id sid tid token lemma pos 0c483j35k1t 1 1 one one NUM 0c483j35k1t 1 2 of of ADP 0c483j35k1t 1 3 the the DET 0c483j35k1t 1 4 primary primary ADJ 0c483j35k1t 1 5 functions function NOUN 0c483j35k1t 1 6 of of ADP 0c483j35k1t 1 7 the the DET 0c483j35k1t 1 8 cell cell NOUN 0c483j35k1t 1 9 mediated mediate VERB 0c483j35k1t 1 10 immune immune ADJ 0c483j35k1t 1 11 response response NOUN 0c483j35k1t 1 12 is be AUX 0c483j35k1t 1 13 the the DET 0c483j35k1t 1 14 recognition recognition NOUN 0c483j35k1t 1 15 and and CCONJ 0c483j35k1t 1 16 elimination elimination NOUN 0c483j35k1t 1 17 of of ADP 0c483j35k1t 1 18 infected infected ADJ 0c483j35k1t 1 19 or or CCONJ 0c483j35k1t 1 20 damaged damaged ADJ 0c483j35k1t 1 21 cells cell NOUN 0c483j35k1t 1 22 . . PUNCT 0c483j35k1t 2 1 this this DET 0c483j35k1t 2 2 process process NOUN 0c483j35k1t 2 3 is be AUX 0c483j35k1t 2 4 facilitated facilitate VERB 0c483j35k1t 2 5 through through ADP 0c483j35k1t 2 6 the the DET 0c483j35k1t 2 7 interactions interaction NOUN 0c483j35k1t 2 8 between between ADP 0c483j35k1t 2 9 the the DET 0c483j35k1t 2 10 t t PROPN 0c483j35k1t 2 11 lymphocyte lymphocyte NOUN 0c483j35k1t 2 12 cell cell NOUN 0c483j35k1t 2 13 surface surface NOUN 0c483j35k1t 2 14 receptor receptor NOUN 0c483j35k1t 2 15 , , PUNCT 0c483j35k1t 2 16 or or CCONJ 0c483j35k1t 2 17 t t PROPN 0c483j35k1t 2 18 - - PUNCT 0c483j35k1t 2 19 cell cell NOUN 0c483j35k1t 2 20 receptor receptor NOUN 0c483j35k1t 2 21 , , PUNCT 0c483j35k1t 2 22 and and CCONJ 0c483j35k1t 2 23 a a DET 0c483j35k1t 2 24 major major ADJ 0c483j35k1t 2 25 histocompatibility histocompatibility NOUN 0c483j35k1t 2 26 complex complex NOUN 0c483j35k1t 2 27 , , PUNCT 0c483j35k1t 2 28 or or CCONJ 0c483j35k1t 2 29 mhc mhc ADV 0c483j35k1t 2 30 , , PUNCT 0c483j35k1t 2 31 presenting present VERB 0c483j35k1t 2 32 a a DET 0c483j35k1t 2 33 peptide peptide NOUN 0c483j35k1t 2 34 on on ADP 0c483j35k1t 2 35 the the DET 0c483j35k1t 2 36 surface surface NOUN 0c483j35k1t 2 37 of of ADP 0c483j35k1t 2 38 antigen antigen NOUN 0c483j35k1t 2 39 presenting present VERB 0c483j35k1t 2 40 cells cell NOUN 0c483j35k1t 2 41 . . PUNCT 0c483j35k1t 3 1 if if SCONJ 0c483j35k1t 3 2 the the DET 0c483j35k1t 3 3 affinity affinity NOUN 0c483j35k1t 3 4 between between ADP 0c483j35k1t 3 5 these these DET 0c483j35k1t 3 6 two two NUM 0c483j35k1t 3 7 molecules molecule NOUN 0c483j35k1t 3 8 is be AUX 0c483j35k1t 3 9 strong strong ADJ 0c483j35k1t 3 10 enough enough ADV 0c483j35k1t 3 11 , , PUNCT 0c483j35k1t 3 12 the the DET 0c483j35k1t 3 13 t t PROPN 0c483j35k1t 3 14 - - PUNCT 0c483j35k1t 3 15 cell cell NOUN 0c483j35k1t 3 16 will will AUX 0c483j35k1t 3 17 become become VERB 0c483j35k1t 3 18 activated activate VERB 0c483j35k1t 3 19 and and CCONJ 0c483j35k1t 3 20 mount mount VERB 0c483j35k1t 3 21 an an DET 0c483j35k1t 3 22 immune immune ADJ 0c483j35k1t 3 23 response response NOUN 0c483j35k1t 3 24 against against ADP 0c483j35k1t 3 25 the the DET 0c483j35k1t 3 26 antigen antigen NOUN 0c483j35k1t 3 27 presenting present VERB 0c483j35k1t 3 28 cell cell NOUN 0c483j35k1t 3 29 . . PUNCT 0c483j35k1t 4 1 amazingly amazingly ADV 0c483j35k1t 4 2 , , PUNCT 0c483j35k1t 4 3 while while SCONJ 0c483j35k1t 4 4 a a DET 0c483j35k1t 4 5 single single ADJ 0c483j35k1t 4 6 tcr tcr NOUN 0c483j35k1t 4 7 can can AUX 0c483j35k1t 4 8 recognize recognize VERB 0c483j35k1t 4 9 over over ADP 0c483j35k1t 4 10 a a DET 0c483j35k1t 4 11 million million NUM 0c483j35k1t 4 12 peptide peptide NOUN 0c483j35k1t 4 13 - - PUNCT 0c483j35k1t 4 14 mhc mhc NOUN 0c483j35k1t 4 15 ligands ligand NOUN 0c483j35k1t 4 16 , , PUNCT 0c483j35k1t 4 17 it it PRON 0c483j35k1t 4 18 is be AUX 0c483j35k1t 4 19 still still ADV 0c483j35k1t 4 20 able able ADJ 0c483j35k1t 4 21 to to PART 0c483j35k1t 4 22 discriminate discriminate VERB 0c483j35k1t 4 23 between between ADP 0c483j35k1t 4 24 peptides peptide NOUN 0c483j35k1t 4 25 sourced source VERB 0c483j35k1t 4 26 from from ADP 0c483j35k1t 4 27 normal normal ADJ 0c483j35k1t 4 28 and and CCONJ 0c483j35k1t 4 29 aberrant aberrant ADJ 0c483j35k1t 4 30 expression expression NOUN 0c483j35k1t 4 31 . . PUNCT 0c483j35k1t 5 1 through through ADP 0c483j35k1t 5 2 the the DET 0c483j35k1t 5 3 study study NOUN 0c483j35k1t 5 4 of of ADP 0c483j35k1t 5 5 crystal crystal PROPN 0c483j35k1t 5 6 structures structure NOUN 0c483j35k1t 5 7 , , PUNCT 0c483j35k1t 5 8 this this DET 0c483j35k1t 5 9 specificity specificity NOUN 0c483j35k1t 5 10 and and CCONJ 0c483j35k1t 5 11 cross cross NOUN 0c483j35k1t 5 12 reactivity reactivity NOUN 0c483j35k1t 5 13 has have AUX 0c483j35k1t 5 14 been be AUX 0c483j35k1t 5 15 attributed attribute VERB 0c483j35k1t 5 16 to to ADP 0c483j35k1t 5 17 a a DET 0c483j35k1t 5 18 structural structural ADJ 0c483j35k1t 5 19 and and CCONJ 0c483j35k1t 5 20 chemical chemical ADJ 0c483j35k1t 5 21 homology homology NOUN 0c483j35k1t 5 22 between between ADP 0c483j35k1t 5 23 the the DET 0c483j35k1t 5 24 tcr tcr NOUN 0c483j35k1t 5 25 and and CCONJ 0c483j35k1t 5 26 the the DET 0c483j35k1t 5 27 peptide peptide NOUN 0c483j35k1t 5 28 - - PUNCT 0c483j35k1t 5 29 mhc mhc NOUN 0c483j35k1t 5 30 . . PUNCT 0c483j35k1t 6 1 while while SCONJ 0c483j35k1t 6 2 the the DET 0c483j35k1t 6 3 structural structural ADJ 0c483j35k1t 6 4 and and CCONJ 0c483j35k1t 6 5 chemical chemical ADJ 0c483j35k1t 6 6 compatibility compatibility NOUN 0c483j35k1t 6 7 between between ADP 0c483j35k1t 6 8 the the DET 0c483j35k1t 6 9 tcr tcr NOUN 0c483j35k1t 6 10 and and CCONJ 0c483j35k1t 6 11 peptidemhc peptidemhc NOUN 0c483j35k1t 6 12 is be AUX 0c483j35k1t 6 13 essential essential ADJ 0c483j35k1t 6 14 for for ADP 0c483j35k1t 6 15 conducive conducive ADJ 0c483j35k1t 6 16 interactions interaction NOUN 0c483j35k1t 6 17 , , PUNCT 0c483j35k1t 6 18 these these DET 0c483j35k1t 6 19 two two NUM 0c483j35k1t 6 20 things thing NOUN 0c483j35k1t 6 21 alone alone ADJ 0c483j35k1t 6 22 neglect neglect VERB 0c483j35k1t 6 23 to to PART 0c483j35k1t 6 24 account account VERB 0c483j35k1t 6 25 for for ADP 0c483j35k1t 6 26 the the DET 0c483j35k1t 6 27 inherent inherent ADJ 0c483j35k1t 6 28 dynamics dynamic NOUN 0c483j35k1t 6 29 of of ADP 0c483j35k1t 6 30 these these DET 0c483j35k1t 6 31 molecules molecule NOUN 0c483j35k1t 6 32 . . PUNCT 0c483j35k1t 7 1 conformational conformational ADJ 0c483j35k1t 7 2 diversity diversity NOUN 0c483j35k1t 7 3 , , PUNCT 0c483j35k1t 7 4 and and CCONJ 0c483j35k1t 7 5 by by ADP 0c483j35k1t 7 6 association association NOUN 0c483j35k1t 7 7 protein protein NOUN 0c483j35k1t 7 8 dynamics dynamic NOUN 0c483j35k1t 7 9 , , PUNCT 0c483j35k1t 7 10 has have AUX 0c483j35k1t 7 11 been be AUX 0c483j35k1t 7 12 observed observe VERB 0c483j35k1t 7 13 for for ADP 0c483j35k1t 7 14 all all DET 0c483j35k1t 7 15 three three NUM 0c483j35k1t 7 16 components component NOUN 0c483j35k1t 7 17 of of ADP 0c483j35k1t 7 18 this this DET 0c483j35k1t 7 19 interaction interaction NOUN 0c483j35k1t 7 20 ; ; PUNCT 0c483j35k1t 7 21 the the DET 0c483j35k1t 7 22 tcr tcr NOUN 0c483j35k1t 7 23 , , PUNCT 0c483j35k1t 7 24 peptide peptide NOUN 0c483j35k1t 7 25 and and CCONJ 0c483j35k1t 7 26 mhc mhc NOUN 0c483j35k1t 7 27 . . PUNCT 0c483j35k1t 8 1 the the DET 0c483j35k1t 8 2 magnitude magnitude NOUN 0c483j35k1t 8 3 of of ADP 0c483j35k1t 8 4 protein protein NOUN 0c483j35k1t 8 5 motion motion NOUN 0c483j35k1t 8 6 , , PUNCT 0c483j35k1t 8 7 however however ADV 0c483j35k1t 8 8 , , PUNCT 0c483j35k1t 8 9 is be AUX 0c483j35k1t 8 10 not not PART 0c483j35k1t 8 11 conserved conserve VERB 0c483j35k1t 8 12 for for ADP 0c483j35k1t 8 13 any any DET 0c483j35k1t 8 14 one one NUM 0c483j35k1t 8 15 of of ADP 0c483j35k1t 8 16 these these DET 0c483j35k1t 8 17 molecules molecule NOUN 0c483j35k1t 8 18 . . PUNCT 0c483j35k1t 9 1 as as ADP 0c483j35k1t 9 2 such such ADJ 0c483j35k1t 9 3 , , PUNCT 0c483j35k1t 9 4 it it PRON 0c483j35k1t 9 5 stands stand VERB 0c483j35k1t 9 6 to to PART 0c483j35k1t 9 7 reason reason VERB 0c483j35k1t 9 8 that that SCONJ 0c483j35k1t 9 9 differential differential ADJ 0c483j35k1t 9 10 dynamics dynamic NOUN 0c483j35k1t 9 11 for for ADP 0c483j35k1t 9 12 any any PRON 0c483j35k1t 9 13 of of ADP 0c483j35k1t 9 14 these these DET 0c483j35k1t 9 15 molecules molecule NOUN 0c483j35k1t 9 16 can can AUX 0c483j35k1t 9 17 have have VERB 0c483j35k1t 9 18 a a DET 0c483j35k1t 9 19 direct direct ADJ 0c483j35k1t 9 20 impact impact NOUN 0c483j35k1t 9 21 on on ADP 0c483j35k1t 9 22 the the DET 0c483j35k1t 9 23 recognition recognition NOUN 0c483j35k1t 9 24 of of ADP 0c483j35k1t 9 25 a a DET 0c483j35k1t 9 26 peptide peptide NOUN 0c483j35k1t 9 27 - - PUNCT 0c483j35k1t 9 28 mhc mhc NOUN 0c483j35k1t 9 29 by by ADP 0c483j35k1t 9 30 a a DET 0c483j35k1t 9 31 tcr tcr NOUN 0c483j35k1t 9 32 . . PUNCT 0c483j35k1t 10 1 to to ADP 0c483j35k1t 10 2 that that DET 0c483j35k1t 10 3 end end NOUN 0c483j35k1t 10 4 , , PUNCT 0c483j35k1t 10 5 in in ADP 0c483j35k1t 10 6 this this DET 0c483j35k1t 10 7 dissertation dissertation NOUN 0c483j35k1t 10 8 i i PRON 0c483j35k1t 10 9 address address VERB 0c483j35k1t 10 10 the the DET 0c483j35k1t 10 11 differential differential ADJ 0c483j35k1t 10 12 dynamics dynamic NOUN 0c483j35k1t 10 13 of of ADP 0c483j35k1t 10 14 these these DET 0c483j35k1t 10 15 molecules molecule NOUN 0c483j35k1t 10 16 . . PUNCT 0c483j35k1t 11 1 through through ADP 0c483j35k1t 11 2 the the DET 0c483j35k1t 11 3 use use NOUN 0c483j35k1t 11 4 of of ADP 0c483j35k1t 11 5 molecular molecular ADJ 0c483j35k1t 11 6 dynamics dynamic NOUN 0c483j35k1t 11 7 simulations simulation NOUN 0c483j35k1t 11 8 , , PUNCT 0c483j35k1t 11 9 i i PRON 0c483j35k1t 11 10 decomposed decompose VERB 0c483j35k1t 11 11 differences difference NOUN 0c483j35k1t 11 12 in in ADP 0c483j35k1t 11 13 protein protein NOUN 0c483j35k1t 11 14 motion motion NOUN 0c483j35k1t 11 15 for for ADP 0c483j35k1t 11 16 all all DET 0c483j35k1t 11 17 components component NOUN 0c483j35k1t 11 18 in in ADP 0c483j35k1t 11 19 the the DET 0c483j35k1t 11 20 tcr tcr PROPN 0c483j35k1t 11 21 / / SYM 0c483j35k1t 11 22 peptide peptide NOUN 0c483j35k1t 11 23 - - PUNCT 0c483j35k1t 11 24 mhc mhc NOUN 0c483j35k1t 11 25 complex complex NOUN 0c483j35k1t 11 26 . . PUNCT 0c483j35k1t 12 1 through through ADP 0c483j35k1t 12 2 critical critical ADJ 0c483j35k1t 12 3 analysis analysis NOUN 0c483j35k1t 12 4 of of ADP 0c483j35k1t 12 5 these these DET 0c483j35k1t 12 6 simulations simulation NOUN 0c483j35k1t 12 7 , , PUNCT 0c483j35k1t 12 8 i i PRON 0c483j35k1t 12 9 was be AUX 0c483j35k1t 12 10 able able ADJ 0c483j35k1t 12 11 to to PART 0c483j35k1t 12 12 identify identify VERB 0c483j35k1t 12 13 key key ADJ 0c483j35k1t 12 14 differences difference NOUN 0c483j35k1t 12 15 in in ADP 0c483j35k1t 12 16 dynamics dynamic NOUN 0c483j35k1t 12 17 for for ADP 0c483j35k1t 12 18 each each PRON 0c483j35k1t 12 19 of of ADP 0c483j35k1t 12 20 the the DET 0c483j35k1t 12 21 three three NUM 0c483j35k1t 12 22 proteins protein NOUN 0c483j35k1t 12 23 involved involve VERB 0c483j35k1t 12 24 . . PUNCT 0c483j35k1t 13 1 i i PRON 0c483j35k1t 13 2 was be AUX 0c483j35k1t 13 3 able able ADJ 0c483j35k1t 13 4 to to PART 0c483j35k1t 13 5 correlate correlate VERB 0c483j35k1t 13 6 these these DET 0c483j35k1t 13 7 differential differential ADJ 0c483j35k1t 13 8 dynamics dynamic NOUN 0c483j35k1t 13 9 to to ADP 0c483j35k1t 13 10 differences difference NOUN 0c483j35k1t 13 11 in in ADP 0c483j35k1t 13 12 mechanisms mechanism NOUN 0c483j35k1t 13 13 of of ADP 0c483j35k1t 13 14 cross cross NOUN 0c483j35k1t 13 15 reactivity reactivity NOUN 0c483j35k1t 13 16 , , PUNCT 0c483j35k1t 13 17 specificity specificity NOUN 0c483j35k1t 13 18 and and CCONJ 0c483j35k1t 13 19 immunogenicity immunogenicity NOUN 0c483j35k1t 13 20 . . PUNCT 0c483j35k1t 14 1 while while SCONJ 0c483j35k1t 14 2 much much ADJ 0c483j35k1t 14 3 is be AUX 0c483j35k1t 14 4 left leave VERB 0c483j35k1t 14 5 to to PART 0c483j35k1t 14 6 be be AUX 0c483j35k1t 14 7 done do VERB 0c483j35k1t 14 8 , , PUNCT 0c483j35k1t 14 9 the the DET 0c483j35k1t 14 10 data datum NOUN 0c483j35k1t 14 11 presented present VERB 0c483j35k1t 14 12 herein herein ADV 0c483j35k1t 14 13 demonstrate demonstrate VERB 0c483j35k1t 14 14 the the DET 0c483j35k1t 14 15 clear clear ADJ 0c483j35k1t 14 16 role role NOUN 0c483j35k1t 14 17 that that PRON 0c483j35k1t 14 18 differential differential ADJ 0c483j35k1t 14 19 dynamics dynamic NOUN 0c483j35k1t 14 20 play play VERB 0c483j35k1t 14 21 in in ADP 0c483j35k1t 14 22 immunological immunological ADJ 0c483j35k1t 14 23 recognition recognition NOUN 0c483j35k1t 14 24 . . PUNCT