id	sid	tid	token	lemma	pos
2f75r783q8n	1	1	emergence	emergence	NOUN
2f75r783q8n	1	2	of	of	ADP
2f75r783q8n	1	3	methicillin	methicillin	NOUN
2f75r783q8n	1	4	-	-	PUNCT
2f75r783q8n	1	5	resistant	resistant	ADJ
2f75r783q8n	1	6	staphylococcus	staphylococcus	PROPN
2f75r783q8n	1	7	aureus	aureus	PROPN
2f75r783q8n	1	8	(	(	PUNCT
2f75r783q8n	1	9	mrsa	mrsa	PROPN
2f75r783q8n	1	10	)	)	PUNCT
2f75r783q8n	1	11	has	have	AUX
2f75r783q8n	1	12	created	create	VERB
2f75r783q8n	1	13	challenges	challenge	NOUN
2f75r783q8n	1	14	in	in	ADP
2f75r783q8n	1	15	treatment	treatment	NOUN
2f75r783q8n	1	16	of	of	ADP
2f75r783q8n	1	17	nosocomial	nosocomial	ADJ
2f75r783q8n	1	18	infections	infection	NOUN
2f75r783q8n	1	19	.	.	PUNCT
2f75r783q8n	2	1	the	the	DET
2f75r783q8n	2	2	recent	recent	ADJ
2f75r783q8n	2	3	emergence	emergence	NOUN
2f75r783q8n	2	4	of	of	ADP
2f75r783q8n	2	5	vancomycin	vancomycin	PROPN
2f75r783q8n	2	6	-	-	PUNCT
2f75r783q8n	2	7	resistant	resistant	ADJ
2f75r783q8n	2	8	mrsa	mrsa	PROPN
2f75r783q8n	2	9	(	(	PUNCT
2f75r783q8n	2	10	vrsa	vrsa	PROPN
2f75r783q8n	2	11	)	)	PUNCT
2f75r783q8n	2	12	is	be	AUX
2f75r783q8n	2	13	a	a	DET
2f75r783q8n	2	14	disconcerting	disconcert	VERB
2f75r783q8n	2	15	chapter	chapter	NOUN
2f75r783q8n	2	16	in	in	ADP
2f75r783q8n	2	17	the	the	DET
2f75r783q8n	2	18	evolution	evolution	NOUN
2f75r783q8n	2	19	of	of	ADP
2f75r783q8n	2	20	these	these	DET
2f75r783q8n	2	21	strains	strain	NOUN
2f75r783q8n	2	22	.	.	PUNCT
2f75r783q8n	3	1	s.	s.	PROPN
2f75r783q8n	3	2	aureus	aureus	PROPN
2f75r783q8n	3	3	normally	normally	ADV
2f75r783q8n	3	4	produces	produce	VERB
2f75r783q8n	3	5	four	four	NUM
2f75r783q8n	3	6	pbps	pbps	NOUN
2f75r783q8n	3	7	,	,	PUNCT
2f75r783q8n	3	8	which	which	PRON
2f75r783q8n	3	9	are	be	AUX
2f75r783q8n	3	10	susceptible	susceptible	ADJ
2f75r783q8n	3	11	to	to	ADP
2f75r783q8n	3	12	modification	modification	NOUN
2f75r783q8n	3	13	by	by	ADP
2f75r783q8n	3	14	&	&	CCONJ
2f75r783q8n	3	15	#	#	SYM
2f75r783q8n	3	16	946;-lactam	946;-lactam	NUM
2f75r783q8n	3	17	antibiotics	antibiotic	NOUN
2f75r783q8n	3	18	,	,	PUNCT
2f75r783q8n	3	19	an	an	DET
2f75r783q8n	3	20	event	event	NOUN
2f75r783q8n	3	21	that	that	PRON
2f75r783q8n	3	22	leads	lead	VERB
2f75r783q8n	3	23	to	to	ADP
2f75r783q8n	3	24	bacterial	bacterial	ADJ
2f75r783q8n	3	25	death	death	NOUN
2f75r783q8n	3	26	.	.	PUNCT
2f75r783q8n	4	1	the	the	DET
2f75r783q8n	4	2	gene	gene	NOUN
2f75r783q8n	4	3	product	product	NOUN
2f75r783q8n	4	4	of	of	ADP
2f75r783q8n	4	5	meca	meca	NOUN
2f75r783q8n	4	6	from	from	ADP
2f75r783q8n	4	7	mrsa	mrsa	PROPN
2f75r783q8n	4	8	is	be	AUX
2f75r783q8n	4	9	a	a	DET
2f75r783q8n	4	10	penicillin	penicillin	NOUN
2f75r783q8n	4	11	-	-	PUNCT
2f75r783q8n	4	12	binding	bind	VERB
2f75r783q8n	4	13	protein	protein	NOUN
2f75r783q8n	4	14	(	(	PUNCT
2f75r783q8n	4	15	pbp	pbp	NOUN
2f75r783q8n	4	16	)	)	PUNCT
2f75r783q8n	4	17	designated	designated	PROPN
2f75r783q8n	4	18	pbp	pbp	PROPN
2f75r783q8n	4	19	2a	2a	PROPN
2f75r783q8n	4	20	.	.	PUNCT
2f75r783q8n	5	1	pbp	pbp	PROPN
2f75r783q8n	5	2	2a	2a	NUM
2f75r783q8n	5	3	is	be	AUX
2f75r783q8n	5	4	refractory	refractory	ADJ
2f75r783q8n	5	5	to	to	ADP
2f75r783q8n	5	6	inhibition	inhibition	NOUN
2f75r783q8n	5	7	by	by	ADP
2f75r783q8n	5	8	all	all	PRON
2f75r783q8n	5	9	commercially	commercially	ADV
2f75r783q8n	5	10	available	available	ADJ
2f75r783q8n	5	11	&	&	CCONJ
2f75r783q8n	5	12	#	#	SYM
2f75r783q8n	5	13	946;-lactam	946;-lactam	NUM
2f75r783q8n	5	14	antibiotics	antibiotic	NOUN
2f75r783q8n	5	15	.	.	PUNCT
2f75r783q8n	6	1	furthermore	furthermore	ADV
2f75r783q8n	6	2	,	,	PUNCT
2f75r783q8n	6	3	pbp	pbp	PROPN
2f75r783q8n	6	4	2a	2a	NUM
2f75r783q8n	6	5	is	be	AUX
2f75r783q8n	6	6	capable	capable	ADJ
2f75r783q8n	6	7	of	of	ADP
2f75r783q8n	6	8	taking	take	VERB
2f75r783q8n	6	9	over	over	ADP
2f75r783q8n	6	10	the	the	DET
2f75r783q8n	6	11	functions	function	NOUN
2f75r783q8n	6	12	of	of	ADP
2f75r783q8n	6	13	the	the	DET
2f75r783q8n	6	14	other	other	ADJ
2f75r783q8n	6	15	pbps	pbps	NOUN
2f75r783q8n	6	16	of	of	ADP
2f75r783q8n	6	17	s.	s.	PROPN
2f75r783q8n	6	18	aureus	aureus	PROPN
2f75r783q8n	6	19	in	in	ADP
2f75r783q8n	6	20	the	the	DET
2f75r783q8n	6	21	face	face	NOUN
2f75r783q8n	6	22	of	of	ADP
2f75r783q8n	6	23	the	the	DET
2f75r783q8n	6	24	challenge	challenge	NOUN
2f75r783q8n	6	25	by	by	ADP
2f75r783q8n	6	26	&	&	CCONJ
2f75r783q8n	6	27	#	#	SYM
2f75r783q8n	6	28	946;-lactam	946;-lactam	NUM
2f75r783q8n	6	29	antibiotics	antibiotic	NOUN
2f75r783q8n	6	30	.	.	PUNCT
2f75r783q8n	7	1	pbp	pbp	PROPN
2f75r783q8n	7	2	2a	2a	NUM
2f75r783q8n	7	3	was	be	AUX
2f75r783q8n	7	4	cloned	clone	VERB
2f75r783q8n	7	5	and	and	CCONJ
2f75r783q8n	7	6	purified	purify	VERB
2f75r783q8n	7	7	to	to	ADP
2f75r783q8n	7	8	homogeneity	homogeneity	NOUN
2f75r783q8n	7	9	and	and	CCONJ
2f75r783q8n	7	10	the	the	DET
2f75r783q8n	7	11	kinetic	kinetic	ADJ
2f75r783q8n	7	12	parameters	parameter	NOUN
2f75r783q8n	7	13	for	for	ADP
2f75r783q8n	7	14	interactions	interaction	NOUN
2f75r783q8n	7	15	with	with	ADP
2f75r783q8n	7	16	several	several	ADJ
2f75r783q8n	7	17	&	&	CCONJ
2f75r783q8n	7	18	#	#	SYM
2f75r783q8n	7	19	946;-lactam	946;-lactam	NUM
2f75r783q8n	7	20	antibiotics	antibiotic	NOUN
2f75r783q8n	7	21	evaluated	evaluate	VERB
2f75r783q8n	7	22	.	.	PUNCT
2f75r783q8n	8	1	the	the	DET
2f75r783q8n	8	2	enzyme	enzyme	NOUN
2f75r783q8n	8	3	manifests	manifest	VERB
2f75r783q8n	8	4	resistance	resistance	NOUN
2f75r783q8n	8	5	to	to	ADP
2f75r783q8n	8	6	&	&	CCONJ
2f75r783q8n	8	7	#	#	SYM
2f75r783q8n	8	8	946;-lactams	946;-lactams	NUM
2f75r783q8n	8	9	through	through	ADP
2f75r783q8n	8	10	unfavorable	unfavorable	ADJ
2f75r783q8n	8	11	changes	change	NOUN
2f75r783q8n	8	12	in	in	ADP
2f75r783q8n	8	13	the	the	DET
2f75r783q8n	8	14	microscopic	microscopic	ADJ
2f75r783q8n	8	15	rate	rate	NOUN
2f75r783q8n	8	16	constants	constant	NOUN
2f75r783q8n	8	17	for	for	ADP
2f75r783q8n	8	18	acylation	acylation	NOUN
2f75r783q8n	8	19	(	(	PUNCT
2f75r783q8n	8	20	k2	k2	PROPN
2f75r783q8n	8	21	)	)	PUNCT
2f75r783q8n	8	22	and	and	CCONJ
2f75r783q8n	8	23	elevated	elevated	ADJ
2f75r783q8n	8	24	dissociation	dissociation	NOUN
2f75r783q8n	8	25	constants	constant	NOUN
2f75r783q8n	8	26	(	(	PUNCT
2f75r783q8n	8	27	kd	kd	PROPN
2f75r783q8n	8	28	)	)	PUNCT
2f75r783q8n	8	29	.	.	PUNCT
2f75r783q8n	9	1	both	both	DET
2f75r783q8n	9	2	factors	factor	NOUN
2f75r783q8n	9	3	are	be	AUX
2f75r783q8n	9	4	believed	believe	VERB
2f75r783q8n	9	5	to	to	PART
2f75r783q8n	9	6	work	work	VERB
2f75r783q8n	9	7	in	in	ADP
2f75r783q8n	9	8	concert	concert	NOUN
2f75r783q8n	9	9	to	to	PART
2f75r783q8n	9	10	prevent	prevent	VERB
2f75r783q8n	9	11	enzyme	enzyme	NOUN
2f75r783q8n	9	12	acylation	acylation	NOUN
2f75r783q8n	9	13	by	by	ADP
2f75r783q8n	9	14	antibiotics	antibiotic	NOUN
2f75r783q8n	9	15	in	in	ADP
2f75r783q8n	9	16	vivo	vivo	PROPN
2f75r783q8n	9	17	.	.	PUNCT
2f75r783q8n	10	1	we	we	PRON
2f75r783q8n	10	2	demonstrated	demonstrate	VERB
2f75r783q8n	10	3	that	that	SCONJ
2f75r783q8n	10	4	synthetic	synthetic	ADJ
2f75r783q8n	10	5	fragments	fragment	NOUN
2f75r783q8n	10	6	of	of	ADP
2f75r783q8n	10	7	the	the	DET
2f75r783q8n	10	8	bacterial	bacterial	ADJ
2f75r783q8n	10	9	cell	cell	NOUN
2f75r783q8n	10	10	wall	wall	NOUN
2f75r783q8n	10	11	bind	bind	VERB
2f75r783q8n	10	12	to	to	AUX
2f75r783q8n	10	13	pbp	pbp	VERB
2f75r783q8n	10	14	2a	2a	NUM
2f75r783q8n	10	15	in	in	ADP
2f75r783q8n	10	16	a	a	DET
2f75r783q8n	10	17	saturable	saturable	ADJ
2f75r783q8n	10	18	manner	manner	NOUN
2f75r783q8n	10	19	,	,	PUNCT
2f75r783q8n	10	20	causing	cause	VERB
2f75r783q8n	10	21	a	a	DET
2f75r783q8n	10	22	conformational	conformational	ADJ
2f75r783q8n	10	23	change	change	NOUN
2f75r783q8n	10	24	that	that	PRON
2f75r783q8n	10	25	makes	make	VERB
2f75r783q8n	10	26	the	the	DET
2f75r783q8n	10	27	protein	protein	NOUN
2f75r783q8n	10	28	's	's	PART
2f75r783q8n	10	29	active	active	ADJ
2f75r783q8n	10	30	site	site	NOUN
2f75r783q8n	10	31	more	more	ADV
2f75r783q8n	10	32	accessible	accessible	ADJ
2f75r783q8n	10	33	to	to	PART
2f75r783q8n	10	34	bind	bind	VERB
2f75r783q8n	10	35	&	&	CCONJ
2f75r783q8n	10	36	#	#	SYM
2f75r783q8n	10	37	946;-lactam	946;-lactam	NUM
2f75r783q8n	10	38	antibiotics	antibiotic	NOUN
2f75r783q8n	10	39	.	.	PUNCT
2f75r783q8n	11	1	these	these	DET
2f75r783q8n	11	2	observations	observation	NOUN
2f75r783q8n	11	3	and	and	CCONJ
2f75r783q8n	11	4	measurements	measurement	NOUN
2f75r783q8n	11	5	point	point	VERB
2f75r783q8n	11	6	to	to	ADP
2f75r783q8n	11	7	a	a	DET
2f75r783q8n	11	8	novel	novel	ADJ
2f75r783q8n	11	9	strategy	strategy	NOUN
2f75r783q8n	11	10	by	by	ADP
2f75r783q8n	11	11	nature	nature	NOUN
2f75r783q8n	11	12	to	to	PART
2f75r783q8n	11	13	keep	keep	VERB
2f75r783q8n	11	14	the	the	DET
2f75r783q8n	11	15	active	active	ADJ
2f75r783q8n	11	16	site	site	NOUN
2f75r783q8n	11	17	of	of	ADP
2f75r783q8n	11	18	pbp	pbp	PROPN
2f75r783q8n	11	19	2a	2a	PROPN
2f75r783q8n	11	20	sheltered	shelter	VERB
2f75r783q8n	11	21	from	from	ADP
2f75r783q8n	11	22	the	the	DET
2f75r783q8n	11	23	inhibitory	inhibitory	ADJ
2f75r783q8n	11	24	activity	activity	NOUN
2f75r783q8n	11	25	of	of	ADP
2f75r783q8n	11	26	the	the	DET
2f75r783q8n	11	27	antibiotics	antibiotic	NOUN
2f75r783q8n	11	28	,	,	PUNCT
2f75r783q8n	11	29	yet	yet	CCONJ
2f75r783q8n	11	30	it	it	PRON
2f75r783q8n	11	31	becomes	become	VERB
2f75r783q8n	11	32	available	available	ADJ
2f75r783q8n	11	33	to	to	ADP
2f75r783q8n	11	34	the	the	DET
2f75r783q8n	11	35	polymeric	polymeric	ADJ
2f75r783q8n	11	36	cell	cell	NOUN
2f75r783q8n	11	37	wall	wall	NOUN
2f75r783q8n	11	38	by	by	ADP
2f75r783q8n	11	39	a	a	DET
2f75r783q8n	11	40	requisite	requisite	ADJ
2f75r783q8n	11	41	conformational	conformational	ADJ
2f75r783q8n	11	42	change	change	NOUN
2f75r783q8n	11	43	for	for	ADP
2f75r783q8n	11	44	the	the	DET
2f75r783q8n	11	45	critical	critical	ADJ
2f75r783q8n	11	46	cell	cell	NOUN
2f75r783q8n	11	47	wall	wall	PROPN
2f75r783q8n	11	48	cross	cross	ADJ
2f75r783q8n	11	49	-	-	ADJ
2f75r783q8n	11	50	linking	linking	ADJ
2f75r783q8n	11	51	reaction	reaction	NOUN
2f75r783q8n	11	52	.	.	PUNCT
2f75r783q8n	12	1	our	our	PRON
2f75r783q8n	12	2	incremental	incremental	ADJ
2f75r783q8n	12	3	understanding	understanding	NOUN
2f75r783q8n	12	4	of	of	ADP
2f75r783q8n	12	5	the	the	DET
2f75r783q8n	12	6	interactions	interaction	NOUN
2f75r783q8n	12	7	of	of	ADP
2f75r783q8n	12	8	pbp	pbp	PROPN
2f75r783q8n	12	9	2a	2a	NUM
2f75r783q8n	12	10	with	with	ADP
2f75r783q8n	12	11	&	&	CCONJ
2f75r783q8n	12	12	#	#	SYM
2f75r783q8n	12	13	946;-lactams	946;-lactams	NUM
2f75r783q8n	12	14	and	and	CCONJ
2f75r783q8n	12	15	cell	cell	NOUN
2f75r783q8n	12	16	wall	wall	NOUN
2f75r783q8n	12	17	was	be	AUX
2f75r783q8n	12	18	used	use	VERB
2f75r783q8n	12	19	to	to	PART
2f75r783q8n	12	20	elucidate	elucidate	VERB
2f75r783q8n	12	21	the	the	DET
2f75r783q8n	12	22	mechanism	mechanism	NOUN
2f75r783q8n	12	23	of	of	ADP
2f75r783q8n	12	24	action	action	NOUN
2f75r783q8n	12	25	for	for	ADP
2f75r783q8n	12	26	three	three	NUM
2f75r783q8n	12	27	cephaloporins	cephaloporin	NOUN
2f75r783q8n	12	28	active	active	ADJ
2f75r783q8n	12	29	against	against	ADP
2f75r783q8n	12	30	mrsa	mrsa	PROPN
2f75r783q8n	12	31	and	and	CCONJ
2f75r783q8n	12	32	vrsa	vrsa	PROPN
2f75r783q8n	12	33	.	.	PUNCT
2f75r783q8n	13	1	we	we	PRON
2f75r783q8n	13	2	also	also	ADV
2f75r783q8n	13	3	applied	apply	VERB
2f75r783q8n	13	4	our	our	PRON
2f75r783q8n	13	5	understanding	understanding	NOUN
2f75r783q8n	13	6	of	of	ADP
2f75r783q8n	13	7	pbp	pbp	PROPN
2f75r783q8n	13	8	2a	2a	NUM
2f75r783q8n	13	9	to	to	PART
2f75r783q8n	13	10	study	study	VERB
2f75r783q8n	13	11	the	the	DET
2f75r783q8n	13	12	meca	meca	PROPN
2f75r783q8n	13	13	gene	gene	NOUN
2f75r783q8n	13	14	of	of	ADP
2f75r783q8n	13	15	s.	s.	PROPN
2f75r783q8n	13	16	sciuri	sciuri	PROPN
2f75r783q8n	13	17	,	,	PUNCT
2f75r783q8n	13	18	a	a	DET
2f75r783q8n	13	19	gene	gene	NOUN
2f75r783q8n	13	20	believed	believe	VERB
2f75r783q8n	13	21	to	to	PART
2f75r783q8n	13	22	be	be	AUX
2f75r783q8n	13	23	the	the	DET
2f75r783q8n	13	24	origin	origin	NOUN
2f75r783q8n	13	25	of	of	ADP
2f75r783q8n	13	26	meca	meca	PROPN
2f75r783q8n	13	27	of	of	ADP
2f75r783q8n	13	28	mrsa	mrsa	PROPN
2f75r783q8n	13	29	based	base	VERB
2f75r783q8n	13	30	on	on	ADP
2f75r783q8n	13	31	epidemiological	epidemiological	ADJ
2f75r783q8n	13	32	and	and	CCONJ
2f75r783q8n	13	33	genetic	genetic	ADJ
2f75r783q8n	13	34	evidence	evidence	NOUN
2f75r783q8n	13	35	.	.	PUNCT
2f75r783q8n	14	1	the	the	DET
2f75r783q8n	14	2	biochemical	biochemical	ADJ
2f75r783q8n	14	3	properties	property	NOUN
2f75r783q8n	14	4	of	of	ADP
2f75r783q8n	14	5	the	the	DET
2f75r783q8n	14	6	meca	meca	NOUN
2f75r783q8n	14	7	proteins	protein	NOUN
2f75r783q8n	14	8	from	from	ADP
2f75r783q8n	14	9	both	both	DET
2f75r783q8n	14	10	s.	s.	PROPN
2f75r783q8n	14	11	aureus	aureus	PROPN
2f75r783q8n	14	12	and	and	CCONJ
2f75r783q8n	14	13	s.	s.	PROPN
2f75r783q8n	14	14	sciuri	sciuri	PROPN
2f75r783q8n	14	15	are	be	AUX
2f75r783q8n	14	16	uncannily	uncannily	ADV
2f75r783q8n	14	17	similar	similar	ADJ
2f75r783q8n	14	18	in	in	ADP
2f75r783q8n	14	19	regard	regard	NOUN
2f75r783q8n	14	20	to	to	ADP
2f75r783q8n	14	21	biochemical	biochemical	ADJ
2f75r783q8n	14	22	behavior	behavior	NOUN
2f75r783q8n	14	23	in	in	ADP
2f75r783q8n	14	24	inhibition	inhibition	NOUN
2f75r783q8n	14	25	by	by	ADP
2f75r783q8n	14	26	&	&	CCONJ
2f75r783q8n	14	27	#	#	SYM
2f75r783q8n	14	28	946;-lactam	946;-lactam	NUM
2f75r783q8n	14	29	antibiotics	antibiotic	NOUN
2f75r783q8n	14	30	and	and	CCONJ
2f75r783q8n	14	31	the	the	DET
2f75r783q8n	14	32	existence	existence	NOUN
2f75r783q8n	14	33	of	of	ADP
2f75r783q8n	14	34	the	the	DET
2f75r783q8n	14	35	allosteric	allosteric	NOUN
2f75r783q8n	14	36	site	site	NOUN
2f75r783q8n	14	37	for	for	ADP
2f75r783q8n	14	38	binding	binding	NOUN
2f75r783q8n	14	39	of	of	ADP
2f75r783q8n	14	40	peptidoglycan	peptidoglycan	NOUN
2f75r783q8n	14	41	.	.	PUNCT