id sid tid token lemma pos 3b591833765 1 1 a a DET 3b591833765 1 2 look look NOUN 3b591833765 1 3 at at ADP 3b591833765 1 4 the the DET 3b591833765 1 5 phylogenetically phylogenetically ADV 3b591833765 1 6 widespread widespread ADJ 3b591833765 1 7 class class NOUN 3b591833765 1 8 of of ADP 3b591833765 1 9 flavin flavin NOUN 3b591833765 1 10 - - PUNCT 3b591833765 1 11 dependent dependent ADJ 3b591833765 1 12 monooxygenases monooxygenase NOUN 3b591833765 1 13 shows show VERB 3b591833765 1 14 that that SCONJ 3b591833765 1 15 little little ADJ 3b591833765 1 16 is be AUX 3b591833765 1 17 known know VERB 3b591833765 1 18 of of ADP 3b591833765 1 19 those those PRON 3b591833765 1 20 involved involve VERB 3b591833765 1 21 in in ADP 3b591833765 1 22 biosynthetic biosynthetic ADJ 3b591833765 1 23 pathways pathway NOUN 3b591833765 1 24 . . PUNCT 3b591833765 2 1 two two NUM 3b591833765 2 2 homologous homologous ADJ 3b591833765 2 3 flavin flavin NOUN 3b591833765 2 4 - - PUNCT 3b591833765 2 5 dependent dependent ADJ 3b591833765 2 6 enzymes enzyme NOUN 3b591833765 2 7 described describe VERB 3b591833765 2 8 in in ADP 3b591833765 2 9 this this DET 3b591833765 2 10 work work NOUN 3b591833765 2 11 , , PUNCT 3b591833765 2 12 ornithine ornithine NOUN 3b591833765 2 13 monooxygenase monooxygenase NOUN 3b591833765 2 14 ( ( PUNCT 3b591833765 2 15 omo omo PROPN 3b591833765 2 16 ) ) PUNCT 3b591833765 2 17 from from ADP 3b591833765 2 18 aspergillus aspergillus NOUN 3b591833765 2 19 fumigatus fumigatus NOUN 3b591833765 2 20 and and CCONJ 3b591833765 2 21 lysine lysine NOUN 3b591833765 2 22 monooxygenase monooxygenase NOUN 3b591833765 2 23 ( ( PUNCT 3b591833765 2 24 lmo lmo PROPN 3b591833765 2 25 ) ) PUNCT 3b591833765 2 26 from from ADP 3b591833765 2 27 klebsiella klebsiella PROPN 3b591833765 2 28 pneumoniae pneumoniae NOUN 3b591833765 2 29 , , PUNCT 3b591833765 2 30 initiate initiate VERB 3b591833765 2 31 hydroxamate hydroxamate ADJ 3b591833765 2 32 siderophore siderophore NOUN 3b591833765 2 33 biosynthesis biosynthesis NOUN 3b591833765 2 34 in in ADP 3b591833765 2 35 their their PRON 3b591833765 2 36 respective respective ADJ 3b591833765 2 37 pathogens pathogen NOUN 3b591833765 2 38 . . PUNCT 3b591833765 3 1 understanding understand VERB 3b591833765 3 2 how how SCONJ 3b591833765 3 3 the the DET 3b591833765 3 4 enzyme enzyme NOUN 3b591833765 3 5 class class NOUN 3b591833765 3 6 functions function NOUN 3b591833765 3 7 could could AUX 3b591833765 3 8 lead lead VERB 3b591833765 3 9 to to ADP 3b591833765 3 10 design design NOUN 3b591833765 3 11 of of ADP 3b591833765 3 12 rational rational ADJ 3b591833765 3 13 inhibitors inhibitor NOUN 3b591833765 3 14 to to PART 3b591833765 3 15 be be AUX 3b591833765 3 16 used use VERB 3b591833765 3 17 for for ADP 3b591833765 3 18 the the DET 3b591833765 3 19 eradication eradication NOUN 3b591833765 3 20 of of ADP 3b591833765 3 21 hydroxamate hydroxamate ADJ 3b591833765 3 22 siderophore siderophore NOUN 3b591833765 3 23 - - PUNCT 3b591833765 3 24 producing produce VERB 3b591833765 3 25 pathogens pathogen NOUN 3b591833765 3 26 . . PUNCT 3b591833765 4 1 at at ADP 3b591833765 4 2 the the DET 3b591833765 4 3 inception inception NOUN 3b591833765 4 4 of of ADP 3b591833765 4 5 this this DET 3b591833765 4 6 project project NOUN 3b591833765 4 7 , , PUNCT 3b591833765 4 8 the the DET 3b591833765 4 9 omo omo PROPN 3b591833765 4 10 and and CCONJ 3b591833765 4 11 intact intact ADJ 3b591833765 4 12 lmo lmo PROPN 3b591833765 4 13 proteins protein NOUN 3b591833765 4 14 had have AUX 3b591833765 4 15 not not PART 3b591833765 4 16 yet yet ADV 3b591833765 4 17 been be AUX 3b591833765 4 18 expressed express VERB 3b591833765 4 19 or or CCONJ 3b591833765 4 20 characterized characterize VERB 3b591833765 4 21 from from ADP 3b591833765 4 22 any any DET 3b591833765 4 23 organism organism NOUN 3b591833765 4 24 . . PUNCT 3b591833765 5 1 the the DET 3b591833765 5 2 chemical chemical ADJ 3b591833765 5 3 and and CCONJ 3b591833765 5 4 kinetic kinetic NOUN 3b591833765 5 5 mechanisms mechanism NOUN 3b591833765 5 6 , , PUNCT 3b591833765 5 7 as as ADV 3b591833765 5 8 well well ADV 3b591833765 5 9 as as ADP 3b591833765 5 10 3d 3d NOUN 3b591833765 5 11 - - PUNCT 3b591833765 5 12 structure structure NOUN 3b591833765 5 13 , , PUNCT 3b591833765 5 14 for for ADP 3b591833765 5 15 any any DET 3b591833765 5 16 representative representative ADJ 3b591833765 5 17 siderophore siderophore NOUN 3b591833765 5 18 - - PUNCT 3b591833765 5 19 associated associate VERB 3b591833765 5 20 monooxygenase monooxygenase NOUN 3b591833765 5 21 , , PUNCT 3b591833765 5 22 were be AUX 3b591833765 5 23 unknown unknown ADJ 3b591833765 5 24 . . PUNCT 3b591833765 6 1 omo omo PROPN 3b591833765 6 2 was be AUX 3b591833765 6 3 especially especially ADV 3b591833765 6 4 amenable amenable ADJ 3b591833765 6 5 to to ADP 3b591833765 6 6 spectroscopic spectroscopic ADJ 3b591833765 6 7 characterization characterization NOUN 3b591833765 6 8 and and CCONJ 3b591833765 6 9 therefore therefore ADV 3b591833765 6 10 the the DET 3b591833765 6 11 focus focus NOUN 3b591833765 6 12 of of ADP 3b591833765 6 13 the the DET 3b591833765 6 14 majority majority NOUN 3b591833765 6 15 of of ADP 3b591833765 6 16 this this DET 3b591833765 6 17 work work NOUN 3b591833765 6 18 . . PUNCT 3b591833765 7 1 omo omo PROPN 3b591833765 7 2 was be AUX 3b591833765 7 3 first first ADV 3b591833765 7 4 characterized characterize VERB 3b591833765 7 5 in in ADP 3b591833765 7 6 the the DET 3b591833765 7 7 steady steady ADJ 3b591833765 7 8 - - PUNCT 3b591833765 7 9 state state NOUN 3b591833765 7 10 , , PUNCT 3b591833765 7 11 as as SCONJ 3b591833765 7 12 it it PRON 3b591833765 7 13 would would AUX 3b591833765 7 14 exist exist VERB 3b591833765 7 15 in in ADP 3b591833765 7 16 the the DET 3b591833765 7 17 cell cell NOUN 3b591833765 7 18 . . PUNCT 3b591833765 8 1 transient transient ADJ 3b591833765 8 2 steps step NOUN 3b591833765 8 3 were be AUX 3b591833765 8 4 then then ADV 3b591833765 8 5 examined examine VERB 3b591833765 8 6 , , PUNCT 3b591833765 8 7 allowing allow VERB 3b591833765 8 8 derivation derivation NOUN 3b591833765 8 9 of of ADP 3b591833765 8 10 a a DET 3b591833765 8 11 more more ADV 3b591833765 8 12 detailed detailed ADJ 3b591833765 8 13 mechanism mechanism NOUN 3b591833765 8 14 and and CCONJ 3b591833765 8 15 gave give VERB 3b591833765 8 16 the the DET 3b591833765 8 17 first first ADJ 3b591833765 8 18 insights insight NOUN 3b591833765 8 19 into into ADP 3b591833765 8 20 how how SCONJ 3b591833765 8 21 the the DET 3b591833765 8 22 biosynthetic biosynthetic ADJ 3b591833765 8 23 enzymes enzyme NOUN 3b591833765 8 24 might might AUX 3b591833765 8 25 be be AUX 3b591833765 8 26 distinct distinct ADJ 3b591833765 8 27 among among ADP 3b591833765 8 28 all all DET 3b591833765 8 29 those those PRON 3b591833765 8 30 that that PRON 3b591833765 8 31 use use VERB 3b591833765 8 32 flavin flavin NOUN 3b591833765 8 33 . . PUNCT 3b591833765 9 1 the the DET 3b591833765 9 2 substrate substrate NOUN 3b591833765 9 3 l l NOUN 3b591833765 9 4 - - PUNCT 3b591833765 9 5 ornithine ornithine NOUN 3b591833765 9 6 plays play VERB 3b591833765 9 7 a a DET 3b591833765 9 8 unique unique ADJ 3b591833765 9 9 regulatory regulatory ADJ 3b591833765 9 10 role role NOUN 3b591833765 9 11 in in ADP 3b591833765 9 12 the the DET 3b591833765 9 13 oxidative oxidative ADJ 3b591833765 9 14 half half NOUN 3b591833765 9 15 reaction reaction NOUN 3b591833765 9 16 , , PUNCT 3b591833765 9 17 which which PRON 3b591833765 9 18 has have AUX 3b591833765 9 19 never never ADV 3b591833765 9 20 been be AUX 3b591833765 9 21 described describe VERB 3b591833765 9 22 for for ADP 3b591833765 9 23 a a DET 3b591833765 9 24 flavin flavin NOUN 3b591833765 9 25 - - PUNCT 3b591833765 9 26 dependent dependent ADJ 3b591833765 9 27 monooxygenase monooxygenase NOUN 3b591833765 9 28 . . PUNCT 3b591833765 10 1 this this PRON 3b591833765 10 2 led lead VERB 3b591833765 10 3 to to ADP 3b591833765 10 4 the the DET 3b591833765 10 5 pursuit pursuit NOUN 3b591833765 10 6 of of ADP 3b591833765 10 7 a a DET 3b591833765 10 8 study study NOUN 3b591833765 10 9 on on ADP 3b591833765 10 10 the the DET 3b591833765 10 11 oxygen oxygen NOUN 3b591833765 10 12 - - PUNCT 3b591833765 10 13 dependent dependent ADJ 3b591833765 10 14 reaction reaction NOUN 3b591833765 10 15 as as ADP 3b591833765 10 16 a a DET 3b591833765 10 17 function function NOUN 3b591833765 10 18 of of ADP 3b591833765 10 19 substrate substrate NOUN 3b591833765 10 20 analogs analog NOUN 3b591833765 10 21 and and CCONJ 3b591833765 10 22 as as ADP 3b591833765 10 23 a a DET 3b591833765 10 24 function function NOUN 3b591833765 10 25 of of ADP 3b591833765 10 26 ph ph PROPN 3b591833765 10 27 . . PUNCT 3b591833765 11 1 a a DET 3b591833765 11 2 type type NOUN 3b591833765 11 3 of of ADP 3b591833765 11 4 protein protein NOUN 3b591833765 11 5 regulation regulation NOUN 3b591833765 11 6 yet yet ADV 3b591833765 11 7 again again ADV 3b591833765 11 8 unforeseen unforeseen ADJ 3b591833765 11 9 in in ADP 3b591833765 11 10 this this DET 3b591833765 11 11 class class NOUN 3b591833765 11 12 of of ADP 3b591833765 11 13 enzymes enzyme NOUN 3b591833765 11 14 is be AUX 3b591833765 11 15 demonstrated demonstrate VERB 3b591833765 11 16 , , PUNCT 3b591833765 11 17 which which PRON 3b591833765 11 18 may may AUX 3b591833765 11 19 help help VERB 3b591833765 11 20 to to PART 3b591833765 11 21 explain explain VERB 3b591833765 11 22 how how SCONJ 3b591833765 11 23 biology biology NOUN 3b591833765 11 24 regulates regulate VERB 3b591833765 11 25 , , PUNCT 3b591833765 11 26 temporally temporally ADV 3b591833765 11 27 and and CCONJ 3b591833765 11 28 spatially spatially ADV 3b591833765 11 29 , , PUNCT 3b591833765 11 30 the the DET 3b591833765 11 31 production production NOUN 3b591833765 11 32 of of ADP 3b591833765 11 33 the the DET 3b591833765 11 34 important important ADJ 3b591833765 11 35 metabolites metabolite NOUN 3b591833765 11 36 that that PRON 3b591833765 11 37 they they PRON 3b591833765 11 38 produce produce VERB 3b591833765 11 39 . . PUNCT 3b591833765 12 1 the the DET 3b591833765 12 2 structure structure NOUN 3b591833765 12 3 of of ADP 3b591833765 12 4 a a DET 3b591833765 12 5 homolog homolog NOUN 3b591833765 12 6 of of ADP 3b591833765 12 7 omo omo PROPN 3b591833765 12 8 shows show VERB 3b591833765 12 9 that that SCONJ 3b591833765 12 10 a a DET 3b591833765 12 11 strictly strictly ADV 3b591833765 12 12 conserved conserve VERB 3b591833765 12 13 histidine histidine NOUN 3b591833765 12 14 in in ADP 3b591833765 12 15 n n NOUN 3b591833765 12 16 - - PUNCT 3b591833765 12 17 hydroxylating hydroxylating NOUN 3b591833765 12 18 monooxygenases monooxygenase NOUN 3b591833765 12 19 resides reside VERB 3b591833765 12 20 on on ADP 3b591833765 12 21 the the DET 3b591833765 12 22 side side NOUN 3b591833765 12 23 of of ADP 3b591833765 12 24 the the DET 3b591833765 12 25 flavin flavin NOUN 3b591833765 12 26 opposite opposite ADV 3b591833765 12 27 to to ADP 3b591833765 12 28 the the DET 3b591833765 12 29 site site NOUN 3b591833765 12 30 of of ADP 3b591833765 12 31 substrate substrate NOUN 3b591833765 12 32 binding bind VERB 3b591833765 12 33 . . PUNCT 3b591833765 13 1 his91 his91 ADJ 3b591833765 13 2 mutagenesis mutagenesis NOUN 3b591833765 13 3 in in ADP 3b591833765 13 4 omo omo PROPN 3b591833765 13 5 shows show VERB 3b591833765 13 6 that that SCONJ 3b591833765 13 7 this this DET 3b591833765 13 8 residue residue NOUN 3b591833765 13 9 plays play VERB 3b591833765 13 10 a a DET 3b591833765 13 11 role role NOUN 3b591833765 13 12 in in ADP 3b591833765 13 13 the the DET 3b591833765 13 14 formation formation NOUN 3b591833765 13 15 of of ADP 3b591833765 13 16 a a DET 3b591833765 13 17 stable stable ADJ 3b591833765 13 18 flavin flavin NOUN 3b591833765 13 19 - - PUNCT 3b591833765 13 20 peroxide peroxide NOUN 3b591833765 13 21 species specie NOUN 3b591833765 13 22 , , PUNCT 3b591833765 13 23 fundamental fundamental ADJ 3b591833765 13 24 to to AUX 3b591833765 13 25 substrate substrate NOUN 3b591833765 13 26 hydroxylation hydroxylation NOUN 3b591833765 13 27 . . PUNCT 3b591833765 14 1 altogether altogether ADV 3b591833765 14 2 these these DET 3b591833765 14 3 findings finding NOUN 3b591833765 14 4 define define VERB 3b591833765 14 5 the the DET 3b591833765 14 6 behavior behavior NOUN 3b591833765 14 7 of of ADP 3b591833765 14 8 a a DET 3b591833765 14 9 new new ADJ 3b591833765 14 10 subclass subclass NOUN 3b591833765 14 11 of of ADP 3b591833765 14 12 flavin flavin NOUN 3b591833765 14 13 - - PUNCT 3b591833765 14 14 dependent dependent ADJ 3b591833765 14 15 monooxygenases monooxygenase NOUN 3b591833765 14 16 that that PRON 3b591833765 14 17 are be AUX 3b591833765 14 18 involved involve VERB 3b591833765 14 19 in in ADP 3b591833765 14 20 important important ADJ 3b591833765 14 21 biosynthetic biosynthetic ADJ 3b591833765 14 22 processes process NOUN 3b591833765 14 23 . . PUNCT 3b591833765 15 1 the the DET 3b591833765 15 2 results result NOUN 3b591833765 15 3 may may AUX 3b591833765 15 4 help help VERB 3b591833765 15 5 explain explain VERB 3b591833765 15 6 how how SCONJ 3b591833765 15 7 diverse diverse ADJ 3b591833765 15 8 and and CCONJ 3b591833765 15 9 biologically biologically ADV 3b591833765 15 10 vital vital ADJ 3b591833765 15 11 biosynthetic biosynthetic ADJ 3b591833765 15 12 pathways pathway NOUN 3b591833765 15 13 are be AUX 3b591833765 15 14 regulated regulate VERB 3b591833765 15 15 , , PUNCT 3b591833765 15 16 in in ADP 3b591833765 15 17 diverse diverse ADJ 3b591833765 15 18 organisms organism NOUN 3b591833765 15 19 from from ADP 3b591833765 15 20 bacteria bacteria NOUN 3b591833765 15 21 to to ADP 3b591833765 15 22 plants plant NOUN 3b591833765 15 23 . . PUNCT