id sid tid token lemma pos 1r66j100r5h 1 1 one one NUM 1r66j100r5h 1 2 of of ADP 1r66j100r5h 1 3 the the DET 1r66j100r5h 1 4 challenges challenge NOUN 1r66j100r5h 1 5 in in ADP 1r66j100r5h 1 6 current current ADJ 1r66j100r5h 1 7 therapies therapy NOUN 1r66j100r5h 1 8 used use VERB 1r66j100r5h 1 9 to to PART 1r66j100r5h 1 10 treat treat VERB 1r66j100r5h 1 11 allergies allergy NOUN 1r66j100r5h 1 12 is be AUX 1r66j100r5h 1 13 the the DET 1r66j100r5h 1 14 non non ADJ 1r66j100r5h 1 15 - - ADJ 1r66j100r5h 1 16 specific specific ADJ 1r66j100r5h 1 17 suppression suppression NOUN 1r66j100r5h 1 18 of of ADP 1r66j100r5h 1 19 the the DET 1r66j100r5h 1 20 immune immune ADJ 1r66j100r5h 1 21 system system NOUN 1r66j100r5h 1 22 which which PRON 1r66j100r5h 1 23 puts put VERB 1r66j100r5h 1 24 patients patient NOUN 1r66j100r5h 1 25 at at ADP 1r66j100r5h 1 26 increased increase VERB 1r66j100r5h 1 27 risk risk NOUN 1r66j100r5h 1 28 for for ADP 1r66j100r5h 1 29 infections infection NOUN 1r66j100r5h 1 30 and and CCONJ 1r66j100r5h 1 31 development development NOUN 1r66j100r5h 1 32 of of ADP 1r66j100r5h 1 33 cancers cancer NOUN 1r66j100r5h 1 34 . . PUNCT 1r66j100r5h 2 1 this this PRON 1r66j100r5h 2 2 underlines underline VERB 1r66j100r5h 2 3 the the DET 1r66j100r5h 2 4 need need NOUN 1r66j100r5h 2 5 to to PART 1r66j100r5h 2 6 develop develop VERB 1r66j100r5h 2 7 more more ADV 1r66j100r5h 2 8 specific specific ADJ 1r66j100r5h 2 9 treatments treatment NOUN 1r66j100r5h 2 10 without without ADP 1r66j100r5h 2 11 the the DET 1r66j100r5h 2 12 overall overall ADJ 1r66j100r5h 2 13 suppression suppression NOUN 1r66j100r5h 2 14 of of ADP 1r66j100r5h 2 15 the the DET 1r66j100r5h 2 16 immune immune ADJ 1r66j100r5h 2 17 system system NOUN 1r66j100r5h 2 18 . . PUNCT 1r66j100r5h 3 1 this this DET 1r66j100r5h 3 2 work work NOUN 1r66j100r5h 3 3 demonstrates demonstrate VERB 1r66j100r5h 3 4 the the DET 1r66j100r5h 3 5 proof proof NOUN 1r66j100r5h 3 6 of of ADP 1r66j100r5h 3 7 principle principle ADJ 1r66j100r5h 3 8 studies study NOUN 1r66j100r5h 3 9 of of ADP 1r66j100r5h 3 10 a a DET 1r66j100r5h 3 11 new new ADJ 1r66j100r5h 3 12 approach approach NOUN 1r66j100r5h 3 13 that that PRON 1r66j100r5h 3 14 has have VERB 1r66j100r5h 3 15 the the DET 1r66j100r5h 3 16 potential potential NOUN 1r66j100r5h 3 17 to to PART 1r66j100r5h 3 18 respond respond VERB 1r66j100r5h 3 19 to to ADP 1r66j100r5h 3 20 this this DET 1r66j100r5h 3 21 need need NOUN 1r66j100r5h 3 22 by by ADP 1r66j100r5h 3 23 selectively selectively ADV 1r66j100r5h 3 24 inhibiting inhibit VERB 1r66j100r5h 3 25 mast mast NOUN 1r66j100r5h 3 26 cell cell NOUN 1r66j100r5h 3 27 degranulation degranulation NOUN 1r66j100r5h 3 28 . . PUNCT 1r66j100r5h 4 1 specifically specifically ADV 1r66j100r5h 4 2 , , PUNCT 1r66j100r5h 4 3 heterobivalent heterobivalent ADJ 1r66j100r5h 4 4 inhibitors inhibitor NOUN 1r66j100r5h 4 5 ( ( PUNCT 1r66j100r5h 4 6 hbi hbi PROPN 1r66j100r5h 4 7 ) ) PUNCT 1r66j100r5h 4 8 were be AUX 1r66j100r5h 4 9 designed design VERB 1r66j100r5h 4 10 that that SCONJ 1r66j100r5h 4 11 simultaneously simultaneously ADV 1r66j100r5h 4 12 bound bind VERB 1r66j100r5h 4 13 to to ADP 1r66j100r5h 4 14 two two NUM 1r66j100r5h 4 15 nearby nearby ADJ 1r66j100r5h 4 16 sites site NOUN 1r66j100r5h 4 17 located locate VERB 1r66j100r5h 4 18 on on ADP 1r66j100r5h 4 19 the the DET 1r66j100r5h 4 20 fab fab ADJ 1r66j100r5h 4 21 domains domain NOUN 1r66j100r5h 4 22 of of ADP 1r66j100r5h 4 23 ige ige ADJ 1r66j100r5h 4 24 antibodies?the antibodies?the DET 1r66j100r5h 4 25 antigen antigen NOUN 1r66j100r5h 4 26 and and CCONJ 1r66j100r5h 4 27 nucleotide nucleotide ADJ 1r66j100r5h 4 28 binding bind VERB 1r66j100r5h 4 29 sites site NOUN 1r66j100r5h 4 30 . . PUNCT 1r66j100r5h 5 1 these these DET 1r66j100r5h 5 2 dual dual ADJ 1r66j100r5h 5 3 targeting targeting NOUN 1r66j100r5h 5 4 hbis hbis NOUN 1r66j100r5h 5 5 had have VERB 1r66j100r5h 5 6 greater great ADJ 1r66j100r5h 5 7 than than ADP 1r66j100r5h 5 8 120 120 NUM 1r66j100r5h 5 9 fold fold VERB 1r66j100r5h 5 10 increased increase VERB 1r66j100r5h 5 11 affinity affinity NOUN 1r66j100r5h 5 12 for for ADP 1r66j100r5h 5 13 the the DET 1r66j100r5h 5 14 target target NOUN 1r66j100r5h 5 15 ige ige PROPN 1r66j100r5h 5 16 compared compare VERB 1r66j100r5h 5 17 to to ADP 1r66j100r5h 5 18 the the DET 1r66j100r5h 5 19 monovalent monovalent NOUN 1r66j100r5h 5 20 hapten hapten NOUN 1r66j100r5h 5 21 and and CCONJ 1r66j100r5h 5 22 prevented prevent VERB 1r66j100r5h 5 23 mast mast NOUN 1r66j100r5h 5 24 cell cell NOUN 1r66j100r5h 5 25 degranulation degranulation NOUN 1r66j100r5h 5 26 in in ADP 1r66j100r5h 5 27 a a DET 1r66j100r5h 5 28 variant variant NOUN 1r66j100r5h 5 29 of of ADP 1r66j100r5h 5 30 the the DET 1r66j100r5h 5 31 commonly commonly ADV 1r66j100r5h 5 32 used use VERB 1r66j100r5h 5 33 dnp dnp PROPN 1r66j100r5h 5 34 / / SYM 1r66j100r5h 5 35 igednp igednp PROPN 1r66j100r5h 5 36 allergy allergy PROPN 1r66j100r5h 5 37 model model PROPN 1r66j100r5h 5 38 , , PUNCT 1r66j100r5h 5 39 however however ADV 1r66j100r5h 5 40 due due ADP 1r66j100r5h 5 41 to to ADP 1r66j100r5h 5 42 the the DET 1r66j100r5h 5 43 many many ADJ 1r66j100r5h 5 44 simplifications simplification NOUN 1r66j100r5h 5 45 of of ADP 1r66j100r5h 5 46 this this DET 1r66j100r5h 5 47 allergy allergy NOUN 1r66j100r5h 5 48 model model NOUN 1r66j100r5h 5 49 a a DET 1r66j100r5h 5 50 more more ADV 1r66j100r5h 5 51 advanced advanced ADJ 1r66j100r5h 5 52 heterotetravalent heterotetravalent ADJ 1r66j100r5h 5 53 allergen allergen NOUN 1r66j100r5h 5 54 ( ( PUNCT 1r66j100r5h 5 55 htta htta NOUN 1r66j100r5h 5 56 ) ) PUNCT 1r66j100r5h 5 57 model model NOUN 1r66j100r5h 5 58 was be AUX 1r66j100r5h 5 59 developed develop VERB 1r66j100r5h 5 60 . . PUNCT 1r66j100r5h 6 1 the the DET 1r66j100r5h 6 2 htta htta PROPN 1r66j100r5h 6 3 allergy allergy PROPN 1r66j100r5h 6 4 model model NOUN 1r66j100r5h 6 5 allowed allow VERB 1r66j100r5h 6 6 an an DET 1r66j100r5h 6 7 integrative integrative ADJ 1r66j100r5h 6 8 approach approach NOUN 1r66j100r5h 6 9 to to PART 1r66j100r5h 6 10 study study VERB 1r66j100r5h 6 11 mast mast NOUN 1r66j100r5h 6 12 cell cell NOUN 1r66j100r5h 6 13 degranulation degranulation NOUN 1r66j100r5h 6 14 by by ADP 1r66j100r5h 6 15 presenting present VERB 1r66j100r5h 6 16 2 2 NUM 1r66j100r5h 6 17 haptens hapten VERB 1r66j100r5h 6 18 each each PRON 1r66j100r5h 6 19 with with ADP 1r66j100r5h 6 20 a a DET 1r66j100r5h 6 21 valency valency NOUN 1r66j100r5h 6 22 of of ADP 1r66j100r5h 6 23 2 2 NUM 1r66j100r5h 6 24 and and CCONJ 1r66j100r5h 6 25 requiring require VERB 1r66j100r5h 6 26 both both DET 1r66j100r5h 6 27 hapten hapten NOUN 1r66j100r5h 6 28 specific specific ADJ 1r66j100r5h 6 29 iges ige NOUN 1r66j100r5h 6 30 to to PART 1r66j100r5h 6 31 be be AUX 1r66j100r5h 6 32 present present ADJ 1r66j100r5h 6 33 on on ADP 1r66j100r5h 6 34 the the DET 1r66j100r5h 6 35 mast mast NOUN 1r66j100r5h 6 36 cell cell NOUN 1r66j100r5h 6 37 surface surface NOUN 1r66j100r5h 6 38 to to PART 1r66j100r5h 6 39 stimulate stimulate VERB 1r66j100r5h 6 40 degranulation degranulation NOUN 1r66j100r5h 6 41 . . PUNCT 1r66j100r5h 7 1 this this DET 1r66j100r5h 7 2 model model NOUN 1r66j100r5h 7 3 better well ADV 1r66j100r5h 7 4 reflected reflect VERB 1r66j100r5h 7 5 the the DET 1r66j100r5h 7 6 polyclonal polyclonal ADJ 1r66j100r5h 7 7 response response NOUN 1r66j100r5h 7 8 observed observe VERB 1r66j100r5h 7 9 in in ADP 1r66j100r5h 7 10 natural natural ADJ 1r66j100r5h 7 11 allergy allergy NOUN 1r66j100r5h 7 12 systems system NOUN 1r66j100r5h 7 13 and and CCONJ 1r66j100r5h 7 14 by by ADP 1r66j100r5h 7 15 chemically chemically ADV 1r66j100r5h 7 16 modifying modify VERB 1r66j100r5h 7 17 the the DET 1r66j100r5h 7 18 haptens hapten NOUN 1r66j100r5h 7 19 , , PUNCT 1r66j100r5h 7 20 httas htta NOUN 1r66j100r5h 7 21 that that PRON 1r66j100r5h 7 22 presented present VERB 1r66j100r5h 7 23 combinations combination NOUN 1r66j100r5h 7 24 of of ADP 1r66j100r5h 7 25 high high ADJ 1r66j100r5h 7 26 and and CCONJ 1r66j100r5h 7 27 low low ADJ 1r66j100r5h 7 28 affinity affinity NOUN 1r66j100r5h 7 29 haptens hapten VERB 1r66j100r5h 7 30 were be AUX 1r66j100r5h 7 31 evaluated evaluate VERB 1r66j100r5h 7 32 . . PUNCT 1r66j100r5h 8 1 using use VERB 1r66j100r5h 8 2 this this DET 1r66j100r5h 8 3 model model NOUN 1r66j100r5h 8 4 we we PRON 1r66j100r5h 8 5 demonstrated demonstrate VERB 1r66j100r5h 8 6 the the DET 1r66j100r5h 8 7 significance significance NOUN 1r66j100r5h 8 8 of of ADP 1r66j100r5h 8 9 low low ADJ 1r66j100r5h 8 10 affinity affinity NOUN 1r66j100r5h 8 11 epitopes epitope NOUN 1r66j100r5h 8 12 and and CCONJ 1r66j100r5h 8 13 that that DET 1r66j100r5h 8 14 selective selective ADJ 1r66j100r5h 8 15 inhibition inhibition NOUN 1r66j100r5h 8 16 of of ADP 1r66j100r5h 8 17 only only ADV 1r66j100r5h 8 18 the the DET 1r66j100r5h 8 19 low low ADJ 1r66j100r5h 8 20 affinity affinity NOUN 1r66j100r5h 8 21 hapten hapten NOUN 1r66j100r5h 8 22 , , PUNCT 1r66j100r5h 8 23 of of ADP 1r66j100r5h 8 24 an an DET 1r66j100r5h 8 25 allergen allergen NOUN 1r66j100r5h 8 26 made make VERB 1r66j100r5h 8 27 up up ADP 1r66j100r5h 8 28 of of ADP 1r66j100r5h 8 29 high high ADJ 1r66j100r5h 8 30 and and CCONJ 1r66j100r5h 8 31 low low ADJ 1r66j100r5h 8 32 affinity affinity NOUN 1r66j100r5h 8 33 hatpens hatpen NOUN 1r66j100r5h 8 34 , , PUNCT 1r66j100r5h 8 35 was be AUX 1r66j100r5h 8 36 sufficient sufficient ADJ 1r66j100r5h 8 37 to to PART 1r66j100r5h 8 38 prevent prevent VERB 1r66j100r5h 8 39 mast mast NOUN 1r66j100r5h 8 40 cell cell NOUN 1r66j100r5h 8 41 degranulation degranulation NOUN 1r66j100r5h 8 42 . . PUNCT 1r66j100r5h 9 1 the the DET 1r66j100r5h 9 2 inhibition inhibition NOUN 1r66j100r5h 9 3 of of ADP 1r66j100r5h 9 4 mast mast NOUN 1r66j100r5h 9 5 cell cell NOUN 1r66j100r5h 9 6 degranulation degranulation NOUN 1r66j100r5h 9 7 observed observe VERB 1r66j100r5h 9 8 in in ADP 1r66j100r5h 9 9 the the DET 1r66j100r5h 9 10 in in ADP 1r66j100r5h 9 11 vitro vitro X 1r66j100r5h 9 12 rat rat NOUN 1r66j100r5h 9 13 basophilic basophilic ADJ 1r66j100r5h 9 14 leukemia leukemia NOUN 1r66j100r5h 9 15 mast mast NOUN 1r66j100r5h 9 16 cell cell NOUN 1r66j100r5h 9 17 model model NOUN 1r66j100r5h 9 18 was be AUX 1r66j100r5h 9 19 used use VERB 1r66j100r5h 9 20 to to PART 1r66j100r5h 9 21 define define VERB 1r66j100r5h 9 22 the the DET 1r66j100r5h 9 23 parameters parameter NOUN 1r66j100r5h 9 24 for for ADP 1r66j100r5h 9 25 the the DET 1r66j100r5h 9 26 passive passive ADJ 1r66j100r5h 9 27 cutaneous cutaneous ADJ 1r66j100r5h 9 28 anaphylaxis anaphylaxis ADJ 1r66j100r5h 9 29 mouse mouse NOUN 1r66j100r5h 9 30 model model NOUN 1r66j100r5h 9 31 of of ADP 1r66j100r5h 9 32 allergy allergy NOUN 1r66j100r5h 9 33 where where SCONJ 1r66j100r5h 9 34 similar similar ADJ 1r66j100r5h 9 35 stimulation stimulation NOUN 1r66j100r5h 9 36 and and CCONJ 1r66j100r5h 9 37 inhibition inhibition NOUN 1r66j100r5h 9 38 of of ADP 1r66j100r5h 9 39 allergy allergy NOUN 1r66j100r5h 9 40 were be AUX 1r66j100r5h 9 41 observed observe VERB 1r66j100r5h 9 42 , , PUNCT 1r66j100r5h 9 43 demonstrating demonstrate VERB 1r66j100r5h 9 44 the the DET 1r66j100r5h 9 45 utility utility NOUN 1r66j100r5h 9 46 of of ADP 1r66j100r5h 9 47 the the DET 1r66j100r5h 9 48 design design NOUN 1r66j100r5h 9 49 . . PUNCT 1r66j100r5h 10 1 the the DET 1r66j100r5h 10 2 described describe VERB 1r66j100r5h 10 3 method method NOUN 1r66j100r5h 10 4 of of ADP 1r66j100r5h 10 5 targeted target VERB 1r66j100r5h 10 6 inhibition inhibition NOUN 1r66j100r5h 10 7 has have VERB 1r66j100r5h 10 8 broad broad ADJ 1r66j100r5h 10 9 applications application NOUN 1r66j100r5h 10 10 in in ADP 1r66j100r5h 10 11 inhibiting inhibit VERB 1r66j100r5h 10 12 drug drug NOUN 1r66j100r5h 10 13 , , PUNCT 1r66j100r5h 10 14 food food NOUN 1r66j100r5h 10 15 , , PUNCT 1r66j100r5h 10 16 and and CCONJ 1r66j100r5h 10 17 environmental environmental ADJ 1r66j100r5h 10 18 allergies allergy NOUN 1r66j100r5h 10 19 where where SCONJ 1r66j100r5h 10 20 the the DET 1r66j100r5h 10 21 allergy allergy NOUN 1r66j100r5h 10 22 epitopes epitope NOUN 1r66j100r5h 10 23 are be AUX 1r66j100r5h 10 24 known know VERB 1r66j100r5h 10 25 and and CCONJ 1r66j100r5h 10 26 this this DET 1r66j100r5h 10 27 study study NOUN 1r66j100r5h 10 28 establishes establish VERB 1r66j100r5h 10 29 a a DET 1r66j100r5h 10 30 new new ADJ 1r66j100r5h 10 31 practical practical ADJ 1r66j100r5h 10 32 use use NOUN 1r66j100r5h 10 33 for for ADP 1r66j100r5h 10 34 the the DET 1r66j100r5h 10 35 nucleotide nucleotide ADJ 1r66j100r5h 10 36 binding bind VERB 1r66j100r5h 10 37 site site NOUN 1r66j100r5h 10 38 . . PUNCT