id	sid	tid	token	lemma	pos
08612n51m2b	1	1	this	this	DET
08612n51m2b	1	2	dissertation	dissertation	NOUN
08612n51m2b	1	3	comprises	comprise	VERB
08612n51m2b	1	4	two	two	NUM
08612n51m2b	1	5	major	major	ADJ
08612n51m2b	1	6	components	component	NOUN
08612n51m2b	1	7	that	that	PRON
08612n51m2b	1	8	sequentially	sequentially	ADV
08612n51m2b	1	9	describe	describe	VERB
08612n51m2b	1	10	literature	literature	NOUN
08612n51m2b	1	11	reviews	review	NOUN
08612n51m2b	1	12	pertinent	pertinent	ADJ
08612n51m2b	1	13	to	to	ADP
08612n51m2b	1	14	tetrahydropyran	tetrahydropyran	NOUN
08612n51m2b	1	15	-	-	PUNCT
08612n51m2b	1	16	containing	contain	VERB
08612n51m2b	1	17	small	small	ADJ
08612n51m2b	1	18	macrolides	macrolide	NOUN
08612n51m2b	1	19	of	of	ADP
08612n51m2b	1	20	cyanobacterial	cyanobacterial	ADJ
08612n51m2b	1	21	origins	origin	NOUN
08612n51m2b	1	22	and	and	CCONJ
08612n51m2b	1	23	research	research	NOUN
08612n51m2b	1	24	in	in	ADP
08612n51m2b	1	25	the	the	DET
08612n51m2b	1	26	field	field	NOUN
08612n51m2b	1	27	of	of	ADP
08612n51m2b	1	28	synthetic	synthetic	ADJ
08612n51m2b	1	29	organic	organic	ADJ
08612n51m2b	1	30	chemistry	chemistry	NOUN
08612n51m2b	1	31	that	that	PRON
08612n51m2b	1	32	demonstrates	demonstrate	VERB
08612n51m2b	1	33	synthetic	synthetic	ADJ
08612n51m2b	1	34	methodology	methodology	NOUN
08612n51m2b	1	35	development	development	NOUN
08612n51m2b	1	36	directed	direct	VERB
08612n51m2b	1	37	for	for	ADP
08612n51m2b	1	38	stereoselective	stereoselective	ADJ
08612n51m2b	1	39	production	production	NOUN
08612n51m2b	1	40	of	of	ADP
08612n51m2b	1	41	highly	highly	ADV
08612n51m2b	1	42	functionalized	functionalize	VERB
08612n51m2b	1	43	oxacycles	oxacycle	NOUN
08612n51m2b	1	44	and	and	CCONJ
08612n51m2b	1	45	their	their	PRON
08612n51m2b	1	46	applications	application	NOUN
08612n51m2b	1	47	in	in	ADP
08612n51m2b	1	48	complex	complex	ADJ
08612n51m2b	1	49	molecule	molecule	NOUN
08612n51m2b	1	50	synthesis	synthesis	NOUN
08612n51m2b	1	51	.	.	PUNCT
08612n51m2b	2	1	the	the	DET
08612n51m2b	2	2	research	research	NOUN
08612n51m2b	2	3	discussion	discussion	NOUN
08612n51m2b	2	4	commences	commence	VERB
08612n51m2b	2	5	with	with	ADP
08612n51m2b	2	6	a	a	DET
08612n51m2b	2	7	systematic	systematic	ADJ
08612n51m2b	2	8	study	study	NOUN
08612n51m2b	2	9	towards	towards	ADP
08612n51m2b	2	10	the	the	DET
08612n51m2b	2	11	total	total	ADJ
08612n51m2b	2	12	synthesis	synthesis	NOUN
08612n51m2b	2	13	of	of	ADP
08612n51m2b	2	14	(	(	PUNCT
08612n51m2b	2	15	+	+	NOUN
08612n51m2b	2	16	)	)	PUNCT
08612n51m2b	2	17	-acutiphycin	-acutiphycin	PROPN
08612n51m2b	2	18	,	,	PUNCT
08612n51m2b	2	19	a	a	DET
08612n51m2b	2	20	highly	highly	ADV
08612n51m2b	2	21	cytotoxic	cytotoxic	ADJ
08612n51m2b	2	22	macrolide	macrolide	NOUN
08612n51m2b	2	23	with	with	ADP
08612n51m2b	2	24	an	an	DET
08612n51m2b	2	25	unknown	unknown	ADJ
08612n51m2b	2	26	mode	mode	NOUN
08612n51m2b	2	27	of	of	ADP
08612n51m2b	2	28	action	action	NOUN
08612n51m2b	2	29	.	.	PUNCT
08612n51m2b	3	1	our	our	PRON
08612n51m2b	3	2	convergent	convergent	ADJ
08612n51m2b	3	3	route	route	NOUN
08612n51m2b	3	4	was	be	AUX
08612n51m2b	3	5	highlighted	highlight	VERB
08612n51m2b	3	6	by	by	ADP
08612n51m2b	3	7	an	an	DET
08612n51m2b	3	8	extensive	extensive	ADJ
08612n51m2b	3	9	utilization	utilization	NOUN
08612n51m2b	3	10	of	of	ADP
08612n51m2b	3	11	the	the	DET
08612n51m2b	3	12	vinylogous	vinylogous	ADJ
08612n51m2b	3	13	mukaiyama	mukaiyama	PROPN
08612n51m2b	3	14	aldol	aldol	PROPN
08612n51m2b	3	15	reactions	reaction	NOUN
08612n51m2b	3	16	for	for	ADP
08612n51m2b	3	17	the	the	DET
08612n51m2b	3	18	construction	construction	NOUN
08612n51m2b	3	19	of	of	ADP
08612n51m2b	3	20	both	both	DET
08612n51m2b	3	21	southern	southern	ADJ
08612n51m2b	3	22	and	and	CCONJ
08612n51m2b	3	23	northern	northern	ADJ
08612n51m2b	3	24	hemispheres	hemisphere	NOUN
08612n51m2b	3	25	of	of	ADP
08612n51m2b	3	26	the	the	DET
08612n51m2b	3	27	macrolide	macrolide	NOUN
08612n51m2b	3	28	.	.	PUNCT
08612n51m2b	4	1	the	the	DET
08612n51m2b	4	2	acutiphycin	acutiphycin	PROPN
08612n51m2b	4	3	study	study	NOUN
08612n51m2b	4	4	concluded	conclude	VERB
08612n51m2b	4	5	with	with	ADP
08612n51m2b	4	6	a	a	DET
08612n51m2b	4	7	thorough	thorough	ADJ
08612n51m2b	4	8	investigation	investigation	NOUN
08612n51m2b	4	9	of	of	ADP
08612n51m2b	4	10	aldol	aldol	PROPN
08612n51m2b	4	11	-	-	PUNCT
08612n51m2b	4	12	mediated	mediate	VERB
08612n51m2b	4	13	advanced	advanced	ADJ
08612n51m2b	4	14	fragments	fragment	NOUN
08612n51m2b	4	15	coupling	coupling	NOUN
08612n51m2b	4	16	strategy	strategy	NOUN
08612n51m2b	4	17	.	.	PUNCT
08612n51m2b	5	1	our	our	PRON
08612n51m2b	5	2	research	research	NOUN
08612n51m2b	5	3	continues	continue	VERB
08612n51m2b	5	4	with	with	ADP
08612n51m2b	5	5	the	the	DET
08612n51m2b	5	6	development	development	NOUN
08612n51m2b	5	7	of	of	ADP
08612n51m2b	5	8	electrophile	electrophile	NOUN
08612n51m2b	5	9	-	-	PUNCT
08612n51m2b	5	10	induced	induce	VERB
08612n51m2b	5	11	ether	ether	NOUN
08612n51m2b	5	12	transfer	transfer	NOUN
08612n51m2b	5	13	reaction	reaction	NOUN
08612n51m2b	5	14	.	.	PUNCT
08612n51m2b	6	1	this	this	DET
08612n51m2b	6	2	novel	novel	ADJ
08612n51m2b	6	3	synthetic	synthetic	ADJ
08612n51m2b	6	4	method	method	NOUN
08612n51m2b	6	5	readily	readily	ADV
08612n51m2b	6	6	generated	generate	VERB
08612n51m2b	6	7	1,3	1,3	PROPN
08612n51m2b	6	8	-	-	PUNCT
08612n51m2b	6	9	syn	syn	PROPN
08612n51m2b	6	10	diol	diol	PROPN
08612n51m2b	6	11	monoether	monoether	PROPN
08612n51m2b	6	12	,	,	PUNCT
08612n51m2b	6	13	a	a	DET
08612n51m2b	6	14	common	common	ADJ
08612n51m2b	6	15	functionality	functionality	NOUN
08612n51m2b	6	16	in	in	ADP
08612n51m2b	6	17	polyketide	polyketide	NOUN
08612n51m2b	6	18	that	that	PRON
08612n51m2b	6	19	presents	present	VERB
08612n51m2b	6	20	a	a	DET
08612n51m2b	6	21	significant	significant	ADJ
08612n51m2b	6	22	synthetic	synthetic	ADJ
08612n51m2b	6	23	challenge	challenge	NOUN
08612n51m2b	6	24	.	.	PUNCT
08612n51m2b	7	1	this	this	DET
08612n51m2b	7	2	transformation	transformation	NOUN
08612n51m2b	7	3	was	be	AUX
08612n51m2b	7	4	accomplished	accomplish	VERB
08612n51m2b	7	5	by	by	ADP
08612n51m2b	7	6	simply	simply	ADV
08612n51m2b	7	7	exposing	expose	VERB
08612n51m2b	7	8	homoallylic	homoallylic	ADJ
08612n51m2b	7	9	alkoxymethyl	alkoxymethyl	NOUN
08612n51m2b	7	10	ether	ether	PROPN
08612n51m2b	7	11	to	to	ADP
08612n51m2b	7	12	iodine	iodine	NOUN
08612n51m2b	7	13	monochloride	monochloride	PROPN
08612n51m2b	7	14	.	.	PUNCT
08612n51m2b	8	1	the	the	DET
08612n51m2b	8	2	reaction	reaction	NOUN
08612n51m2b	8	3	mechanism	mechanism	NOUN
08612n51m2b	8	4	was	be	AUX
08612n51m2b	8	5	proposed	propose	VERB
08612n51m2b	8	6	via	via	ADP
08612n51m2b	8	7	an	an	DET
08612n51m2b	8	8	intermediacy	intermediacy	NOUN
08612n51m2b	8	9	of	of	ADP
08612n51m2b	8	10	chloromethyl	chloromethyl	PROPN
08612n51m2b	8	11	ether	ether	PROPN
08612n51m2b	8	12	as	as	SCONJ
08612n51m2b	8	13	observed	observe	VERB
08612n51m2b	8	14	by	by	ADP
08612n51m2b	8	15	in	in	ADP
08612n51m2b	8	16	situ	situ	ADJ
08612n51m2b	8	17	nmr	nmr	NOUN
08612n51m2b	8	18	experiments	experiment	NOUN
08612n51m2b	8	19	.	.	PUNCT
08612n51m2b	9	1	the	the	DET
08612n51m2b	9	2	ability	ability	NOUN
08612n51m2b	9	3	to	to	PART
08612n51m2b	9	4	quench	quench	VERB
08612n51m2b	9	5	the	the	DET
08612n51m2b	9	6	chloromethyl	chloromethyl	NOUN
08612n51m2b	9	7	ether	ether	NOUN
08612n51m2b	9	8	intermediate	intermediate	ADJ
08612n51m2b	9	9	with	with	ADP
08612n51m2b	9	10	various	various	ADJ
08612n51m2b	9	11	nucleophiles	nucleophile	NOUN
08612n51m2b	9	12	,	,	PUNCT
08612n51m2b	9	13	such	such	ADJ
08612n51m2b	9	14	as	as	ADP
08612n51m2b	9	15	cyanide	cyanide	NOUN
08612n51m2b	9	16	or	or	CCONJ
08612n51m2b	9	17	thiophenol	thiophenol	NOUN
08612n51m2b	9	18	,	,	PUNCT
08612n51m2b	9	19	showcased	showcase	VERB
08612n51m2b	9	20	the	the	DET
08612n51m2b	9	21	versatility	versatility	NOUN
08612n51m2b	9	22	of	of	ADP
08612n51m2b	9	23	the	the	DET
08612n51m2b	9	24	ether	ether	NOUN
08612n51m2b	9	25	transfer	transfer	NOUN
08612n51m2b	9	26	reaction	reaction	NOUN
08612n51m2b	9	27	.	.	PUNCT
08612n51m2b	10	1	this	this	DET
08612n51m2b	10	2	strategy	strategy	NOUN
08612n51m2b	10	3	readily	readily	ADV
08612n51m2b	10	4	yielded	yield	VERB
08612n51m2b	10	5	precursors	precursor	NOUN
08612n51m2b	10	6	for	for	ADP
08612n51m2b	10	7	the	the	DET
08612n51m2b	10	8	production	production	NOUN
08612n51m2b	10	9	of	of	ADP
08612n51m2b	10	10	six	six	NUM
08612n51m2b	10	11	-	-	PUNCT
08612n51m2b	10	12	membered	membered	ADJ
08612n51m2b	10	13	oxygen	oxygen	NOUN
08612n51m2b	10	14	heterocycles	heterocycle	NOUN
08612n51m2b	10	15	via	via	ADP
08612n51m2b	10	16	a	a	DET
08612n51m2b	10	17	general	general	ADJ
08612n51m2b	10	18	three	three	NUM
08612n51m2b	10	19	-	-	PUNCT
08612n51m2b	10	20	step	step	NOUN
08612n51m2b	10	21	sequence	sequence	NOUN
08612n51m2b	10	22	:	:	PUNCT
08612n51m2b	10	23	ether	ether	NOUN
08612n51m2b	10	24	transfer	transfer	NOUN
08612n51m2b	10	25	,	,	PUNCT
08612n51m2b	10	26	cyclization	cyclization	NOUN
08612n51m2b	10	27	,	,	PUNCT
08612n51m2b	10	28	and	and	CCONJ
08612n51m2b	10	29	functionalization	functionalization	NOUN
08612n51m2b	10	30	reactions	reaction	NOUN
08612n51m2b	10	31	.	.	PUNCT
08612n51m2b	11	1	depending	depend	VERB
08612n51m2b	11	2	upon	upon	SCONJ
08612n51m2b	11	3	the	the	DET
08612n51m2b	11	4	functionalization	functionalization	NOUN
08612n51m2b	11	5	step	step	NOUN
08612n51m2b	11	6	,	,	PUNCT
08612n51m2b	11	7	a	a	DET
08612n51m2b	11	8	robust	robust	ADJ
08612n51m2b	11	9	production	production	NOUN
08612n51m2b	11	10	of	of	ADP
08612n51m2b	11	11	stereocomplementary	stereocomplementary	ADJ
08612n51m2b	11	12	4	4	NUM
08612n51m2b	11	13	-	-	PUNCT
08612n51m2b	11	14	alkoxy-2,6	alkoxy-2,6	NOUN
08612n51m2b	11	15	-	-	PUNCT
08612n51m2b	11	16	cisand	cisand	NOUN
08612n51m2b	11	17	trans	trans	ADJ
08612n51m2b	11	18	-	-	ADJ
08612n51m2b	11	19	disubstituted	disubstitute	VERB
08612n51m2b	11	20	tetrahydropyrans	tetrahydropyran	NOUN
08612n51m2b	11	21	and	and	CCONJ
08612n51m2b	11	22	trans-2,6	trans-2,6	PROPN
08612n51m2b	11	23	-	-	PUNCT
08612n51m2b	11	24	disubstituted-3,4	disubstituted-3,4	ADJ
08612n51m2b	11	25	-	-	PUNCT
08612n51m2b	11	26	dihydropyrans	dihydropyran	NOUN
08612n51m2b	11	27	was	be	AUX
08612n51m2b	11	28	successfully	successfully	ADV
08612n51m2b	11	29	achieved	achieve	VERB
08612n51m2b	11	30	in	in	ADP
08612n51m2b	11	31	a	a	DET
08612n51m2b	11	32	stereoselective	stereoselective	ADJ
08612n51m2b	11	33	fashion	fashion	NOUN
08612n51m2b	11	34	.	.	PUNCT
08612n51m2b	12	1	these	these	DET
08612n51m2b	12	2	methods	method	NOUN
08612n51m2b	12	3	were	be	AUX
08612n51m2b	12	4	then	then	ADV
08612n51m2b	12	5	successfully	successfully	ADV
08612n51m2b	12	6	applied	apply	VERB
08612n51m2b	12	7	to	to	ADP
08612n51m2b	12	8	an	an	DET
08612n51m2b	12	9	efficient	efficient	ADJ
08612n51m2b	12	10	construction	construction	NOUN
08612n51m2b	12	11	of	of	ADP
08612n51m2b	12	12	the	the	DET
08612n51m2b	12	13	oxacycle	oxacycle	ADJ
08612n51m2b	12	14	core	core	NOUN
08612n51m2b	12	15	of	of	ADP
08612n51m2b	12	16	phorboxazole	phorboxazole	PROPN
08612n51m2b	12	17	a	a	DET
08612n51m2b	12	18	and	and	CCONJ
08612n51m2b	12	19	swinholide	swinholide	PROPN
08612n51m2b	12	20	a.	a.	PROPN
08612n51m2b	12	21	our	our	PRON
08612n51m2b	12	22	final	final	ADJ
08612n51m2b	12	23	research	research	NOUN
08612n51m2b	12	24	project	project	NOUN
08612n51m2b	12	25	describes	describe	VERB
08612n51m2b	12	26	a	a	DET
08612n51m2b	12	27	concise	concise	ADJ
08612n51m2b	12	28	enantioselective	enantioselective	ADJ
08612n51m2b	12	29	total	total	ADJ
08612n51m2b	12	30	synthesis	synthesis	NOUN
08612n51m2b	12	31	of	of	ADP
08612n51m2b	12	32	neopeltolide	neopeltolide	ADJ
08612n51m2b	12	33	macrolactone	macrolactone	NOUN
08612n51m2b	12	34	.	.	PUNCT
08612n51m2b	13	1	the	the	DET
08612n51m2b	13	2	successful	successful	ADJ
08612n51m2b	13	3	synthetic	synthetic	ADJ
08612n51m2b	13	4	approach	approach	NOUN
08612n51m2b	13	5	was	be	AUX
08612n51m2b	13	6	highlighted	highlight	VERB
08612n51m2b	13	7	by	by	ADP
08612n51m2b	13	8	sequential	sequential	ADJ
08612n51m2b	13	9	utilization	utilization	NOUN
08612n51m2b	13	10	of	of	ADP
08612n51m2b	13	11	the	the	DET
08612n51m2b	13	12	ether	ether	NOUN
08612n51m2b	13	13	transfer	transfer	NOUN
08612n51m2b	13	14	methodology	methodology	NOUN
08612n51m2b	13	15	,	,	PUNCT
08612n51m2b	13	16	functionalization	functionalization	NOUN
08612n51m2b	13	17	,	,	PUNCT
08612n51m2b	13	18	and	and	CCONJ
08612n51m2b	13	19	radical	radical	ADJ
08612n51m2b	13	20	cyclization	cyclization	NOUN
08612n51m2b	13	21	to	to	PART
08612n51m2b	13	22	directly	directly	ADV
08612n51m2b	13	23	install	install	VERB
08612n51m2b	13	24	the	the	DET
08612n51m2b	13	25	requisite	requisite	ADJ
08612n51m2b	13	26	stereochemistry	stereochemistry	NOUN
08612n51m2b	13	27	embedded	embed	VERB
08612n51m2b	13	28	within	within	ADP
08612n51m2b	13	29	neopeltolide	neopeltolide	NOUN
08612n51m2b	13	30	's	's	PART
08612n51m2b	13	31	tetrahydropyran	tetrahydropyran	NOUN
08612n51m2b	13	32	ring	ring	NOUN
08612n51m2b	13	33	.	.	PUNCT
08612n51m2b	14	1	our	our	PRON
08612n51m2b	14	2	synthesis	synthesis	NOUN
08612n51m2b	14	3	only	only	ADV
08612n51m2b	14	4	required	require	VERB
08612n51m2b	14	5	14	14	NUM
08612n51m2b	14	6	steps	step	NOUN
08612n51m2b	14	7	in	in	ADP
08612n51m2b	14	8	the	the	DET
08612n51m2b	14	9	longest	long	ADJ
08612n51m2b	14	10	linear	linear	ADJ
08612n51m2b	14	11	sequence	sequence	NOUN
08612n51m2b	14	12	,	,	PUNCT
08612n51m2b	14	13	15	15	NUM
08612n51m2b	14	14	steps	step	NOUN
08612n51m2b	14	15	overall	overall	ADV
08612n51m2b	14	16	.	.	PUNCT
08612n51m2b	15	1	more	more	ADV
08612n51m2b	15	2	importantly	importantly	ADV
08612n51m2b	15	3	,	,	PUNCT
08612n51m2b	15	4	it	it	PRON
08612n51m2b	15	5	was	be	AUX
08612n51m2b	15	6	free	free	ADJ
08612n51m2b	15	7	of	of	ADP
08612n51m2b	15	8	discreet	discreet	ADJ
08612n51m2b	15	9	installation	installation	NOUN
08612n51m2b	15	10	steps	step	NOUN
08612n51m2b	15	11	for	for	ADP
08612n51m2b	15	12	protecting	protect	VERB
08612n51m2b	15	13	groups	group	NOUN
08612n51m2b	15	14	,	,	PUNCT
08612n51m2b	15	15	thus	thus	ADV
08612n51m2b	15	16	representing	represent	VERB
08612n51m2b	15	17	a	a	DET
08612n51m2b	15	18	rare	rare	ADJ
08612n51m2b	15	19	example	example	NOUN
08612n51m2b	15	20	in	in	ADP
08612n51m2b	15	21	complex	complex	ADJ
08612n51m2b	15	22	polyketide	polyketide	NOUN
08612n51m2b	15	23	synthesis	synthesis	NOUN
08612n51m2b	15	24	.	.	PUNCT