id	sid	tid	token	lemma	pos
02870v85201	1	1	the	the	DET
02870v85201	1	2	myriaporones	myriaporone	NOUN
02870v85201	1	3	and	and	CCONJ
02870v85201	1	4	the	the	DET
02870v85201	1	5	tedanolides	tedanolide	NOUN
02870v85201	1	6	are	be	AUX
02870v85201	1	7	two	two	NUM
02870v85201	1	8	distinct	distinct	ADJ
02870v85201	1	9	classes	class	NOUN
02870v85201	1	10	of	of	ADP
02870v85201	1	11	polyketide	polyketide	PROPN
02870v85201	1	12	natural	natural	ADJ
02870v85201	1	13	products	product	NOUN
02870v85201	1	14	that	that	PRON
02870v85201	1	15	exhibit	exhibit	VERB
02870v85201	1	16	strong	strong	ADJ
02870v85201	1	17	structural	structural	ADJ
02870v85201	1	18	similarities	similarity	NOUN
02870v85201	1	19	as	as	ADV
02870v85201	1	20	well	well	ADV
02870v85201	1	21	as	as	ADP
02870v85201	1	22	interesting	interesting	ADJ
02870v85201	1	23	antitumor	antitumor	PROPN
02870v85201	1	24	activities	activity	NOUN
02870v85201	1	25	.	.	PUNCT
02870v85201	2	1	although	although	SCONJ
02870v85201	2	2	the	the	DET
02870v85201	2	3	latter	latter	ADJ
02870v85201	2	4	was	be	AUX
02870v85201	2	5	isolated	isolate	VERB
02870v85201	2	6	in	in	ADP
02870v85201	2	7	1984	1984	NUM
02870v85201	2	8	,	,	PUNCT
02870v85201	2	9	the	the	DET
02870v85201	2	10	complexity	complexity	NOUN
02870v85201	2	11	of	of	ADP
02870v85201	2	12	its	its	PRON
02870v85201	2	13	architecture	architecture	NOUN
02870v85201	2	14	proved	prove	VERB
02870v85201	2	15	to	to	PART
02870v85201	2	16	be	be	AUX
02870v85201	2	17	a	a	DET
02870v85201	2	18	great	great	ADJ
02870v85201	2	19	challenge	challenge	NOUN
02870v85201	2	20	;	;	PUNCT
02870v85201	2	21	the	the	DET
02870v85201	2	22	first	first	ADJ
02870v85201	2	23	synthesis	synthesis	NOUN
02870v85201	2	24	was	be	AUX
02870v85201	2	25	only	only	ADV
02870v85201	2	26	reported	report	VERB
02870v85201	2	27	in	in	ADP
02870v85201	2	28	2006	2006	NUM
02870v85201	2	29	.	.	PUNCT
02870v85201	3	1	conversely	conversely	ADV
02870v85201	3	2	,	,	PUNCT
02870v85201	3	3	the	the	DET
02870v85201	3	4	myriaporones	myriaporone	NOUN
02870v85201	3	5	represent	represent	VERB
02870v85201	3	6	a	a	DET
02870v85201	3	7	much	much	ADV
02870v85201	3	8	simpler	simple	ADJ
02870v85201	3	9	target	target	NOUN
02870v85201	3	10	.	.	PUNCT
02870v85201	4	1	isolated	isolate	VERB
02870v85201	4	2	from	from	ADP
02870v85201	4	3	a	a	DET
02870v85201	4	4	different	different	ADJ
02870v85201	4	5	source	source	NOUN
02870v85201	4	6	in	in	ADP
02870v85201	4	7	1995	1995	NUM
02870v85201	4	8	by	by	ADP
02870v85201	4	9	rinehart	rinehart	NOUN
02870v85201	4	10	et	et	PROPN
02870v85201	4	11	al	al	PROPN
02870v85201	4	12	.	.	PROPN
02870v85201	4	13	,	,	PUNCT
02870v85201	4	14	the	the	DET
02870v85201	4	15	first	first	ADJ
02870v85201	4	16	total	total	ADJ
02870v85201	4	17	synthesis	synthesis	NOUN
02870v85201	4	18	was	be	AUX
02870v85201	4	19	achieved	achieve	VERB
02870v85201	4	20	simultaneously	simultaneously	ADV
02870v85201	4	21	by	by	ADP
02870v85201	4	22	our	our	PRON
02870v85201	4	23	group	group	NOUN
02870v85201	4	24	and	and	CCONJ
02870v85201	4	25	cuevas	cuevas	PROPN
02870v85201	4	26	et	et	PROPN
02870v85201	4	27	al	al	PROPN
02870v85201	4	28	.	.	PUNCT
02870v85201	4	29	in	in	ADP
02870v85201	4	30	2004	2004	NUM
02870v85201	4	31	.	.	PUNCT
02870v85201	5	1	our	our	PRON
02870v85201	5	2	highly	highly	ADV
02870v85201	5	3	efficient	efficient	ADJ
02870v85201	5	4	synthesis	synthesis	NOUN
02870v85201	5	5	allowed	allow	VERB
02870v85201	5	6	us	we	PRON
02870v85201	5	7	to	to	PART
02870v85201	5	8	prepare	prepare	VERB
02870v85201	5	9	enough	enough	ADJ
02870v85201	5	10	material	material	NOUN
02870v85201	5	11	to	to	PART
02870v85201	5	12	investigate	investigate	VERB
02870v85201	5	13	the	the	DET
02870v85201	5	14	mode	mode	NOUN
02870v85201	5	15	of	of	ADP
02870v85201	5	16	action	action	NOUN
02870v85201	5	17	,	,	PUNCT
02870v85201	5	18	which	which	PRON
02870v85201	5	19	is	be	AUX
02870v85201	5	20	herein	herein	ADV
02870v85201	5	21	disclosed	disclose	VERB
02870v85201	5	22	.	.	PUNCT
02870v85201	6	1	additionally	additionally	ADV
02870v85201	6	2	,	,	PUNCT
02870v85201	6	3	it	it	PRON
02870v85201	6	4	placed	place	VERB
02870v85201	6	5	us	we	PRON
02870v85201	6	6	in	in	ADP
02870v85201	6	7	excellent	excellent	ADJ
02870v85201	6	8	position	position	NOUN
02870v85201	6	9	for	for	ADP
02870v85201	6	10	undertaking	undertake	VERB
02870v85201	6	11	a	a	DET
02870v85201	6	12	structure	structure	NOUN
02870v85201	6	13	-	-	PUNCT
02870v85201	6	14	activity	activity	NOUN
02870v85201	6	15	relationship	relationship	NOUN
02870v85201	6	16	study	study	NOUN
02870v85201	6	17	of	of	ADP
02870v85201	6	18	these	these	DET
02870v85201	6	19	compounds	compound	NOUN
02870v85201	6	20	.	.	PUNCT
02870v85201	7	1	the	the	DET
02870v85201	7	2	efforts	effort	NOUN
02870v85201	7	3	to	to	PART
02870v85201	7	4	identify	identify	VERB
02870v85201	7	5	the	the	DET
02870v85201	7	6	pharmacophore	pharmacophore	NOUN
02870v85201	7	7	of	of	ADP
02870v85201	7	8	the	the	DET
02870v85201	7	9	myriaporones	myriaporone	NOUN
02870v85201	7	10	also	also	ADV
02870v85201	7	11	are	be	AUX
02870v85201	7	12	presented	present	VERB
02870v85201	7	13	in	in	ADP
02870v85201	7	14	this	this	DET
02870v85201	7	15	thesis	thesis	NOUN
02870v85201	7	16	.	.	PUNCT
02870v85201	8	1	the	the	DET
02870v85201	8	2	most	most	ADV
02870v85201	8	3	potent	potent	ADJ
02870v85201	8	4	compounds	compound	NOUN
02870v85201	8	5	in	in	ADP
02870v85201	8	6	the	the	DET
02870v85201	8	7	myriaporone	myriaporone	NOUN
02870v85201	8	8	family	family	NOUN
02870v85201	8	9	,	,	PUNCT
02870v85201	8	10	namely	namely	ADV
02870v85201	8	11	myriaporone	myriaporone	NOUN
02870v85201	8	12	3	3	NUM
02870v85201	8	13	and	and	CCONJ
02870v85201	8	14	myriaporone	myriaporone	NOUN
02870v85201	8	15	4	4	NUM
02870v85201	8	16	,	,	PUNCT
02870v85201	8	17	exist	exist	VERB
02870v85201	8	18	in	in	ADP
02870v85201	8	19	a	a	DET
02870v85201	8	20	dynamic	dynamic	ADJ
02870v85201	8	21	equilibrium	equilibrium	NOUN
02870v85201	8	22	due	due	ADP
02870v85201	8	23	to	to	ADP
02870v85201	8	24	the	the	DET
02870v85201	8	25	lability	lability	NOUN
02870v85201	8	26	of	of	ADP
02870v85201	8	27	myriaporone	myriaporone	NOUN
02870v85201	8	28	3	3	NUM
02870v85201	8	29	's	's	PART
02870v85201	8	30	hemiketal	hemiketal	ADJ
02870v85201	8	31	moiety	moiety	NOUN
02870v85201	8	32	.	.	PUNCT
02870v85201	9	1	it	it	PRON
02870v85201	9	2	is	be	AUX
02870v85201	9	3	possible	possible	ADJ
02870v85201	9	4	that	that	SCONJ
02870v85201	9	5	only	only	ADV
02870v85201	9	6	one	one	NUM
02870v85201	9	7	of	of	ADP
02870v85201	9	8	the	the	DET
02870v85201	9	9	components	component	NOUN
02870v85201	9	10	of	of	ADP
02870v85201	9	11	myriaporone	myriaporone	NOUN
02870v85201	9	12	3/4	3/4	NUM
02870v85201	9	13	equilibrium	equilibrium	NOUN
02870v85201	9	14	is	be	AUX
02870v85201	9	15	active	active	ADJ
02870v85201	9	16	.	.	PUNCT
02870v85201	10	1	if	if	SCONJ
02870v85201	10	2	so	so	ADV
02870v85201	10	3	,	,	PUNCT
02870v85201	10	4	the	the	DET
02870v85201	10	5	other	other	ADJ
02870v85201	10	6	component	component	NOUN
02870v85201	10	7	may	may	AUX
02870v85201	10	8	diminish	diminish	VERB
02870v85201	10	9	the	the	DET
02870v85201	10	10	activity	activity	NOUN
02870v85201	10	11	and	and	CCONJ
02870v85201	10	12	destabilize	destabilize	VERB
02870v85201	10	13	the	the	DET
02870v85201	10	14	binding	binding	NOUN
02870v85201	10	15	of	of	ADP
02870v85201	10	16	the	the	DET
02870v85201	10	17	biological	biological	ADJ
02870v85201	10	18	target	target	NOUN
02870v85201	10	19	.	.	PUNCT
02870v85201	11	1	several	several	ADJ
02870v85201	11	2	analogues	analogue	NOUN
02870v85201	11	3	were	be	AUX
02870v85201	11	4	designed	design	VERB
02870v85201	11	5	to	to	PART
02870v85201	11	6	lock	lock	VERB
02870v85201	11	7	either	either	PRON
02870v85201	11	8	of	of	ADP
02870v85201	11	9	the	the	DET
02870v85201	11	10	two	two	NUM
02870v85201	11	11	conformations	conformation	NOUN
02870v85201	11	12	in	in	ADP
02870v85201	11	13	an	an	DET
02870v85201	11	14	attempt	attempt	NOUN
02870v85201	11	15	to	to	PART
02870v85201	11	16	find	find	VERB
02870v85201	11	17	the	the	DET
02870v85201	11	18	biological	biological	ADJ
02870v85201	11	19	active	active	ADJ
02870v85201	11	20	one	one	NUM
02870v85201	11	21	;	;	PUNCT
02870v85201	11	22	however	however	ADV
02870v85201	11	23	,	,	PUNCT
02870v85201	11	24	all	all	PRON
02870v85201	11	25	of	of	ADP
02870v85201	11	26	them	they	PRON
02870v85201	11	27	exhibited	exhibit	VERB
02870v85201	11	28	a	a	DET
02870v85201	11	29	significant	significant	ADJ
02870v85201	11	30	decrease	decrease	NOUN
02870v85201	11	31	in	in	ADP
02870v85201	11	32	biological	biological	ADJ
02870v85201	11	33	activity	activity	NOUN
02870v85201	11	34	.	.	PUNCT
02870v85201	12	1	myriaporone	myriaporone	NOUN
02870v85201	12	2	3/4	3/4	NUM
02870v85201	12	3	and	and	CCONJ
02870v85201	12	4	the	the	DET
02870v85201	12	5	southern	southern	ADJ
02870v85201	12	6	hemisphere	hemisphere	NOUN
02870v85201	12	7	(	(	PUNCT
02870v85201	12	8	c10	c10	PROPN
02870v85201	12	9	-	-	PUNCT
02870v85201	12	10	c23	c23	PROPN
02870v85201	12	11	portion	portion	NOUN
02870v85201	12	12	)	)	PUNCT
02870v85201	12	13	of	of	ADP
02870v85201	12	14	tedanolide	tedanolide	PROPN
02870v85201	12	15	are	be	AUX
02870v85201	12	16	structurally	structurally	ADV
02870v85201	12	17	closely	closely	ADV
02870v85201	12	18	related	related	ADJ
02870v85201	12	19	.	.	PUNCT
02870v85201	13	1	we	we	PRON
02870v85201	13	2	hypothesized	hypothesize	VERB
02870v85201	13	3	that	that	SCONJ
02870v85201	13	4	myriaporone	myriaporone	NOUN
02870v85201	13	5	3/4	3/4	NUM
02870v85201	13	6	is	be	AUX
02870v85201	13	7	a	a	DET
02870v85201	13	8	naturally	naturally	ADV
02870v85201	13	9	occurring	occur	VERB
02870v85201	13	10	analogue	analogue	NOUN
02870v85201	13	11	of	of	ADP
02870v85201	13	12	tedanolide	tedanolide	PROPN
02870v85201	13	13	,	,	PUNCT
02870v85201	13	14	and	and	CCONJ
02870v85201	13	15	,	,	PUNCT
02870v85201	13	16	thus	thus	ADV
02870v85201	13	17	,	,	PUNCT
02870v85201	13	18	shared	share	VERB
02870v85201	13	19	an	an	DET
02870v85201	13	20	identical	identical	ADJ
02870v85201	13	21	pharmacophore	pharmacophore	NOUN
02870v85201	13	22	.	.	PUNCT
02870v85201	14	1	considering	consider	VERB
02870v85201	14	2	the	the	DET
02870v85201	14	3	complexity	complexity	NOUN
02870v85201	14	4	and	and	CCONJ
02870v85201	14	5	the	the	DET
02870v85201	14	6	difficulties	difficulty	NOUN
02870v85201	14	7	associated	associate	VERB
02870v85201	14	8	with	with	ADP
02870v85201	14	9	tedanolide	tedanolide	PROPN
02870v85201	14	10	,	,	PUNCT
02870v85201	14	11	the	the	DET
02870v85201	14	12	study	study	NOUN
02870v85201	14	13	of	of	ADP
02870v85201	14	14	myriaporone	myriaporone	PROPN
02870v85201	14	15	's	's	PART
02870v85201	14	16	analogues	analogue	NOUN
02870v85201	14	17	would	would	AUX
02870v85201	14	18	then	then	ADV
02870v85201	14	19	provide	provide	VERB
02870v85201	14	20	useful	useful	ADJ
02870v85201	14	21	information	information	NOUN
02870v85201	14	22	on	on	ADP
02870v85201	14	23	both	both	DET
02870v85201	14	24	families	family	NOUN
02870v85201	14	25	,	,	PUNCT
02870v85201	14	26	thereby	thereby	ADV
02870v85201	14	27	,	,	PUNCT
02870v85201	14	28	ultimately	ultimately	ADV
02870v85201	14	29	providing	provide	VERB
02870v85201	14	30	better	well	ADJ
02870v85201	14	31	drug	drug	NOUN
02870v85201	14	32	candidates	candidate	NOUN
02870v85201	14	33	.	.	PUNCT
02870v85201	15	1	simple	simple	ADJ
02870v85201	15	2	modifications	modification	NOUN
02870v85201	15	3	of	of	ADP
02870v85201	15	4	the	the	DET
02870v85201	15	5	myriaporone	myriaporone	NOUN
02870v85201	15	6	3/4	3/4	NUM
02870v85201	15	7	synthesis	synthesis	NOUN
02870v85201	15	8	allowed	allow	VERB
02870v85201	15	9	access	access	NOUN
02870v85201	15	10	to	to	ADP
02870v85201	15	11	the	the	DET
02870v85201	15	12	southern	southern	ADJ
02870v85201	15	13	hemisphere	hemisphere	NOUN
02870v85201	15	14	of	of	ADP
02870v85201	15	15	tedanolide	tedanolide	PROPN
02870v85201	15	16	.	.	PUNCT
02870v85201	16	1	13	13	NUM
02870v85201	16	2	-	-	PUNCT
02870v85201	16	3	deoxytedanolide	deoxytedanolide	NOUN
02870v85201	16	4	is	be	AUX
02870v85201	16	5	a	a	DET
02870v85201	16	6	natural	natural	ADJ
02870v85201	16	7	product	product	NOUN
02870v85201	16	8	possessing	possess	VERB
02870v85201	16	9	the	the	DET
02870v85201	16	10	same	same	ADJ
02870v85201	16	11	activity	activity	NOUN
02870v85201	16	12	as	as	ADP
02870v85201	16	13	tedanolide	tedanolide	NOUN
02870v85201	16	14	and	and	CCONJ
02870v85201	16	15	differing	differ	VERB
02870v85201	16	16	from	from	ADP
02870v85201	16	17	the	the	DET
02870v85201	16	18	latter	latter	ADJ
02870v85201	16	19	only	only	ADV
02870v85201	16	20	by	by	ADP
02870v85201	16	21	one	one	NUM
02870v85201	16	22	hydroxyl	hydroxyl	PROPN
02870v85201	16	23	group	group	NOUN
02870v85201	16	24	at	at	ADP
02870v85201	16	25	the	the	DET
02870v85201	16	26	13	13	NUM
02870v85201	16	27	position	position	NOUN
02870v85201	16	28	.	.	PUNCT
02870v85201	17	1	some	some	DET
02870v85201	17	2	analogues	analogue	NOUN
02870v85201	17	3	of	of	ADP
02870v85201	17	4	myriaporone	myriaporone	NOUN
02870v85201	17	5	were	be	AUX
02870v85201	17	6	designed	design	VERB
02870v85201	17	7	without	without	ADP
02870v85201	17	8	the	the	DET
02870v85201	17	9	corresponding	corresponding	PROPN
02870v85201	17	10	hydroxyl	hydroxyl	PROPN
02870v85201	17	11	group	group	PROPN
02870v85201	17	12	to	to	PART
02870v85201	17	13	determine	determine	VERB
02870v85201	17	14	if	if	SCONJ
02870v85201	17	15	the	the	DET
02870v85201	17	16	myriaporones	myriaporone	NOUN
02870v85201	17	17	and	and	CCONJ
02870v85201	17	18	the	the	DET
02870v85201	17	19	tedanolides	tedanolide	NOUN
02870v85201	17	20	followed	follow	VERB
02870v85201	17	21	similar	similar	ADJ
02870v85201	17	22	trends	trend	NOUN
02870v85201	17	23	.	.	PUNCT
02870v85201	18	1	additionally	additionally	ADV
02870v85201	18	2	,	,	PUNCT
02870v85201	18	3	analogues	analogue	NOUN
02870v85201	18	4	of	of	ADP
02870v85201	18	5	myriaporone	myriaporone	NOUN
02870v85201	18	6	possessing	possess	VERB
02870v85201	18	7	a	a	DET
02870v85201	18	8	simpler	simple	ADJ
02870v85201	18	9	structure	structure	NOUN
02870v85201	18	10	were	be	AUX
02870v85201	18	11	generated	generate	VERB
02870v85201	18	12	.	.	PUNCT
02870v85201	19	1	again	again	ADV
02870v85201	19	2	,	,	PUNCT
02870v85201	19	3	all	all	PRON
02870v85201	19	4	of	of	ADP
02870v85201	19	5	the	the	DET
02870v85201	19	6	analogues	analogue	NOUN
02870v85201	19	7	synthesized	synthesize	VERB
02870v85201	19	8	exhibited	exhibit	VERB
02870v85201	19	9	a	a	DET
02870v85201	19	10	significant	significant	ADJ
02870v85201	19	11	decrease	decrease	NOUN
02870v85201	19	12	in	in	ADP
02870v85201	19	13	biological	biological	ADJ
02870v85201	19	14	activity	activity	NOUN
02870v85201	19	15	.	.	PUNCT
02870v85201	20	1	a	a	DET
02870v85201	20	2	fortiori	fortiori	NOUN
02870v85201	20	3	,	,	PUNCT
02870v85201	20	4	based	base	VERB
02870v85201	20	5	on	on	ADP
02870v85201	20	6	biosynthetic	biosynthetic	ADJ
02870v85201	20	7	considerations	consideration	NOUN
02870v85201	20	8	,	,	PUNCT
02870v85201	20	9	we	we	PRON
02870v85201	20	10	propose	propose	VERB
02870v85201	20	11	that	that	SCONJ
02870v85201	20	12	the	the	DET
02870v85201	20	13	unique	unique	ADJ
02870v85201	20	14	macrolactone	macrolactone	NOUN
02870v85201	20	15	linkage	linkage	NOUN
02870v85201	20	16	of	of	ADP
02870v85201	20	17	tedanolide	tedanolide	NOUN
02870v85201	20	18	arise	arise	VERB
02870v85201	20	19	from	from	ADP
02870v85201	20	20	a	a	DET
02870v85201	20	21	skeleton	skeleton	NOUN
02870v85201	20	22	rearrangement	rearrangement	NOUN
02870v85201	20	23	.	.	PUNCT
02870v85201	21	1	the	the	DET
02870v85201	21	2	synthesis	synthesis	NOUN
02870v85201	21	3	of	of	ADP
02870v85201	21	4	the	the	DET
02870v85201	21	5	potential	potential	ADJ
02870v85201	21	6	biosynthetic	biosynthetic	ADJ
02870v85201	21	7	precursor	precursor	NOUN
02870v85201	21	8	,	,	PUNCT
02870v85201	21	9	isotedanolide	isotedanolide	PROPN
02870v85201	21	10	,	,	PUNCT
02870v85201	21	11	was	be	AUX
02870v85201	21	12	undertaken	undertake	VERB
02870v85201	21	13	in	in	ADP
02870v85201	21	14	order	order	NOUN
02870v85201	21	15	to	to	PART
02870v85201	21	16	study	study	VERB
02870v85201	21	17	the	the	DET
02870v85201	21	18	proposed	propose	VERB
02870v85201	21	19	rearrangement	rearrangement	NOUN
02870v85201	21	20	and	and	CCONJ
02870v85201	21	21	to	to	PART
02870v85201	21	22	validate	validate	VERB
02870v85201	21	23	our	our	PRON
02870v85201	21	24	hypothesis	hypothesis	NOUN
02870v85201	21	25	.	.	PUNCT
02870v85201	22	1	progress	progress	NOUN
02870v85201	22	2	toward	toward	ADP
02870v85201	22	3	the	the	DET
02870v85201	22	4	synthesis	synthesis	NOUN
02870v85201	22	5	of	of	ADP
02870v85201	22	6	isotedanolide	isotedanolide	PROPN
02870v85201	22	7	is	be	AUX
02870v85201	22	8	also	also	ADV
02870v85201	22	9	presented	present	VERB
02870v85201	22	10	.	.	PUNCT