id	sid	tid	token	lemma	pos
3b59183374g	1	1	the	the	DET
3b59183374g	1	2	preservation	preservation	NOUN
3b59183374g	1	3	of	of	ADP
3b59183374g	1	4	blood	blood	NOUN
3b59183374g	1	5	flow	flow	NOUN
3b59183374g	1	6	is	be	AUX
3b59183374g	1	7	essential	essential	ADJ
3b59183374g	1	8	for	for	ADP
3b59183374g	1	9	the	the	DET
3b59183374g	1	10	delivery	delivery	NOUN
3b59183374g	1	11	of	of	ADP
3b59183374g	1	12	vital	vital	ADJ
3b59183374g	1	13	nutrients	nutrient	NOUN
3b59183374g	1	14	and	and	CCONJ
3b59183374g	1	15	metabolites	metabolite	NOUN
3b59183374g	1	16	to	to	ADP
3b59183374g	1	17	the	the	DET
3b59183374g	1	18	different	different	ADJ
3b59183374g	1	19	organs	organ	NOUN
3b59183374g	1	20	of	of	ADP
3b59183374g	1	21	the	the	DET
3b59183374g	1	22	body	body	NOUN
3b59183374g	1	23	.	.	PUNCT
3b59183374g	2	1	in	in	ADP
3b59183374g	2	2	case	case	NOUN
3b59183374g	2	3	of	of	ADP
3b59183374g	2	4	vascular	vascular	ADJ
3b59183374g	2	5	damage	damage	NOUN
3b59183374g	2	6	,	,	PUNCT
3b59183374g	2	7	well	well	ADV
3b59183374g	2	8	equilibrated	equilibrated	ADJ
3b59183374g	2	9	coagulation	coagulation	NOUN
3b59183374g	2	10	and	and	CCONJ
3b59183374g	2	11	fibrinolysis	fibrinolysis	NOUN
3b59183374g	2	12	are	be	AUX
3b59183374g	2	13	required	require	VERB
3b59183374g	2	14	to	to	PART
3b59183374g	2	15	maintain	maintain	VERB
3b59183374g	2	16	homeostasis	homeostasis	NOUN
3b59183374g	2	17	so	so	SCONJ
3b59183374g	2	18	that	that	DET
3b59183374g	2	19	repair	repair	NOUN
3b59183374g	2	20	occurs	occur	VERB
3b59183374g	2	21	promptly	promptly	ADV
3b59183374g	2	22	and	and	CCONJ
3b59183374g	2	23	efficiently	efficiently	ADV
3b59183374g	2	24	,	,	PUNCT
3b59183374g	2	25	without	without	ADP
3b59183374g	2	26	severe	severe	ADJ
3b59183374g	2	27	stenosis	stenosis	NOUN
3b59183374g	2	28	or	or	CCONJ
3b59183374g	2	29	thromboembolism	thromboembolism	NOUN
3b59183374g	2	30	.	.	PUNCT
3b59183374g	3	1	anticoagulant	anticoagulant	ADJ
3b59183374g	3	2	protein	protein	NOUN
3b59183374g	3	3	c	c	NOUN
3b59183374g	3	4	(	(	PUNCT
3b59183374g	3	5	pc	pc	NOUN
3b59183374g	3	6	)	)	PUNCT
3b59183374g	3	7	is	be	AUX
3b59183374g	3	8	an	an	DET
3b59183374g	3	9	important	important	ADJ
3b59183374g	3	10	serine	serine	NOUN
3b59183374g	3	11	protease	protease	NOUN
3b59183374g	3	12	that	that	PRON
3b59183374g	3	13	down	down	ADV
3b59183374g	3	14	-	-	PUNCT
3b59183374g	3	15	regulates	regulates	VERB
3b59183374g	3	16	thrombin	thrombin	NOUN
3b59183374g	3	17	generation	generation	NOUN
3b59183374g	3	18	by	by	ADP
3b59183374g	3	19	proteolytic	proteolytic	ADJ
3b59183374g	3	20	cleavage	cleavage	NOUN
3b59183374g	3	21	of	of	ADP
3b59183374g	3	22	coagulation	coagulation	NOUN
3b59183374g	3	23	factors	factor	NOUN
3b59183374g	3	24	(	(	PUNCT
3b59183374g	3	25	f)viiia	f)viiia	NOUN
3b59183374g	3	26	and	and	CCONJ
3b59183374g	3	27	fva	fva	ADJ
3b59183374g	3	28	,	,	PUNCT
3b59183374g	3	29	cofactors	cofactor	NOUN
3b59183374g	3	30	that	that	PRON
3b59183374g	3	31	participate	participate	VERB
3b59183374g	3	32	in	in	ADP
3b59183374g	3	33	the	the	DET
3b59183374g	3	34	xase	xase	ADJ
3b59183374g	3	35	and	and	CCONJ
3b59183374g	3	36	prothrombinase	prothrombinase	NOUN
3b59183374g	3	37	complexes	complex	NOUN
3b59183374g	3	38	,	,	PUNCT
3b59183374g	3	39	respectively	respectively	ADV
3b59183374g	3	40	.	.	PUNCT
3b59183374g	4	1	additionally	additionally	ADV
3b59183374g	4	2	,	,	PUNCT
3b59183374g	4	3	it	it	PRON
3b59183374g	4	4	was	be	AUX
3b59183374g	4	5	shown	show	VERB
3b59183374g	4	6	that	that	SCONJ
3b59183374g	4	7	pc	pc	NOUN
3b59183374g	4	8	behaves	behave	VERB
3b59183374g	4	9	as	as	ADP
3b59183374g	4	10	an	an	DET
3b59183374g	4	11	anti	anti	ADJ
3b59183374g	4	12	-	-	ADJ
3b59183374g	4	13	inflammatory	inflammatory	ADJ
3b59183374g	4	14	agent	agent	NOUN
3b59183374g	4	15	when	when	SCONJ
3b59183374g	4	16	it	it	PRON
3b59183374g	4	17	binds	bind	VERB
3b59183374g	4	18	to	to	ADP
3b59183374g	4	19	its	its	PRON
3b59183374g	4	20	receptor	receptor	NOUN
3b59183374g	4	21	epcr	epcr	ADV
3b59183374g	4	22	and/or	and/or	CCONJ
3b59183374g	4	23	the	the	DET
3b59183374g	4	24	protease	protease	NOUN
3b59183374g	4	25	activated	activate	VERB
3b59183374g	4	26	receptor	receptor	NOUN
3b59183374g	4	27	par-1	par-1	SPACE
3b59183374g	4	28	,	,	PUNCT
3b59183374g	4	29	diminishing	diminish	VERB
3b59183374g	4	30	cytokine	cytokine	NOUN
3b59183374g	4	31	and	and	CCONJ
3b59183374g	4	32	chemokine	chemokine	NOUN
3b59183374g	4	33	production	production	NOUN
3b59183374g	4	34	by	by	ADP
3b59183374g	4	35	endothelial	endothelial	ADJ
3b59183374g	4	36	and	and	CCONJ
3b59183374g	4	37	inflammatory	inflammatory	ADJ
3b59183374g	4	38	cells	cell	NOUN
3b59183374g	4	39	.	.	PUNCT
3b59183374g	5	1	administration	administration	NOUN
3b59183374g	5	2	of	of	ADP
3b59183374g	5	3	pc	pc	NOUN
3b59183374g	5	4	to	to	ADP
3b59183374g	5	5	patients	patient	NOUN
3b59183374g	5	6	undergoing	undergo	VERB
3b59183374g	5	7	septic	septic	ADJ
3b59183374g	5	8	shock	shock	NOUN
3b59183374g	5	9	,	,	PUNCT
3b59183374g	5	10	as	as	ADV
3b59183374g	5	11	well	well	ADV
3b59183374g	5	12	as	as	ADP
3b59183374g	5	13	animals	animal	NOUN
3b59183374g	5	14	in	in	ADP
3b59183374g	5	15	different	different	ADJ
3b59183374g	5	16	models	model	NOUN
3b59183374g	5	17	of	of	ADP
3b59183374g	5	18	inflammation	inflammation	NOUN
3b59183374g	5	19	,	,	PUNCT
3b59183374g	5	20	not	not	PART
3b59183374g	5	21	only	only	ADV
3b59183374g	5	22	decreased	decrease	VERB
3b59183374g	5	23	the	the	DET
3b59183374g	5	24	inflammatory	inflammatory	ADJ
3b59183374g	5	25	response	response	NOUN
3b59183374g	5	26	but	but	CCONJ
3b59183374g	5	27	also	also	ADV
3b59183374g	5	28	improved	improve	VERB
3b59183374g	5	29	the	the	DET
3b59183374g	5	30	survival	survival	NOUN
3b59183374g	5	31	effectively	effectively	ADV
3b59183374g	5	32	.	.	PUNCT
3b59183374g	6	1	on	on	ADP
3b59183374g	6	2	the	the	DET
3b59183374g	6	3	contrary	contrary	NOUN
3b59183374g	6	4	,	,	PUNCT
3b59183374g	6	5	individuals	individual	NOUN
3b59183374g	6	6	with	with	ADP
3b59183374g	6	7	hereditary	hereditary	ADJ
3b59183374g	6	8	pc	pc	NOUN
3b59183374g	6	9	deficiencies	deficiency	NOUN
3b59183374g	6	10	have	have	VERB
3b59183374g	6	11	propensity	propensity	NOUN
3b59183374g	6	12	to	to	ADP
3b59183374g	6	13	coagulopathies	coagulopathie	NOUN
3b59183374g	6	14	that	that	PRON
3b59183374g	6	15	could	could	AUX
3b59183374g	6	16	result	result	VERB
3b59183374g	6	17	in	in	ADP
3b59183374g	6	18	disseminated	disseminate	VERB
3b59183374g	6	19	intravascular	intravascular	ADJ
3b59183374g	6	20	coagulopathy	coagulopathy	NOUN
3b59183374g	6	21	(	(	PUNCT
3b59183374g	6	22	dic	dic	NOUN
3b59183374g	6	23	)	)	PUNCT
3b59183374g	6	24	and	and	CCONJ
3b59183374g	6	25	death	death	NOUN
3b59183374g	6	26	.	.	PUNCT
3b59183374g	7	1	moreover	moreover	ADV
3b59183374g	7	2	,	,	PUNCT
3b59183374g	7	3	pc	pc	NOUN
3b59183374g	7	4	deficiency	deficiency	NOUN
3b59183374g	7	5	is	be	AUX
3b59183374g	7	6	a	a	DET
3b59183374g	7	7	major	major	ADJ
3b59183374g	7	8	risk	risk	NOUN
3b59183374g	7	9	factor	factor	NOUN
3b59183374g	7	10	in	in	ADP
3b59183374g	7	11	atherothrombosis	atherothrombosis	NOUN
3b59183374g	7	12	and	and	CCONJ
3b59183374g	7	13	atherogenesis	atherogenesis	NOUN
3b59183374g	7	14	.	.	PUNCT
3b59183374g	8	1	nonetheless	nonetheless	ADV
3b59183374g	8	2	,	,	PUNCT
3b59183374g	8	3	the	the	DET
3b59183374g	8	4	response	response	NOUN
3b59183374g	8	5	to	to	ADP
3b59183374g	8	6	inflammatory	inflammatory	ADJ
3b59183374g	8	7	events	event	NOUN
3b59183374g	8	8	has	have	AUX
3b59183374g	8	9	not	not	PART
3b59183374g	8	10	been	be	AUX
3b59183374g	8	11	extensively	extensively	ADV
3b59183374g	8	12	studied	study	VERB
3b59183374g	8	13	in	in	ADP
3b59183374g	8	14	pc	pc	NOUN
3b59183374g	8	15	deficient	deficient	ADJ
3b59183374g	8	16	individuals	individual	NOUN
3b59183374g	8	17	and	and	CCONJ
3b59183374g	8	18	therefore	therefore	ADV
3b59183374g	8	19	needs	need	VERB
3b59183374g	8	20	to	to	PART
3b59183374g	8	21	be	be	AUX
3b59183374g	8	22	further	far	ADV
3b59183374g	8	23	examined	examine	VERB
3b59183374g	8	24	to	to	PART
3b59183374g	8	25	clarify	clarify	VERB
3b59183374g	8	26	the	the	DET
3b59183374g	8	27	role	role	NOUN
3b59183374g	8	28	of	of	ADP
3b59183374g	8	29	pc	pc	NOUN
3b59183374g	8	30	in	in	ADP
3b59183374g	8	31	such	such	ADJ
3b59183374g	8	32	processes	process	NOUN
3b59183374g	8	33	.	.	PUNCT
3b59183374g	9	1	recently	recently	ADV
3b59183374g	9	2	,	,	PUNCT
3b59183374g	9	3	mice	mouse	NOUN
3b59183374g	9	4	with	with	ADP
3b59183374g	9	5	pc	pc	NOUN
3b59183374g	9	6	deficiencies	deficiency	NOUN
3b59183374g	9	7	were	be	AUX
3b59183374g	9	8	generated	generate	VERB
3b59183374g	9	9	by	by	ADP
3b59183374g	9	10	targeted	target	VERB
3b59183374g	9	11	complete	complete	ADJ
3b59183374g	9	12	gene	gene	NOUN
3b59183374g	9	13	deletion	deletion	NOUN
3b59183374g	9	14	and	and	CCONJ
3b59183374g	9	15	replacement	replacement	NOUN
3b59183374g	9	16	by	by	ADP
3b59183374g	9	17	a	a	DET
3b59183374g	9	18	neomycin	neomycin	PROPN
3b59183374g	9	19	resistant	resistant	ADJ
3b59183374g	9	20	cassette	cassette	NOUN
3b59183374g	9	21	.	.	PUNCT
3b59183374g	10	1	as	as	ADP
3b59183374g	10	2	a	a	DET
3b59183374g	10	3	result	result	NOUN
3b59183374g	10	4	,	,	PUNCT
3b59183374g	10	5	mice	mouse	NOUN
3b59183374g	10	6	with	with	ADP
3b59183374g	10	7	a	a	DET
3b59183374g	10	8	homozygous	homozygous	ADJ
3b59183374g	10	9	deficiency	deficiency	NOUN
3b59183374g	10	10	(	(	PUNCT
3b59183374g	10	11	$	$	SYM
3b59183374g	10	12	pc^{-/-}$	pc^{-/-}$	NUM
3b59183374g	10	13	)	)	PUNCT
3b59183374g	10	14	survived	survive	VERB
3b59183374g	10	15	up	up	ADP
3b59183374g	10	16	to	to	PART
3b59183374g	10	17	5	5	NUM
3b59183374g	10	18	days	day	NOUN
3b59183374g	10	19	after	after	ADP
3b59183374g	10	20	birth	birth	NOUN
3b59183374g	10	21	due	due	ADP
3b59183374g	10	22	to	to	ADP
3b59183374g	10	23	severe	severe	ADJ
3b59183374g	10	24	coagulopathies	coagulopathie	NOUN
3b59183374g	10	25	with	with	ADP
3b59183374g	10	26	consequent	consequent	ADJ
3b59183374g	10	27	hepatic	hepatic	ADJ
3b59183374g	10	28	and	and	CCONJ
3b59183374g	10	29	cerebral	cerebral	ADJ
3b59183374g	10	30	necrosis	necrosis	NOUN
3b59183374g	10	31	.	.	PUNCT
3b59183374g	11	1	thus	thus	ADV
3b59183374g	11	2	,	,	PUNCT
3b59183374g	11	3	$	$	SYM
3b59183374g	11	4	pc^{-/-}$	pc^{-/-}$	NOUN
3b59183374g	11	5	mice	mouse	NOUN
3b59183374g	11	6	were	be	AUX
3b59183374g	11	7	not	not	PART
3b59183374g	11	8	viable	viable	ADJ
3b59183374g	11	9	for	for	ADP
3b59183374g	11	10	coagulation	coagulation	NOUN
3b59183374g	11	11	and	and	CCONJ
3b59183374g	11	12	inflammatory	inflammatory	ADJ
3b59183374g	11	13	studies	study	NOUN
3b59183374g	11	14	.	.	PUNCT
3b59183374g	12	1	to	to	PART
3b59183374g	12	2	analyze	analyze	VERB
3b59183374g	12	3	whether	whether	SCONJ
3b59183374g	12	4	an	an	DET
3b59183374g	12	5	additional	additional	ADJ
3b59183374g	12	6	deficiency	deficiency	NOUN
3b59183374g	12	7	in	in	ADP
3b59183374g	12	8	a	a	DET
3b59183374g	12	9	procoagulant	procoagulant	NOUN
3b59183374g	12	10	such	such	ADJ
3b59183374g	12	11	as	as	ADP
3b59183374g	12	12	fxi	fxi	NOUN
3b59183374g	12	13	alleviates	alleviate	VERB
3b59183374g	12	14	the	the	DET
3b59183374g	12	15	hypercoagulable	hypercoagulable	NOUN
3b59183374g	12	16	state	state	NOUN
3b59183374g	12	17	induced	induce	VERB
3b59183374g	12	18	by	by	ADP
3b59183374g	12	19	a	a	DET
3b59183374g	12	20	pc	pc	NOUN
3b59183374g	12	21	deficiency	deficiency	NOUN
3b59183374g	12	22	and	and	CCONJ
3b59183374g	12	23	hence	hence	ADV
3b59183374g	12	24	improves	improve	VERB
3b59183374g	12	25	the	the	DET
3b59183374g	12	26	viability	viability	NOUN
3b59183374g	12	27	of	of	ADP
3b59183374g	12	28	these	these	DET
3b59183374g	12	29	mice	mouse	NOUN
3b59183374g	12	30	,	,	PUNCT
3b59183374g	12	31	$	$	SYM
3b59183374g	12	32	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	12	33	mice	mouse	NOUN
3b59183374g	12	34	were	be	AUX
3b59183374g	12	35	crossbred	crossbreed	VERB
3b59183374g	12	36	with	with	ADP
3b59183374g	12	37	$	$	SYM
3b59183374g	12	38	fxi^{-/-}$	fxi^{-/-}$	NOUN
3b59183374g	12	39	mice	mouse	NOUN
3b59183374g	12	40	in	in	ADP
3b59183374g	12	41	successive	successive	ADJ
3b59183374g	12	42	rounds	round	NOUN
3b59183374g	12	43	.	.	PUNCT
3b59183374g	13	1	consequently	consequently	ADV
3b59183374g	13	2	,	,	PUNCT
3b59183374g	13	3	the	the	DET
3b59183374g	13	4	generated	generate	VERB
3b59183374g	13	5	mice	mouse	NOUN
3b59183374g	13	6	with	with	ADP
3b59183374g	13	7	a	a	DET
3b59183374g	13	8	combined	combined	ADJ
3b59183374g	13	9	deficiency	deficiency	NOUN
3b59183374g	13	10	in	in	ADP
3b59183374g	13	11	pc	pc	NOUN
3b59183374g	13	12	and	and	CCONJ
3b59183374g	13	13	fxi	fxi	NOUN
3b59183374g	13	14	(	(	PUNCT
3b59183374g	13	15	$	$	SYM
3b59183374g	13	16	pc^{-/-}fxi^{-/-}$	pc^{-/-}fxi^{-/-}$	NUM
3b59183374g	13	17	)	)	PUNCT
3b59183374g	13	18	presented	present	VERB
3b59183374g	13	19	improved	improve	VERB
3b59183374g	13	20	survival	survival	NOUN
3b59183374g	13	21	and	and	CCONJ
3b59183374g	13	22	lived	live	VERB
3b59183374g	13	23	up	up	ADP
3b59183374g	13	24	to	to	PART
3b59183374g	13	25	100	100	NUM
3b59183374g	13	26	days	day	NOUN
3b59183374g	13	27	.	.	PUNCT
3b59183374g	14	1	nonetheless	nonetheless	ADV
3b59183374g	14	2	,	,	PUNCT
3b59183374g	14	3	these	these	DET
3b59183374g	14	4	animals	animal	NOUN
3b59183374g	14	5	presented	present	VERB
3b59183374g	14	6	symptoms	symptom	NOUN
3b59183374g	14	7	of	of	ADP
3b59183374g	14	8	coagulopathies	coagulopathie	NOUN
3b59183374g	14	9	with	with	ADP
3b59183374g	14	10	fibrin(ogen	fibrin(ogen	SPACE
3b59183374g	14	11	)	)	PUNCT
3b59183374g	14	12	deposits	deposit	NOUN
3b59183374g	14	13	and	and	CCONJ
3b59183374g	14	14	fibrosis	fibrosis	NOUN
3b59183374g	14	15	as	as	ADV
3b59183374g	14	16	well	well	ADV
3b59183374g	14	17	as	as	ADP
3b59183374g	14	18	increased	increase	VERB
3b59183374g	14	19	inflammation	inflammation	NOUN
3b59183374g	14	20	in	in	ADP
3b59183374g	14	21	the	the	DET
3b59183374g	14	22	major	major	ADJ
3b59183374g	14	23	organs	organ	NOUN
3b59183374g	14	24	.	.	PUNCT
3b59183374g	15	1	additionally	additionally	ADV
3b59183374g	15	2	,	,	PUNCT
3b59183374g	15	3	the	the	DET
3b59183374g	15	4	supplementary	supplementary	ADJ
3b59183374g	15	5	fxi	fxi	NOUN
3b59183374g	15	6	deficiency	deficiency	NOUN
3b59183374g	15	7	rescued	rescue	VERB
3b59183374g	15	8	$	$	SYM
3b59183374g	15	9	pc^{-/-}$	pc^{-/-}$	NOUN
3b59183374g	15	10	embryos	embryo	NOUN
3b59183374g	15	11	from	from	ADP
3b59183374g	15	12	pre	pre	ADJ
3b59183374g	15	13	-	-	ADJ
3b59183374g	15	14	natal	natal	ADJ
3b59183374g	15	15	coagulopathies	coagulopathie	NOUN
3b59183374g	15	16	in	in	ADP
3b59183374g	15	17	the	the	DET
3b59183374g	15	18	late	late	ADJ
3b59183374g	15	19	gestational	gestational	ADJ
3b59183374g	15	20	stage	stage	NOUN
3b59183374g	15	21	proving	prove	VERB
3b59183374g	15	22	the	the	DET
3b59183374g	15	23	importance	importance	NOUN
3b59183374g	15	24	of	of	ADP
3b59183374g	15	25	fxi	fxi	NOUN
3b59183374g	15	26	in	in	ADP
3b59183374g	15	27	the	the	DET
3b59183374g	15	28	activation	activation	NOUN
3b59183374g	15	29	of	of	ADP
3b59183374g	15	30	coagulation	coagulation	NOUN
3b59183374g	15	31	in	in	ADP
3b59183374g	15	32	this	this	DET
3b59183374g	15	33	developmental	developmental	ADJ
3b59183374g	15	34	period	period	NOUN
3b59183374g	15	35	.	.	PUNCT
3b59183374g	16	1	unfortunately	unfortunately	ADV
3b59183374g	16	2	,	,	PUNCT
3b59183374g	16	3	only	only	ADV
3b59183374g	16	4	a	a	DET
3b59183374g	16	5	small	small	ADJ
3b59183374g	16	6	fraction	fraction	NOUN
3b59183374g	16	7	of	of	ADP
3b59183374g	16	8	$	$	SYM
3b59183374g	16	9	pc^{-/-}fxi^{-/-}$	pc^{-/-}fxi^{-/-}$	NOUN
3b59183374g	16	10	mice	mouse	NOUN
3b59183374g	16	11	survived	survive	VERB
3b59183374g	16	12	birth	birth	NOUN
3b59183374g	16	13	which	which	PRON
3b59183374g	16	14	rendered	render	VERB
3b59183374g	16	15	them	they	PRON
3b59183374g	16	16	unsuitable	unsuitable	ADJ
3b59183374g	16	17	for	for	ADP
3b59183374g	16	18	inflammatory	inflammatory	ADJ
3b59183374g	16	19	-	-	PUNCT
3b59183374g	16	20	challenge	challenge	NOUN
3b59183374g	16	21	studies	study	NOUN
3b59183374g	16	22	.	.	PUNCT
3b59183374g	17	1	subsequently	subsequently	ADV
3b59183374g	17	2	,	,	PUNCT
3b59183374g	17	3	systemic	systemic	ADJ
3b59183374g	17	4	and	and	CCONJ
3b59183374g	17	5	focal	focal	ADJ
3b59183374g	17	6	inflammatory	inflammatory	ADJ
3b59183374g	17	7	responses	response	NOUN
3b59183374g	17	8	were	be	AUX
3b59183374g	17	9	studied	study	VERB
3b59183374g	17	10	in	in	ADP
3b59183374g	17	11	mice	mouse	NOUN
3b59183374g	17	12	with	with	ADP
3b59183374g	17	13	heterozygous	heterozygous	ADJ
3b59183374g	17	14	deficiencies	deficiency	NOUN
3b59183374g	17	15	in	in	ADP
3b59183374g	17	16	pc	pc	NOUN
3b59183374g	17	17	.	.	PUNCT
3b59183374g	18	1	for	for	ADP
3b59183374g	18	2	this	this	DET
3b59183374g	18	3	purpose	purpose	NOUN
3b59183374g	18	4	,	,	PUNCT
3b59183374g	18	5	we	we	PRON
3b59183374g	18	6	chose	choose	VERB
3b59183374g	18	7	the	the	DET
3b59183374g	18	8	cecal	cecal	ADJ
3b59183374g	18	9	ligation	ligation	NOUN
3b59183374g	18	10	and	and	CCONJ
3b59183374g	18	11	puncture	puncture	NOUN
3b59183374g	18	12	(	(	PUNCT
3b59183374g	18	13	clp	clp	PROPN
3b59183374g	18	14	)	)	PUNCT
3b59183374g	18	15	model	model	NOUN
3b59183374g	18	16	of	of	ADP
3b59183374g	18	17	sepsis	sepsis	NOUN
3b59183374g	18	18	,	,	PUNCT
3b59183374g	18	19	a	a	DET
3b59183374g	18	20	systemic	systemic	ADJ
3b59183374g	18	21	inflammatory	inflammatory	ADJ
3b59183374g	18	22	response	response	NOUN
3b59183374g	18	23	syndrome	syndrome	NOUN
3b59183374g	18	24	,	,	PUNCT
3b59183374g	18	25	and	and	CCONJ
3b59183374g	18	26	the	the	DET
3b59183374g	18	27	copper	copper	NOUN
3b59183374g	18	28	/	/	SYM
3b59183374g	18	29	silicone	silicone	NOUN
3b59183374g	18	30	cuff	cuff	NOUN
3b59183374g	18	31	model	model	NOUN
3b59183374g	18	32	of	of	ADP
3b59183374g	18	33	arterial	arterial	ADJ
3b59183374g	18	34	injury	injury	NOUN
3b59183374g	18	35	and	and	CCONJ
3b59183374g	18	36	inflammation	inflammation	NOUN
3b59183374g	18	37	.	.	PUNCT
3b59183374g	19	1	in	in	ADP
3b59183374g	19	2	the	the	DET
3b59183374g	19	3	sepsis	sepsis	NOUN
3b59183374g	19	4	studies	study	NOUN
3b59183374g	19	5	,	,	PUNCT
3b59183374g	19	6	a	a	DET
3b59183374g	19	7	partial	partial	ADJ
3b59183374g	19	8	deficiency	deficiency	NOUN
3b59183374g	19	9	in	in	ADP
3b59183374g	19	10	protein	protein	NOUN
3b59183374g	19	11	c	c	PROPN
3b59183374g	19	12	conferred	confer	VERB
3b59183374g	19	13	clp	clp	PROPN
3b59183374g	19	14	-	-	PUNCT
3b59183374g	19	15	treated	treat	VERB
3b59183374g	19	16	mice	mouse	NOUN
3b59183374g	19	17	increased	increase	VERB
3b59183374g	19	18	mortality	mortality	NOUN
3b59183374g	19	19	in	in	ADP
3b59183374g	19	20	comparison	comparison	NOUN
3b59183374g	19	21	with	with	ADP
3b59183374g	19	22	treated	treat	VERB
3b59183374g	19	23	{	{	PUNCT
3b59183374g	19	24	it	it	PRON
3b59183374g	19	25	wt	wt	NOUN
3b59183374g	19	26	}	}	PUNCT
3b59183374g	19	27	mice	mouse	NOUN
3b59183374g	19	28	.	.	PUNCT
3b59183374g	20	1	plasma	plasma	NOUN
3b59183374g	20	2	cytokine	cytokine	NOUN
3b59183374g	20	3	levels	level	NOUN
3b59183374g	20	4	as	as	ADV
3b59183374g	20	5	well	well	ADV
3b59183374g	20	6	as	as	ADP
3b59183374g	20	7	cytokine	cytokine	NOUN
3b59183374g	20	8	expression	expression	NOUN
3b59183374g	20	9	in	in	ADP
3b59183374g	20	10	liver	liver	NOUN
3b59183374g	20	11	,	,	PUNCT
3b59183374g	20	12	kidney	kidney	NOUN
3b59183374g	20	13	and	and	CCONJ
3b59183374g	20	14	lung	lung	NOUN
3b59183374g	20	15	were	be	AUX
3b59183374g	20	16	more	more	ADV
3b59183374g	20	17	elevated	elevated	ADJ
3b59183374g	20	18	in	in	ADP
3b59183374g	20	19	$	$	SYM
3b59183374g	20	20	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	20	21	mice	mouse	NOUN
3b59183374g	20	22	compared	compare	VERB
3b59183374g	20	23	to	to	ADP
3b59183374g	20	24	{	{	PUNCT
3b59183374g	20	25	it	it	PRON
3b59183374g	20	26	wt	wt	NOUN
3b59183374g	20	27	}	}	PUNCT
3b59183374g	20	28	mice	mouse	NOUN
3b59183374g	20	29	at	at	ADP
3b59183374g	20	30	24	24	NUM
3b59183374g	20	31	hours	hour	NOUN
3b59183374g	20	32	post	post	ADJ
3b59183374g	20	33	-	-	ADJ
3b59183374g	20	34	clp	clp	ADJ
3b59183374g	20	35	surgery	surgery	NOUN
3b59183374g	20	36	.	.	PUNCT
3b59183374g	21	1	additionally	additionally	ADV
3b59183374g	21	2	,	,	PUNCT
3b59183374g	21	3	renal	renal	ADJ
3b59183374g	21	4	and	and	CCONJ
3b59183374g	21	5	hepatic	hepatic	ADJ
3b59183374g	21	6	damage	damage	NOUN
3b59183374g	21	7	were	be	AUX
3b59183374g	21	8	more	more	ADV
3b59183374g	21	9	severe	severe	ADJ
3b59183374g	21	10	in	in	ADP
3b59183374g	21	11	$	$	SYM
3b59183374g	21	12	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	21	13	treated	treat	VERB
3b59183374g	21	14	mice	mouse	NOUN
3b59183374g	21	15	relative	relative	ADJ
3b59183374g	21	16	to	to	ADP
3b59183374g	21	17	similar	similar	ADJ
3b59183374g	21	18	{	{	PUNCT
3b59183374g	21	19	it	it	PRON
3b59183374g	21	20	wt	wt	NOUN
3b59183374g	21	21	}	}	PUNCT
3b59183374g	21	22	mice	mouse	NOUN
3b59183374g	21	23	.	.	PUNCT
3b59183374g	22	1	hepatic	hepatic	ADJ
3b59183374g	22	2	and	and	CCONJ
3b59183374g	22	3	renal	renal	ADJ
3b59183374g	22	4	expression	expression	NOUN
3b59183374g	22	5	of	of	ADP
3b59183374g	22	6	pc	pc	NOUN
3b59183374g	22	7	as	as	ADV
3b59183374g	22	8	well	well	ADV
3b59183374g	22	9	as	as	ADP
3b59183374g	22	10	plasma	plasma	NOUN
3b59183374g	22	11	levels	level	NOUN
3b59183374g	22	12	of	of	ADP
3b59183374g	22	13	the	the	DET
3b59183374g	22	14	protein	protein	NOUN
3b59183374g	22	15	decreased	decrease	VERB
3b59183374g	22	16	to	to	ADP
3b59183374g	22	17	under	under	ADP
3b59183374g	22	18	50,\%	50,\%	NUM
3b59183374g	22	19	of	of	ADP
3b59183374g	22	20	the	the	DET
3b59183374g	22	21	original	original	ADJ
3b59183374g	22	22	values	value	NOUN
3b59183374g	22	23	in	in	ADP
3b59183374g	22	24	both	both	PRON
3b59183374g	22	25	{	{	PUNCT
3b59183374g	22	26	it	it	PRON
3b59183374g	22	27	wt	wt	PROPN
3b59183374g	22	28	}	}	PUNCT
3b59183374g	22	29	and	and	CCONJ
3b59183374g	22	30	$	$	SYM
3b59183374g	22	31	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	22	32	mice	mouse	NOUN
3b59183374g	22	33	24	24	NUM
3b59183374g	22	34	hours	hour	NOUN
3b59183374g	22	35	after	after	ADP
3b59183374g	22	36	surgery	surgery	NOUN
3b59183374g	22	37	,	,	PUNCT
3b59183374g	22	38	although	although	SCONJ
3b59183374g	22	39	a	a	DET
3b59183374g	22	40	more	more	ADV
3b59183374g	22	41	significant	significant	ADJ
3b59183374g	22	42	diminution	diminution	NOUN
3b59183374g	22	43	in	in	ADP
3b59183374g	22	44	these	these	DET
3b59183374g	22	45	parameters	parameter	NOUN
3b59183374g	22	46	was	be	AUX
3b59183374g	22	47	observed	observe	VERB
3b59183374g	22	48	in	in	ADP
3b59183374g	22	49	$	$	SYM
3b59183374g	22	50	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	22	51	mice	mouse	NOUN
3b59183374g	22	52	,	,	PUNCT
3b59183374g	22	53	relative	relative	ADJ
3b59183374g	22	54	to	to	ADP
3b59183374g	22	55	{	{	PUNCT
3b59183374g	22	56	it	it	PRON
3b59183374g	22	57	wt	wt	NOUN
3b59183374g	22	58	}	}	PUNCT
3b59183374g	22	59	mice	mouse	NOUN
3b59183374g	22	60	.	.	PUNCT
3b59183374g	23	1	further	far	ADV
3b59183374g	23	2	,	,	PUNCT
3b59183374g	23	3	up	up	ADP
3b59183374g	23	4	-	-	PUNCT
3b59183374g	23	5	regulation	regulation	NOUN
3b59183374g	23	6	of	of	ADP
3b59183374g	23	7	coagulation	coagulation	NOUN
3b59183374g	23	8	and	and	CCONJ
3b59183374g	23	9	consumption	consumption	NOUN
3b59183374g	23	10	of	of	ADP
3b59183374g	23	11	intrinsic	intrinsic	ADJ
3b59183374g	23	12	coagulation	coagulation	NOUN
3b59183374g	23	13	factors	factor	NOUN
3b59183374g	23	14	was	be	AUX
3b59183374g	23	15	seen	see	VERB
3b59183374g	23	16	in	in	ADP
3b59183374g	23	17	both	both	PRON
3b59183374g	23	18	{	{	PUNCT
3b59183374g	23	19	it	it	PRON
3b59183374g	23	20	wt	wt	PROPN
3b59183374g	23	21	}	}	PUNCT
3b59183374g	23	22	and	and	CCONJ
3b59183374g	23	23	$	$	SYM
3b59183374g	23	24	pc^{+/-}$	pc^{+/-}$	VERB
3b59183374g	23	25	mice	mouse	NOUN
3b59183374g	23	26	to	to	ADP
3b59183374g	23	27	a	a	DET
3b59183374g	23	28	similar	similar	ADJ
3b59183374g	23	29	degree	degree	NOUN
3b59183374g	23	30	.	.	PUNCT
3b59183374g	24	1	hence	hence	ADV
3b59183374g	24	2	,	,	PUNCT
3b59183374g	24	3	the	the	DET
3b59183374g	24	4	difference	difference	NOUN
3b59183374g	24	5	in	in	ADP
3b59183374g	24	6	outcome	outcome	NOUN
3b59183374g	24	7	of	of	ADP
3b59183374g	24	8	$	$	SYM
3b59183374g	24	9	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	24	10	and	and	CCONJ
3b59183374g	24	11	{	{	PUNCT
3b59183374g	24	12	it	it	PRON
3b59183374g	24	13	wt	wt	NOUN
3b59183374g	24	14	}	}	PUNCT
3b59183374g	24	15	mice	mouse	NOUN
3b59183374g	24	16	after	after	ADP
3b59183374g	24	17	sepsis	sepsis	NOUN
3b59183374g	24	18	seems	seem	VERB
3b59183374g	24	19	to	to	PART
3b59183374g	24	20	be	be	AUX
3b59183374g	24	21	related	relate	VERB
3b59183374g	24	22	to	to	ADP
3b59183374g	24	23	the	the	DET
3b59183374g	24	24	anti	anti	ADJ
3b59183374g	24	25	-	-	ADJ
3b59183374g	24	26	inflammatory	inflammatory	ADJ
3b59183374g	24	27	properties	property	NOUN
3b59183374g	24	28	of	of	ADP
3b59183374g	24	29	pc	pc	NOUN
3b59183374g	24	30	in	in	ADP
3b59183374g	24	31	contrast	contrast	NOUN
3b59183374g	24	32	with	with	ADP
3b59183374g	24	33	its	its	PRON
3b59183374g	24	34	anticoagulant	anticoagulant	ADJ
3b59183374g	24	35	activity	activity	NOUN
3b59183374g	24	36	.	.	PUNCT
3b59183374g	25	1	importantly	importantly	ADV
3b59183374g	25	2	,	,	PUNCT
3b59183374g	25	3	bradycardia	bradycardia	NOUN
3b59183374g	25	4	and	and	CCONJ
3b59183374g	25	5	hypotension	hypotension	NOUN
3b59183374g	25	6	were	be	AUX
3b59183374g	25	7	more	more	ADV
3b59183374g	25	8	severe	severe	ADJ
3b59183374g	25	9	in	in	ADP
3b59183374g	25	10	$	$	SYM
3b59183374g	25	11	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	25	12	mice	mouse	NOUN
3b59183374g	25	13	during	during	ADP
3b59183374g	25	14	septic	septic	ADJ
3b59183374g	25	15	shock	shock	NOUN
3b59183374g	25	16	which	which	PRON
3b59183374g	25	17	reveals	reveal	VERB
3b59183374g	25	18	a	a	DET
3b59183374g	25	19	previously	previously	ADV
3b59183374g	25	20	unknown	unknown	ADJ
3b59183374g	25	21	activity	activity	NOUN
3b59183374g	25	22	of	of	ADP
3b59183374g	25	23	pc	pc	NOUN
3b59183374g	25	24	in	in	ADP
3b59183374g	25	25	the	the	DET
3b59183374g	25	26	modulation	modulation	NOUN
3b59183374g	25	27	of	of	ADP
3b59183374g	25	28	blood	blood	NOUN
3b59183374g	25	29	pressure	pressure	NOUN
3b59183374g	25	30	,	,	PUNCT
3b59183374g	25	31	indeed	indeed	ADV
3b59183374g	25	32	indispensable	indispensable	ADJ
3b59183374g	25	33	for	for	ADP
3b59183374g	25	34	the	the	DET
3b59183374g	25	35	survival	survival	NOUN
3b59183374g	25	36	of	of	ADP
3b59183374g	25	37	the	the	DET
3b59183374g	25	38	animals	animal	NOUN
3b59183374g	25	39	during	during	ADP
3b59183374g	25	40	sepsis	sepsis	NOUN
3b59183374g	25	41	.	.	PUNCT
3b59183374g	26	1	arterial	arterial	ADJ
3b59183374g	26	2	inflammation	inflammation	NOUN
3b59183374g	26	3	was	be	AUX
3b59183374g	26	4	more	more	ADV
3b59183374g	26	5	prominent	prominent	ADJ
3b59183374g	26	6	in	in	ADP
3b59183374g	26	7	mice	mouse	NOUN
3b59183374g	26	8	with	with	ADP
3b59183374g	26	9	a	a	DET
3b59183374g	26	10	heterozygous	heterozygous	ADJ
3b59183374g	26	11	pc	pc	NOUN
3b59183374g	26	12	deficiency	deficiency	NOUN
3b59183374g	26	13	after	after	ADP
3b59183374g	26	14	copper	copper	NOUN
3b59183374g	26	15	-	-	PUNCT
3b59183374g	26	16	silicone	silicone	NOUN
3b59183374g	26	17	cuff	cuff	NOUN
3b59183374g	26	18	placement	placement	NOUN
3b59183374g	26	19	around	around	ADP
3b59183374g	26	20	the	the	DET
3b59183374g	26	21	left	left	ADJ
3b59183374g	26	22	carotid	carotid	NOUN
3b59183374g	26	23	artery	artery	NOUN
3b59183374g	26	24	.	.	PUNCT
3b59183374g	27	1	at	at	ADP
3b59183374g	27	2	an	an	DET
3b59183374g	27	3	early	early	ADJ
3b59183374g	27	4	time	time	NOUN
3b59183374g	27	5	point	point	NOUN
3b59183374g	27	6	,	,	PUNCT
3b59183374g	27	7	7	7	NUM
3b59183374g	27	8	days	day	NOUN
3b59183374g	27	9	after	after	ADP
3b59183374g	27	10	cuff	cuff	NOUN
3b59183374g	27	11	placement	placement	NOUN
3b59183374g	27	12	,	,	PUNCT
3b59183374g	27	13	the	the	DET
3b59183374g	27	14	areas	area	NOUN
3b59183374g	27	15	of	of	ADP
3b59183374g	27	16	the	the	DET
3b59183374g	27	17	different	different	ADJ
3b59183374g	27	18	arterial	arterial	ADJ
3b59183374g	27	19	compartments	compartment	NOUN
3b59183374g	27	20	in	in	ADP
3b59183374g	27	21	transversal	transversal	ADJ
3b59183374g	27	22	sections	section	NOUN
3b59183374g	27	23	of	of	ADP
3b59183374g	27	24	the	the	DET
3b59183374g	27	25	arteries	artery	NOUN
3b59183374g	27	26	,	,	PUNCT
3b59183374g	27	27	presented	present	VERB
3b59183374g	27	28	no	no	DET
3b59183374g	27	29	significant	significant	ADJ
3b59183374g	27	30	differences	difference	NOUN
3b59183374g	27	31	,	,	PUNCT
3b59183374g	27	32	although	although	SCONJ
3b59183374g	27	33	the	the	DET
3b59183374g	27	34	percentage	percentage	NOUN
3b59183374g	27	35	of	of	ADP
3b59183374g	27	36	inflammatory	inflammatory	ADJ
3b59183374g	27	37	and	and	CCONJ
3b59183374g	27	38	proliferating	proliferate	VERB
3b59183374g	27	39	cells	cell	NOUN
3b59183374g	27	40	was	be	AUX
3b59183374g	27	41	higher	high	ADJ
3b59183374g	27	42	in	in	ADP
3b59183374g	27	43	$	$	SYM
3b59183374g	27	44	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	27	45	carotids	carotid	NOUN
3b59183374g	27	46	,	,	PUNCT
3b59183374g	27	47	relative	relative	ADJ
3b59183374g	27	48	to	to	ADP
3b59183374g	27	49	{	{	PUNCT
3b59183374g	27	50	it	it	PRON
3b59183374g	27	51	wt	wt	PROPN
3b59183374g	27	52	}	}	PUNCT
3b59183374g	27	53	treated	treat	VERB
3b59183374g	27	54	controls	control	NOUN
3b59183374g	27	55	.	.	PUNCT
3b59183374g	28	1	at	at	ADP
3b59183374g	28	2	the	the	DET
3b59183374g	28	3	chronic	chronic	ADJ
3b59183374g	28	4	stage	stage	NOUN
3b59183374g	28	5	,	,	PUNCT
3b59183374g	28	6	21	21	NUM
3b59183374g	28	7	days	day	NOUN
3b59183374g	28	8	after	after	ADP
3b59183374g	28	9	cuff	cuff	NOUN
3b59183374g	28	10	placement	placement	NOUN
3b59183374g	28	11	,	,	PUNCT
3b59183374g	28	12	the	the	DET
3b59183374g	28	13	areas	area	NOUN
3b59183374g	28	14	of	of	ADP
3b59183374g	28	15	the	the	DET
3b59183374g	28	16	different	different	ADJ
3b59183374g	28	17	compartments	compartment	NOUN
3b59183374g	28	18	were	be	AUX
3b59183374g	28	19	significantly	significantly	ADV
3b59183374g	28	20	larger	large	ADJ
3b59183374g	28	21	in	in	ADP
3b59183374g	28	22	$	$	SYM
3b59183374g	28	23	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	28	24	carotids	carotid	NOUN
3b59183374g	28	25	,	,	PUNCT
3b59183374g	28	26	as	as	SCONJ
3b59183374g	28	27	compared	compare	VERB
3b59183374g	28	28	to	to	ADP
3b59183374g	28	29	{	{	PUNCT
3b59183374g	28	30	it	it	PRON
3b59183374g	28	31	wt	wt	NOUN
3b59183374g	28	32	}	}	PUNCT
3b59183374g	28	33	arteries	artery	NOUN
3b59183374g	28	34	.	.	PUNCT
3b59183374g	29	1	additionally	additionally	ADV
3b59183374g	29	2	,	,	PUNCT
3b59183374g	29	3	arterial	arterial	ADJ
3b59183374g	29	4	occlusion	occlusion	NOUN
3b59183374g	29	5	,	,	PUNCT
3b59183374g	29	6	cell	cell	NOUN
3b59183374g	29	7	proliferation	proliferation	NOUN
3b59183374g	29	8	,	,	PUNCT
3b59183374g	29	9	and	and	CCONJ
3b59183374g	29	10	inflammation	inflammation	NOUN
3b59183374g	29	11	were	be	AUX
3b59183374g	29	12	more	more	ADV
3b59183374g	29	13	elevated	elevated	ADJ
3b59183374g	29	14	in	in	ADP
3b59183374g	29	15	$	$	SYM
3b59183374g	29	16	pc^{+/-}$	pc^{+/-}$	NOUN
3b59183374g	29	17	arteries	artery	NOUN
3b59183374g	29	18	.	.	PUNCT
3b59183374g	30	1	these	these	DET
3b59183374g	30	2	results	result	NOUN
3b59183374g	30	3	show	show	VERB
3b59183374g	30	4	the	the	DET
3b59183374g	30	5	importance	importance	NOUN
3b59183374g	30	6	of	of	ADP
3b59183374g	30	7	pc	pc	NOUN
3b59183374g	30	8	in	in	ADP
3b59183374g	30	9	the	the	DET
3b59183374g	30	10	modulation	modulation	NOUN
3b59183374g	30	11	of	of	ADP
3b59183374g	30	12	initiation	initiation	NOUN
3b59183374g	30	13	,	,	PUNCT
3b59183374g	30	14	progression	progression	NOUN
3b59183374g	30	15	,	,	PUNCT
3b59183374g	30	16	and	and	CCONJ
3b59183374g	30	17	resolution	resolution	NOUN
3b59183374g	30	18	of	of	ADP
3b59183374g	30	19	arterial	arterial	ADJ
3b59183374g	30	20	inflammation	inflammation	NOUN
3b59183374g	30	21	.	.	PUNCT
3b59183374g	31	1	during	during	ADP
3b59183374g	31	2	the	the	DET
3b59183374g	31	3	analysis	analysis	NOUN
3b59183374g	31	4	of	of	ADP
3b59183374g	31	5	control	control	NOUN
3b59183374g	31	6	$	$	SYM
3b59183374g	31	7	pc^{+/+}fxi^{-/-}$	pc^{+/+}fxi^{-/-}$	NOUN
3b59183374g	31	8	animals	animal	NOUN
3b59183374g	31	9	in	in	ADP
3b59183374g	31	10	the	the	DET
3b59183374g	31	11	characterization	characterization	NOUN
3b59183374g	31	12	of	of	ADP
3b59183374g	31	13	$	$	SYM
3b59183374g	31	14	pc^{-/-}fxi^{-/-}$	pc^{-/-}fxi^{-/-}$	NOUN
3b59183374g	31	15	mice	mouse	NOUN
3b59183374g	31	16	,	,	PUNCT
3b59183374g	31	17	some	some	DET
3b59183374g	31	18	surprising	surprising	ADJ
3b59183374g	31	19	anomalies	anomaly	NOUN
3b59183374g	31	20	were	be	AUX
3b59183374g	31	21	found	find	VERB
3b59183374g	31	22	in	in	ADP
3b59183374g	31	23	the	the	DET
3b59183374g	31	24	vasculature	vasculature	NOUN
3b59183374g	31	25	of	of	ADP
3b59183374g	31	26	$	$	SYM
3b59183374g	31	27	fxi^{-/-}$	fxi^{-/-}$	X
3b59183374g	31	28	mice	mouse	NOUN
3b59183374g	31	29	.	.	PUNCT
3b59183374g	32	1	the	the	DET
3b59183374g	32	2	arteries	artery	NOUN
3b59183374g	32	3	of	of	ADP
3b59183374g	32	4	these	these	DET
3b59183374g	32	5	mice	mouse	NOUN
3b59183374g	32	6	showed	show	VERB
3b59183374g	32	7	signs	sign	NOUN
3b59183374g	32	8	of	of	ADP
3b59183374g	32	9	vascular	vascular	ADJ
3b59183374g	32	10	relaxation	relaxation	NOUN
3b59183374g	32	11	denoted	denote	VERB
3b59183374g	32	12	by	by	ADP
3b59183374g	32	13	arterial	arterial	ADJ
3b59183374g	32	14	dilatation	dilatation	NOUN
3b59183374g	32	15	and	and	CCONJ
3b59183374g	32	16	flattening	flattening	NOUN
3b59183374g	32	17	,	,	PUNCT
3b59183374g	32	18	in	in	ADP
3b59183374g	32	19	opposition	opposition	NOUN
3b59183374g	32	20	to	to	ADP
3b59183374g	32	21	the	the	DET
3b59183374g	32	22	corrugated	corrugate	VERB
3b59183374g	32	23	phenotype	phenotype	NOUN
3b59183374g	32	24	displayed	display	VERB
3b59183374g	32	25	by	by	ADP
3b59183374g	32	26	{	{	PUNCT
3b59183374g	32	27	it	it	PRON
3b59183374g	32	28	wt	wt	NOUN
3b59183374g	32	29	}	}	PUNCT
3b59183374g	32	30	arteries	artery	NOUN
3b59183374g	32	31	.	.	PUNCT
3b59183374g	33	1	in	in	ADP
3b59183374g	33	2	addition	addition	NOUN
3b59183374g	33	3	,	,	PUNCT
3b59183374g	33	4	endothelial	endothelial	ADJ
3b59183374g	33	5	integrity	integrity	NOUN
3b59183374g	33	6	was	be	AUX
3b59183374g	33	7	occasionally	occasionally	ADV
3b59183374g	33	8	compromised	compromise	VERB
3b59183374g	33	9	in	in	ADP
3b59183374g	33	10	$	$	SYM
3b59183374g	33	11	fxi^{-/-}$	fxi^{-/-}$	X
3b59183374g	33	12	arteries	artery	NOUN
3b59183374g	33	13	.	.	PUNCT
3b59183374g	34	1	considering	consider	VERB
3b59183374g	34	2	these	these	DET
3b59183374g	34	3	observations	observation	NOUN
3b59183374g	34	4	and	and	CCONJ
3b59183374g	34	5	the	the	DET
3b59183374g	34	6	evidence	evidence	NOUN
3b59183374g	34	7	of	of	ADP
3b59183374g	34	8	increased	increase	VERB
3b59183374g	34	9	granulocyte	granulocyte	NOUN
3b59183374g	34	10	activation	activation	NOUN
3b59183374g	34	11	in	in	ADP
3b59183374g	34	12	$	$	SYM
3b59183374g	34	13	fxi^{-/-}$	fxi^{-/-}$	X
3b59183374g	34	14	cattle	cattle	NOUN
3b59183374g	34	15	,	,	PUNCT
3b59183374g	34	16	we	we	PRON
3b59183374g	34	17	decided	decide	VERB
3b59183374g	34	18	to	to	PART
3b59183374g	34	19	include	include	VERB
3b59183374g	34	20	$	$	SYM
3b59183374g	34	21	fxi^{-/-}$	fxi^{-/-}$	NOUN
3b59183374g	34	22	mice	mouse	NOUN
3b59183374g	34	23	in	in	ADP
3b59183374g	34	24	the	the	DET
3b59183374g	34	25	study	study	NOUN
3b59183374g	34	26	of	of	ADP
3b59183374g	34	27	copper	copper	NOUN
3b59183374g	34	28	-	-	PUNCT
3b59183374g	34	29	induced	induce	VERB
3b59183374g	34	30	arterial	arterial	ADJ
3b59183374g	34	31	inflammation	inflammation	NOUN
3b59183374g	34	32	.	.	PUNCT
3b59183374g	35	1	as	as	ADP
3b59183374g	35	2	a	a	DET
3b59183374g	35	3	result	result	NOUN
3b59183374g	35	4	,	,	PUNCT
3b59183374g	35	5	arterial	arterial	ADJ
3b59183374g	35	6	inflammation	inflammation	NOUN
3b59183374g	35	7	and	and	CCONJ
3b59183374g	35	8	cell	cell	NOUN
3b59183374g	35	9	proliferation	proliferation	NOUN
3b59183374g	35	10	were	be	AUX
3b59183374g	35	11	remarkably	remarkably	ADV
3b59183374g	35	12	more	more	ADV
3b59183374g	35	13	elevated	elevated	ADJ
3b59183374g	35	14	in	in	ADP
3b59183374g	35	15	$	$	SYM
3b59183374g	35	16	fxi^{-/-}$	fxi^{-/-}$	NOUN
3b59183374g	35	17	arteries	artery	NOUN
3b59183374g	35	18	,	,	PUNCT
3b59183374g	35	19	compared	compare	VERB
3b59183374g	35	20	to	to	ADP
3b59183374g	35	21	similar	similar	ADJ
3b59183374g	35	22	{	{	PUNCT
3b59183374g	35	23	it	it	PRON
3b59183374g	35	24	wt	wt	NOUN
3b59183374g	35	25	}	}	PUNCT
3b59183374g	35	26	arteries	artery	NOUN
3b59183374g	35	27	,	,	PUNCT
3b59183374g	35	28	at	at	ADP
3b59183374g	35	29	early	early	ADJ
3b59183374g	35	30	and	and	CCONJ
3b59183374g	35	31	late	late	ADJ
3b59183374g	35	32	time	time	NOUN
3b59183374g	35	33	points	point	NOUN
3b59183374g	35	34	.	.	PUNCT
3b59183374g	36	1	however	however	ADV
3b59183374g	36	2	,	,	PUNCT
3b59183374g	36	3	the	the	DET
3b59183374g	36	4	areas	area	NOUN
3b59183374g	36	5	of	of	ADP
3b59183374g	36	6	arterial	arterial	ADJ
3b59183374g	36	7	transversal	transversal	ADJ
3b59183374g	36	8	sections	section	NOUN
3b59183374g	36	9	were	be	AUX
3b59183374g	36	10	larger	large	ADJ
3b59183374g	36	11	in	in	ADP
3b59183374g	36	12	$	$	SYM
3b59183374g	36	13	fxi^{-/-}$	fxi^{-/-}$	NOUN
3b59183374g	36	14	arteries	artery	NOUN
3b59183374g	36	15	than	than	ADP
3b59183374g	36	16	in	in	ADP
3b59183374g	36	17	{	{	PUNCT
3b59183374g	36	18	it	it	PRON
3b59183374g	36	19	wt	wt	NOUN
3b59183374g	36	20	}	}	PUNCT
3b59183374g	36	21	arteries	artery	NOUN
3b59183374g	36	22	,	,	PUNCT
3b59183374g	36	23	only	only	ADV
3b59183374g	36	24	in	in	ADP
3b59183374g	36	25	the	the	DET
3b59183374g	36	26	earlier	early	ADJ
3b59183374g	36	27	time	time	NOUN
3b59183374g	36	28	point	point	NOUN
3b59183374g	36	29	.	.	PUNCT
3b59183374g	37	1	these	these	DET
3b59183374g	37	2	observations	observation	NOUN
3b59183374g	37	3	suggest	suggest	VERB
3b59183374g	37	4	that	that	SCONJ
3b59183374g	37	5	the	the	DET
3b59183374g	37	6	initial	initial	ADJ
3b59183374g	37	7	condition	condition	NOUN
3b59183374g	37	8	of	of	ADP
3b59183374g	37	9	the	the	DET
3b59183374g	37	10	arteries	artery	NOUN
3b59183374g	37	11	as	as	ADV
3b59183374g	37	12	well	well	ADV
3b59183374g	37	13	as	as	ADP
3b59183374g	37	14	the	the	DET
3b59183374g	37	15	favorable	favorable	ADJ
3b59183374g	37	16	pro	pro	ADJ
3b59183374g	37	17	-	-	ADJ
3b59183374g	37	18	inflammatory	inflammatory	ADJ
3b59183374g	37	19	state	state	NOUN
3b59183374g	37	20	in	in	ADP
3b59183374g	37	21	$	$	SYM
3b59183374g	37	22	fxi^{-/-}$	fxi^{-/-}$	X
3b59183374g	37	23	arteries	artery	NOUN
3b59183374g	37	24	was	be	AUX
3b59183374g	37	25	important	important	ADJ
3b59183374g	37	26	in	in	ADP
3b59183374g	37	27	the	the	DET
3b59183374g	37	28	initiation	initiation	NOUN
3b59183374g	37	29	of	of	ADP
3b59183374g	37	30	the	the	DET
3b59183374g	37	31	arterial	arterial	ADJ
3b59183374g	37	32	damage	damage	NOUN
3b59183374g	37	33	and	and	CCONJ
3b59183374g	37	34	repair	repair	NOUN
3b59183374g	37	35	.	.	PUNCT
3b59183374g	38	1	however	however	ADV
3b59183374g	38	2	,	,	PUNCT
3b59183374g	38	3	a	a	DET
3b59183374g	38	4	deficiency	deficiency	NOUN
3b59183374g	38	5	in	in	ADP
3b59183374g	38	6	a	a	DET
3b59183374g	38	7	pro	pro	ADJ
3b59183374g	38	8	-	-	ADJ
3b59183374g	38	9	coagulant	coagulant	ADJ
3b59183374g	38	10	such	such	ADJ
3b59183374g	38	11	as	as	ADP
3b59183374g	38	12	fxi	fxi	NOUN
3b59183374g	38	13	may	may	AUX
3b59183374g	38	14	play	play	VERB
3b59183374g	38	15	a	a	DET
3b59183374g	38	16	compensatory	compensatory	ADJ
3b59183374g	38	17	role	role	NOUN
3b59183374g	38	18	in	in	ADP
3b59183374g	38	19	the	the	DET
3b59183374g	38	20	progression	progression	NOUN
3b59183374g	38	21	of	of	ADP
3b59183374g	38	22	the	the	DET
3b59183374g	38	23	disease	disease	NOUN
3b59183374g	38	24	,	,	PUNCT
3b59183374g	38	25	albeit	albeit	SCONJ
3b59183374g	38	26	the	the	DET
3b59183374g	38	27	existing	exist	VERB
3b59183374g	38	28	inflammatory	inflammatory	ADJ
3b59183374g	38	29	propensity	propensity	NOUN
3b59183374g	38	30	.	.	PUNCT
3b59183374g	39	1	we	we	PRON
3b59183374g	39	2	believe	believe	VERB
3b59183374g	39	3	that	that	SCONJ
3b59183374g	39	4	elevated	elevated	ADJ
3b59183374g	39	5	kallikrein	kallikrein	ADJ
3b59183374g	39	6	and	and	CCONJ
3b59183374g	39	7	bradykinin	bradykinin	NOUN
3b59183374g	39	8	(	(	PUNCT
3b59183374g	39	9	bk	bk	NOUN
3b59183374g	39	10	)	)	PUNCT
3b59183374g	39	11	generation	generation	NOUN
3b59183374g	39	12	are	be	AUX
3b59183374g	39	13	crucial	crucial	ADJ
3b59183374g	39	14	in	in	ADP
3b59183374g	39	15	the	the	DET
3b59183374g	39	16	development	development	NOUN
3b59183374g	39	17	of	of	ADP
3b59183374g	39	18	the	the	DET
3b59183374g	39	19	arterial	arterial	ADJ
3b59183374g	39	20	pathology	pathology	NOUN
3b59183374g	39	21	in	in	ADP
3b59183374g	39	22	$	$	SYM
3b59183374g	39	23	fxi^{-/-}$	fxi^{-/-}$	X
3b59183374g	39	24	mice	mouse	NOUN
3b59183374g	39	25	,	,	PUNCT
3b59183374g	39	26	balancing	balance	VERB
3b59183374g	39	27	the	the	DET
3b59183374g	39	28	up	up	NOUN
3b59183374g	39	29	-	-	PUNCT
3b59183374g	39	30	regulation	regulation	NOUN
3b59183374g	39	31	of	of	ADP
3b59183374g	39	32	inflammation	inflammation	NOUN
3b59183374g	39	33	through	through	ADP
3b59183374g	39	34	complement	complement	NOUN
3b59183374g	39	35	and	and	CCONJ
3b59183374g	39	36	neutrophil	neutrophil	NOUN
3b59183374g	39	37	activation	activation	NOUN
3b59183374g	39	38	,	,	PUNCT
3b59183374g	39	39	with	with	ADP
3b59183374g	39	40	the	the	DET
3b59183374g	39	41	enhancement	enhancement	NOUN
3b59183374g	39	42	of	of	ADP
3b59183374g	39	43	fibrinolysis	fibrinolysis	NOUN
3b59183374g	39	44	or	or	CCONJ
3b59183374g	39	45	decrease	decrease	NOUN
3b59183374g	39	46	of	of	ADP
3b59183374g	39	47	blood	blood	NOUN
3b59183374g	39	48	pressure	pressure	NOUN
3b59183374g	39	49	through	through	ADP
3b59183374g	39	50	bk	bk	PRON
3b59183374g	39	51	and	and	CCONJ
3b59183374g	39	52	its	its	PRON
3b59183374g	39	53	cellular	cellular	ADJ
3b59183374g	39	54	receptor	receptor	NOUN
3b59183374g	39	55	.	.	PUNCT