384s 5 32 mt mt NOUN 3b59183384s 5 33 cross cross NOUN 3b59183384s 5 34 - - NOUN 3b59183384s 5 35 talk talk NOUN 3b59183384s 5 36 . . PUNCT 3b59183384s 6 1 eb1 eb1 PRON 3b59183384s 6 2 is be AUX 3b59183384s 6 3 a a DET 3b59183384s 6 4 highly highly ADV 3b59183384s 6 5 conserved conserve VERB 3b59183384s 6 6 mt mt PROPN 3b59183384s 6 7 binding bind VERB 3b59183384s 6 8 protein protein NOUN 3b59183384s 6 9 that that PRON 3b59183384s 6 10 dynamic dynamic ADJ 3b59183384s 6 11 tracks track NOUN 3b59183384s 6 12 mt mt PROPN 3b59183384s 6 13 plus plus CCONJ 3b59183384s 6 14 ends end VERB 3b59183384s 6 15 , , PUNCT 3b59183384s 6 16 and and CCONJ 3b59183384s 6 17 it it PRON 3b59183384s 6 18 plays play VERB 3b59183384s 6 19 a a DET 3b59183384s 6 20 pivotal pivotal ADJ 3b59183384s 6 21 role role NOUN 3b59183384s 6 22 in in ADP 3b59183384s 6 23 mt mt PROPN 3b59183384s 6 24 dynamics dynamic NOUN 3b59183384s 6 25 . . PUNCT 3b59183384s 7 1 however however ADV 3b59183384s 7 2 , , PUNCT 3b59183384s 7 3 its its PRON 3b59183384s 7 4 activity activity NOUN 3b59183384s 7 5 and and CCONJ 3b59183384s 7 6 mechanism mechanism NOUN 3b59183384s 7 7 remain remain VERB 3b59183384s 7 8 unclear unclear ADJ 3b59183384s 7 9 , , PUNCT 3b59183384s 7 10 in in ADP 3b59183384s 7 11 part part NOUN 3b59183384s 7 12 because because SCONJ 3b59183384s 7 13 of of ADP 3b59183384s 7 14 variability variability NOUN 3b59183384s 7 15 in in ADP 3b59183384s 7 16 the the DET 3b59183384s 7 17 reported reported ADJ 3b59183384s 7 18 behavior behavior NOUN 3b59183384s 7 19 of of ADP 3b59183384s 7 20 eb1 eb1 PRON 3b59183384s 7 21 in in ADP 3b59183384s 7 22 the the DET 3b59183384s 7 23 literature literature NOUN 3b59183384s 7 24 . . PUNCT 3b59183384s 8 1 we we PRON 3b59183384s 8 2 hypothesized hypothesize VERB 3b59183384s 8 3 that that SCONJ 3b59183384s 8 4 some some PRON 3b59183384s 8 5 of of ADP 3b59183384s 8 6 the the DET 3b59183384s 8 7 variability variability NOUN 3b59183384s 8 8 came come VERB 3b59183384s 8 9 from from ADP 3b59183384s 8 10 differences difference NOUN 3b59183384s 8 11 in in ADP 3b59183384s 8 12 how how SCONJ 3b59183384s 8 13 the the DET 3b59183384s 8 14 eb1 eb1 ADJ 3b59183384s 8 15 proteins protein NOUN 3b59183384s 8 16 were be AUX 3b59183384s 8 17 prepared prepare VERB 3b59183384s 8 18 . . PUNCT 3b59183384s 9 1 in in ADP 3b59183384s 9 2 particular particular ADJ 3b59183384s 9 3 , , PUNCT 3b59183384s 9 4 we we PRON 3b59183384s 9 5 were be AUX 3b59183384s 9 6 concerned concern VERB 3b59183384s 9 7 that that SCONJ 3b59183384s 9 8 purification purification NOUN 3b59183384s 9 9 tags tag NOUN 3b59183384s 9 10 might might AUX 3b59183384s 9 11 influence influence VERB 3b59183384s 9 12 eb1 eb1 ADJ 3b59183384s 9 13 behavior behavior NOUN 3b59183384s 9 14 . . PUNCT 3b59183384s 10 1 the the DET 3b59183384s 10 2 first first ADJ 3b59183384s 10 3 part part NOUN 3b59183384s 10 4 of of ADP 3b59183384s 10 5 this this DET 3b59183384s 10 6 thesis thesis NOUN 3b59183384s 10 7 describes describe VERB 3b59183384s 10 8 my my PRON 3b59183384s 10 9 work work NOUN 3b59183384s 10 10 to to PART 3b59183384s 10 11 determine determine VERB 3b59183384s 10 12 eb1 eb1 ADJ 3b59183384s 10 13 activity activity NOUN 3b59183384s 10 14 by by ADP 3b59183384s 10 15 testing test VERB 3b59183384s 10 16 the the DET 3b59183384s 10 17 interaction interaction NOUN 3b59183384s 10 18 between between ADP 3b59183384s 10 19 native native ADJ 3b59183384s 10 20 ( ( PUNCT 3b59183384s 10 21 untagged untagged ADJ 3b59183384s 10 22 ) ) PUNCT 3b59183384s 10 23 eb1 eb1 PROPN 3b59183384s 10 24 and and CCONJ 3b59183384s 10 25 mt mt PROPN 3b59183384s 10 26 . . PUNCT 3b59183384s 11 1 because because SCONJ 3b59183384s 11 2 eb1 eb1 PRON 3b59183384s 11 3 contains contain VERB 3b59183384s 11 4 a a DET 3b59183384s 11 5 calponin calponin ADJ 3b59183384s 11 6 homology homology NOUN 3b59183384s 11 7 ( ( PUNCT 3b59183384s 11 8 ch ch PROPN 3b59183384s 11 9 ) ) PUNCT 3b59183384s 11 10 domain domain NOUN 3b59183384s 11 11 ( ( PUNCT 3b59183384s 11 12 a a DET 3b59183384s 11 13 domain domain NOUN 3b59183384s 11 14 that that PRON 3b59183384s 11 15 typically typically ADV 3b59183384s 11 16 binds bind VERB 3b59183384s 11 17 actin actin NOUN 3b59183384s 11 18 ) ) PUNCT 3b59183384s 11 19 , , PUNCT 3b59183384s 11 20 we we PRON 3b59183384s 11 21 were be AUX 3b59183384s 11 22 suspicious suspicious ADJ 3b59183384s 11 23 eb1 eb1 ADJ 3b59183384s 11 24 may may AUX 3b59183384s 11 25 interact interact VERB 3b59183384s 11 26 with with ADP 3b59183384s 11 27 the the DET 3b59183384s 11 28 actin actin NOUN 3b59183384s 11 29 . . PUNCT 3b59183384s 12 1 i i PRON 3b59183384s 12 2 address address VERB 3b59183384s 12 3 the the DET 3b59183384s 12 4 interaction interaction NOUN 3b59183384s 12 5 between between ADP 3b59183384s 12 6 eb1 eb1 NUM 3b59183384s 12 7 and and CCONJ 3b59183384s 12 8 actin actin NOUN 3b59183384s 12 9 in in ADP 3b59183384s 12 10 the the DET 3b59183384s 12 11 second second ADJ 3b59183384s 12 12 part part NOUN 3b59183384s 12 13 of of ADP 3b59183384s 12 14 this this DET 3b59183384s 12 15 study study NOUN 3b59183384s 12 16 . . PUNCT 3b59183384s 13 1 to to PART 3b59183384s 13 2 investigate investigate VERB 3b59183384s 13 3 the the DET 3b59183384s 13 4 eb1 eb1 SPACE 3b59183384s 13 5 - - ADJ 3b59183384s 13 6 mt mt NOUN 3b59183384s 13 7 interaction interaction NOUN 3b59183384s 13 8 , , PUNCT 3b59183384s 13 9 we we PRON 3b59183384s 13 10 initially initially ADV 3b59183384s 13 11 used use VERB 3b59183384s 13 12 his his PRON 3b59183384s 13 13 - - PUNCT 3b59183384s 13 14 tagged tagged ADJ 3b59183384s 13 15 eb1 eb1 ADJ 3b59183384s 13 16 proteins protein NOUN 3b59183384s 13 17 . . PUNCT 3b59183384s 14 1 however however ADV 3b59183384s 14 2 , , PUNCT 3b59183384s 14 3 we we PRON 3b59183384s 14 4 found find VERB 3b59183384s 14 5 that that SCONJ 3b59183384s 14 6 the the DET 3b59183384s 14 7 activities activity NOUN 3b59183384s 14 8 of of ADP 3b59183384s 14 9 his his PRON 3b59183384s 14 10 - - PUNCT 3b59183384s 14 11 tagged tag VERB 3b59183384s 14 12 proteins protein NOUN 3b59183384s 14 13 were be AUX 3b59183384s 14 14 significantly significantly ADV 3b59183384s 14 15 different different ADJ 3b59183384s 14 16 from from ADP 3b59183384s 14 17 the the DET 3b59183384s 14 18 proteins protein NOUN 3b59183384s 14 19 with with ADP 3b59183384s 14 20 the the DET 3b59183384s 14 21 his his PRON 3b59183384s 14 22 - - PUNCT 3b59183384s 14 23 tags tag NOUN 3b59183384s 14 24 removed remove VERB 3b59183384s 14 25 . . PUNCT 3b59183384s 15 1 this this DET 3b59183384s 15 2 result result NOUN 3b59183384s 15 3 suggested suggest VERB 3b59183384s 15 4 that that SCONJ 3b59183384s 15 5 the the DET 3b59183384s 15 6 his his PRON 3b59183384s 15 7 - - PUNCT 3b59183384s 15 8 tag tag NOUN 3b59183384s 15 9 could could AUX 3b59183384s 15 10 influence influence VERB 3b59183384s 15 11 eb1 eb1 ADJ 3b59183384s 15 12 activity activity NOUN 3b59183384s 15 13 . . PUNCT 3b59183384s 16 1 to to PART 3b59183384s 16 2 resolve resolve VERB 3b59183384s 16 3 this this DET 3b59183384s 16 4 issue issue NOUN 3b59183384s 16 5 and and CCONJ 3b59183384s 16 6 define define VERB 3b59183384s 16 7 the the DET 3b59183384s 16 8 native native ADJ 3b59183384s 16 9 eb1 eb1 ADJ 3b59183384s 16 10 activity activity NOUN 3b59183384s 16 11 , , PUNCT 3b59183384s 16 12 we we PRON 3b59183384s 16 13 developed develop VERB 3b59183384s 16 14 a a DET 3b59183384s 16 15 de de X 3b59183384s 16 16 novo novo X 3b59183384s 16 17 purification purification NOUN 3b59183384s 16 18 strategy strategy NOUN 3b59183384s 16 19 for for ADP 3b59183384s 16 20 eb1 eb1 PRON 3b59183384s 16 21 proteins protein NOUN 3b59183384s 16 22 and and CCONJ 3b59183384s 16 23 successfully successfully ADV 3b59183384s 16 24 purified purify VERB 3b59183384s 16 25 several several ADJ 3b59183384s 16 26 native native ADJ 3b59183384s 16 27 ( ( PUNCT 3b59183384s 16 28 untagged untagged ADJ 3b59183384s 16 29 ) ) PUNCT 3b59183384s 16 30 eb1 eb1 PROPN 3b59183384s 16 31 constructs construct NOUN 3b59183384s 16 32 . . PUNCT 3b59183384s 17 1 we we PRON 3b59183384s 17 2 found find VERB 3b59183384s 17 3 that that SCONJ 3b59183384s 17 4 n n NOUN 3b59183384s 17 5 - - ADJ 3b59183384s 17 6 terminal terminal VERB 3b59183384s 17 7 his his PRON 3b59183384s 17 8 - - PUNCT 3b59183384s 17 9 tags tag NOUN 3b59183384s 17 10 does do AUX 3b59183384s 17 11 directly directly ADV 3b59183384s 17 12 influence influence VERB 3b59183384s 17 13 the the DET 3b59183384s 17 14 interaction interaction NOUN 3b59183384s 17 15 between between ADP 3b59183384s 17 16 eb1 eb1 NUM 3b59183384s 17 17 and and CCONJ 3b59183384s 17 18 mts mts NOUN 3b59183384s 17 19 , , PUNCT 3b59183384s 17 20 significantly significantly ADV 3b59183384s 17 21 increasing increase VERB 3b59183384s 17 22 both both PRON 3b59183384s 17 23 affinity affinity NOUN 3b59183384s 17 24 and and CCONJ 3b59183384s 17 25 activity activity NOUN 3b59183384s 17 26 . . PUNCT 3b59183384s 18 1 moreover moreover ADV 3b59183384s 18 2 , , PUNCT 3b59183384s 18 3 we we PRON 3b59183384s 18 4 also also ADV 3b59183384s 18 5 noticed notice VERB 3b59183384s 18 6 that that SCONJ 3b59183384s 18 7 the the DET 3b59183384s 18 8 binding bind VERB 3b59183384s 18 9 ratio ratio NOUN 3b59183384s 18 10 between between ADP 3b59183384s 18 11 eb1 eb1 PRON 3b59183384s 18 12 and and CCONJ 3b59183384s 18 13 tubulin tubulin NOUN 3b59183384s 18 14 can can AUX 3b59183384s 18 15 exceed exceed VERB 3b59183384s 18 16 1:1 1:1 NUM 3b59183384s 18 17 , , PUNCT 3b59183384s 18 18 and and CCONJ 3b59183384s 18 19 eb1 eb1 PUNCT 3b59183384s 18 20 - - ADJ 3b59183384s 18 21 mt mt ADJ 3b59183384s 18 22 binding binding ADJ 3b59183384s 18 23 curves curve NOUN 3b59183384s 18 24 do do AUX 3b59183384s 18 25 not not PART 3b59183384s 18 26 fit fit VERB 3b59183384s 18 27 simple simple ADJ 3b59183384s 18 28 binding bind VERB 3b59183384s 18 29 models model NOUN 3b59183384s 18 30 . . PUNCT 3b59183384s 19 1 all all DET 3b59183384s 19 2 these these DET 3b59183384s 19 3 observations observation NOUN 3b59183384s 19 4 demonstrate demonstrate VERB 3b59183384s 19 5 that that SCONJ 3b59183384s 19 6 eb1 eb1 PRON 3b59183384s 19 7 binding bind VERB 3b59183384s 19 8 is be AUX 3b59183384s 19 9 not not PART 3b59183384s 19 10 limited limit VERB 3b59183384s 19 11 to to ADP 3b59183384s 19 12 the the DET 3b59183384s 19 13 mt mt PROPN 3b59183384s 19 14 seam seam NOUN 3b59183384s 19 15 ( ( PUNCT 3b59183384s 19 16 as as SCONJ 3b59183384s 19 17 had have AUX 3b59183384s 19 18 been be AUX 3b59183384s 19 19 implied imply VERB 3b59183384s 19 20 by by ADP 3b59183384s 19 21 previous previous ADJ 3b59183384s 19 22 studies study NOUN 3b59183384s 19 23 ) ) PUNCT 3b59183384s 19 24 , , PUNCT 3b59183384s 19 25 and and CCONJ 3b59183384s 19 26 they they PRON 3b59183384s 19 27 suggest suggest VERB 3b59183384s 19 28 that that SCONJ 3b59183384s 19 29 eb1 eb1 PRON 3b59183384s 19 30 binds bind VERB 3b59183384s 19 31 cooperatively cooperatively ADV 3b59183384s 19 32 to to ADP 3b59183384s 19 33 mts mts VERB 3b59183384s 19 34 . . PUNCT 3b59183384s 20 1 we we PRON 3b59183384s 20 2 believed believe VERB 3b59183384s 20 3 that that SCONJ 3b59183384s 20 4 these these DET 3b59183384s 20 5 binding bind VERB 3b59183384s 20 6 relationships relationship NOUN 3b59183384s 20 7 are be AUX 3b59183384s 20 8 important important ADJ 3b59183384s 20 9 for for ADP 3b59183384s 20 10 helping help VERB 3b59183384s 20 11 to to PART 3b59183384s 20 12 elucidate elucidate VERB 3b59183384s 20 13 the the DET 3b59183384s 20 14 complex complex NOUN 3b59183384s 20 15 of of ADP 3b59183384s 20 16 proteins protein NOUN 3b59183384s 20 17 at at ADP 3b59183384s 20 18 the the DET 3b59183384s 20 19 mt mt PROPN 3b59183384s 20 20 tip tip NOUN 3b59183384s 20 21 . . PUNCT 3b59183384s 21 1 to to PART 3b59183384s 21 2 address address VERB 3b59183384s 21 3 the the DET 3b59183384s 21 4 interaction interaction NOUN 3b59183384s 21 5 between between ADP 3b59183384s 21 6 eb1 eb1 NUM 3b59183384s 21 7 and and CCONJ 3b59183384s 21 8 actin actin NOUN 3b59183384s 21 9 , , PUNCT 3b59183384s 21 10 similar similar ADJ 3b59183384s 21 11 strategies strategy NOUN 3b59183384s 21 12 were be AUX 3b59183384s 21 13 used use VERB 3b59183384s 21 14 as as ADP 3b59183384s 21 15 in in ADP 3b59183384s 21 16 our our PRON 3b59183384s 21 17 previous previous ADJ 3b59183384s 21 18 eb1 eb1 SPACE 3b59183384s 21 19 - - PUNCT 3b59183384s 21 20 mt mt PROPN 3b59183384s 21 21 studies study NOUN 3b59183384s 21 22 . . PUNCT 3b59183384s 22 1 remarkably remarkably ADV 3b59183384s 22 2 , , PUNCT 3b59183384s 22 3 we we PRON 3b59183384s 22 4 discovered discover VERB 3b59183384s 22 5 that that SCONJ 3b59183384s 22 6 eb1 eb1 PRON 3b59183384s 22 7 is be AUX 3b59183384s 22 8 able able ADJ 3b59183384s 22 9 to to PART 3b59183384s 22 10 directly directly ADV 3b59183384s 22 11 bind bind VERB 3b59183384s 22 12 to to ADP 3b59183384s 22 13 actin actin NOUN 3b59183384s 22 14 filaments filament NOUN 3b59183384s 22 15 , , PUNCT 3b59183384s 22 16 and and CCONJ 3b59183384s 22 17 it it PRON 3b59183384s 22 18 also also ADV 3b59183384s 22 19 greatly greatly ADV 3b59183384s 22 20 promotes promote VERB 3b59183384s 22 21 actin actin NOUN 3b59183384s 22 22 polymerization polymerization NOUN 3b59183384s 22 23 . . PUNCT 3b59183384s 23 1 this this PRON 3b59183384s 23 2 was be AUX 3b59183384s 23 3 surprising surprising ADJ 3b59183384s 23 4 because because SCONJ 3b59183384s 23 5 up up ADP 3b59183384s 23 6 to to ADP 3b59183384s 23 7 this this DET 3b59183384s 23 8 time time NOUN 3b59183384s 23 9 , , PUNCT 3b59183384s 23 10 all all DET 3b59183384s 23 11 studies study NOUN 3b59183384s 23 12 of of ADP 3b59183384s 23 13 eb1 eb1 PRON 3b59183384s 23 14 had have AUX 3b59183384s 23 15 focused focus VERB 3b59183384s 23 16 it it PRON 3b59183384s 23 17 is be AUX 3b59183384s 23 18 mt mt PROPN 3b59183384s 23 19 - - PUNCT 3b59183384s 23 20 related relate VERB 3b59183384s 23 21 functions function NOUN 3b59183384s 23 22 . . PUNCT 3b59183384s 24 1 moreover moreover ADV 3b59183384s 24 2 , , PUNCT 3b59183384s 24 3 we we PRON 3b59183384s 24 4 found find VERB 3b59183384s 24 5 that that SCONJ 3b59183384s 24 6 the the DET 3b59183384s 24 7 interaction interaction NOUN 3b59183384s 24 8 between between ADP 3b59183384s 24 9 eb1 eb1 PRON 3b59183384s 24 10 and and CCONJ 3b59183384s 24 11 actin actin NOUN 3b59183384s 24 12 is be AUX 3b59183384s 24 13 mediated mediate VERB 3b59183384s 24 14 by by ADP 3b59183384s 24 15 the the DET 3b59183384s 24 16 eb1 eb1 ADJ 3b59183384s 24 17 ch ch NOUN 3b59183384s 24 18 - - PUNCT 3b59183384s 24 19 domain domain NOUN 3b59183384s 24 20 , , PUNCT 3b59183384s 24 21 which which PRON 3b59183384s 24 22 is be AUX 3b59183384s 24 23 responsible responsible ADJ 3b59183384s 24 24 for for ADP 3b59183384s 24 25 eb1 eb1 SPACE 3b59183384s 24 26 - - PUNCT 3b59183384s 24 27 mt mt PROPN 3b59183384s 24 28 interactions interaction NOUN 3b59183384s 24 29 . . PUNCT 3b59183384s 25 1 interestingly interestingly ADV 3b59183384s 25 2 , , PUNCT 3b59183384s 25 3 the the DET 3b59183384s 25 4 binding binding NOUN 3b59183384s 25 5 of of ADP 3b59183384s 25 6 eb1 eb1 PRON 3b59183384s 25 7 to to PART 3b59183384s 25 8 actin actin NOUN 3b59183384s 25 9 , , PUNCT 3b59183384s 25 10 like like ADP 3b59183384s 25 11 mt mt PROPN 3b59183384s 25 12 - - PUNCT 3b59183384s 25 13 binding binding PROPN 3b59183384s 25 14 , , PUNCT 3b59183384s 25 15 is be AUX 3b59183384s 25 16 auto auto NOUN 3b59183384s 25 17 - - PUNCT 3b59183384s 25 18 inhibited inhibit VERB 3b59183384s 25 19 by by ADP 3b59183384s 25 20 the the DET 3b59183384s 25 21 eb1 eb1 ADJ 3b59183384s 25 22 c c NOUN 3b59183384s 25 23 - - PUNCT 3b59183384s 25 24 terminal terminal ADJ 3b59183384s 25 25 tail tail NOUN 3b59183384s 25 26 . . PUNCT 3b59183384s 26 1 these these DET 3b59183384s 26 2 data datum NOUN 3b59183384s 26 3 provide provide VERB 3b59183384s 26 4 evidence evidence NOUN 3b59183384s 26 5 that that SCONJ 3b59183384s 26 6 eb1 eb1 PRON 3b59183384s 26 7 can can AUX 3b59183384s 26 8 directly directly ADV 3b59183384s 26 9 regulate regulate VERB 3b59183384s 26 10 actin actin NOUN 3b59183384s 26 11 - - PUNCT 3b59183384s 26 12 mediated mediate VERB 3b59183384s 26 13 processes process NOUN 3b59183384s 26 14 . . PUNCT 3b59183384s 27 1 since since SCONJ 3b59183384s 27 2 eb1 eb1 PRON 3b59183384s 27 3 has have VERB 3b59183384s 27 4 such such DET 3b59183384s 27 5 an an DET 3b59183384s 27 6 important important ADJ 3b59183384s 27 7 and and CCONJ 3b59183384s 27 8 conserved conserved ADJ 3b59183384s 27 9 role role NOUN 3b59183384s 27 10 in in ADP 3b59183384s 27 11 mt mt PROPN 3b59183384s 27 12 dynamics dynamic NOUN 3b59183384s 27 13 , , PUNCT 3b59183384s 27 14 these these DET 3b59183384s 27 15 observations observation NOUN 3b59183384s 27 16 suggest suggest VERB 3b59183384s 27 17 that that SCONJ 3b59183384s 27 18 eb1 eb1 PRON 3b59183384s 27 19 might might AUX 3b59183384s 27 20 have have VERB 3b59183384s 27 21 a a DET 3b59183384s 27 22 role role NOUN 3b59183384s 27 23 in in ADP 3b59183384s 27 24 actin actin NOUN 3b59183384s 27 25 - - PUNCT 3b59183384s 27 26 mt mt PROPN 3b59183384s 27 27 coordination coordination NOUN 3b59183384s 27 28 . . PUNCT