id sid tid token lemma pos 2514nk35139 1 1 plasmodium plasmodium NOUN 2514nk35139 1 2 falciparum falciparum NOUN 2514nk35139 1 3 malaria malaria NOUN 2514nk35139 1 4 remains remain VERB 2514nk35139 1 5 one one NUM 2514nk35139 1 6 of of ADP 2514nk35139 1 7 the the DET 2514nk35139 1 8 world world NOUN 2514nk35139 1 9 's 's PART 2514nk35139 1 10 most most ADV 2514nk35139 1 11 serious serious ADJ 2514nk35139 1 12 infectious infectious ADJ 2514nk35139 1 13 diseases disease NOUN 2514nk35139 1 14 , , PUNCT 2514nk35139 1 15 but but CCONJ 2514nk35139 1 16 the the DET 2514nk35139 1 17 use use NOUN 2514nk35139 1 18 of of ADP 2514nk35139 1 19 artemisinin artemisinin PROPN 2514nk35139 1 20 ( ( PUNCT 2514nk35139 1 21 art art NOUN 2514nk35139 1 22 ) ) PUNCT 2514nk35139 1 23 in in ADP 2514nk35139 1 24 combination combination NOUN 2514nk35139 1 25 with with ADP 2514nk35139 1 26 other other ADJ 2514nk35139 1 27 antimalarials antimalarial NOUN 2514nk35139 1 28 has have AUX 2514nk35139 1 29 been be AUX 2514nk35139 1 30 important important ADJ 2514nk35139 1 31 in in ADP 2514nk35139 1 32 reducing reduce VERB 2514nk35139 1 33 deaths death NOUN 2514nk35139 1 34 and and CCONJ 2514nk35139 1 35 disease disease NOUN 2514nk35139 1 36 . . PUNCT 2514nk35139 2 1 however however ADV 2514nk35139 2 2 , , PUNCT 2514nk35139 2 3 the the DET 2514nk35139 2 4 recent recent ADJ 2514nk35139 2 5 rise rise NOUN 2514nk35139 2 6 in in ADP 2514nk35139 2 7 resistance resistance NOUN 2514nk35139 2 8 in in ADP 2514nk35139 2 9 the the DET 2514nk35139 2 10 greater great ADJ 2514nk35139 2 11 mekong mekong PROPN 2514nk35139 2 12 subregion subregion NOUN 2514nk35139 2 13 of of ADP 2514nk35139 2 14 southeast southeast PROPN 2514nk35139 2 15 asia asia PROPN 2514nk35139 2 16 threatens threaten VERB 2514nk35139 2 17 the the DET 2514nk35139 2 18 efficacy efficacy NOUN 2514nk35139 2 19 of of ADP 2514nk35139 2 20 art art NOUN 2514nk35139 2 21 and and CCONJ 2514nk35139 2 22 raises raise VERB 2514nk35139 2 23 the the DET 2514nk35139 2 24 concern concern NOUN 2514nk35139 2 25 that that SCONJ 2514nk35139 2 26 malaria malaria NOUN 2514nk35139 2 27 cases case NOUN 2514nk35139 2 28 will will AUX 2514nk35139 2 29 rise rise VERB 2514nk35139 2 30 and and CCONJ 2514nk35139 2 31 resistance resistance NOUN 2514nk35139 2 32 will will AUX 2514nk35139 2 33 spread spread VERB 2514nk35139 2 34 . . PUNCT 2514nk35139 3 1 the the DET 2514nk35139 3 2 spread spread NOUN 2514nk35139 3 3 of of ADP 2514nk35139 3 4 resistant resistant ADJ 2514nk35139 3 5 strains strain NOUN 2514nk35139 3 6 to to ADP 2514nk35139 3 7 sub sub ADJ 2514nk35139 3 8 - - ADJ 2514nk35139 3 9 saharan saharan ADJ 2514nk35139 3 10 africa africa PROPN 2514nk35139 3 11 would would AUX 2514nk35139 3 12 be be AUX 2514nk35139 3 13 devastating devastating ADJ 2514nk35139 3 14 in in ADP 2514nk35139 3 15 an an DET 2514nk35139 3 16 area area NOUN 2514nk35139 3 17 with with ADP 2514nk35139 3 18 the the DET 2514nk35139 3 19 highest high ADJ 2514nk35139 3 20 malaria malaria NOUN 2514nk35139 3 21 mortality mortality NOUN 2514nk35139 3 22 rates rate NOUN 2514nk35139 3 23 in in ADP 2514nk35139 3 24 the the DET 2514nk35139 3 25 world world NOUN 2514nk35139 3 26 . . PUNCT 2514nk35139 4 1 to to PART 2514nk35139 4 2 combat combat VERB 2514nk35139 4 3 the the DET 2514nk35139 4 4 spread spread NOUN 2514nk35139 4 5 of of ADP 2514nk35139 4 6 art art NOUN 2514nk35139 4 7 resistance resistance NOUN 2514nk35139 4 8 , , PUNCT 2514nk35139 4 9 there there PRON 2514nk35139 4 10 is be VERB 2514nk35139 4 11 a a DET 2514nk35139 4 12 critical critical ADJ 2514nk35139 4 13 need need NOUN 2514nk35139 4 14 to to PART 2514nk35139 4 15 understand understand VERB 2514nk35139 4 16 what what PRON 2514nk35139 4 17 drives drive VERB 2514nk35139 4 18 its its PRON 2514nk35139 4 19 emergence emergence NOUN 2514nk35139 4 20 and and CCONJ 2514nk35139 4 21 spread.the spread.the DET 2514nk35139 4 22 rate rate NOUN 2514nk35139 4 23 of of ADP 2514nk35139 4 24 emergence emergence NOUN 2514nk35139 4 25 and and CCONJ 2514nk35139 4 26 spread spread NOUN 2514nk35139 4 27 of of ADP 2514nk35139 4 28 resistance resistance NOUN 2514nk35139 4 29 is be AUX 2514nk35139 4 30 closely closely ADV 2514nk35139 4 31 related related ADJ 2514nk35139 4 32 to to ADP 2514nk35139 4 33 the the DET 2514nk35139 4 34 fitness fitness NOUN 2514nk35139 4 35 of of ADP 2514nk35139 4 36 resistant resistant ADJ 2514nk35139 4 37 parasites parasite NOUN 2514nk35139 4 38 . . PUNCT 2514nk35139 5 1 the the DET 2514nk35139 5 2 fitness fitness NOUN 2514nk35139 5 3 cost cost NOUN 2514nk35139 5 4 of of ADP 2514nk35139 5 5 resistance resistance NOUN 2514nk35139 5 6 mutations mutation NOUN 2514nk35139 5 7 and and CCONJ 2514nk35139 5 8 the the DET 2514nk35139 5 9 compensatory compensatory ADJ 2514nk35139 5 10 mutations mutation NOUN 2514nk35139 5 11 that that PRON 2514nk35139 5 12 accompany accompany VERB 2514nk35139 5 13 resistance resistance NOUN 2514nk35139 5 14 mutations mutation NOUN 2514nk35139 5 15 play play VERB 2514nk35139 5 16 a a DET 2514nk35139 5 17 role role NOUN 2514nk35139 5 18 in in ADP 2514nk35139 5 19 determining determine VERB 2514nk35139 5 20 whether whether SCONJ 2514nk35139 5 21 resistance resistance NOUN 2514nk35139 5 22 will will AUX 2514nk35139 5 23 spread spread VERB 2514nk35139 5 24 in in ADP 2514nk35139 5 25 a a DET 2514nk35139 5 26 population population NOUN 2514nk35139 5 27 . . PUNCT 2514nk35139 6 1 knowledge knowledge NOUN 2514nk35139 6 2 of of ADP 2514nk35139 6 3 the the DET 2514nk35139 6 4 molecular molecular ADJ 2514nk35139 6 5 basis basis NOUN 2514nk35139 6 6 of of ADP 2514nk35139 6 7 the the DET 2514nk35139 6 8 cost cost NOUN 2514nk35139 6 9 of of ADP 2514nk35139 6 10 resistance resistance NOUN 2514nk35139 6 11 is be AUX 2514nk35139 6 12 important important ADJ 2514nk35139 6 13 for for ADP 2514nk35139 6 14 understanding understand VERB 2514nk35139 6 15 how how SCONJ 2514nk35139 6 16 resistance resistance NOUN 2514nk35139 6 17 mutations mutation NOUN 2514nk35139 6 18 arise arise VERB 2514nk35139 6 19 and and CCONJ 2514nk35139 6 20 stabilize stabilize VERB 2514nk35139 6 21 in in ADP 2514nk35139 6 22 populations.the populations.the DET 2514nk35139 6 23 costs cost NOUN 2514nk35139 6 24 of of ADP 2514nk35139 6 25 resistance resistance NOUN 2514nk35139 6 26 can can AUX 2514nk35139 6 27 be be AUX 2514nk35139 6 28 studied study VERB 2514nk35139 6 29 in in ADP 2514nk35139 6 30 vitro vitro X 2514nk35139 6 31 by by ADP 2514nk35139 6 32 using use VERB 2514nk35139 6 33 fitness fitness NOUN 2514nk35139 6 34 assays assay NOUN 2514nk35139 6 35 , , PUNCT 2514nk35139 6 36 including include VERB 2514nk35139 6 37 individual individual ADJ 2514nk35139 6 38 growth growth NOUN 2514nk35139 6 39 assays assay NOUN 2514nk35139 6 40 , , PUNCT 2514nk35139 6 41 competitive competitive ADJ 2514nk35139 6 42 growth growth NOUN 2514nk35139 6 43 assays assay NOUN 2514nk35139 6 44 , , PUNCT 2514nk35139 6 45 and and CCONJ 2514nk35139 6 46 bulk bulk ADJ 2514nk35139 6 47 segregant segregant ADJ 2514nk35139 6 48 analysis analysis NOUN 2514nk35139 6 49 . . PUNCT 2514nk35139 7 1 individual individual ADJ 2514nk35139 7 2 growth growth NOUN 2514nk35139 7 3 assays assay NOUN 2514nk35139 7 4 , , PUNCT 2514nk35139 7 5 such such ADJ 2514nk35139 7 6 as as ADP 2514nk35139 7 7 parasite parasite NOUN 2514nk35139 7 8 growth growth NOUN 2514nk35139 7 9 rate rate NOUN 2514nk35139 7 10 , , PUNCT 2514nk35139 7 11 determine determine VERB 2514nk35139 7 12 which which PRON 2514nk35139 7 13 parasites parasite NOUN 2514nk35139 7 14 have have VERB 2514nk35139 7 15 high high ADJ 2514nk35139 7 16 fitness fitness NOUN 2514nk35139 7 17 . . PUNCT 2514nk35139 8 1 competitive competitive ADJ 2514nk35139 8 2 growth growth NOUN 2514nk35139 8 3 assays assay NOUN 2514nk35139 8 4 measure measure VERB 2514nk35139 8 5 the the DET 2514nk35139 8 6 relative relative ADJ 2514nk35139 8 7 fitness fitness NOUN 2514nk35139 8 8 between between ADP 2514nk35139 8 9 co co ADJ 2514nk35139 8 10 - - ADJ 2514nk35139 8 11 infecting infecting ADJ 2514nk35139 8 12 parasites parasite NOUN 2514nk35139 8 13 and and CCONJ 2514nk35139 8 14 reveal reveal VERB 2514nk35139 8 15 fitness fitness NOUN 2514nk35139 8 16 disparities disparity NOUN 2514nk35139 8 17 between between ADP 2514nk35139 8 18 the the DET 2514nk35139 8 19 parasites parasite NOUN 2514nk35139 8 20 . . PUNCT 2514nk35139 9 1 bulk bulk ADJ 2514nk35139 9 2 segregant segregant ADJ 2514nk35139 9 3 analysis analysis NOUN 2514nk35139 9 4 measures measure NOUN 2514nk35139 9 5 the the DET 2514nk35139 9 6 change change NOUN 2514nk35139 9 7 in in ADP 2514nk35139 9 8 allele allele NOUN 2514nk35139 9 9 frequencies frequency NOUN 2514nk35139 9 10 due due ADJ 2514nk35139 9 11 to to ADP 2514nk35139 9 12 parasite parasite NOUN 2514nk35139 9 13 growth growth NOUN 2514nk35139 9 14 over over ADP 2514nk35139 9 15 time time NOUN 2514nk35139 9 16 to to PART 2514nk35139 9 17 determine determine VERB 2514nk35139 9 18 loci locus NOUN 2514nk35139 9 19 related relate VERB 2514nk35139 9 20 to to ADP 2514nk35139 9 21 fitness fitness NOUN 2514nk35139 9 22 . . PUNCT 2514nk35139 10 1 these these DET 2514nk35139 10 2 assays assay NOUN 2514nk35139 10 3 highlight highlight VERB 2514nk35139 10 4 the the DET 2514nk35139 10 5 phenotypes phenotype NOUN 2514nk35139 10 6 necessary necessary ADJ 2514nk35139 10 7 to to PART 2514nk35139 10 8 have have VERB 2514nk35139 10 9 a a DET 2514nk35139 10 10 " " PUNCT 2514nk35139 10 11 fit fit ADJ 2514nk35139 10 12 " " PUNCT 2514nk35139 10 13 parasite parasite NOUN 2514nk35139 10 14 and and CCONJ 2514nk35139 10 15 as as ADP 2514nk35139 10 16 quantitative quantitative ADJ 2514nk35139 10 17 measures measure NOUN 2514nk35139 10 18 of of ADP 2514nk35139 10 19 fitness fitness NOUN 2514nk35139 10 20 , , PUNCT 2514nk35139 10 21 they they PRON 2514nk35139 10 22 can can AUX 2514nk35139 10 23 be be AUX 2514nk35139 10 24 used use VERB 2514nk35139 10 25 for for ADP 2514nk35139 10 26 quantitative quantitative ADJ 2514nk35139 10 27 trait trait NOUN 2514nk35139 10 28 locus locus NOUN 2514nk35139 10 29 ( ( PUNCT 2514nk35139 10 30 qtl qtl PROPN 2514nk35139 10 31 ) ) PUNCT 2514nk35139 10 32 mapping mapping NOUN 2514nk35139 10 33 to to PART 2514nk35139 10 34 identify identify VERB 2514nk35139 10 35 genetic genetic ADJ 2514nk35139 10 36 loci locus NOUN 2514nk35139 10 37 that that PRON 2514nk35139 10 38 correlate correlate VERB 2514nk35139 10 39 with with ADP 2514nk35139 10 40 that that DET 2514nk35139 10 41 fitness fitness NOUN 2514nk35139 10 42 phenotype phenotype NOUN 2514nk35139 10 43 . . PUNCT 2514nk35139 11 1 by by ADP 2514nk35139 11 2 phenotyping phenotype VERB 2514nk35139 11 3 parasites parasite NOUN 2514nk35139 11 4 isolated isolate VERB 2514nk35139 11 5 from from ADP 2514nk35139 11 6 patients patient NOUN 2514nk35139 11 7 in in ADP 2514nk35139 11 8 southeast southeast PROPN 2514nk35139 11 9 asia asia PROPN 2514nk35139 11 10 and and CCONJ 2514nk35139 11 11 africa africa PROPN 2514nk35139 11 12 and and CCONJ 2514nk35139 11 13 using use VERB 2514nk35139 11 14 these these DET 2514nk35139 11 15 parasites parasite NOUN 2514nk35139 11 16 as as ADP 2514nk35139 11 17 parents parent NOUN 2514nk35139 11 18 in in ADP 2514nk35139 11 19 genetic genetic ADJ 2514nk35139 11 20 crosses crosse NOUN 2514nk35139 11 21 , , PUNCT 2514nk35139 11 22 we we PRON 2514nk35139 11 23 can can AUX 2514nk35139 11 24 study study VERB 2514nk35139 11 25 a a DET 2514nk35139 11 26 variety variety NOUN 2514nk35139 11 27 of of ADP 2514nk35139 11 28 drug drug NOUN 2514nk35139 11 29 resistance resistance NOUN 2514nk35139 11 30 and and CCONJ 2514nk35139 11 31 fitness fitness NOUN 2514nk35139 11 32 phenotypes phenotype NOUN 2514nk35139 11 33 . . PUNCT 2514nk35139 12 1 improved improve VERB 2514nk35139 12 2 understanding understanding NOUN 2514nk35139 12 3 of of ADP 2514nk35139 12 4 the the DET 2514nk35139 12 5 in in ADP 2514nk35139 12 6 vitro vitro X 2514nk35139 12 7 fitness fitness NOUN 2514nk35139 12 8 costs cost NOUN 2514nk35139 12 9 of of ADP 2514nk35139 12 10 different different ADJ 2514nk35139 12 11 parasites parasite NOUN 2514nk35139 12 12 and and CCONJ 2514nk35139 12 13 the the DET 2514nk35139 12 14 role role NOUN 2514nk35139 12 15 different different ADJ 2514nk35139 12 16 resistance resistance NOUN 2514nk35139 12 17 and and CCONJ 2514nk35139 12 18 compensatory compensatory ADJ 2514nk35139 12 19 mutations mutation NOUN 2514nk35139 12 20 play play VERB 2514nk35139 12 21 will will AUX 2514nk35139 12 22 contribute contribute VERB 2514nk35139 12 23 to to ADP 2514nk35139 12 24 an an DET 2514nk35139 12 25 understanding understanding NOUN 2514nk35139 12 26 of of ADP 2514nk35139 12 27 the the DET 2514nk35139 12 28 potential potential NOUN 2514nk35139 12 29 for for ADP 2514nk35139 12 30 specific specific ADJ 2514nk35139 12 31 mutations mutation NOUN 2514nk35139 12 32 to to PART 2514nk35139 12 33 spread spread VERB 2514nk35139 12 34 in in ADP 2514nk35139 12 35 populations population NOUN 2514nk35139 12 36 . . PUNCT