id	sid	tid	token	lemma	pos
0k225b01f5m	1	1	this	this	DET
0k225b01f5m	1	2	thesis	thesis	NOUN
0k225b01f5m	1	3	describes	describe	VERB
0k225b01f5m	1	4	our	our	PRON
0k225b01f5m	1	5	endeavors	endeavor	NOUN
0k225b01f5m	1	6	towards	towards	ADP
0k225b01f5m	1	7	the	the	DET
0k225b01f5m	1	8	development	development	NOUN
0k225b01f5m	1	9	of	of	ADP
0k225b01f5m	1	10	therapeutic	therapeutic	ADJ
0k225b01f5m	1	11	agents	agent	NOUN
0k225b01f5m	1	12	for	for	ADP
0k225b01f5m	1	13	niemann	niemann	PROPN
0k225b01f5m	1	14	-	-	PUNCT
0k225b01f5m	1	15	pick	pick	NOUN
0k225b01f5m	1	16	type	type	NOUN
0k225b01f5m	1	17	c	c	NOUN
0k225b01f5m	1	18	disease	disease	NOUN
0k225b01f5m	1	19	(	(	PUNCT
0k225b01f5m	1	20	npc	npc	PROPN
0k225b01f5m	1	21	)	)	PUNCT
0k225b01f5m	1	22	,	,	PUNCT
0k225b01f5m	1	23	which	which	PRON
0k225b01f5m	1	24	is	be	AUX
0k225b01f5m	1	25	a	a	DET
0k225b01f5m	1	26	rare	rare	ADJ
0k225b01f5m	1	27	,	,	PUNCT
0k225b01f5m	1	28	autosomal	autosomal	ADJ
0k225b01f5m	1	29	recessive	recessive	ADJ
0k225b01f5m	1	30	lipid	lipid	NOUN
0k225b01f5m	1	31	storage	storage	NOUN
0k225b01f5m	1	32	disorder	disorder	NOUN
0k225b01f5m	1	33	.	.	PUNCT
0k225b01f5m	2	1	this	this	DET
0k225b01f5m	2	2	fatal	fatal	ADJ
0k225b01f5m	2	3	disease	disease	NOUN
0k225b01f5m	2	4	mainly	mainly	ADV
0k225b01f5m	2	5	affects	affect	VERB
0k225b01f5m	2	6	children	child	NOUN
0k225b01f5m	2	7	and	and	CCONJ
0k225b01f5m	2	8	nowadays	nowadays	ADV
0k225b01f5m	2	9	only	only	ADV
0k225b01f5m	2	10	supportive	supportive	ADJ
0k225b01f5m	2	11	treatments	treatment	NOUN
0k225b01f5m	2	12	exist	exist	VERB
0k225b01f5m	2	13	,	,	PUNCT
0k225b01f5m	2	14	although	although	SCONJ
0k225b01f5m	2	15	two	two	NUM
0k225b01f5m	2	16	experimental	experimental	ADJ
0k225b01f5m	2	17	therapies	therapy	NOUN
0k225b01f5m	2	18	are	be	AUX
0k225b01f5m	2	19	currently	currently	ADV
0k225b01f5m	2	20	in	in	ADP
0k225b01f5m	2	21	initial	initial	ADJ
0k225b01f5m	2	22	human	human	ADJ
0k225b01f5m	2	23	clinical	clinical	ADJ
0k225b01f5m	2	24	trials	trial	NOUN
0k225b01f5m	2	25	.	.	PUNCT
0k225b01f5m	3	1	in	in	ADP
0k225b01f5m	3	2	collaboration	collaboration	NOUN
0k225b01f5m	3	3	with	with	ADP
0k225b01f5m	3	4	the	the	DET
0k225b01f5m	3	5	maxfield	maxfield	PROPN
0k225b01f5m	3	6	laboratory	laboratory	PROPN
0k225b01f5m	3	7	at	at	ADP
0k225b01f5m	3	8	the	the	DET
0k225b01f5m	3	9	cornell	cornell	PROPN
0k225b01f5m	3	10	weill	weill	ADV
0k225b01f5m	3	11	medical	medical	ADJ
0k225b01f5m	3	12	school	school	NOUN
0k225b01f5m	3	13	,	,	PUNCT
0k225b01f5m	3	14	potential	potential	ADJ
0k225b01f5m	3	15	therapeutic	therapeutic	ADJ
0k225b01f5m	3	16	agents	agent	NOUN
0k225b01f5m	3	17	were	be	AUX
0k225b01f5m	3	18	developed	develop	VERB
0k225b01f5m	3	19	.	.	PUNCT
0k225b01f5m	4	1	the	the	DET
0k225b01f5m	4	2	maxfield	maxfield	PROPN
0k225b01f5m	4	3	group	group	NOUN
0k225b01f5m	4	4	had	have	AUX
0k225b01f5m	4	5	developed	develop	VERB
0k225b01f5m	4	6	an	an	DET
0k225b01f5m	4	7	automated	automate	VERB
0k225b01f5m	4	8	high	high	ADJ
0k225b01f5m	4	9	-	-	PUNCT
0k225b01f5m	4	10	throughput	throughput	NOUN
0k225b01f5m	4	11	screening	screening	NOUN
0k225b01f5m	4	12	procedure	procedure	NOUN
0k225b01f5m	4	13	that	that	PRON
0k225b01f5m	4	14	measures	measure	VERB
0k225b01f5m	4	15	the	the	DET
0k225b01f5m	4	16	level	level	NOUN
0k225b01f5m	4	17	of	of	ADP
0k225b01f5m	4	18	cholesterol	cholesterol	NOUN
0k225b01f5m	4	19	in	in	ADP
0k225b01f5m	4	20	cells	cell	NOUN
0k225b01f5m	4	21	and	and	CCONJ
0k225b01f5m	4	22	organelles	organelle	NOUN
0k225b01f5m	4	23	and	and	CCONJ
0k225b01f5m	4	24	identified	identify	VERB
0k225b01f5m	4	25	pyrrolinones	pyrrolinone	NOUN
0k225b01f5m	4	26	as	as	ADP
0k225b01f5m	4	27	a	a	DET
0k225b01f5m	4	28	class	class	NOUN
0k225b01f5m	4	29	of	of	ADP
0k225b01f5m	4	30	compounds	compound	NOUN
0k225b01f5m	4	31	that	that	PRON
0k225b01f5m	4	32	reduces	reduce	VERB
0k225b01f5m	4	33	the	the	DET
0k225b01f5m	4	34	level	level	NOUN
0k225b01f5m	4	35	of	of	ADP
0k225b01f5m	4	36	cholesterol	cholesterol	NOUN
0k225b01f5m	4	37	in	in	ADP
0k225b01f5m	4	38	the	the	DET
0k225b01f5m	4	39	lysosomal	lysosomal	NOUN
0k225b01f5m	4	40	storage	storage	NOUN
0k225b01f5m	4	41	compartment	compartment	NOUN
0k225b01f5m	4	42	.	.	PUNCT
0k225b01f5m	5	1	based	base	VERB
0k225b01f5m	5	2	on	on	ADP
0k225b01f5m	5	3	these	these	DET
0k225b01f5m	5	4	results	result	NOUN
0k225b01f5m	5	5	,	,	PUNCT
0k225b01f5m	5	6	analogues	analogue	NOUN
0k225b01f5m	5	7	of	of	ADP
0k225b01f5m	5	8	this	this	DET
0k225b01f5m	5	9	class	class	NOUN
0k225b01f5m	5	10	of	of	ADP
0k225b01f5m	5	11	compounds	compound	NOUN
0k225b01f5m	5	12	were	be	AUX
0k225b01f5m	5	13	synthesized	synthesize	VERB
0k225b01f5m	5	14	.	.	PUNCT
0k225b01f5m	6	1	subsequently	subsequently	ADV
0k225b01f5m	6	2	,	,	PUNCT
0k225b01f5m	6	3	different	different	ADJ
0k225b01f5m	6	4	histone	histone	NOUN
0k225b01f5m	6	5	deacetylase	deacetylase	NOUN
0k225b01f5m	6	6	inhibitors	inhibitor	NOUN
0k225b01f5m	6	7	(	(	PUNCT
0k225b01f5m	6	8	hdaci	hdaci	NUM
0k225b01f5m	6	9	)	)	PUNCT
0k225b01f5m	6	10	as	as	SCONJ
0k225b01f5m	6	11	potential	potential	ADJ
0k225b01f5m	6	12	therapy	therapy	NOUN
0k225b01f5m	6	13	options	option	NOUN
0k225b01f5m	6	14	were	be	AUX
0k225b01f5m	6	15	explored	explore	VERB
0k225b01f5m	6	16	.	.	PUNCT
0k225b01f5m	7	1	different	different	ADJ
0k225b01f5m	7	2	classes	class	NOUN
0k225b01f5m	7	3	of	of	ADP
0k225b01f5m	7	4	selective	selective	ADJ
0k225b01f5m	7	5	and	and	CCONJ
0k225b01f5m	7	6	non	non	ADJ
0k225b01f5m	7	7	-	-	ADJ
0k225b01f5m	7	8	selective	selective	ADJ
0k225b01f5m	7	9	hdaci	hdaci	NOUN
0k225b01f5m	7	10	were	be	AUX
0k225b01f5m	7	11	synthesized	synthesize	VERB
0k225b01f5m	7	12	.	.	PUNCT
0k225b01f5m	8	1	the	the	DET
0k225b01f5m	8	2	most	most	ADV
0k225b01f5m	8	3	potent	potent	ADJ
0k225b01f5m	8	4	compound	compound	NOUN
0k225b01f5m	8	5	was	be	AUX
0k225b01f5m	8	6	lbh-589	lbh-589	VERB
0k225b01f5m	8	7	with	with	ADP
0k225b01f5m	8	8	an	an	DET
0k225b01f5m	8	9	ec50	ec50	PROPN
0k225b01f5m	8	10	of	of	ADP
0k225b01f5m	8	11	less	less	ADJ
0k225b01f5m	8	12	than	than	ADP
0k225b01f5m	8	13	5	5	NUM
0k225b01f5m	8	14	nm	nm	NOUN
0k225b01f5m	8	15	.	.	PUNCT
0k225b01f5m	9	1	the	the	DET
0k225b01f5m	9	2	third	third	ADJ
0k225b01f5m	9	3	project	project	NOUN
0k225b01f5m	9	4	was	be	AUX
0k225b01f5m	9	5	to	to	PART
0k225b01f5m	9	6	develop	develop	VERB
0k225b01f5m	9	7	tools	tool	NOUN
0k225b01f5m	9	8	to	to	PART
0k225b01f5m	9	9	gain	gain	VERB
0k225b01f5m	9	10	a	a	DET
0k225b01f5m	9	11	better	well	ADJ
0k225b01f5m	9	12	understanding	understanding	NOUN
0k225b01f5m	9	13	of	of	ADP
0k225b01f5m	9	14	cholesterol	cholesterol	NOUN
0k225b01f5m	9	15	biosynthesis	biosynthesis	NOUN
0k225b01f5m	9	16	and	and	CCONJ
0k225b01f5m	9	17	trafficking	trafficking	NOUN
0k225b01f5m	9	18	.	.	PUNCT
0k225b01f5m	10	1	the	the	DET
0k225b01f5m	10	2	rate	rate	NOUN
0k225b01f5m	10	3	limiting	limit	VERB
0k225b01f5m	10	4	step	step	NOUN
0k225b01f5m	10	5	of	of	ADP
0k225b01f5m	10	6	cholesterol	cholesterol	NOUN
0k225b01f5m	10	7	biosynthesis	biosynthesis	NOUN
0k225b01f5m	10	8	is	be	AUX
0k225b01f5m	10	9	the	the	DET
0k225b01f5m	10	10	interconversion	interconversion	NOUN
0k225b01f5m	10	11	of	of	ADP
0k225b01f5m	10	12	hmg	hmg	NOUN
0k225b01f5m	10	13	-	-	PUNCT
0k225b01f5m	10	14	coa	coa	NOUN
0k225b01f5m	10	15	to	to	PART
0k225b01f5m	10	16	mevalonate	mevalonate	VERB
0k225b01f5m	10	17	using	use	VERB
0k225b01f5m	10	18	the	the	DET
0k225b01f5m	10	19	enzyme	enzyme	PROPN
0k225b01f5m	10	20	hmg	hmg	PROPN
0k225b01f5m	10	21	-	-	PUNCT
0k225b01f5m	10	22	coa	coa	NOUN
0k225b01f5m	10	23	reductase	reductase	NOUN
0k225b01f5m	10	24	and	and	CCONJ
0k225b01f5m	10	25	presently	presently	ADV
0k225b01f5m	10	26	there	there	PRON
0k225b01f5m	10	27	remain	remain	VERB
0k225b01f5m	10	28	a	a	DET
0k225b01f5m	10	29	number	number	NOUN
0k225b01f5m	10	30	of	of	ADP
0k225b01f5m	10	31	questions	question	NOUN
0k225b01f5m	10	32	to	to	PART
0k225b01f5m	10	33	be	be	AUX
0k225b01f5m	10	34	answered	answer	VERB
0k225b01f5m	10	35	about	about	ADP
0k225b01f5m	10	36	this	this	DET
0k225b01f5m	10	37	catalytic	catalytic	ADJ
0k225b01f5m	10	38	reaction	reaction	NOUN
0k225b01f5m	10	39	.	.	PUNCT
0k225b01f5m	11	1	in	in	ADP
0k225b01f5m	11	2	order	order	NOUN
0k225b01f5m	11	3	to	to	PART
0k225b01f5m	11	4	elucidate	elucidate	VERB
0k225b01f5m	11	5	the	the	DET
0k225b01f5m	11	6	mechanism	mechanism	NOUN
0k225b01f5m	11	7	of	of	ADP
0k225b01f5m	11	8	this	this	DET
0k225b01f5m	11	9	reaction	reaction	NOUN
0k225b01f5m	11	10	by	by	ADP
0k225b01f5m	11	11	laue	laue	NOUN
0k225b01f5m	11	12	crystallography	crystallography	NOUN
0k225b01f5m	11	13	,	,	PUNCT
0k225b01f5m	11	14	model	model	NOUN
0k225b01f5m	11	15	caged	caged	PROPN
0k225b01f5m	11	16	coumarin	coumarin	NOUN
0k225b01f5m	11	17	of	of	ADP
0k225b01f5m	11	18	nicotinamide	nicotinamide	NOUN
0k225b01f5m	11	19	were	be	AUX
0k225b01f5m	11	20	synthesized	synthesize	VERB
0k225b01f5m	11	21	.	.	PUNCT
0k225b01f5m	12	1	the	the	DET
0k225b01f5m	12	2	best	good	ADJ
0k225b01f5m	12	3	caged	cage	VERB
0k225b01f5m	12	4	nicotinamide	nicotinamide	NOUN
0k225b01f5m	12	5	had	have	VERB
0k225b01f5m	12	6	a	a	DET
0k225b01f5m	12	7	quantum	quantum	ADJ
0k225b01f5m	12	8	yield	yield	NOUN
0k225b01f5m	12	9	of	of	ADP
0k225b01f5m	12	10	0.016	0.016	NUM
0k225b01f5m	12	11	.	.	PUNCT
0k225b01f5m	13	1	additionally	additionally	ADV
0k225b01f5m	13	2	,	,	PUNCT
0k225b01f5m	13	3	it	it	PRON
0k225b01f5m	13	4	was	be	AUX
0k225b01f5m	13	5	initially	initially	ADV
0k225b01f5m	13	6	demonstrated	demonstrate	VERB
0k225b01f5m	13	7	that	that	SCONJ
0k225b01f5m	13	8	caged	caged	ADJ
0k225b01f5m	13	9	coumarin	coumarin	NOUN
0k225b01f5m	13	10	-	-	PUNCT
0k225b01f5m	13	11	nicotinamide	nicotinamide	NOUN
0k225b01f5m	13	12	bearing	bear	VERB
0k225b01f5m	13	13	a	a	DET
0k225b01f5m	13	14	simple	simple	ADJ
0k225b01f5m	13	15	amide	amide	NOUN
0k225b01f5m	13	16	bond	bond	NOUN
0k225b01f5m	13	17	could	could	AUX
0k225b01f5m	13	18	not	not	PART
0k225b01f5m	13	19	go	go	VERB
0k225b01f5m	13	20	under	under	ADP
0k225b01f5m	13	21	cleavage	cleavage	NOUN
0k225b01f5m	13	22	by	by	ADP
0k225b01f5m	13	23	photolysis	photolysis	NOUN
0k225b01f5m	13	24	.	.	PUNCT
0k225b01f5m	14	1	also	also	ADV
0k225b01f5m	14	2	,	,	PUNCT
0k225b01f5m	14	3	as	as	ADP
0k225b01f5m	14	4	a	a	DET
0k225b01f5m	14	5	tool	tool	NOUN
0k225b01f5m	14	6	to	to	PART
0k225b01f5m	14	7	study	study	VERB
0k225b01f5m	14	8	cholesterol	cholesterol	NOUN
0k225b01f5m	14	9	trafficking	traffic	VERB
0k225b01f5m	14	10	different	different	ADJ
0k225b01f5m	14	11	caged	cage	VERB
0k225b01f5m	14	12	cholesterol	cholesterol	NOUN
0k225b01f5m	14	13	were	be	AUX
0k225b01f5m	14	14	made	make	VERB
0k225b01f5m	14	15	.	.	PUNCT
0k225b01f5m	15	1	the	the	DET
0k225b01f5m	15	2	bhc	bhc	NOUN
0k225b01f5m	15	3	cholesterol	cholesterol	NOUN
0k225b01f5m	15	4	could	could	AUX
0k225b01f5m	15	5	photolysize	photolysize	VERB
0k225b01f5m	15	6	at	at	ADP
0k225b01f5m	15	7	350	350	NUM
0k225b01f5m	15	8	nm	nm	NOUN
0k225b01f5m	15	9	with	with	ADP
0k225b01f5m	15	10	a	a	DET
0k225b01f5m	15	11	quantum	quantum	ADJ
0k225b01f5m	15	12	yied	yied	NOUN
0k225b01f5m	15	13	of	of	ADP
0k225b01f5m	15	14	0.032	0.032	NUM
0k225b01f5m	15	15	.	.	PUNCT