id sid tid token lemma pos 3b59183371f 1 1 zebrafish zebrafish NOUN 3b59183371f 1 2 can can AUX 3b59183371f 1 3 regenerate regenerate VERB 3b59183371f 1 4 damaged damaged ADJ 3b59183371f 1 5 photoreceptors photoreceptor NOUN 3b59183371f 1 6 following follow VERB 3b59183371f 1 7 constant constant ADJ 3b59183371f 1 8 intense intense ADJ 3b59183371f 1 9 light light ADJ 3b59183371f 1 10 treatment treatment NOUN 3b59183371f 1 11 . . PUNCT 3b59183371f 2 1 during during ADP 3b59183371f 2 2 regeneration regeneration NOUN 3b59183371f 2 3 , , PUNCT 3b59183371f 2 4 the the DET 3b59183371f 2 5 müller müller PROPN 3b59183371f 2 6 glial glial ADJ 3b59183371f 2 7 cell cell NOUN 3b59183371f 2 8 dedifferentiates dedifferentiate NOUN 3b59183371f 2 9 and and CCONJ 3b59183371f 2 10 reenters reenter VERB 3b59183371f 2 11 the the DET 3b59183371f 2 12 cell cell NOUN 3b59183371f 2 13 cycle cycle NOUN 3b59183371f 2 14 to to PART 3b59183371f 2 15 produce produce VERB 3b59183371f 2 16 neuronal neuronal ADJ 3b59183371f 2 17 progenitor progenitor NOUN 3b59183371f 2 18 cells cell NOUN 3b59183371f 2 19 , , PUNCT 3b59183371f 2 20 which which PRON 3b59183371f 2 21 continue continue VERB 3b59183371f 2 22 to to PART 3b59183371f 2 23 divide divide VERB 3b59183371f 2 24 , , PUNCT 3b59183371f 2 25 migrate migrate VERB 3b59183371f 2 26 to to ADP 3b59183371f 2 27 the the DET 3b59183371f 2 28 photoreceptor photoreceptor NOUN 3b59183371f 2 29 layer layer NOUN 3b59183371f 2 30 and and CCONJ 3b59183371f 2 31 differentiate differentiate VERB 3b59183371f 2 32 into into ADP 3b59183371f 2 33 rod rod NOUN 3b59183371f 2 34 and and CCONJ 3b59183371f 2 35 cone cone NOUN 3b59183371f 2 36 photoreceptors photoreceptor NOUN 3b59183371f 2 37 . . PUNCT 3b59183371f 3 1 the the DET 3b59183371f 3 2 mechanisms mechanism NOUN 3b59183371f 3 3 regulating regulate VERB 3b59183371f 3 4 dedifferentiation dedifferentiation NOUN 3b59183371f 3 5 and and CCONJ 3b59183371f 3 6 proliferation proliferation NOUN 3b59183371f 3 7 of of ADP 3b59183371f 3 8 müller müller NOUN 3b59183371f 3 9 glia glia NOUN 3b59183371f 3 10 , , PUNCT 3b59183371f 3 11 the the DET 3b59183371f 3 12 formation formation NOUN 3b59183371f 3 13 and and CCONJ 3b59183371f 3 14 amplification amplification NOUN 3b59183371f 3 15 of of ADP 3b59183371f 3 16 progenitor progenitor NOUN 3b59183371f 3 17 cells cell NOUN 3b59183371f 3 18 , , PUNCT 3b59183371f 3 19 and and CCONJ 3b59183371f 3 20 their their PRON 3b59183371f 3 21 subsequent subsequent ADJ 3b59183371f 3 22 differentiation differentiation NOUN 3b59183371f 3 23 to to ADP 3b59183371f 3 24 photoreceptors photoreceptor NOUN 3b59183371f 3 25 remain remain VERB 3b59183371f 3 26 unknown unknown ADJ 3b59183371f 3 27 . . PUNCT 3b59183371f 4 1 one one NUM 3b59183371f 4 2 signaling signal VERB 3b59183371f 4 3 pathway pathway NOUN 3b59183371f 4 4 associated associate VERB 3b59183371f 4 5 with with ADP 3b59183371f 4 6 these these DET 3b59183371f 4 7 processes process NOUN 3b59183371f 4 8 during during ADP 3b59183371f 4 9 both both DET 3b59183371f 4 10 development development NOUN 3b59183371f 4 11 and and CCONJ 3b59183371f 4 12 regeneration regeneration NOUN 3b59183371f 4 13 is be AUX 3b59183371f 4 14 the the DET 3b59183371f 4 15 notch notch ADJ 3b59183371f 4 16 - - PUNCT 3b59183371f 4 17 delta delta NOUN 3b59183371f 4 18 signaling signal VERB 3b59183371f 4 19 pathway pathway NOUN 3b59183371f 4 20 . . PUNCT 3b59183371f 5 1 while while SCONJ 3b59183371f 5 2 notch notch NOUN 3b59183371f 5 3 has have VERB 3b59183371f 5 4 different different ADJ 3b59183371f 5 5 functions function NOUN 3b59183371f 5 6 in in ADP 3b59183371f 5 7 various various ADJ 3b59183371f 5 8 cell cell NOUN 3b59183371f 5 9 types type NOUN 3b59183371f 5 10 , , PUNCT 3b59183371f 5 11 it it PRON 3b59183371f 5 12 primarily primarily ADV 3b59183371f 5 13 regulates regulate VERB 3b59183371f 5 14 cell cell NOUN 3b59183371f 5 15 proliferation proliferation NOUN 3b59183371f 5 16 , , PUNCT 3b59183371f 5 17 cell cell NOUN 3b59183371f 5 18 fate fate NOUN 3b59183371f 5 19 choice choice NOUN 3b59183371f 5 20 and and CCONJ 3b59183371f 5 21 differentiation differentiation NOUN 3b59183371f 5 22 . . PUNCT 3b59183371f 6 1 to to PART 3b59183371f 6 2 better well ADV 3b59183371f 6 3 understand understand VERB 3b59183371f 6 4 the the DET 3b59183371f 6 5 potential potential ADJ 3b59183371f 6 6 roles role NOUN 3b59183371f 6 7 notch notch NOUN 3b59183371f 6 8 signaling signal VERB 3b59183371f 6 9 may may AUX 3b59183371f 6 10 play play VERB 3b59183371f 6 11 and and CCONJ 3b59183371f 6 12 differentiation differentiation NOUN 3b59183371f 6 13 . . PUNCT 3b59183371f 7 1 to to PART 3b59183371f 7 2 better well ADV 3b59183371f 7 3 understand understand VERB 3b59183371f 7 4 the the DET 3b59183371f 7 5 potential potential ADJ 3b59183371f 7 6 roles role NOUN 3b59183371f 7 7 notch notch NOUN 3b59183371f 7 8 signaling signal VERB 3b59183371f 7 9 may may AUX 3b59183371f 7 10 play play VERB 3b59183371f 7 11 during during ADP 3b59183371f 7 12 regeneration regeneration NOUN 3b59183371f 7 13 , , PUNCT 3b59183371f 7 14 & & CCONJ 3b59183371f 7 15 # # SYM 3b59183371f 7 16 947;-secretase 947;-secretase NUM 3b59183371f 7 17 inhibitors inhibitor NOUN 3b59183371f 7 18 ( ( PUNCT 3b59183371f 7 19 gsis gsis NOUN 3b59183371f 7 20 ) ) PUNCT 3b59183371f 7 21 , , PUNCT 3b59183371f 7 22 which which PRON 3b59183371f 7 23 block block VERB 3b59183371f 7 24 notch notch NOUN 3b59183371f 7 25 signaling signaling NOUN 3b59183371f 7 26 , , PUNCT 3b59183371f 7 27 were be AUX 3b59183371f 7 28 injected inject VERB 3b59183371f 7 29 into into ADP 3b59183371f 7 30 retinas retina NOUN 3b59183371f 7 31 during during ADP 3b59183371f 7 32 light light ADJ 3b59183371f 7 33 treatment treatment NOUN 3b59183371f 7 34 and and CCONJ 3b59183371f 7 35 these these DET 3b59183371f 7 36 retinas retina NOUN 3b59183371f 7 37 exhibited exhibit VERB 3b59183371f 7 38 increased increase VERB 3b59183371f 7 39 numbers number NOUN 3b59183371f 7 40 of of ADP 3b59183371f 7 41 pcna pcna PROPN 3b59183371f 7 42 - - PUNCT 3b59183371f 7 43 positive positive ADJ 3b59183371f 7 44 inl inl ADJ 3b59183371f 7 45 cells cell NOUN 3b59183371f 7 46 during during ADP 3b59183371f 7 47 regeneration regeneration NOUN 3b59183371f 7 48 . . PUNCT 3b59183371f 8 1 the the DET 3b59183371f 8 2 increased increase VERB 3b59183371f 8 3 number number NOUN 3b59183371f 8 4 of of ADP 3b59183371f 8 5 pcna pcna PROPN 3b59183371f 8 6 - - PUNCT 3b59183371f 8 7 positive positive ADJ 3b59183371f 8 8 inl inl PROPN 3b59183371f 8 9 cells cell NOUN 3b59183371f 8 10 was be AUX 3b59183371f 8 11 due due ADJ 3b59183371f 8 12 to to ADP 3b59183371f 8 13 , , PUNCT 3b59183371f 8 14 at at ADP 3b59183371f 8 15 least least ADJ 3b59183371f 8 16 in in ADP 3b59183371f 8 17 part part NOUN 3b59183371f 8 18 , , PUNCT 3b59183371f 8 19 extra extra ADJ 3b59183371f 8 20 müller müller PROPN 3b59183371f 8 21 glia glia NOUN 3b59183371f 8 22 reentering reentere VERB 3b59183371f 8 23 the the DET 3b59183371f 8 24 cell cell NOUN 3b59183371f 8 25 cycle cycle NOUN 3b59183371f 8 26 , , PUNCT 3b59183371f 8 27 suggesting suggest VERB 3b59183371f 8 28 notch notch ADJ 3b59183371f 8 29 signaling signaling NOUN 3b59183371f 8 30 may may AUX 3b59183371f 8 31 maintain maintain VERB 3b59183371f 8 32 müller müller PROPN 3b59183371f 8 33 glial glial ADJ 3b59183371f 8 34 quiescence quiescence NOUN 3b59183371f 8 35 . . PUNCT 3b59183371f 9 1 at at ADP 3b59183371f 9 2 14 14 NUM 3b59183371f 9 3 and and CCONJ 3b59183371f 9 4 28 28 NUM 3b59183371f 9 5 days day NOUN 3b59183371f 9 6 post post NOUN 3b59183371f 9 7 injection injection NOUN 3b59183371f 9 8 , , PUNCT 3b59183371f 9 9 the the DET 3b59183371f 9 10 number number NOUN 3b59183371f 9 11 of of ADP 3b59183371f 9 12 müller müller NOUN 3b59183371f 9 13 glia glia NOUN 3b59183371f 9 14 were be AUX 3b59183371f 9 15 significantly significantly ADV 3b59183371f 9 16 reduced reduce VERB 3b59183371f 9 17 in in ADP 3b59183371f 9 18 gsi gsi PROPN 3b59183371f 9 19 - - PUNCT 3b59183371f 9 20 treated treat VERB 3b59183371f 9 21 retinas retina NOUN 3b59183371f 9 22 relative relative ADJ 3b59183371f 9 23 to to ADP 3b59183371f 9 24 controls control NOUN 3b59183371f 9 25 , , PUNCT 3b59183371f 9 26 while while SCONJ 3b59183371f 9 27 both both PRON 3b59183371f 9 28 uv uv NOUN 3b59183371f 9 29 and and CCONJ 3b59183371f 9 30 blue blue ADJ 3b59183371f 9 31 single single ADJ 3b59183371f 9 32 cones cone NOUN 3b59183371f 9 33 were be AUX 3b59183371f 9 34 increased increase VERB 3b59183371f 9 35 , , PUNCT 3b59183371f 9 36 suggesting suggest VERB 3b59183371f 9 37 that that SCONJ 3b59183371f 9 38 notch notch NOUN 3b59183371f 9 39 signaling signal VERB 3b59183371f 9 40 is be AUX 3b59183371f 9 41 required require VERB 3b59183371f 9 42 for for ADP 3b59183371f 9 43 müller müller PROPN 3b59183371f 9 44 glia glia NOUN 3b59183371f 9 45 redifferentiation redifferentiation NOUN 3b59183371f 9 46 and and CCONJ 3b59183371f 9 47 plays play VERB 3b59183371f 9 48 a a DET 3b59183371f 9 49 role role NOUN 3b59183371f 9 50 in in ADP 3b59183371f 9 51 balancing balance VERB 3b59183371f 9 52 cell cell NOUN 3b59183371f 9 53 fate fate NOUN 3b59183371f 9 54 choice choice NOUN 3b59183371f 9 55 of of ADP 3b59183371f 9 56 progenitor progenitor NOUN 3b59183371f 9 57 cells cell NOUN 3b59183371f 9 58 . . PUNCT 3b59183371f 10 1 undamaged undamaged ADJ 3b59183371f 10 2 retinas retina NOUN 3b59183371f 10 3 injected inject VERB 3b59183371f 10 4 intraperitoneally intraperitoneally ADV 3b59183371f 10 5 with with ADP 3b59183371f 10 6 gsis gsis NOUN 3b59183371f 10 7 exhibited exhibit VERB 3b59183371f 10 8 significantly significantly ADV 3b59183371f 10 9 greater great ADJ 3b59183371f 10 10 numbers number NOUN 3b59183371f 10 11 of of ADP 3b59183371f 10 12 pcna pcna PROPN 3b59183371f 10 13 - - PUNCT 3b59183371f 10 14 positive positive ADJ 3b59183371f 10 15 inl inl ADJ 3b59183371f 10 16 cells cell NOUN 3b59183371f 10 17 , , PUNCT 3b59183371f 10 18 which which PRON 3b59183371f 10 19 were be AUX 3b59183371f 10 20 also also ADV 3b59183371f 10 21 ascl1 ascl1 ADJ 3b59183371f 10 22 and and CCONJ 3b59183371f 10 23 stat3 stat3 NOUN 3b59183371f 10 24 - - PUNCT 3b59183371f 10 25 positive positive ADJ 3b59183371f 10 26 . . PUNCT 3b59183371f 11 1 these these DET 3b59183371f 11 2 two two NUM 3b59183371f 11 3 transcription transcription NOUN 3b59183371f 11 4 factors factor NOUN 3b59183371f 11 5 are be AUX 3b59183371f 11 6 both both PRON 3b59183371f 11 7 required require VERB 3b59183371f 11 8 for for ADP 3b59183371f 11 9 the the DET 3b59183371f 11 10 presence presence NOUN 3b59183371f 11 11 of of ADP 3b59183371f 11 12 these these DET 3b59183371f 11 13 proliferative proliferative ADJ 3b59183371f 11 14 cells cell NOUN 3b59183371f 11 15 . . PUNCT 3b59183371f 12 1 at at ADP 3b59183371f 12 2 7 7 NUM 3b59183371f 12 3 , , PUNCT 3b59183371f 12 4 9 9 NUM 3b59183371f 12 5 , , PUNCT 3b59183371f 12 6 and and CCONJ 3b59183371f 12 7 11 11 NUM 3b59183371f 12 8 days day NOUN 3b59183371f 12 9 after after ADP 3b59183371f 12 10 initial initial ADJ 3b59183371f 12 11 injection injection NOUN 3b59183371f 12 12 , , PUNCT 3b59183371f 12 13 there there PRON 3b59183371f 12 14 were be VERB 3b59183371f 12 15 very very ADV 3b59183371f 12 16 few few ADJ 3b59183371f 12 17 ath5 ath5 NOUN 3b59183371f 12 18 - - PUNCT 3b59183371f 12 19 positive positive ADJ 3b59183371f 12 20 cells cell NOUN 3b59183371f 12 21 , , PUNCT 3b59183371f 12 22 an an DET 3b59183371f 12 23 early early ADJ 3b59183371f 12 24 neuronal neuronal ADJ 3b59183371f 12 25 cell cell NOUN 3b59183371f 12 26 marker marker NOUN 3b59183371f 12 27 , , PUNCT 3b59183371f 12 28 and and CCONJ 3b59183371f 12 29 several several ADJ 3b59183371f 12 30 tunel tunel ADJ 3b59183371f 12 31 - - PUNCT 3b59183371f 12 32 positive positive ADJ 3b59183371f 12 33 cells cell NOUN 3b59183371f 12 34 suggested suggest VERB 3b59183371f 12 35 that that SCONJ 3b59183371f 12 36 the the DET 3b59183371f 12 37 proliferating proliferate VERB 3b59183371f 12 38 cells cell NOUN 3b59183371f 12 39 may may AUX 3b59183371f 12 40 be be AUX 3b59183371f 12 41 undergoing undergo VERB 3b59183371f 12 42 cell cell NOUN 3b59183371f 12 43 death death NOUN 3b59183371f 12 44 instead instead ADV 3b59183371f 12 45 of of ADP 3b59183371f 12 46 committing commit VERB 3b59183371f 12 47 to to ADP 3b59183371f 12 48 a a DET 3b59183371f 12 49 neuronal neuronal ADJ 3b59183371f 12 50 lineage lineage NOUN 3b59183371f 12 51 . . PUNCT 3b59183371f 13 1 however however ADV 3b59183371f 13 2 , , PUNCT 3b59183371f 13 3 the the DET 3b59183371f 13 4 addition addition NOUN 3b59183371f 13 5 of of ADP 3b59183371f 13 6 tnfα tnfα PROPN 3b59183371f 13 7 ; ; PUNCT 3b59183371f 13 8 significantly significantly ADV 3b59183371f 13 9 increased increase VERB 3b59183371f 13 10 the the DET 3b59183371f 13 11 number number NOUN 3b59183371f 13 12 of of ADP 3b59183371f 13 13 pcna pcna PROPN 3b59183371f 13 14 - - PUNCT 3b59183371f 13 15 positive positive ADJ 3b59183371f 13 16 cells cell NOUN 3b59183371f 13 17 and and CCONJ 3b59183371f 13 18 ath5 ath5 NOUN 3b59183371f 13 19 - - PUNCT 3b59183371f 13 20 positive positive ADJ 3b59183371f 13 21 clusters cluster NOUN 3b59183371f 13 22 relative relative ADJ 3b59183371f 13 23 to to ADP 3b59183371f 13 24 gsi gsi ADJ 3b59183371f 13 25 injections injection NOUN 3b59183371f 13 26 alone alone ADV 3b59183371f 13 27 . . PUNCT 3b59183371f 14 1 overall overall ADV 3b59183371f 14 2 , , PUNCT 3b59183371f 14 3 these these DET 3b59183371f 14 4 data datum NOUN 3b59183371f 14 5 demonstrate demonstrate VERB 3b59183371f 14 6 that that SCONJ 3b59183371f 14 7 notch notch NOUN 3b59183371f 14 8 signaling signal VERB 3b59183371f 14 9 is be AUX 3b59183371f 14 10 important important ADJ 3b59183371f 14 11 to to ADP 3b59183371f 14 12 müller müller NOUN 3b59183371f 14 13 glial glial ADJ 3b59183371f 14 14 quiescence quiescence NOUN 3b59183371f 14 15 , , PUNCT 3b59183371f 14 16 cell cell NOUN 3b59183371f 14 17 fate fate NOUN 3b59183371f 14 18 choice choice NOUN 3b59183371f 14 19 and and CCONJ 3b59183371f 14 20 differentiation differentiation NOUN 3b59183371f 14 21 in in ADP 3b59183371f 14 22 the the DET 3b59183371f 14 23 regenerating regenerate VERB 3b59183371f 14 24 zebrafish zebrafish NOUN 3b59183371f 14 25 retina retina NOUN 3b59183371f 14 26 . . PUNCT