id sid tid token lemma pos 2514nk34z4r 1 1 kidney kidney NOUN 2514nk34z4r 1 2 disease disease NOUN 2514nk34z4r 1 3 is be AUX 2514nk34z4r 1 4 among among ADP 2514nk34z4r 1 5 the the DET 2514nk34z4r 1 6 most most ADV 2514nk34z4r 1 7 common common ADJ 2514nk34z4r 1 8 disorders disorder NOUN 2514nk34z4r 1 9 in in ADP 2514nk34z4r 1 10 the the DET 2514nk34z4r 1 11 united united PROPN 2514nk34z4r 1 12 states states PROPN 2514nk34z4r 1 13 as as SCONJ 2514nk34z4r 1 14 37 37 NUM 2514nk34z4r 1 15 million million NUM 2514nk34z4r 1 16 americans american NOUN 2514nk34z4r 1 17 suffer suffer VERB 2514nk34z4r 1 18 from from ADP 2514nk34z4r 1 19 chronic chronic ADJ 2514nk34z4r 1 20 kidney kidney NOUN 2514nk34z4r 1 21 disease disease NOUN 2514nk34z4r 1 22 ( ( PUNCT 2514nk34z4r 1 23 ckd ckd NOUN 2514nk34z4r 1 24 ) ) PUNCT 2514nk34z4r 1 25 . . PUNCT 2514nk34z4r 2 1 unfortunately unfortunately ADV 2514nk34z4r 2 2 , , PUNCT 2514nk34z4r 2 3 current current ADJ 2514nk34z4r 2 4 treatments treatment NOUN 2514nk34z4r 2 5 for for ADP 2514nk34z4r 2 6 kidney kidney NOUN 2514nk34z4r 2 7 diseases disease NOUN 2514nk34z4r 2 8 are be AUX 2514nk34z4r 2 9 lacking lack VERB 2514nk34z4r 2 10 and and CCONJ 2514nk34z4r 2 11 those those PRON 2514nk34z4r 2 12 that that PRON 2514nk34z4r 2 13 do do AUX 2514nk34z4r 2 14 exist exist VERB 2514nk34z4r 2 15 , , PUNCT 2514nk34z4r 2 16 transplantation transplantation NOUN 2514nk34z4r 2 17 and and CCONJ 2514nk34z4r 2 18 dialysis dialysis NOUN 2514nk34z4r 2 19 , , PUNCT 2514nk34z4r 2 20 are be AUX 2514nk34z4r 2 21 either either CCONJ 2514nk34z4r 2 22 very very ADV 2514nk34z4r 2 23 limited limited ADJ 2514nk34z4r 2 24 in in ADP 2514nk34z4r 2 25 availability availability NOUN 2514nk34z4r 2 26 or or CCONJ 2514nk34z4r 2 27 not not PART 2514nk34z4r 2 28 suitable suitable ADJ 2514nk34z4r 2 29 for for ADP 2514nk34z4r 2 30 long long ADJ 2514nk34z4r 2 31 - - PUNCT 2514nk34z4r 2 32 term term NOUN 2514nk34z4r 2 33 quality quality NOUN 2514nk34z4r 2 34 of of ADP 2514nk34z4r 2 35 life life NOUN 2514nk34z4r 2 36 . . PUNCT 2514nk34z4r 3 1 additionally additionally ADV 2514nk34z4r 3 2 , , PUNCT 2514nk34z4r 3 3 over over ADP 2514nk34z4r 3 4 20 20 NUM 2514nk34z4r 3 5 % % NOUN 2514nk34z4r 3 6 of of ADP 2514nk34z4r 3 7 birth birth NOUN 2514nk34z4r 3 8 defects defect NOUN 2514nk34z4r 3 9 are be AUX 2514nk34z4r 3 10 congenital congenital ADJ 2514nk34z4r 3 11 anomalies anomaly NOUN 2514nk34z4r 3 12 of of ADP 2514nk34z4r 3 13 the the DET 2514nk34z4r 3 14 kidney kidney NOUN 2514nk34z4r 3 15 and and CCONJ 2514nk34z4r 3 16 urinary urinary ADJ 2514nk34z4r 3 17 tract tract NOUN 2514nk34z4r 3 18 ( ( PUNCT 2514nk34z4r 3 19 cakut cakut ADJ 2514nk34z4r 3 20 ) ) PUNCT 2514nk34z4r 3 21 making make VERB 2514nk34z4r 3 22 it it PRON 2514nk34z4r 3 23 the the DET 2514nk34z4r 3 24 most most ADV 2514nk34z4r 3 25 common common ADJ 2514nk34z4r 3 26 condition condition NOUN 2514nk34z4r 3 27 in in ADP 2514nk34z4r 3 28 neonates neonate NOUN 2514nk34z4r 3 29 . . PUNCT 2514nk34z4r 4 1 a a DET 2514nk34z4r 4 2 better well ADJ 2514nk34z4r 4 3 understanding understanding NOUN 2514nk34z4r 4 4 of of ADP 2514nk34z4r 4 5 kidney kidney NOUN 2514nk34z4r 4 6 development development NOUN 2514nk34z4r 4 7 and and CCONJ 2514nk34z4r 4 8 disease disease NOUN 2514nk34z4r 4 9 is be AUX 2514nk34z4r 4 10 necessary necessary ADJ 2514nk34z4r 4 11 to to PART 2514nk34z4r 4 12 improve improve VERB 2514nk34z4r 4 13 the the DET 2514nk34z4r 4 14 lives life NOUN 2514nk34z4r 4 15 of of ADP 2514nk34z4r 4 16 those those PRON 2514nk34z4r 4 17 suffering suffer VERB 2514nk34z4r 4 18 from from ADP 2514nk34z4r 4 19 renal renal ADJ 2514nk34z4r 4 20 ailments ailment NOUN 2514nk34z4r 4 21 . . PUNCT 2514nk34z4r 5 1 one one NUM 2514nk34z4r 5 2 tool tool NOUN 2514nk34z4r 5 3 that that PRON 2514nk34z4r 5 4 can can AUX 2514nk34z4r 5 5 be be AUX 2514nk34z4r 5 6 used use VERB 2514nk34z4r 5 7 to to PART 2514nk34z4r 5 8 gain gain VERB 2514nk34z4r 5 9 a a DET 2514nk34z4r 5 10 better well ADJ 2514nk34z4r 5 11 understanding understanding NOUN 2514nk34z4r 5 12 of of ADP 2514nk34z4r 5 13 the the DET 2514nk34z4r 5 14 molecular molecular ADJ 2514nk34z4r 5 15 events event NOUN 2514nk34z4r 5 16 resulting result VERB 2514nk34z4r 5 17 in in ADP 2514nk34z4r 5 18 kidney kidney NOUN 2514nk34z4r 5 19 development development NOUN 2514nk34z4r 5 20 and and CCONJ 2514nk34z4r 5 21 disease disease NOUN 2514nk34z4r 5 22 is be AUX 2514nk34z4r 5 23 the the DET 2514nk34z4r 5 24 embryonic embryonic ADJ 2514nk34z4r 5 25 zebrafish zebrafish NOUN 2514nk34z4r 5 26 . . PUNCT 2514nk34z4r 6 1 the the DET 2514nk34z4r 6 2 zebrafish zebrafish NOUN 2514nk34z4r 6 3 pronephros pronephro NOUN 2514nk34z4r 6 4 , , PUNCT 2514nk34z4r 6 5 or or CCONJ 2514nk34z4r 6 6 embryonic embryonic NOUN 2514nk34z4r 6 7 kidney kidney NOUN 2514nk34z4r 6 8 provides provide VERB 2514nk34z4r 6 9 a a DET 2514nk34z4r 6 10 simple simple ADJ 2514nk34z4r 6 11 yet yet CCONJ 2514nk34z4r 6 12 conserved conserved ADJ 2514nk34z4r 6 13 nephron nephron NOUN 2514nk34z4r 6 14 structure structure NOUN 2514nk34z4r 6 15 that that PRON 2514nk34z4r 6 16 allows allow VERB 2514nk34z4r 6 17 for for ADP 2514nk34z4r 6 18 rapid rapid ADJ 2514nk34z4r 6 19 results result NOUN 2514nk34z4r 6 20 while while SCONJ 2514nk34z4r 6 21 conducting conduct VERB 2514nk34z4r 6 22 genetic genetic ADJ 2514nk34z4r 6 23 studies study NOUN 2514nk34z4r 6 24 . . PUNCT 2514nk34z4r 7 1 the the DET 2514nk34z4r 7 2 numerous numerous ADJ 2514nk34z4r 7 3 benefits benefit NOUN 2514nk34z4r 7 4 of of ADP 2514nk34z4r 7 5 the the DET 2514nk34z4r 7 6 zebrafish zebrafish NOUN 2514nk34z4r 7 7 allow allow VERB 2514nk34z4r 7 8 for for ADP 2514nk34z4r 7 9 high high ADJ 2514nk34z4r 7 10 throughput throughput NOUN 2514nk34z4r 7 11 screens screen NOUN 2514nk34z4r 7 12 to to PART 2514nk34z4r 7 13 identify identify VERB 2514nk34z4r 7 14 novel novel NOUN 2514nk34z4r 7 15 roles role NOUN 2514nk34z4r 7 16 and and CCONJ 2514nk34z4r 7 17 interactions interaction NOUN 2514nk34z4r 7 18 among among ADP 2514nk34z4r 7 19 molecular molecular ADJ 2514nk34z4r 7 20 pathways pathway NOUN 2514nk34z4r 7 21 . . PUNCT 2514nk34z4r 8 1 here here ADV 2514nk34z4r 8 2 , , PUNCT 2514nk34z4r 8 3 we we PRON 2514nk34z4r 8 4 performed perform VERB 2514nk34z4r 8 5 a a DET 2514nk34z4r 8 6 chemical chemical ADJ 2514nk34z4r 8 7 genetic genetic ADJ 2514nk34z4r 8 8 screen screen NOUN 2514nk34z4r 8 9 that that PRON 2514nk34z4r 8 10 identified identify VERB 2514nk34z4r 8 11 peroxisome peroxisome NOUN 2514nk34z4r 8 12 proliferator proliferator NOUN 2514nk34z4r 8 13 - - PUNCT 2514nk34z4r 8 14 activated activate VERB 2514nk34z4r 8 15 receptor receptor NOUN 2514nk34z4r 8 16 gamma gamma NOUN 2514nk34z4r 8 17 coactivator coactivator NOUN 2514nk34z4r 8 18 1 1 NUM 2514nk34z4r 8 19 alpha alpha NOUN 2514nk34z4r 8 20 ( ( PUNCT 2514nk34z4r 8 21 ppargc1a ppargc1a SPACE 2514nk34z4r 8 22 , , PUNCT 2514nk34z4r 8 23 or or CCONJ 2514nk34z4r 8 24 pgc-1a pgc-1a PROPN 2514nk34z4r 8 25 ) ) PUNCT 2514nk34z4r 8 26 as as ADP 2514nk34z4r 8 27 a a DET 2514nk34z4r 8 28 novel novel ADJ 2514nk34z4r 8 29 regulator regulator NOUN 2514nk34z4r 8 30 of of ADP 2514nk34z4r 8 31 kidney kidney NOUN 2514nk34z4r 8 32 ontogeny ontogeny ADP 2514nk34z4r 8 33 . . PUNCT 2514nk34z4r 9 1 multiple multiple ADJ 2514nk34z4r 9 2 models model NOUN 2514nk34z4r 9 3 of of ADP 2514nk34z4r 9 4 ppargc1a ppargc1a ADJ 2514nk34z4r 9 5 deficiency deficiency NOUN 2514nk34z4r 9 6 including include VERB 2514nk34z4r 9 7 mutants mutant NOUN 2514nk34z4r 9 8 and and CCONJ 2514nk34z4r 9 9 morpholino morpholino ADJ 2514nk34z4r 9 10 injected inject VERB 2514nk34z4r 9 11 zebrafish zebrafish NOUN 2514nk34z4r 9 12 models model NOUN 2514nk34z4r 9 13 were be AUX 2514nk34z4r 9 14 used use VERB 2514nk34z4r 9 15 to to PART 2514nk34z4r 9 16 interrogate interrogate VERB 2514nk34z4r 9 17 the the DET 2514nk34z4r 9 18 molecular molecular ADJ 2514nk34z4r 9 19 pathways pathway NOUN 2514nk34z4r 9 20 involved involve VERB 2514nk34z4r 9 21 in in ADP 2514nk34z4r 9 22 nephron nephron NOUN 2514nk34z4r 9 23 segmentation segmentation NOUN 2514nk34z4r 9 24 . . PUNCT 2514nk34z4r 10 1 we we PRON 2514nk34z4r 10 2 discovered discover VERB 2514nk34z4r 10 3 unique unique ADJ 2514nk34z4r 10 4 interactions interaction NOUN 2514nk34z4r 10 5 where where SCONJ 2514nk34z4r 10 6 ppargc1a ppargc1a PUNCT 2514nk34z4r 10 7 acts act VERB 2514nk34z4r 10 8 upstream upstream ADV 2514nk34z4r 10 9 of of ADP 2514nk34z4r 10 10 tbx2b tbx2b PROPN 2514nk34z4r 10 11 to to PART 2514nk34z4r 10 12 properly properly ADV 2514nk34z4r 10 13 form form VERB 2514nk34z4r 10 14 the the DET 2514nk34z4r 10 15 distal distal ADJ 2514nk34z4r 10 16 late late ADJ 2514nk34z4r 10 17 tubule tubule NOUN 2514nk34z4r 10 18 domain domain NOUN 2514nk34z4r 10 19 . . PUNCT 2514nk34z4r 11 1 also also ADV 2514nk34z4r 11 2 , , PUNCT 2514nk34z4r 11 3 data datum NOUN 2514nk34z4r 11 4 suggests suggest VERB 2514nk34z4r 11 5 a a DET 2514nk34z4r 11 6 rare rare ADJ 2514nk34z4r 11 7 reciprocal reciprocal ADJ 2514nk34z4r 11 8 antagonistic antagonistic ADJ 2514nk34z4r 11 9 role role NOUN 2514nk34z4r 11 10 between between ADP 2514nk34z4r 11 11 ppargc1a ppargc1a PROPN 2514nk34z4r 11 12 and and CCONJ 2514nk34z4r 11 13 sim1a sim1a PROPN 2514nk34z4r 11 14 to to PART 2514nk34z4r 11 15 negotiate negotiate VERB 2514nk34z4r 11 16 proximal proximal ADJ 2514nk34z4r 11 17 straight straight ADJ 2514nk34z4r 11 18 tubule tubule NOUN 2514nk34z4r 11 19 development development NOUN 2514nk34z4r 11 20 . . PUNCT 2514nk34z4r 12 1 further far ADV 2514nk34z4r 12 2 , , PUNCT 2514nk34z4r 12 3 loss loss NOUN 2514nk34z4r 12 4 of of ADP 2514nk34z4r 12 5 ppargc1a ppargc1a ADJ 2514nk34z4r 12 6 results result NOUN 2514nk34z4r 12 7 in in ADP 2514nk34z4r 12 8 phenotypes phenotype NOUN 2514nk34z4r 12 9 associated associate VERB 2514nk34z4r 12 10 with with ADP 2514nk34z4r 12 11 ciliopathies ciliopathie NOUN 2514nk34z4r 12 12 including include VERB 2514nk34z4r 12 13 polycystic polycystic ADJ 2514nk34z4r 12 14 kidney kidney NOUN 2514nk34z4r 12 15 disease disease NOUN 2514nk34z4r 12 16 ( ( PUNCT 2514nk34z4r 12 17 pkd pkd PROPN 2514nk34z4r 12 18 ) ) PUNCT 2514nk34z4r 12 19 . . PUNCT 2514nk34z4r 13 1 investigations investigation NOUN 2514nk34z4r 13 2 found find VERB 2514nk34z4r 13 3 ppargc1a ppargc1a PUNCT 2514nk34z4r 13 4 is be AUX 2514nk34z4r 13 5 necessary necessary ADJ 2514nk34z4r 13 6 for for ADP 2514nk34z4r 13 7 proper proper ADJ 2514nk34z4r 13 8 multiciliated multiciliated ADJ 2514nk34z4r 13 9 cell cell NOUN 2514nk34z4r 13 10 ( ( PUNCT 2514nk34z4r 13 11 mcc mcc NOUN 2514nk34z4r 13 12 ) ) PUNCT 2514nk34z4r 13 13 development development NOUN 2514nk34z4r 13 14 and and CCONJ 2514nk34z4r 13 15 ciliogenesis ciliogenesis NOUN 2514nk34z4r 13 16 throughout throughout ADP 2514nk34z4r 13 17 the the DET 2514nk34z4r 13 18 zebrafish zebrafish NOUN 2514nk34z4r 13 19 . . PUNCT 2514nk34z4r 14 1 interestingly interestingly ADV 2514nk34z4r 14 2 , , PUNCT 2514nk34z4r 14 3 a a DET 2514nk34z4r 14 4 novel novel ADJ 2514nk34z4r 14 5 interaction interaction NOUN 2514nk34z4r 14 6 between between ADP 2514nk34z4r 14 7 ppargc1a ppargc1a PUNCT 2514nk34z4r 14 8 and and CCONJ 2514nk34z4r 14 9 the the DET 2514nk34z4r 14 10 prostaglandin prostaglandin NOUN 2514nk34z4r 14 11 pathway pathway NOUN 2514nk34z4r 14 12 component component NOUN 2514nk34z4r 14 13 cox-1 cox-1 SPACE 2514nk34z4r 14 14 ( ( PUNCT 2514nk34z4r 14 15 ptgs1 ptgs1 PROPN 2514nk34z4r 14 16 ) ) PUNCT 2514nk34z4r 14 17 was be AUX 2514nk34z4r 14 18 identified identify VERB 2514nk34z4r 14 19 as as SCONJ 2514nk34z4r 14 20 evidence evidence NOUN 2514nk34z4r 14 21 supports support VERB 2514nk34z4r 14 22 the the DET 2514nk34z4r 14 23 hypothesis hypothesis NOUN 2514nk34z4r 14 24 that that SCONJ 2514nk34z4r 14 25 ppargc1a ppargc1a PUNCT 2514nk34z4r 14 26 regulates regulate VERB 2514nk34z4r 14 27 prostaglandin prostaglandin NOUN 2514nk34z4r 14 28 e2 e2 PROPN 2514nk34z4r 14 29 levels level NOUN 2514nk34z4r 14 30 via via ADP 2514nk34z4r 14 31 ptgs1 ptgs1 NOUN 2514nk34z4r 14 32 in in ADP 2514nk34z4r 14 33 order order NOUN 2514nk34z4r 14 34 to to PART 2514nk34z4r 14 35 properly properly ADV 2514nk34z4r 14 36 develop develop VERB 2514nk34z4r 14 37 mccs mccs PROPN 2514nk34z4r 14 38 and and CCONJ 2514nk34z4r 14 39 cilia cilia ADJ 2514nk34z4r 14 40 outgrowth outgrowth NOUN 2514nk34z4r 14 41 in in ADP 2514nk34z4r 14 42 the the DET 2514nk34z4r 14 43 pronephros pronephro NOUN 2514nk34z4r 14 44 . . PUNCT 2514nk34z4r 15 1 in in ADP 2514nk34z4r 15 2 an an DET 2514nk34z4r 15 3 attempt attempt NOUN 2514nk34z4r 15 4 to to PART 2514nk34z4r 15 5 ascertain ascertain VERB 2514nk34z4r 15 6 upstream upstream ADJ 2514nk34z4r 15 7 regulators regulator NOUN 2514nk34z4r 15 8 of of ADP 2514nk34z4r 15 9 ppargc1a ppargc1a PUNCT 2514nk34z4r 15 10 we we PRON 2514nk34z4r 15 11 cross cross VERB 2514nk34z4r 15 12 referenced reference VERB 2514nk34z4r 15 13 known know VERB 2514nk34z4r 15 14 pkd pkd NOUN 2514nk34z4r 15 15 causing cause VERB 2514nk34z4r 15 16 genes gene NOUN 2514nk34z4r 15 17 with with ADP 2514nk34z4r 15 18 literature literature NOUN 2514nk34z4r 15 19 suggesting suggest VERB 2514nk34z4r 15 20 relationships relationship NOUN 2514nk34z4r 15 21 with with ADP 2514nk34z4r 15 22 ppargc1a ppargc1a SPACE 2514nk34z4r 15 23 . . PUNCT 2514nk34z4r 16 1 the the DET 2514nk34z4r 16 2 transcription transcription NOUN 2514nk34z4r 16 3 factor factor NOUN 2514nk34z4r 16 4 hepatocyte hepatocyte NOUN 2514nk34z4r 16 5 nuclear nuclear PROPN 2514nk34z4r 16 6 factor-1 factor-1 PROPN 2514nk34z4r 16 7 homeobox homeobox PROPN 2514nk34z4r 16 8 β β PROPN 2514nk34z4r 16 9 had have AUX 2514nk34z4r 16 10 been be AUX 2514nk34z4r 16 11 shown show VERB 2514nk34z4r 16 12 to to PART 2514nk34z4r 16 13 regulate regulate VERB 2514nk34z4r 16 14 renal renal ADJ 2514nk34z4r 16 15 mitochondria mitochondria NOUN 2514nk34z4r 16 16 via via ADP 2514nk34z4r 16 17 ppargc1a ppargc1a X 2514nk34z4r 16 18 in in ADP 2514nk34z4r 16 19 human human NOUN 2514nk34z4r 16 20 and and CCONJ 2514nk34z4r 16 21 mice mouse NOUN 2514nk34z4r 16 22 . . PUNCT 2514nk34z4r 17 1 interestingly interestingly ADV 2514nk34z4r 17 2 , , PUNCT 2514nk34z4r 17 3 zebrafish zebrafish VERB 2514nk34z4r 17 4 lacking lack VERB 2514nk34z4r 17 5 hnf1ba hnf1ba PROPN 2514nk34z4r 17 6 present present ADJ 2514nk34z4r 17 7 with with ADP 2514nk34z4r 17 8 similar similar ADJ 2514nk34z4r 17 9 phenotypes phenotype NOUN 2514nk34z4r 17 10 as as ADP 2514nk34z4r 17 11 ppargc1a ppargc1a X 2514nk34z4r 17 12 deficient deficient ADJ 2514nk34z4r 17 13 samples sample NOUN 2514nk34z4r 17 14 . . PUNCT 2514nk34z4r 18 1 because because SCONJ 2514nk34z4r 18 2 of of ADP 2514nk34z4r 18 3 this this PRON 2514nk34z4r 18 4 , , PUNCT 2514nk34z4r 18 5 we we PRON 2514nk34z4r 18 6 investigated investigate VERB 2514nk34z4r 18 7 the the DET 2514nk34z4r 18 8 relationship relationship NOUN 2514nk34z4r 18 9 further far ADV 2514nk34z4r 18 10 and and CCONJ 2514nk34z4r 18 11 found find VERB 2514nk34z4r 18 12 a a DET 2514nk34z4r 18 13 drastic drastic ADJ 2514nk34z4r 18 14 decrease decrease NOUN 2514nk34z4r 18 15 in in ADP 2514nk34z4r 18 16 ppargc1a ppargc1a ADJ 2514nk34z4r 18 17 expression expression NOUN 2514nk34z4r 18 18 in in ADP 2514nk34z4r 18 19 hnf1ba hnf1ba PROPN 2514nk34z4r 18 20 mutants mutant VERB 2514nk34z4r 18 21 and and CCONJ 2514nk34z4r 18 22 ppargc1a ppargc1a ADJ 2514nk34z4r 18 23 overexpression overexpression NOUN 2514nk34z4r 18 24 is be AUX 2514nk34z4r 18 25 able able ADJ 2514nk34z4r 18 26 to to PART 2514nk34z4r 18 27 partially partially ADV 2514nk34z4r 18 28 rescue rescue VERB 2514nk34z4r 18 29 the the DET 2514nk34z4r 18 30 number number NOUN 2514nk34z4r 18 31 mccs mccs NOUN 2514nk34z4r 18 32 in in ADP 2514nk34z4r 18 33 the the DET 2514nk34z4r 18 34 zebrafish zebrafish NOUN 2514nk34z4r 18 35 pronephros pronephro NOUN 2514nk34z4r 18 36 . . PUNCT 2514nk34z4r 19 1 by by ADP 2514nk34z4r 19 2 gaining gain VERB 2514nk34z4r 19 3 a a DET 2514nk34z4r 19 4 better well ADJ 2514nk34z4r 19 5 understanding understanding NOUN 2514nk34z4r 19 6 of of ADP 2514nk34z4r 19 7 the the DET 2514nk34z4r 19 8 molecular molecular ADJ 2514nk34z4r 19 9 interactions interaction NOUN 2514nk34z4r 19 10 resulting result VERB 2514nk34z4r 19 11 in in ADP 2514nk34z4r 19 12 disease disease NOUN 2514nk34z4r 19 13 states state NOUN 2514nk34z4r 19 14 such such ADJ 2514nk34z4r 19 15 as as ADP 2514nk34z4r 19 16 pkd pkd NOUN 2514nk34z4r 19 17 we we PRON 2514nk34z4r 19 18 can can AUX 2514nk34z4r 19 19 continue continue VERB 2514nk34z4r 19 20 to to PART 2514nk34z4r 19 21 develop develop VERB 2514nk34z4r 19 22 approaches approach NOUN 2514nk34z4r 19 23 to to PART 2514nk34z4r 19 24 treat treat VERB 2514nk34z4r 19 25 or or CCONJ 2514nk34z4r 19 26 perhaps perhaps ADV 2514nk34z4r 19 27 cure cure VERB 2514nk34z4r 19 28 underlying underlie VERB 2514nk34z4r 19 29 genetic genetic ADJ 2514nk34z4r 19 30 issues issue NOUN 2514nk34z4r 19 31 that that PRON 2514nk34z4r 19 32 result result VERB 2514nk34z4r 19 33 in in ADP 2514nk34z4r 19 34 decreased decrease VERB 2514nk34z4r 19 35 quality quality NOUN 2514nk34z4r 19 36 of of ADP 2514nk34z4r 19 37 life life NOUN 2514nk34z4r 19 38 among among ADP 2514nk34z4r 19 39 patients patient NOUN 2514nk34z4r 19 40 . . PUNCT