id sid tid token lemma pos 2j62s467038 1 1 the the DET 2j62s467038 1 2 active active ADJ 2j62s467038 1 3 metabolite metabolite NOUN 2j62s467038 1 4 of of ADP 2j62s467038 1 5 vitamin vitamin NOUN 2j62s467038 1 6 d3 d3 PROPN 2j62s467038 1 7 , , PUNCT 2j62s467038 1 8 1,25d 1,25d NUM 2j62s467038 1 9 , , PUNCT 2j62s467038 1 10 induces induce VERB 2j62s467038 1 11 growth growth NOUN 2j62s467038 1 12 arrest arrest NOUN 2j62s467038 1 13 and and CCONJ 2j62s467038 1 14 apoptosis apoptosis NOUN 2j62s467038 1 15 in in ADP 2j62s467038 1 16 mcf-7 mcf-7 PUNCT 2j62s467038 1 17 breast breast NOUN 2j62s467038 1 18 cancer cancer NOUN 2j62s467038 1 19 cells cell NOUN 2j62s467038 1 20 through through ADP 2j62s467038 1 21 a a DET 2j62s467038 1 22 mechanism mechanism NOUN 2j62s467038 1 23 involving involve VERB 2j62s467038 1 24 mitochondrial mitochondrial ADJ 2j62s467038 1 25 disruption disruption NOUN 2j62s467038 1 26 , , PUNCT 2j62s467038 1 27 reactive reactive ADJ 2j62s467038 1 28 oxygen oxygen NOUN 2j62s467038 1 29 species specie NOUN 2j62s467038 1 30 ( ( PUNCT 2j62s467038 1 31 ros ros PROPN 2j62s467038 1 32 ) ) PUNCT 2j62s467038 1 33 generation generation NOUN 2j62s467038 1 34 and and CCONJ 2j62s467038 1 35 autophagy autophagy NOUN 2j62s467038 1 36 . . PUNCT 2j62s467038 2 1 the the DET 2j62s467038 2 2 purpose purpose NOUN 2j62s467038 2 3 of of ADP 2j62s467038 2 4 these these DET 2j62s467038 2 5 studies study NOUN 2j62s467038 2 6 was be AUX 2j62s467038 2 7 to to PART 2j62s467038 2 8 further far ADV 2j62s467038 2 9 investigate investigate VERB 2j62s467038 2 10 the the DET 2j62s467038 2 11 signaling signal VERB 2j62s467038 2 12 pathways pathway NOUN 2j62s467038 2 13 impacted impact VERB 2j62s467038 2 14 by by ADP 2j62s467038 2 15 1,25d 1,25d NUM 2j62s467038 2 16 in in ADP 2j62s467038 2 17 mcf-7 mcf-7 NOUN 2j62s467038 2 18 cells cell NOUN 2j62s467038 2 19 and and CCONJ 2j62s467038 2 20 a a DET 2j62s467038 2 21 1,25d 1,25d NUM 2j62s467038 2 22 resistant resistant ADJ 2j62s467038 2 23 variant variant NOUN 2j62s467038 2 24 , , PUNCT 2j62s467038 2 25 mcf-7dr mcf-7dr SPACE 2j62s467038 2 26 . . PUNCT 2j62s467038 3 1 characterization characterization NOUN 2j62s467038 3 2 of of ADP 2j62s467038 3 3 mcf-7dr mcf-7dr NOUN 2j62s467038 3 4 cells cell NOUN 2j62s467038 3 5 revealed reveal VERB 2j62s467038 3 6 lower low ADJ 2j62s467038 3 7 expression expression NOUN 2j62s467038 3 8 and and CCONJ 2j62s467038 3 9 activity activity NOUN 2j62s467038 3 10 of of ADP 2j62s467038 3 11 vdr vdr NOUN 2j62s467038 3 12 which which PRON 2j62s467038 3 13 probably probably ADV 2j62s467038 3 14 underlies underlie VERB 2j62s467038 3 15 resistance resistance NOUN 2j62s467038 3 16 of of ADP 2j62s467038 3 17 these these DET 2j62s467038 3 18 cells cell NOUN 2j62s467038 3 19 to to ADP 2j62s467038 3 20 1,25d 1,25d NUM 2j62s467038 3 21 . . PUNCT 2j62s467038 4 1 disruption disruption NOUN 2j62s467038 4 2 of of ADP 2j62s467038 4 3 redox redox ADJ 2j62s467038 4 4 balance balance NOUN 2j62s467038 4 5 and and CCONJ 2j62s467038 4 6 ros ros PROPN 2j62s467038 4 7 generation generation NOUN 2j62s467038 4 8 is be AUX 2j62s467038 4 9 characteristic characteristic ADJ 2j62s467038 4 10 of of ADP 2j62s467038 4 11 1,25d 1,25d NUM 2j62s467038 4 12 induced induce VERB 2j62s467038 4 13 apoptosis apoptosis NOUN 2j62s467038 4 14 in in ADP 2j62s467038 4 15 mcf-7 mcf-7 NOUN 2j62s467038 4 16 cells cell NOUN 2j62s467038 4 17 . . PUNCT 2j62s467038 5 1 vdup1 vdup1 NOUN 2j62s467038 5 2 is be AUX 2j62s467038 5 3 a a DET 2j62s467038 5 4 1,25d 1,25d NUM 2j62s467038 5 5 regulated regulated ADJ 2j62s467038 5 6 protein protein NOUN 2j62s467038 5 7 that that PRON 2j62s467038 5 8 binds bind VERB 2j62s467038 5 9 to to ADP 2j62s467038 5 10 the the DET 2j62s467038 5 11 small small ADJ 2j62s467038 5 12 redox redox ADJ 2j62s467038 5 13 protein protein NOUN 2j62s467038 5 14 thioredoxin thioredoxin NOUN 2j62s467038 5 15 , , PUNCT 2j62s467038 5 16 which which PRON 2j62s467038 5 17 is be AUX 2j62s467038 5 18 responsible responsible ADJ 2j62s467038 5 19 for for ADP 2j62s467038 5 20 neutralizing neutralize VERB 2j62s467038 5 21 ros ros PROPN 2j62s467038 5 22 . . PUNCT 2j62s467038 6 1 in in ADP 2j62s467038 6 2 mcf-7 mcf-7 NOUN 2j62s467038 6 3 cells cell NOUN 2j62s467038 6 4 1,25d 1,25d NUM 2j62s467038 6 5 altered altered ADJ 2j62s467038 6 6 thioredoxin thioredoxin NOUN 2j62s467038 6 7 localization localization NOUN 2j62s467038 6 8 and and CCONJ 2j62s467038 6 9 redox redox ADJ 2j62s467038 6 10 status status NOUN 2j62s467038 6 11 . . PUNCT 2j62s467038 7 1 to to PART 2j62s467038 7 2 further far ADV 2j62s467038 7 3 elucidate elucidate VERB 2j62s467038 7 4 the the DET 2j62s467038 7 5 pathways pathway NOUN 2j62s467038 7 6 affected affect VERB 2j62s467038 7 7 by by ADP 2j62s467038 7 8 1,25d 1,25d NUM 2j62s467038 7 9 a a DET 2j62s467038 7 10 large large ADJ 2j62s467038 7 11 screen screen NOUN 2j62s467038 7 12 for for ADP 2j62s467038 7 13 apoptosis apoptosis NOUN 2j62s467038 7 14 related relate VERB 2j62s467038 7 15 proteins protein NOUN 2j62s467038 7 16 was be AUX 2j62s467038 7 17 carried carry VERB 2j62s467038 7 18 out out ADP 2j62s467038 7 19 . . PUNCT 2j62s467038 8 1 this this DET 2j62s467038 8 2 screen screen NOUN 2j62s467038 8 3 identified identify VERB 2j62s467038 8 4 grim19 grim19 NOUN 2j62s467038 8 5 as as ADP 2j62s467038 8 6 a a DET 2j62s467038 8 7 1,25d 1,25d NUM 2j62s467038 8 8 regulated regulated ADJ 2j62s467038 8 9 protein protein NOUN 2j62s467038 8 10 in in ADP 2j62s467038 8 11 mcf-7 mcf-7 NOUN 2j62s467038 8 12 cells cell NOUN 2j62s467038 8 13 . . PUNCT 2j62s467038 9 1 in in ADP 2j62s467038 9 2 follow follow NOUN 2j62s467038 9 3 - - PUNCT 2j62s467038 9 4 up up ADP 2j62s467038 9 5 analysis analysis NOUN 2j62s467038 9 6 1,25d 1,25d NUM 2j62s467038 9 7 significantly significantly ADV 2j62s467038 9 8 reduced reduce VERB 2j62s467038 9 9 grim19 grim19 NOUN 2j62s467038 9 10 protein protein NOUN 2j62s467038 9 11 in in ADP 2j62s467038 9 12 mcf-7 mcf-7 NOUN 2j62s467038 9 13 cells cell NOUN 2j62s467038 9 14 and and CCONJ 2j62s467038 9 15 induced induce VERB 2j62s467038 9 16 its its PRON 2j62s467038 9 17 nuclear nuclear ADJ 2j62s467038 9 18 localization localization NOUN 2j62s467038 9 19 . . PUNCT 2j62s467038 9 20 grim19 grim19 PUNCT 2j62s467038 10 1 binds bind VERB 2j62s467038 10 2 to to ADP 2j62s467038 10 3 and and CCONJ 2j62s467038 10 4 negatively negatively ADV 2j62s467038 10 5 regulates regulate VERB 2j62s467038 10 6 stat3 stat3 NOUN 2j62s467038 10 7 , , PUNCT 2j62s467038 10 8 a a DET 2j62s467038 10 9 member member NOUN 2j62s467038 10 10 of of ADP 2j62s467038 10 11 the the DET 2j62s467038 10 12 signal signal ADJ 2j62s467038 10 13 transducer transducer NOUN 2j62s467038 10 14 and and CCONJ 2j62s467038 10 15 activator activator NOUN 2j62s467038 10 16 of of ADP 2j62s467038 10 17 transcription transcription NOUN 2j62s467038 10 18 family family NOUN 2j62s467038 10 19 of of ADP 2j62s467038 10 20 proteins protein NOUN 2j62s467038 10 21 . . PUNCT 2j62s467038 11 1 1,25d 1,25d NUM 2j62s467038 11 2 treatment treatment NOUN 2j62s467038 11 3 reduced reduce VERB 2j62s467038 11 4 stat3 stat3 NOUN 2j62s467038 11 5 phosphorylation phosphorylation NOUN 2j62s467038 11 6 at at ADP 2j62s467038 11 7 tyrosine tyrosine NOUN 2j62s467038 11 8 705 705 NUM 2j62s467038 11 9 , , PUNCT 2j62s467038 11 10 which which PRON 2j62s467038 11 11 is be AUX 2j62s467038 11 12 necessary necessary ADJ 2j62s467038 11 13 for for ADP 2j62s467038 11 14 stat3 stat3 NOUN 2j62s467038 11 15 activity activity NOUN 2j62s467038 11 16 . . PUNCT 2j62s467038 12 1 through through ADP 2j62s467038 12 2 these these DET 2j62s467038 12 3 studies study NOUN 2j62s467038 12 4 a a DET 2j62s467038 12 5 newly newly ADV 2j62s467038 12 6 characterized characterize VERB 2j62s467038 12 7 protein protein NOUN 2j62s467038 12 8 , , PUNCT 2j62s467038 12 9 grim19 grim19 NOUN 2j62s467038 12 10 , , PUNCT 2j62s467038 12 11 was be AUX 2j62s467038 12 12 identified identify VERB 2j62s467038 12 13 as as ADP 2j62s467038 12 14 a a DET 2j62s467038 12 15 1,25d 1,25d NUM 2j62s467038 12 16 target target NOUN 2j62s467038 12 17 and and CCONJ 2j62s467038 12 18 the the DET 2j62s467038 12 19 stat3 stat3 NOUN 2j62s467038 12 20 pathway pathway NOUN 2j62s467038 12 21 was be AUX 2j62s467038 12 22 implicated implicate VERB 2j62s467038 12 23 in in ADP 2j62s467038 12 24 1,25d 1,25d NUM 2j62s467038 12 25 mediated mediate VERB 2j62s467038 12 26 apoptosis apoptosis NOUN 2j62s467038 12 27 and and CCONJ 2j62s467038 12 28 signaling signaling NOUN 2j62s467038 12 29 . . PUNCT