id sid tid token lemma pos 02870v85232 1 1 clip-170 clip-170 PRON 02870v85232 1 2 is be AUX 02870v85232 1 3 a a DET 02870v85232 1 4 microtubule microtubule NOUN 02870v85232 1 5 ( ( PUNCT 02870v85232 1 6 mt mt PROPN 02870v85232 1 7 ) ) PUNCT 02870v85232 1 8 binding bind VERB 02870v85232 1 9 protein protein NOUN 02870v85232 1 10 that that PRON 02870v85232 1 11 binds bind VERB 02870v85232 1 12 preferentially preferentially ADV 02870v85232 1 13 to to ADP 02870v85232 1 14 the the DET 02870v85232 1 15 mt mt PROPN 02870v85232 1 16 plus plus CCONJ 02870v85232 1 17 - - PUNCT 02870v85232 1 18 end end NOUN 02870v85232 1 19 via via ADP 02870v85232 1 20 its its PRON 02870v85232 1 21 cap cap NOUN 02870v85232 1 22 - - PUNCT 02870v85232 1 23 gly gly NOUN 02870v85232 1 24 domain domain NOUN 02870v85232 1 25 . . PUNCT 02870v85232 2 1 clip-170 clip-170 PRON 02870v85232 2 2 is be AUX 02870v85232 2 3 a a DET 02870v85232 2 4 highly highly ADV 02870v85232 2 5 conserved conserved ADJ 02870v85232 2 6 protein protein NOUN 02870v85232 2 7 that that PRON 02870v85232 2 8 plays play VERB 02870v85232 2 9 multiple multiple ADJ 02870v85232 2 10 roles role NOUN 02870v85232 2 11 in in ADP 02870v85232 2 12 the the DET 02870v85232 2 13 cell cell NOUN 02870v85232 2 14 . . PUNCT 02870v85232 3 1 initially initially ADV 02870v85232 3 2 identified identify VERB 02870v85232 3 3 as as ADP 02870v85232 3 4 a a DET 02870v85232 3 5 linker linker NOUN 02870v85232 3 6 between between ADP 02870v85232 3 7 membranes membrane NOUN 02870v85232 3 8 and and CCONJ 02870v85232 3 9 the the DET 02870v85232 3 10 microtubule microtubule NOUN 02870v85232 3 11 cytoskeleton cytoskeleton NOUN 02870v85232 3 12 ( ( PUNCT 02870v85232 3 13 pierre pierre PROPN 02870v85232 3 14 et et PROPN 02870v85232 3 15 al al PROPN 02870v85232 3 16 . . PROPN 02870v85232 3 17 , , PUNCT 02870v85232 3 18 1992 1992 NUM 02870v85232 3 19 ) ) PUNCT 02870v85232 3 20 , , PUNCT 02870v85232 3 21 more more ADV 02870v85232 3 22 recently recently ADV 02870v85232 3 23 clip-170 clip-170 PRON 02870v85232 3 24 has have AUX 02870v85232 3 25 been be AUX 02870v85232 3 26 shown show VERB 02870v85232 3 27 to to PART 02870v85232 3 28 dynamically dynamically ADV 02870v85232 3 29 track track VERB 02870v85232 3 30 the the DET 02870v85232 3 31 growing grow VERB 02870v85232 3 32 end end NOUN 02870v85232 3 33 ( ( PUNCT 02870v85232 3 34 plus plus CCONJ 02870v85232 3 35 - - PUNCT 02870v85232 3 36 end end NOUN 02870v85232 3 37 ) ) PUNCT 02870v85232 3 38 of of ADP 02870v85232 3 39 mts mts NOUN 02870v85232 3 40 in in ADP 02870v85232 3 41 vivo vivo NOUN 02870v85232 3 42 ( ( PUNCT 02870v85232 3 43 perez perez NOUN 02870v85232 3 44 et et PROPN 02870v85232 3 45 al al PROPN 02870v85232 3 46 . . PROPN 02870v85232 3 47 , , PUNCT 02870v85232 3 48 1999 1999 NUM 02870v85232 3 49 ) ) PUNCT 02870v85232 3 50 and and CCONJ 02870v85232 3 51 enhance enhance VERB 02870v85232 3 52 mt mt PROPN 02870v85232 3 53 polymerization polymerization NOUN 02870v85232 3 54 both both CCONJ 02870v85232 3 55 in in ADP 02870v85232 3 56 vitro vitro X 02870v85232 3 57 and and CCONJ 02870v85232 3 58 in in ADP 02870v85232 3 59 vivo vivo PROPN 02870v85232 3 60 ( ( PUNCT 02870v85232 3 61 diamantopoulos diamantopoulo VERB 02870v85232 3 62 et et PROPN 02870v85232 3 63 al al PROPN 02870v85232 3 64 . . PROPN 02870v85232 3 65 , , PUNCT 02870v85232 3 66 1999 1999 NUM 02870v85232 3 67 ) ) PUNCT 02870v85232 3 68 . . PUNCT 02870v85232 4 1 the the DET 02870v85232 4 2 clip-170 clip-170 SPACE 02870v85232 4 3 - - PUNCT 02870v85232 4 4 mt mt PROPN 02870v85232 4 5 interaction interaction NOUN 02870v85232 4 6 is be AUX 02870v85232 4 7 highly highly ADV 02870v85232 4 8 dynamic dynamic ADJ 02870v85232 4 9 in in ADP 02870v85232 4 10 vivo vivo NOUN 02870v85232 4 11 and and CCONJ 02870v85232 4 12 precipitates precipitate VERB 02870v85232 4 13 the the DET 02870v85232 4 14 question question NOUN 02870v85232 4 15 of of ADP 02870v85232 4 16 how how SCONJ 02870v85232 4 17 clip-170 clip-170 NOUN 02870v85232 4 18 tracks track VERB 02870v85232 4 19 growing grow VERB 02870v85232 4 20 mt mt PROPN 02870v85232 4 21 plus plus CCONJ 02870v85232 4 22 - - PUNCT 02870v85232 4 23 ends end NOUN 02870v85232 4 24 and and CCONJ 02870v85232 4 25 then then ADV 02870v85232 4 26 suddenly suddenly ADV 02870v85232 4 27 disappears disappear VERB 02870v85232 4 28 when when SCONJ 02870v85232 4 29 the the DET 02870v85232 4 30 mt mt PROPN 02870v85232 4 31 stops stop VERB 02870v85232 4 32 growing grow VERB 02870v85232 4 33 . . PUNCT 02870v85232 5 1 one one NUM 02870v85232 5 2 prediction prediction NOUN 02870v85232 5 3 , , PUNCT 02870v85232 5 4 that that SCONJ 02870v85232 5 5 the the DET 02870v85232 5 6 interaction interaction NOUN 02870v85232 5 7 is be AUX 02870v85232 5 8 tightly tightly ADV 02870v85232 5 9 regulated regulate VERB 02870v85232 5 10 , , PUNCT 02870v85232 5 11 is be AUX 02870v85232 5 12 based base VERB 02870v85232 5 13 on on ADP 02870v85232 5 14 several several ADJ 02870v85232 5 15 observations observation NOUN 02870v85232 5 16 . . PUNCT 02870v85232 6 1 previous previous ADJ 02870v85232 6 2 work work NOUN 02870v85232 6 3 has have AUX 02870v85232 6 4 shown show VERB 02870v85232 6 5 that that SCONJ 02870v85232 6 6 the the DET 02870v85232 6 7 clip-170 clip-170 SPACE 02870v85232 6 8 - - PUNCT 02870v85232 6 9 mt mt PROPN 02870v85232 6 10 interaction interaction NOUN 02870v85232 6 11 can can AUX 02870v85232 6 12 be be AUX 02870v85232 6 13 manipulated manipulate VERB 02870v85232 6 14 in in ADP 02870v85232 6 15 lysates lysate NOUN 02870v85232 6 16 using use VERB 02870v85232 6 17 the the DET 02870v85232 6 18 phosphatase phosphatase ADJ 02870v85232 6 19 inhibitor inhibitor NOUN 02870v85232 6 20 okadaic okadaic ADJ 02870v85232 6 21 acid acid PROPN 02870v85232 6 22 and and CCONJ 02870v85232 6 23 potato potato NOUN 02870v85232 6 24 acid acid NOUN 02870v85232 6 25 phosphatase phosphatase NOUN 02870v85232 6 26 ( ( PUNCT 02870v85232 6 27 rickard rickard NOUN 02870v85232 6 28 and and CCONJ 02870v85232 6 29 kreis kreis PROPN 02870v85232 6 30 , , PUNCT 02870v85232 6 31 1991 1991 NUM 02870v85232 6 32 ) ) PUNCT 02870v85232 6 33 . . PUNCT 02870v85232 7 1 the the DET 02870v85232 7 2 dynamic dynamic ADJ 02870v85232 7 3 interaction interaction NOUN 02870v85232 7 4 between between ADP 02870v85232 7 5 p150glued p150glued NOUN 02870v85232 7 6 , , PUNCT 02870v85232 7 7 the the DET 02870v85232 7 8 mt mt PROPN 02870v85232 7 9 binding bind VERB 02870v85232 7 10 component component NOUN 02870v85232 7 11 of of ADP 02870v85232 7 12 dynactin dynactin NOUN 02870v85232 7 13 , , PUNCT 02870v85232 7 14 and and CCONJ 02870v85232 7 15 mts mts NOUN 02870v85232 7 16 is be AUX 02870v85232 7 17 modulated modulate VERB 02870v85232 7 18 by by ADP 02870v85232 7 19 phosphorylation phosphorylation NOUN 02870v85232 7 20 ( ( PUNCT 02870v85232 7 21 vaughan vaughan PROPN 02870v85232 7 22 et et PROPN 02870v85232 7 23 al al PROPN 02870v85232 7 24 . . PROPN 02870v85232 7 25 , , PUNCT 02870v85232 7 26 2002 2002 NUM 02870v85232 7 27 ) ) PUNCT 02870v85232 7 28 . . PUNCT 02870v85232 8 1 finally finally ADV 02870v85232 8 2 , , PUNCT 02870v85232 8 3 the the DET 02870v85232 8 4 kinetics kinetic NOUN 02870v85232 8 5 of of ADP 02870v85232 8 6 clip-170 clip-170 DET 02870v85232 8 7 binding bind VERB 02870v85232 8 8 and and CCONJ 02870v85232 8 9 release release NOUN 02870v85232 8 10 appear appear VERB 02870v85232 8 11 to to PART 02870v85232 8 12 be be AUX 02870v85232 8 13 very very ADV 02870v85232 8 14 different different ADJ 02870v85232 8 15 in in ADP 02870v85232 8 16 vivo vivo NOUN 02870v85232 8 17 and and CCONJ 02870v85232 8 18 in in ADP 02870v85232 8 19 vitro vitro X 02870v85232 8 20 ( ( PUNCT 02870v85232 8 21 folker folker PROPN 02870v85232 8 22 et et PROPN 02870v85232 8 23 al al PROPN 02870v85232 8 24 . . PROPN 02870v85232 8 25 , , PUNCT 02870v85232 8 26 2005 2005 NUM 02870v85232 8 27 ) ) PUNCT 02870v85232 8 28 . . PUNCT 02870v85232 9 1 these these DET 02870v85232 9 2 ideas idea NOUN 02870v85232 9 3 lead lead VERB 02870v85232 9 4 to to ADP 02870v85232 9 5 the the DET 02870v85232 9 6 possibility possibility NOUN 02870v85232 9 7 that that SCONJ 02870v85232 9 8 phosphorylation phosphorylation NOUN 02870v85232 9 9 could could AUX 02870v85232 9 10 be be AUX 02870v85232 9 11 important important ADJ 02870v85232 9 12 in in ADP 02870v85232 9 13 clip-170 clip-170 SPACE 02870v85232 9 14 - - PUNCT 02870v85232 9 15 mt mt PROPN 02870v85232 9 16 associations association NOUN 02870v85232 9 17 . . PUNCT 02870v85232 10 1 to to PART 02870v85232 10 2 test test VERB 02870v85232 10 3 this this DET 02870v85232 10 4 hypothesis hypothesis NOUN 02870v85232 10 5 and and CCONJ 02870v85232 10 6 help help VERB 02870v85232 10 7 define define VERB 02870v85232 10 8 the the DET 02870v85232 10 9 mechanism mechanism NOUN 02870v85232 10 10 of of ADP 02870v85232 10 11 clip-170 clip-170 NOUN 02870v85232 10 12 regulation regulation NOUN 02870v85232 10 13 , , PUNCT 02870v85232 10 14 i i PRON 02870v85232 10 15 have have AUX 02870v85232 10 16 investigated investigate VERB 02870v85232 10 17 the the DET 02870v85232 10 18 role role NOUN 02870v85232 10 19 of of ADP 02870v85232 10 20 phosphorylation phosphorylation NOUN 02870v85232 10 21 in in ADP 02870v85232 10 22 clip-170 clip-170 SPACE 02870v85232 10 23 - - PUNCT 02870v85232 10 24 mt mt PROPN 02870v85232 10 25 interactions interaction NOUN 02870v85232 10 26 . . PUNCT 02870v85232 11 1 more more ADV 02870v85232 11 2 specifically specifically ADV 02870v85232 11 3 , , PUNCT 02870v85232 11 4 6 6 NUM 02870v85232 11 5 amino amino NOUN 02870v85232 11 6 acids acid NOUN 02870v85232 11 7 were be AUX 02870v85232 11 8 identified identify VERB 02870v85232 11 9 as as SCONJ 02870v85232 11 10 phosphorylated phosphorylate VERB 02870v85232 11 11 in in ADP 02870v85232 11 12 the the DET 02870v85232 11 13 clip-170 clip-170 X 02870v85232 11 14 fragment fragment ADJ 02870v85232 11 15 h2 h2 NOUN 02870v85232 11 16 . . PUNCT 02870v85232 12 1 these these DET 02870v85232 12 2 sites site NOUN 02870v85232 12 3 were be AUX 02870v85232 12 4 mutated mutate VERB 02870v85232 12 5 and and CCONJ 02870v85232 12 6 analyzed analyze VERB 02870v85232 12 7 with with ADP 02870v85232 12 8 several several ADJ 02870v85232 12 9 mutants mutant NOUN 02870v85232 12 10 showing show VERB 02870v85232 12 11 altered altered ADJ 02870v85232 12 12 mt mt PROPN 02870v85232 12 13 bindingh1 bindingh1 PROPN 02870v85232 12 14 s195a s195a PROPN 02870v85232 12 15 , , PUNCT 02870v85232 12 16 h1 h1 PROPN 02870v85232 12 17 s204e s204e PROPN 02870v85232 12 18 and and CCONJ 02870v85232 12 19 h1 h1 PROPN 02870v85232 12 20 6e 6e X 02870v85232 12 21 . . PUNCT 02870v85232 13 1 taken take VERB 02870v85232 13 2 as as ADP 02870v85232 13 3 a a DET 02870v85232 13 4 whole whole NOUN 02870v85232 13 5 , , PUNCT 02870v85232 13 6 these these DET 02870v85232 13 7 results result NOUN 02870v85232 13 8 imply imply VERB 02870v85232 13 9 a a DET 02870v85232 13 10 plus plus ADJ 02870v85232 13 11 - - PUNCT 02870v85232 13 12 end end NOUN 02870v85232 13 13 tracking tracking NOUN 02870v85232 13 14 mechanism mechanism NOUN 02870v85232 13 15 where where SCONJ 02870v85232 13 16 clip-170 clip-170 PRON 02870v85232 13 17 binds bind VERB 02870v85232 13 18 the the DET 02870v85232 13 19 mt mt PROPN 02870v85232 13 20 plus plus CCONJ 02870v85232 13 21 end end NOUN 02870v85232 13 22 in in ADP 02870v85232 13 23 a a DET 02870v85232 13 24 phosphorylated phosphorylated ADJ 02870v85232 13 25 state state NOUN 02870v85232 13 26 and and CCONJ 02870v85232 13 27 subsequent subsequent ADJ 02870v85232 13 28 phosphorylations phosphorylation NOUN 02870v85232 13 29 cause cause VERB 02870v85232 13 30 it it PRON 02870v85232 13 31 to to PART 02870v85232 13 32 fall fall VERB 02870v85232 13 33 off off ADP 02870v85232 13 34 the the DET 02870v85232 13 35 mt mt PROPN 02870v85232 13 36 . . PUNCT