id sid tid token lemma pos 0g354f1857r 1 1 a a DET 0g354f1857r 1 2 molecular molecular ADJ 0g354f1857r 1 3 understanding understanding NOUN 0g354f1857r 1 4 of of ADP 0g354f1857r 1 5 protein protein NOUN 0g354f1857r 1 6 - - PUNCT 0g354f1857r 1 7 protein protein NOUN 0g354f1857r 1 8 interactions interaction NOUN 0g354f1857r 1 9 is be AUX 0g354f1857r 1 10 important important ADJ 0g354f1857r 1 11 to to PART 0g354f1857r 1 12 be be AUX 0g354f1857r 1 13 able able ADJ 0g354f1857r 1 14 to to PART 0g354f1857r 1 15 understand understand VERB 0g354f1857r 1 16 cell cell NOUN 0g354f1857r 1 17 cycle cycle NOUN 0g354f1857r 1 18 and and CCONJ 0g354f1857r 1 19 diseases disease NOUN 0g354f1857r 1 20 associated associate VERB 0g354f1857r 1 21 with with ADP 0g354f1857r 1 22 it it PRON 0g354f1857r 1 23 . . PUNCT 0g354f1857r 2 1 the the DET 0g354f1857r 2 2 specificity specificity NOUN 0g354f1857r 2 3 of of ADP 0g354f1857r 2 4 these these DET 0g354f1857r 2 5 proteinprotein proteinprotein ADJ 0g354f1857r 2 6 interactions interaction NOUN 0g354f1857r 2 7 is be AUX 0g354f1857r 2 8 usually usually ADV 0g354f1857r 2 9 associated associate VERB 0g354f1857r 2 10 with with ADP 0g354f1857r 2 11 the the DET 0g354f1857r 2 12 chemical chemical ADJ 0g354f1857r 2 13 properties property NOUN 0g354f1857r 2 14 of of ADP 0g354f1857r 2 15 the the DET 0g354f1857r 2 16 amino amino NOUN 0g354f1857r 2 17 acids acid NOUN 0g354f1857r 2 18 that that PRON 0g354f1857r 2 19 contact contact VERB 0g354f1857r 2 20 the the DET 0g354f1857r 2 21 substrate substrate NOUN 0g354f1857r 2 22 . . PUNCT 0g354f1857r 3 1 this this DET 0g354f1857r 3 2 thesis thesis NOUN 0g354f1857r 3 3 investigates investigate VERB 0g354f1857r 3 4 the the DET 0g354f1857r 3 5 dependence dependence NOUN 0g354f1857r 3 6 of of ADP 0g354f1857r 3 7 protein protein NOUN 0g354f1857r 3 8 binding bind VERB 0g354f1857r 3 9 affinity affinity NOUN 0g354f1857r 3 10 on on ADP 0g354f1857r 3 11 the the DET 0g354f1857r 3 12 sequence sequence NOUN 0g354f1857r 3 13 specific specific ADJ 0g354f1857r 3 14 dynamics dynamic NOUN 0g354f1857r 3 15 of of ADP 0g354f1857r 3 16 the the DET 0g354f1857r 3 17 protein protein NOUN 0g354f1857r 3 18 binding bind VERB 0g354f1857r 3 19 loop loop NOUN 0g354f1857r 3 20 . . PUNCT 0g354f1857r 4 1 the the DET 0g354f1857r 4 2 model model NOUN 0g354f1857r 4 3 system system NOUN 0g354f1857r 4 4 used use VERB 0g354f1857r 4 5 for for ADP 0g354f1857r 4 6 this this DET 0g354f1857r 4 7 study study NOUN 0g354f1857r 4 8 is be AUX 0g354f1857r 4 9 ww ww PROPN 0g354f1857r 4 10 domain domain NOUN 0g354f1857r 4 11 of of ADP 0g354f1857r 4 12 pin1 pin1 NOUN 0g354f1857r 4 13 . . PUNCT 0g354f1857r 5 1 pin1 pin1 NOUN 0g354f1857r 5 2 protein protein NOUN 0g354f1857r 5 3 is be AUX 0g354f1857r 5 4 a a DET 0g354f1857r 5 5 two two NUM 0g354f1857r 5 6 domain domain NOUN 0g354f1857r 5 7 protein protein NOUN 0g354f1857r 5 8 that that PRON 0g354f1857r 5 9 interacts interact VERB 0g354f1857r 5 10 with with ADP 0g354f1857r 5 11 other other ADJ 0g354f1857r 5 12 proteins protein NOUN 0g354f1857r 5 13 important important ADJ 0g354f1857r 5 14 for for ADP 0g354f1857r 5 15 cell cell NOUN 0g354f1857r 5 16 cycle cycle NOUN 0g354f1857r 5 17 . . PUNCT 0g354f1857r 6 1 it it PRON 0g354f1857r 6 2 catalyzes catalyze VERB 0g354f1857r 6 3 cis cis NOUN 0g354f1857r 6 4 - - PUNCT 0g354f1857r 6 5 trans trans NOUN 0g354f1857r 6 6 isomerization isomerization NOUN 0g354f1857r 6 7 of of ADP 0g354f1857r 6 8 p p NOUN 0g354f1857r 6 9 - - PUNCT 0g354f1857r 6 10 ser ser NOUN 0g354f1857r 6 11 / / SYM 0g354f1857r 6 12 pro pro ADJ 0g354f1857r 6 13 or or CCONJ 0g354f1857r 6 14 p p NOUN 0g354f1857r 6 15 - - PUNCT 0g354f1857r 6 16 thr thr NOUN 0g354f1857r 6 17 / / SYM 0g354f1857r 6 18 pro pro ADJ 0g354f1857r 6 19 motifs motif NOUN 0g354f1857r 6 20 . . PUNCT 0g354f1857r 7 1 generally generally ADV 0g354f1857r 7 2 , , PUNCT 0g354f1857r 7 3 ww ww PROPN 0g354f1857r 7 4 domains domain NOUN 0g354f1857r 7 5 are be AUX 0g354f1857r 7 6 involved involve VERB 0g354f1857r 7 7 in in ADP 0g354f1857r 7 8 the the DET 0g354f1857r 7 9 binding binding NOUN 0g354f1857r 7 10 of of ADP 0g354f1857r 7 11 polyproline polyproline PROPN 0g354f1857r 7 12 ii ii PROPN 0g354f1857r 7 13 helix helix NOUN 0g354f1857r 7 14 motifs motif NOUN 0g354f1857r 7 15 to to ADP 0g354f1857r 7 16 the the DET 0g354f1857r 7 17 surface surface NOUN 0g354f1857r 7 18 of of ADP 0g354f1857r 7 19 the the DET 0g354f1857r 7 20 protein protein NOUN 0g354f1857r 7 21 whose whose DET 0g354f1857r 7 22 binding bind VERB 0g354f1857r 7 23 preference preference NOUN 0g354f1857r 7 24 is be AUX 0g354f1857r 7 25 found find VERB 0g354f1857r 7 26 to to PART 0g354f1857r 7 27 depend depend VERB 0g354f1857r 7 28 on on ADP 0g354f1857r 7 29 recognition recognition NOUN 0g354f1857r 7 30 specificity specificity NOUN 0g354f1857r 7 31 loop loop NOUN 0g354f1857r 7 32 . . PUNCT 0g354f1857r 8 1 in in ADP 0g354f1857r 8 2 the the DET 0g354f1857r 8 3 case case NOUN 0g354f1857r 8 4 of of ADP 0g354f1857r 8 5 pin1 pin1 NOUN 0g354f1857r 8 6 - - PUNCT 0g354f1857r 8 7 ww ww PROPN 0g354f1857r 8 8 , , PUNCT 0g354f1857r 8 9 this this DET 0g354f1857r 8 10 loop loop NOUN 0g354f1857r 8 11 prefers prefer VERB 0g354f1857r 8 12 the the DET 0g354f1857r 8 13 p p NOUN 0g354f1857r 8 14 - - PUNCT 0g354f1857r 8 15 ser ser NOUN 0g354f1857r 8 16 / / SYM 0g354f1857r 8 17 pro pro ADJ 0g354f1857r 8 18 or or CCONJ 0g354f1857r 8 19 p p NOUN 0g354f1857r 8 20 - - PUNCT 0g354f1857r 8 21 thr thr NOUN 0g354f1857r 8 22 / / SYM 0g354f1857r 8 23 pro pro ADJ 0g354f1857r 8 24 motifs motif NOUN 0g354f1857r 8 25 . . PUNCT 0g354f1857r 9 1 to to PART 0g354f1857r 9 2 establish establish VERB 0g354f1857r 9 3 the the DET 0g354f1857r 9 4 relationship relationship NOUN 0g354f1857r 9 5 between between ADP 0g354f1857r 9 6 the the DET 0g354f1857r 9 7 dynamics dynamic NOUN 0g354f1857r 9 8 of of ADP 0g354f1857r 9 9 the the DET 0g354f1857r 9 10 sequence sequence NOUN 0g354f1857r 9 11 and and CCONJ 0g354f1857r 9 12 the the DET 0g354f1857r 9 13 binding bind VERB 0g354f1857r 9 14 affinity affinity NOUN 0g354f1857r 9 15 , , PUNCT 0g354f1857r 9 16 ps ps PROPN 0g354f1857r 9 17 - - PUNCT 0g354f1857r 9 18 ns ns PROPN 0g354f1857r 9 19 motion motion NOUN 0g354f1857r 9 20 study study NOUN 0g354f1857r 9 21 using use VERB 0g354f1857r 9 22 nmr nmr PROPN 0g354f1857r 9 23 spectroscopic spectroscopic ADJ 0g354f1857r 9 24 method method NOUN 0g354f1857r 9 25 has have AUX 0g354f1857r 9 26 been be AUX 0g354f1857r 9 27 done do VERB 0g354f1857r 9 28 on on ADP 0g354f1857r 9 29 the the DET 0g354f1857r 9 30 apo apo NOUN 0g354f1857r 9 31 wild wild ADJ 0g354f1857r 9 32 - - PUNCT 0g354f1857r 9 33 type type NOUN 0g354f1857r 9 34 ww ww PROPN 0g354f1857r 9 35 and and CCONJ 0g354f1857r 9 36 its its PRON 0g354f1857r 9 37 mutants mutant NOUN 0g354f1857r 9 38 . . PUNCT 0g354f1857r 10 1 the the DET 0g354f1857r 10 2 mutants mutant NOUN 0g354f1857r 10 3 were be AUX 0g354f1857r 10 4 chosen choose VERB 0g354f1857r 10 5 by by ADP 0g354f1857r 10 6 deleting delete VERB 0g354f1857r 10 7 or or CCONJ 0g354f1857r 10 8 substituting substitute VERB 0g354f1857r 10 9 one one NUM 0g354f1857r 10 10 or or CCONJ 0g354f1857r 10 11 more more ADJ 0g354f1857r 10 12 residues residue NOUN 0g354f1857r 10 13 in in ADP 0g354f1857r 10 14 the the DET 0g354f1857r 10 15 loop loop NOUN 0g354f1857r 10 16 i i PRON 0g354f1857r 10 17 region region NOUN 0g354f1857r 10 18 of of ADP 0g354f1857r 10 19 the the DET 0g354f1857r 10 20 ww ww PROPN 0g354f1857r 10 21 domain domain NOUN 0g354f1857r 10 22 . . PUNCT 0g354f1857r 11 1 the the DET 0g354f1857r 11 2 key key ADJ 0g354f1857r 11 3 residues residue NOUN 0g354f1857r 11 4 responsible responsible ADJ 0g354f1857r 11 5 for for ADP 0g354f1857r 11 6 binding bind VERB 0g354f1857r 11 7 specificity specificity NOUN 0g354f1857r 11 8 are be AUX 0g354f1857r 11 9 ser16 ser16 SPACE 0g354f1857r 11 10 - - PUNCT 0g354f1857r 11 11 arg17 arg17 PROPN 0g354f1857r 11 12 - - PUNCT 0g354f1857r 11 13 ser18 ser18 ADP 0g354f1857r 11 14 - - PUNCT 0g354f1857r 11 15 ser19gly20 ser19gly20 PROPN 0g354f1857r 11 16 - - PUNCT 0g354f1857r 11 17 arg21 arg21 PROPN 0g354f1857r 11 18 , , PUNCT 0g354f1857r 11 19 and and CCONJ 0g354f1857r 11 20 so so ADV 0g354f1857r 11 21 the the DET 0g354f1857r 11 22 mutants mutant NOUN 0g354f1857r 11 23 involved involve VERB 0g354f1857r 11 24 changes change NOUN 0g354f1857r 11 25 in in ADP 0g354f1857r 11 26 these these DET 0g354f1857r 11 27 residues residue NOUN 0g354f1857r 11 28 keeping keep VERB 0g354f1857r 11 29 arg17 arg17 NOUN 0g354f1857r 11 30 intact intact ADJ 0g354f1857r 11 31 whose whose DET 0g354f1857r 11 32 side side NOUN 0g354f1857r 11 33 chain chain NOUN 0g354f1857r 11 34 has have AUX 0g354f1857r 11 35 been be AUX 0g354f1857r 11 36 shown show VERB 0g354f1857r 11 37 to to PART 0g354f1857r 11 38 be be AUX 0g354f1857r 11 39 involved involve VERB 0g354f1857r 11 40 in in ADP 0g354f1857r 11 41 forming form VERB 0g354f1857r 11 42 direct direct ADJ 0g354f1857r 11 43 contacts contact NOUN 0g354f1857r 11 44 with with ADP 0g354f1857r 11 45 substrate substrate NOUN 0g354f1857r 11 46 . . PUNCT 0g354f1857r 12 1 the the DET 0g354f1857r 12 2 plan plan NOUN 0g354f1857r 12 3 is be AUX 0g354f1857r 12 4 to to PART 0g354f1857r 12 5 study study VERB 0g354f1857r 12 6 whether whether SCONJ 0g354f1857r 12 7 the the DET 0g354f1857r 12 8 loop loop NOUN 0g354f1857r 12 9 region region NOUN 0g354f1857r 12 10 dynamics dynamic NOUN 0g354f1857r 12 11 changes change NOUN 0g354f1857r 12 12 even even ADV 0g354f1857r 12 13 though though SCONJ 0g354f1857r 12 14 we we PRON 0g354f1857r 12 15 do do AUX 0g354f1857r 12 16 not not PART 0g354f1857r 12 17 alter alter VERB 0g354f1857r 12 18 the the DET 0g354f1857r 12 19 residue residue NOUN 0g354f1857r 12 20 or or CCONJ 0g354f1857r 12 21 the the DET 0g354f1857r 12 22 side side NOUN 0g354f1857r 12 23 chains chain NOUN 0g354f1857r 12 24 directly directly ADV 0g354f1857r 12 25 involved involve VERB 0g354f1857r 12 26 in in ADP 0g354f1857r 12 27 bonding bonding NOUN 0g354f1857r 12 28 and and CCONJ 0g354f1857r 12 29 thus thus ADV 0g354f1857r 12 30 showing show VERB 0g354f1857r 12 31 that that SCONJ 0g354f1857r 12 32 chemical chemical ADJ 0g354f1857r 12 33 nature nature NOUN 0g354f1857r 12 34 of of ADP 0g354f1857r 12 35 the the DET 0g354f1857r 12 36 sequence sequence NOUN 0g354f1857r 12 37 alone alone ADV 0g354f1857r 12 38 does do AUX 0g354f1857r 12 39 not not PART 0g354f1857r 12 40 govern govern VERB 0g354f1857r 12 41 the the DET 0g354f1857r 12 42 binding bind VERB 0g354f1857r 12 43 preference preference NOUN 0g354f1857r 12 44 of of ADP 0g354f1857r 12 45 the the DET 0g354f1857r 12 46 domain domain NOUN 0g354f1857r 12 47 . . PUNCT 0g354f1857r 13 1 the the DET 0g354f1857r 13 2 binding bind VERB 0g354f1857r 13 3 affinity affinity NOUN 0g354f1857r 13 4 for for ADP 0g354f1857r 13 5 the the DET 0g354f1857r 13 6 wild wild ADJ 0g354f1857r 13 7 - - PUNCT 0g354f1857r 13 8 type type NOUN 0g354f1857r 13 9 [ [ X 0g354f1857r 13 10 1 1 NUM 0g354f1857r 13 11 ] ] PUNCT 0g354f1857r 13 12 and and CCONJ 0g354f1857r 13 13 ww ww PROPN 0g354f1857r 13 14 mutants mutant NOUN 0g354f1857r 13 15 has have AUX 0g354f1857r 13 16 been be AUX 0g354f1857r 13 17 calculated calculate VERB 0g354f1857r 13 18 ( ( PUNCT 0g354f1857r 13 19 by by ADP 0g354f1857r 13 20 tao tao PROPN 0g354f1857r 13 21 peng peng PROPN 0g354f1857r 13 22 ) ) PUNCT 0g354f1857r 13 23 and and CCONJ 0g354f1857r 13 24 the the DET 0g354f1857r 13 25 kd kd PROPN 0g354f1857r 13 26 value value NOUN 0g354f1857r 13 27 for for ADP 0g354f1857r 13 28 wild wild ADJ 0g354f1857r 13 29 - - PUNCT 0g354f1857r 13 30 type type NOUN 0g354f1857r 13 31 ( ( PUNCT 0g354f1857r 13 32 wt wt PROPN 0g354f1857r 13 33 ) ) PUNCT 0g354f1857r 13 34 is be AUX 0g354f1857r 13 35 observed observe VERB 0g354f1857r 13 36 to to PART 0g354f1857r 13 37 be be AUX 0g354f1857r 13 38 much much ADV 0g354f1857r 13 39 less less ADJ 0g354f1857r 13 40 than than ADP 0g354f1857r 13 41 its its PRON 0g354f1857r 13 42 mutants mutant NOUN 0g354f1857r 13 43 for for ADP 0g354f1857r 13 44 the the DET 0g354f1857r 13 45 substrate substrate NOUN 0g354f1857r 13 46 cdc25 cdc25 NOUN 0g354f1857r 13 47 . . PUNCT 0g354f1857r 14 1 the the DET 0g354f1857r 14 2 expected expect VERB 0g354f1857r 14 3 result result NOUN 0g354f1857r 14 4 from from ADP 0g354f1857r 14 5 the the DET 0g354f1857r 14 6 dynamic dynamic ADJ 0g354f1857r 14 7 study study NOUN 0g354f1857r 14 8 would would AUX 0g354f1857r 14 9 be be AUX 0g354f1857r 14 10 to to PART 0g354f1857r 14 11 see see VERB 0g354f1857r 14 12 a a DET 0g354f1857r 14 13 decrease decrease NOUN 0g354f1857r 14 14 in in ADP 0g354f1857r 14 15 the the DET 0g354f1857r 14 16 motion motion NOUN 0g354f1857r 14 17 of of ADP 0g354f1857r 14 18 the the DET 0g354f1857r 14 19 loop loop NOUN 0g354f1857r 14 20 region region NOUN 0g354f1857r 14 21 for for ADP 0g354f1857r 14 22 the the DET 0g354f1857r 14 23 mutants mutant NOUN 0g354f1857r 14 24 of of ADP 0g354f1857r 14 25 ww ww PROPN 0g354f1857r 14 26 and and CCONJ 0g354f1857r 14 27 a a DET 0g354f1857r 14 28 similar similar ADJ 0g354f1857r 14 29 dynamic dynamic ADJ 0g354f1857r 14 30 pattern pattern NOUN 0g354f1857r 14 31 for for ADP 0g354f1857r 14 32 its its PRON 0g354f1857r 14 33 orthologs ortholog NOUN 0g354f1857r 14 34 on on ADP 0g354f1857r 14 35 the the DET 0g354f1857r 14 36 basis basis NOUN 0g354f1857r 14 37 of of ADP 0g354f1857r 14 38 the the DET 0g354f1857r 14 39 hypothesis hypothesis NOUN 0g354f1857r 14 40 that that SCONJ 0g354f1857r 14 41 nature nature NOUN 0g354f1857r 14 42 possibly possibly ADV 0g354f1857r 14 43 selects select VERB 0g354f1857r 14 44 for for ADP 0g354f1857r 14 45 conformational conformational ADJ 0g354f1857r 14 46 dynamics dynamic NOUN 0g354f1857r 14 47 as as ADV 0g354f1857r 14 48 well well ADV 0g354f1857r 14 49 . . PUNCT 0g354f1857r 15 1 to to PART 0g354f1857r 15 2 investigate investigate VERB 0g354f1857r 15 3 and and CCONJ 0g354f1857r 15 4 make make VERB 0g354f1857r 15 5 a a DET 0g354f1857r 15 6 quantitative quantitative ADJ 0g354f1857r 15 7 assessment assessment NOUN 0g354f1857r 15 8 of of ADP 0g354f1857r 15 9 the the DET 0g354f1857r 15 10 dynamic dynamic ADJ 0g354f1857r 15 11 - - PUNCT 0g354f1857r 15 12 binding bind VERB 0g354f1857r 15 13 relationship relationship NOUN 0g354f1857r 15 14 , , PUNCT 0g354f1857r 15 15 the the DET 0g354f1857r 15 16 dynamic dynamic ADJ 0g354f1857r 15 17 information information NOUN 0g354f1857r 15 18 for for ADP 0g354f1857r 15 19 each each PRON 0g354f1857r 15 20 of of ADP 0g354f1857r 15 21 the the DET 0g354f1857r 15 22 sites site NOUN 0g354f1857r 15 23 in in ADP 0g354f1857r 15 24 the the DET 0g354f1857r 15 25 protein protein NOUN 0g354f1857r 15 26 will will AUX 0g354f1857r 15 27 be be AUX 0g354f1857r 15 28 extracted extract VERB 0g354f1857r 15 29 from from ADP 0g354f1857r 15 30 the the DET 0g354f1857r 15 31 relaxation relaxation NOUN 0g354f1857r 15 32 rates rate NOUN 0g354f1857r 15 33 r1 r1 PROPN 0g354f1857r 15 34 ( ( PUNCT 0g354f1857r 15 35 longitudinal longitudinal ADJ 0g354f1857r 15 36 rate rate NOUN 0g354f1857r 15 37 constant constant ADJ 0g354f1857r 15 38 ) ) PUNCT 0g354f1857r 15 39 , , PUNCT 0g354f1857r 15 40 r2 r2 PROPN 0g354f1857r 15 41 ( ( PUNCT 0g354f1857r 15 42 transverse transverse ADJ 0g354f1857r 15 43 rate rate NOUN 0g354f1857r 15 44 constant constant ADJ 0g354f1857r 15 45 ) ) PUNCT 0g354f1857r 15 46 , , PUNCT 0g354f1857r 15 47 r1ì r1ì ADJ 0g354f1857r 15 48 ( ( PUNCT 0g354f1857r 15 49 rotating rotate VERB 0g354f1857r 15 50 frame frame NOUN 0g354f1857r 15 51 spin spin NOUN 0g354f1857r 15 52 lattice lattice NOUN 0g354f1857r 15 53 rate rate NOUN 0g354f1857r 15 54 constant constant ADJ 0g354f1857r 15 55 ) ) PUNCT 0g354f1857r 15 56 and and CCONJ 0g354f1857r 15 57 steady steady ADJ 0g354f1857r 15 58 state state NOUN 0g354f1857r 15 59 heteronuclear heteronuclear NOUN 0g354f1857r 15 60 noe noe PROPN 0g354f1857r 15 61 , , PUNCT 0g354f1857r 15 62 measured measure VERB 0g354f1857r 15 63 using use VERB 0g354f1857r 15 64 nmr nmr NOUN 0g354f1857r 15 65 at at ADP 0g354f1857r 15 66 700 700 NUM 0g354f1857r 15 67 mhz mhz NOUN 0g354f1857r 15 68 and and CCONJ 0g354f1857r 15 69 800 800 NUM 0g354f1857r 15 70 mhz mhz NOUN 0g354f1857r 15 71 field field NOUN 0g354f1857r 15 72 strengths.the strengths.the DET 0g354f1857r 15 73 rate rate NOUN 0g354f1857r 15 74 constants constant NOUN 0g354f1857r 15 75 will will AUX 0g354f1857r 15 76 be be AUX 0g354f1857r 15 77 analyzed analyze VERB 0g354f1857r 15 78 using use VERB 0g354f1857r 15 79 the the DET 0g354f1857r 15 80 lipari lipari PROPN 0g354f1857r 15 81 - - PUNCT 0g354f1857r 15 82 szabo szabo PROPN 0g354f1857r 15 83 model model NOUN 0g354f1857r 15 84 [ [ X 0g354f1857r 15 85 2 2 NUM 0g354f1857r 15 86 ] ] PUNCT 0g354f1857r 15 87 ; ; PUNCT 0g354f1857r 15 88 the the DET 0g354f1857r 15 89 analysis analysis NOUN 0g354f1857r 15 90 will will AUX 0g354f1857r 15 91 provide provide VERB 0g354f1857r 15 92 the the DET 0g354f1857r 15 93 site site NOUN 0g354f1857r 15 94 - - PUNCT 0g354f1857r 15 95 specific specific ADJ 0g354f1857r 15 96 dynamic dynamic ADJ 0g354f1857r 15 97 parameters parameter NOUN 0g354f1857r 15 98 that that PRON 0g354f1857r 15 99 describe describe VERB 0g354f1857r 15 100 the the DET 0g354f1857r 15 101 internal internal ADJ 0g354f1857r 15 102 dynamics dynamic NOUN 0g354f1857r 15 103 of of ADP 0g354f1857r 15 104 the the DET 0g354f1857r 15 105 pin1 pin1 NOUN 0g354f1857r 15 106 - - PUNCT 0g354f1857r 15 107 ww ww NOUN 0g354f1857r 15 108 domain domain NOUN 0g354f1857r 15 109 . . PUNCT 0g354f1857r 16 1 these these DET 0g354f1857r 16 2 motional motional ADJ 0g354f1857r 16 3 parameters parameter NOUN 0g354f1857r 16 4 will will AUX 0g354f1857r 16 5 be be AUX 0g354f1857r 16 6 determined determine VERB 0g354f1857r 16 7 by by ADP 0g354f1857r 16 8 non non ADJ 0g354f1857r 16 9 - - ADJ 0g354f1857r 16 10 linear linear ADJ 0g354f1857r 16 11 least least ADJ 0g354f1857r 16 12 squares square VERB 0g354f1857r 16 13 fitting fitting ADJ 0g354f1857r 16 14 method method NOUN 0g354f1857r 16 15 of of ADP 0g354f1857r 16 16 the the DET 0g354f1857r 16 17 relaxation relaxation NOUN 0g354f1857r 16 18 rates rate NOUN 0g354f1857r 16 19 to to ADP 0g354f1857r 16 20 model model NOUN 0g354f1857r 16 21 functions function NOUN 0g354f1857r 16 22 . . PUNCT 0g354f1857r 17 1 the the DET 0g354f1857r 17 2 fitted fit VERB 0g354f1857r 17 3 parameters parameter NOUN 0g354f1857r 17 4 will will AUX 0g354f1857r 17 5 contain contain VERB 0g354f1857r 17 6 the the DET 0g354f1857r 17 7 information information NOUN 0g354f1857r 17 8 on on ADP 0g354f1857r 17 9 the the DET 0g354f1857r 17 10 amplitude amplitude NOUN 0g354f1857r 17 11 and and CCONJ 0g354f1857r 17 12 the the DET 0g354f1857r 17 13 time time NOUN 0g354f1857r 17 14 - - PUNCT 0g354f1857r 17 15 scale scale NOUN 0g354f1857r 17 16 of of ADP 0g354f1857r 17 17 the the DET 0g354f1857r 17 18 internal internal ADJ 0g354f1857r 17 19 motion motion NOUN 0g354f1857r 17 20 of of ADP 0g354f1857r 17 21 the the DET 0g354f1857r 17 22 backbone backbone NOUN 0g354f1857r 17 23 n n PROPN 0g354f1857r 17 24 - - PUNCT 0g354f1857r 17 25 h h NOUN 0g354f1857r 17 26 bonds bond NOUN 0g354f1857r 17 27 . . PUNCT 0g354f1857r 18 1 a a DET 0g354f1857r 18 2 comparison comparison NOUN 0g354f1857r 18 3 of of ADP 0g354f1857r 18 4 the the DET 0g354f1857r 18 5 dynamic dynamic ADJ 0g354f1857r 18 6 parameters parameter NOUN 0g354f1857r 18 7 will will AUX 0g354f1857r 18 8 be be AUX 0g354f1857r 18 9 done do VERB 0g354f1857r 18 10 for for ADP 0g354f1857r 18 11 the the DET 0g354f1857r 18 12 wt wt PROPN 0g354f1857r 18 13 - - PUNCT 0g354f1857r 18 14 ww ww PROPN 0g354f1857r 18 15 and and CCONJ 0g354f1857r 18 16 its its PRON 0g354f1857r 18 17 mutants mutant NOUN 0g354f1857r 18 18 and and CCONJ 0g354f1857r 18 19 then then ADV 0g354f1857r 18 20 correlated correlate VERB 0g354f1857r 18 21 with with ADP 0g354f1857r 18 22 their their PRON 0g354f1857r 18 23 binding bind VERB 0g354f1857r 18 24 affinity affinity NOUN 0g354f1857r 18 25 . . PUNCT