id	sid	tid	token	lemma	pos
1z40ks67d8x	1	1	this	this	DET
1z40ks67d8x	1	2	thesis	thesis	NOUN
1z40ks67d8x	1	3	describes	describe	VERB
1z40ks67d8x	1	4	the	the	DET
1z40ks67d8x	1	5	efforts	effort	NOUN
1z40ks67d8x	1	6	toward	toward	ADP
1z40ks67d8x	1	7	developing	develop	VERB
1z40ks67d8x	1	8	new	new	ADJ
1z40ks67d8x	1	9	antibacterial	antibacterial	ADJ
1z40ks67d8x	1	10	agents	agent	NOUN
1z40ks67d8x	1	11	for	for	ADP
1z40ks67d8x	1	12	treatment	treatment	NOUN
1z40ks67d8x	1	13	of	of	ADP
1z40ks67d8x	1	14	methicillin	methicillin	NOUN
1z40ks67d8x	1	15	-	-	PUNCT
1z40ks67d8x	1	16	resistant	resistant	ADJ
1z40ks67d8x	1	17	staphylococcus	staphylococcus	PROPN
1z40ks67d8x	1	18	aureus	aureus	PROPN
1z40ks67d8x	1	19	(	(	PUNCT
1z40ks67d8x	1	20	mrsa	mrsa	PROPN
1z40ks67d8x	1	21	)	)	PUNCT
1z40ks67d8x	1	22	,	,	PUNCT
1z40ks67d8x	1	23	a	a	DET
1z40ks67d8x	1	24	gram	gram	ADJ
1z40ks67d8x	1	25	-	-	PUNCT
1z40ks67d8x	1	26	positive	positive	ADJ
1z40ks67d8x	1	27	organism	organism	NOUN
1z40ks67d8x	1	28	that	that	PRON
1z40ks67d8x	1	29	is	be	AUX
1z40ks67d8x	1	30	a	a	DET
1z40ks67d8x	1	31	leading	lead	VERB
1z40ks67d8x	1	32	cause	cause	NOUN
1z40ks67d8x	1	33	of	of	ADP
1z40ks67d8x	1	34	hospital	hospital	NOUN
1z40ks67d8x	1	35	-	-	PUNCT
1z40ks67d8x	1	36	acquired	acquire	VERB
1z40ks67d8x	1	37	infections	infection	NOUN
1z40ks67d8x	1	38	.	.	PUNCT
1z40ks67d8x	2	1	this	this	DET
1z40ks67d8x	2	2	pathogen	pathogen	NOUN
1z40ks67d8x	2	3	is	be	AUX
1z40ks67d8x	2	4	resistant	resistant	ADJ
1z40ks67d8x	2	5	to	to	ADP
1z40ks67d8x	2	6	the	the	DET
1z40ks67d8x	2	7	β	β	ADJ
1z40ks67d8x	2	8	-	-	PUNCT
1z40ks67d8x	2	9	lactam	lactam	NOUN
1z40ks67d8x	2	10	antibiotics	antibiotic	NOUN
1z40ks67d8x	2	11	which	which	PRON
1z40ks67d8x	2	12	inhibit	inhibit	VERB
1z40ks67d8x	2	13	the	the	DET
1z40ks67d8x	2	14	penicillin	penicillin	NOUN
1z40ks67d8x	2	15	-	-	PUNCT
1z40ks67d8x	2	16	binding	bind	VERB
1z40ks67d8x	2	17	proteins	protein	NOUN
1z40ks67d8x	2	18	(	(	PUNCT
1z40ks67d8x	2	19	pbps	pbps	X
1z40ks67d8x	2	20	)	)	PUNCT
1z40ks67d8x	2	21	,	,	PUNCT
1z40ks67d8x	2	22	which	which	PRON
1z40ks67d8x	2	23	are	be	AUX
1z40ks67d8x	2	24	involved	involve	VERB
1z40ks67d8x	2	25	in	in	ADP
1z40ks67d8x	2	26	the	the	DET
1z40ks67d8x	2	27	final	final	ADJ
1z40ks67d8x	2	28	stages	stage	NOUN
1z40ks67d8x	2	29	of	of	ADP
1z40ks67d8x	2	30	bacterial	bacterial	ADJ
1z40ks67d8x	2	31	cell	cell	NOUN
1z40ks67d8x	2	32	-	-	PUNCT
1z40ks67d8x	2	33	wall	wall	NOUN
1z40ks67d8x	2	34	(	(	PUNCT
1z40ks67d8x	2	35	peptidoglycan	peptidoglycan	NOUN
1z40ks67d8x	2	36	)	)	PUNCT
1z40ks67d8x	2	37	biosynthesis	biosynthesis	NOUN
1z40ks67d8x	2	38	.	.	PUNCT
1z40ks67d8x	3	1	mrsa	mrsa	PROPN
1z40ks67d8x	3	2	is	be	AUX
1z40ks67d8x	3	3	able	able	ADJ
1z40ks67d8x	3	4	to	to	PART
1z40ks67d8x	3	5	evade	evade	VERB
1z40ks67d8x	3	6	action	action	NOUN
1z40ks67d8x	3	7	of	of	ADP
1z40ks67d8x	3	8	these	these	DET
1z40ks67d8x	3	9	antibiotics	antibiotic	NOUN
1z40ks67d8x	3	10	by	by	ADP
1z40ks67d8x	3	11	expressing	express	VERB
1z40ks67d8x	3	12	an	an	DET
1z40ks67d8x	3	13	additional	additional	ADJ
1z40ks67d8x	3	14	pbp	pbp	NOUN
1z40ks67d8x	3	15	with	with	ADP
1z40ks67d8x	3	16	a	a	DET
1z40ks67d8x	3	17	low	low	ADJ
1z40ks67d8x	3	18	affinity	affinity	NOUN
1z40ks67d8x	3	19	for	for	ADP
1z40ks67d8x	3	20	the	the	DET
1z40ks67d8x	3	21	β	β	NOUN
1z40ks67d8x	3	22	-	-	PUNCT
1z40ks67d8x	3	23	lactams	lactams	NOUN
1z40ks67d8x	3	24	,	,	PUNCT
1z40ks67d8x	3	25	which	which	PRON
1z40ks67d8x	3	26	is	be	AUX
1z40ks67d8x	3	27	termed	term	VERB
1z40ks67d8x	3	28	pbp2a	pbp2a	PROPN
1z40ks67d8x	3	29	.	.	PUNCT
1z40ks67d8x	4	1	this	this	DET
1z40ks67d8x	4	2	enzyme	enzyme	NOUN
1z40ks67d8x	4	3	has	have	VERB
1z40ks67d8x	4	4	a	a	DET
1z40ks67d8x	4	5	characteristically	characteristically	ADV
1z40ks67d8x	4	6	closed	close	VERB
1z40ks67d8x	4	7	active	active	ADJ
1z40ks67d8x	4	8	-	-	PUNCT
1z40ks67d8x	4	9	site	site	NOUN
1z40ks67d8x	4	10	conformation	conformation	NOUN
1z40ks67d8x	4	11	that	that	PRON
1z40ks67d8x	4	12	is	be	AUX
1z40ks67d8x	4	13	regulated	regulate	VERB
1z40ks67d8x	4	14	allosterically	allosterically	ADV
1z40ks67d8x	4	15	by	by	ADP
1z40ks67d8x	4	16	a	a	DET
1z40ks67d8x	4	17	site	site	NOUN
1z40ks67d8x	4	18	60	60	NUM
1z40ks67d8x	4	19	å	å	PROPN
1z40ks67d8x	4	20	away	away	ADV
1z40ks67d8x	4	21	.	.	PUNCT
1z40ks67d8x	5	1	we	we	PRON
1z40ks67d8x	5	2	set	set	VERB
1z40ks67d8x	5	3	out	out	ADP
1z40ks67d8x	5	4	to	to	PART
1z40ks67d8x	5	5	develop	develop	VERB
1z40ks67d8x	5	6	new	new	ADJ
1z40ks67d8x	5	7	inhibitors	inhibitor	NOUN
1z40ks67d8x	5	8	of	of	ADP
1z40ks67d8x	5	9	pbp2a	pbp2a	PROPN
1z40ks67d8x	5	10	by	by	ADP
1z40ks67d8x	5	11	performing	perform	VERB
1z40ks67d8x	5	12	docking	docking	NOUN
1z40ks67d8x	5	13	and	and	CCONJ
1z40ks67d8x	5	14	scoring	scoring	NOUN
1z40ks67d8x	5	15	at	at	ADP
1z40ks67d8x	5	16	the	the	DET
1z40ks67d8x	5	17	active	active	ADJ
1z40ks67d8x	5	18	site	site	NOUN
1z40ks67d8x	5	19	and	and	CCONJ
1z40ks67d8x	5	20	testing	test	VERB
1z40ks67d8x	5	21	top	top	ADJ
1z40ks67d8x	5	22	compounds	compound	NOUN
1z40ks67d8x	5	23	for	for	ADP
1z40ks67d8x	5	24	antibacterial	antibacterial	ADJ
1z40ks67d8x	5	25	activity	activity	NOUN
1z40ks67d8x	5	26	.	.	PUNCT
1z40ks67d8x	6	1	a	a	DET
1z40ks67d8x	6	2	quinazolinone	quinazolinone	PROPN
1z40ks67d8x	6	3	with	with	ADP
1z40ks67d8x	6	4	good	good	ADJ
1z40ks67d8x	6	5	activity	activity	NOUN
1z40ks67d8x	6	6	against	against	ADP
1z40ks67d8x	6	7	s.	s.	PROPN
1z40ks67d8x	6	8	aureus	aureus	PROPN
1z40ks67d8x	6	9	was	be	AUX
1z40ks67d8x	6	10	identified	identify	VERB
1z40ks67d8x	6	11	from	from	ADP
1z40ks67d8x	6	12	this	this	DET
1z40ks67d8x	6	13	screening	screening	NOUN
1z40ks67d8x	6	14	.	.	PUNCT
1z40ks67d8x	7	1	medicinal	medicinal	ADJ
1z40ks67d8x	7	2	chemistry	chemistry	NOUN
1z40ks67d8x	7	3	optimization	optimization	NOUN
1z40ks67d8x	7	4	of	of	ADP
1z40ks67d8x	7	5	this	this	DET
1z40ks67d8x	7	6	hit	hit	VERB
1z40ks67d8x	7	7	compound	compound	NOUN
1z40ks67d8x	7	8	was	be	AUX
1z40ks67d8x	7	9	performed	perform	VERB
1z40ks67d8x	7	10	to	to	PART
1z40ks67d8x	7	11	optimize	optimize	VERB
1z40ks67d8x	7	12	the	the	DET
1z40ks67d8x	7	13	in	in	ADP
1z40ks67d8x	7	14	vitro	vitro	X
1z40ks67d8x	7	15	antibacterial	antibacterial	ADJ
1z40ks67d8x	7	16	activity	activity	NOUN
1z40ks67d8x	7	17	,	,	PUNCT
1z40ks67d8x	7	18	solubility	solubility	NOUN
1z40ks67d8x	7	19	,	,	PUNCT
1z40ks67d8x	7	20	stability	stability	NOUN
1z40ks67d8x	7	21	,	,	PUNCT
1z40ks67d8x	7	22	pharmacokinetics	pharmacokinetic	NOUN
1z40ks67d8x	7	23	,	,	PUNCT
1z40ks67d8x	7	24	and	and	CCONJ
1z40ks67d8x	7	25	ultimately	ultimately	ADV
1z40ks67d8x	7	26	in	in	ADP
1z40ks67d8x	7	27	vivo	vivo	ADJ
1z40ks67d8x	7	28	efficacy	efficacy	NOUN
1z40ks67d8x	7	29	.	.	PUNCT
1z40ks67d8x	8	1	the	the	DET
1z40ks67d8x	8	2	mechanism	mechanism	NOUN
1z40ks67d8x	8	3	of	of	ADP
1z40ks67d8x	8	4	action	action	NOUN
1z40ks67d8x	8	5	for	for	ADP
1z40ks67d8x	8	6	the	the	DET
1z40ks67d8x	8	7	quinazolinones	quinazolinone	NOUN
1z40ks67d8x	8	8	was	be	AUX
1z40ks67d8x	8	9	investigated	investigate	VERB
1z40ks67d8x	8	10	through	through	ADP
1z40ks67d8x	8	11	use	use	NOUN
1z40ks67d8x	8	12	of	of	ADP
1z40ks67d8x	8	13	a	a	DET
1z40ks67d8x	8	14	macromolecular	macromolecular	ADJ
1z40ks67d8x	8	15	synthesis	synthesis	NOUN
1z40ks67d8x	8	16	assays	assay	NOUN
1z40ks67d8x	8	17	,	,	PUNCT
1z40ks67d8x	8	18	pbp	pbp	NOUN
1z40ks67d8x	8	19	enzyme	enzyme	NOUN
1z40ks67d8x	8	20	activity	activity	NOUN
1z40ks67d8x	8	21	assays	assay	VERB
1z40ks67d8x	8	22	,	,	PUNCT
1z40ks67d8x	8	23	and	and	CCONJ
1z40ks67d8x	8	24	mrna	mrna	PROPN
1z40ks67d8x	8	25	antisense	antisense	NOUN
1z40ks67d8x	8	26	susceptibility	susceptibility	NOUN
1z40ks67d8x	8	27	testing	testing	NOUN
1z40ks67d8x	8	28	.	.	PUNCT
1z40ks67d8x	9	1	additionally	additionally	ADV
1z40ks67d8x	9	2	,	,	PUNCT
1z40ks67d8x	9	3	the	the	DET
1z40ks67d8x	9	4	quinazolinones	quinazolinone	NOUN
1z40ks67d8x	9	5	were	be	AUX
1z40ks67d8x	9	6	tested	test	VERB
1z40ks67d8x	9	7	for	for	ADP
1z40ks67d8x	9	8	synergy	synergy	NOUN
1z40ks67d8x	9	9	with	with	ADP
1z40ks67d8x	9	10	several	several	ADJ
1z40ks67d8x	9	11	classes	class	NOUN
1z40ks67d8x	9	12	of	of	ADP
1z40ks67d8x	9	13	antibiotics	antibiotic	NOUN
1z40ks67d8x	9	14	including	include	VERB
1z40ks67d8x	9	15	β	β	NOUN
1z40ks67d8x	9	16	-	-	PUNCT
1z40ks67d8x	9	17	lactams	lactams	NOUN
1z40ks67d8x	9	18	.	.	PUNCT
1z40ks67d8x	10	1	two	two	NUM
1z40ks67d8x	10	2	lead	lead	NOUN
1z40ks67d8x	10	3	quinazolinones	quinazolinone	NOUN
1z40ks67d8x	10	4	were	be	AUX
1z40ks67d8x	10	5	identified	identify	VERB
1z40ks67d8x	10	6	that	that	PRON
1z40ks67d8x	10	7	demonstrated	demonstrate	VERB
1z40ks67d8x	10	8	good	good	ADJ
1z40ks67d8x	10	9	pharmacokinetic	pharmacokinetic	ADJ
1z40ks67d8x	10	10	properties	property	NOUN
1z40ks67d8x	10	11	and	and	CCONJ
1z40ks67d8x	10	12	thus	thus	ADV
1z40ks67d8x	10	13	achieved	achieve	VERB
1z40ks67d8x	10	14	efficacy	efficacy	NOUN
1z40ks67d8x	10	15	in	in	ADP
1z40ks67d8x	10	16	mouse	mouse	NOUN
1z40ks67d8x	10	17	models	model	NOUN
1z40ks67d8x	10	18	of	of	ADP
1z40ks67d8x	10	19	infections	infection	NOUN
1z40ks67d8x	10	20	.	.	PUNCT
1z40ks67d8x	11	1	additionally	additionally	ADV
1z40ks67d8x	11	2	,	,	PUNCT
1z40ks67d8x	11	3	these	these	DET
1z40ks67d8x	11	4	quinazolinones	quinazolinone	NOUN
1z40ks67d8x	11	5	were	be	AUX
1z40ks67d8x	11	6	demonstrated	demonstrate	VERB
1z40ks67d8x	11	7	to	to	PART
1z40ks67d8x	11	8	inhibit	inhibit	VERB
1z40ks67d8x	11	9	pbp1	pbp1	NOUN
1z40ks67d8x	11	10	and	and	CCONJ
1z40ks67d8x	11	11	pbp2a	pbp2a	ADJ
1z40ks67d8x	11	12	of	of	ADP
1z40ks67d8x	11	13	s.	s.	PROPN
1z40ks67d8x	11	14	aureus	aureus	PROPN
1z40ks67d8x	11	15	.	.	PUNCT
1z40ks67d8x	12	1	in	in	ADP
1z40ks67d8x	12	2	the	the	DET
1z40ks67d8x	12	3	case	case	NOUN
1z40ks67d8x	12	4	of	of	ADP
1z40ks67d8x	12	5	pbp2a	pbp2a	PROPN
1z40ks67d8x	12	6	,	,	PUNCT
1z40ks67d8x	12	7	the	the	DET
1z40ks67d8x	12	8	quinazolinones	quinazolinone	NOUN
1z40ks67d8x	12	9	bind	bind	VERB
1z40ks67d8x	12	10	to	to	ADP
1z40ks67d8x	12	11	both	both	CCONJ
1z40ks67d8x	12	12	the	the	DET
1z40ks67d8x	12	13	allosteric	allosteric	NOUN
1z40ks67d8x	12	14	site	site	NOUN
1z40ks67d8x	12	15	and	and	CCONJ
1z40ks67d8x	12	16	the	the	DET
1z40ks67d8x	12	17	active	active	ADJ
1z40ks67d8x	12	18	site	site	NOUN
1z40ks67d8x	12	19	in	in	ADP
1z40ks67d8x	12	20	order	order	NOUN
1z40ks67d8x	12	21	to	to	PART
1z40ks67d8x	12	22	accomplish	accomplish	VERB
1z40ks67d8x	12	23	inhibition	inhibition	NOUN
1z40ks67d8x	12	24	.	.	PUNCT
1z40ks67d8x	13	1	their	their	PRON
1z40ks67d8x	13	2	ability	ability	NOUN
1z40ks67d8x	13	3	of	of	ADP
1z40ks67d8x	13	4	inhibit	inhibit	NOUN
1z40ks67d8x	13	5	pbp2a	pbp2a	VERB
1z40ks67d8x	13	6	also	also	ADV
1z40ks67d8x	13	7	allowed	allow	VERB
1z40ks67d8x	13	8	for	for	SCONJ
1z40ks67d8x	13	9	the	the	DET
1z40ks67d8x	13	10	quinazolinones	quinazolinone	NOUN
1z40ks67d8x	13	11	to	to	PART
1z40ks67d8x	13	12	achieve	achieve	VERB
1z40ks67d8x	13	13	synergism	synergism	NOUN
1z40ks67d8x	13	14	with	with	ADP
1z40ks67d8x	13	15	several	several	ADJ
1z40ks67d8x	13	16	β	β	NOUN
1z40ks67d8x	13	17	-	-	PUNCT
1z40ks67d8x	13	18	lactam	lactam	NOUN
1z40ks67d8x	13	19	antibiotics	antibiotic	NOUN
1z40ks67d8x	13	20	,	,	PUNCT
1z40ks67d8x	13	21	most	most	ADV
1z40ks67d8x	13	22	notably	notably	ADV
1z40ks67d8x	13	23	piperacillin	piperacillin	NOUN
1z40ks67d8x	13	24	and	and	CCONJ
1z40ks67d8x	13	25	imipenem	imipenem	PROPN
1z40ks67d8x	13	26	.	.	PUNCT