id sid tid token lemma pos 00000001s0d 1 1 the the DET 00000001s0d 1 2 accumulation accumulation NOUN 00000001s0d 1 3 of of ADP 00000001s0d 1 4 microdamage microdamage NOUN 00000001s0d 1 5 has have AUX 00000001s0d 1 6 been be AUX 00000001s0d 1 7 linked link VERB 00000001s0d 1 8 to to ADP 00000001s0d 1 9 clinical clinical ADJ 00000001s0d 1 10 bone bone NOUN 00000001s0d 1 11 fragility fragility NOUN 00000001s0d 1 12 and and CCONJ 00000001s0d 1 13 increased increase VERB 00000001s0d 1 14 fracture fracture NOUN 00000001s0d 1 15 susceptibility susceptibility NOUN 00000001s0d 1 16 . . PUNCT 00000001s0d 2 1 damage damage NOUN 00000001s0d 2 2 is be AUX 00000001s0d 2 3 normally normally ADV 00000001s0d 2 4 repaired repair VERB 00000001s0d 2 5 by by ADP 00000001s0d 2 6 a a DET 00000001s0d 2 7 cellular cellular ADJ 00000001s0d 2 8 remodeling remodeling NOUN 00000001s0d 2 9 process process NOUN 00000001s0d 2 10 . . PUNCT 00000001s0d 3 1 however however ADV 00000001s0d 3 2 , , PUNCT 00000001s0d 3 3 a a DET 00000001s0d 3 4 fracture fracture NOUN 00000001s0d 3 5 may may AUX 00000001s0d 3 6 occur occur VERB 00000001s0d 3 7 if if SCONJ 00000001s0d 3 8 damage damage NOUN 00000001s0d 3 9 accumulates accumulate VERB 00000001s0d 3 10 faster fast ADV 00000001s0d 3 11 than than SCONJ 00000001s0d 3 12 it it PRON 00000001s0d 3 13 can can AUX 00000001s0d 3 14 be be AUX 00000001s0d 3 15 repaired repair VERB 00000001s0d 3 16 . . PUNCT 00000001s0d 4 1 current current ADJ 00000001s0d 4 2 methods method NOUN 00000001s0d 4 3 for for ADP 00000001s0d 4 4 imaging image VERB 00000001s0d 4 5 microdamage microdamage NOUN 00000001s0d 4 6 are be AUX 00000001s0d 4 7 inherently inherently ADV 00000001s0d 4 8 invasive invasive ADJ 00000001s0d 4 9 , , PUNCT 00000001s0d 4 10 destructive destructive ADJ 00000001s0d 4 11 and and CCONJ 00000001s0d 4 12 two two NUM 00000001s0d 4 13 - - PUNCT 00000001s0d 4 14 dimensional dimensional ADJ 00000001s0d 4 15 . . PUNCT 00000001s0d 5 1 the the DET 00000001s0d 5 2 development development NOUN 00000001s0d 5 3 of of ADP 00000001s0d 5 4 a a DET 00000001s0d 5 5 targeted target VERB 00000001s0d 5 6 , , PUNCT 00000001s0d 5 7 deliverable deliverable ADJ 00000001s0d 5 8 x x NOUN 00000001s0d 5 9 - - NOUN 00000001s0d 5 10 ray ray NOUN 00000001s0d 5 11 contrast contrast NOUN 00000001s0d 5 12 agent agent NOUN 00000001s0d 5 13 would would AUX 00000001s0d 5 14 allow allow VERB 00000001s0d 5 15 for for ADP 00000001s0d 5 16 specific specific ADJ 00000001s0d 5 17 and and CCONJ 00000001s0d 5 18 three three NUM 00000001s0d 5 19 - - PUNCT 00000001s0d 5 20 dimensional dimensional ADJ 00000001s0d 5 21 imaging imaging NOUN 00000001s0d 5 22 of of ADP 00000001s0d 5 23 microdamage microdamage NOUN 00000001s0d 5 24 in in ADP 00000001s0d 5 25 vitro vitro X 00000001s0d 5 26 and and CCONJ 00000001s0d 5 27 potentially potentially ADV 00000001s0d 5 28 in in ADP 00000001s0d 5 29 vivo vivo PROPN 00000001s0d 5 30 . . PUNCT 00000001s0d 6 1 therefore therefore ADV 00000001s0d 6 2 , , PUNCT 00000001s0d 6 3 the the DET 00000001s0d 6 4 objective objective NOUN 00000001s0d 6 5 of of ADP 00000001s0d 6 6 this this DET 00000001s0d 6 7 research research NOUN 00000001s0d 6 8 was be AUX 00000001s0d 6 9 to to PART 00000001s0d 6 10 investigate investigate VERB 00000001s0d 6 11 the the DET 00000001s0d 6 12 use use NOUN 00000001s0d 6 13 of of ADP 00000001s0d 6 14 surface surface NOUN 00000001s0d 6 15 functionalized functionalize VERB 00000001s0d 6 16 gold gold NOUN 00000001s0d 6 17 nanoparticles nanoparticle NOUN 00000001s0d 6 18 as as ADP 00000001s0d 6 19 damage damage NOUN 00000001s0d 6 20 - - PUNCT 00000001s0d 6 21 specific specific ADJ 00000001s0d 6 22 x x ADJ 00000001s0d 6 23 - - NOUN 00000001s0d 6 24 ray ray NOUN 00000001s0d 6 25 contrast contrast NOUN 00000001s0d 6 26 agents agent NOUN 00000001s0d 6 27 . . PUNCT 00000001s0d 7 1 gold gold ADJ 00000001s0d 7 2 nanoparticles nanoparticle NOUN 00000001s0d 7 3 were be AUX 00000001s0d 7 4 synthesized synthesize VERB 00000001s0d 7 5 and and CCONJ 00000001s0d 7 6 functionalized functionalize VERB 00000001s0d 7 7 with with ADP 00000001s0d 7 8 carboxylate carboxylate NOUN 00000001s0d 7 9 , , PUNCT 00000001s0d 7 10 phosphonate phosphonate NOUN 00000001s0d 7 11 , , PUNCT 00000001s0d 7 12 or or CCONJ 00000001s0d 7 13 bisphosphonate bisphosphonate NOUN 00000001s0d 7 14 molecules molecule NOUN 00000001s0d 7 15 for for ADP 00000001s0d 7 16 targeting target VERB 00000001s0d 7 17 calcium calcium NOUN 00000001s0d 7 18 . . PUNCT 00000001s0d 8 1 functionalized functionalize VERB 00000001s0d 8 2 gold gold NOUN 00000001s0d 8 3 nanoparticles nanoparticle NOUN 00000001s0d 8 4 were be AUX 00000001s0d 8 5 characterized characterize VERB 00000001s0d 8 6 and and CCONJ 00000001s0d 8 7 compared compare VERB 00000001s0d 8 8 based base VERB 00000001s0d 8 9 on on ADP 00000001s0d 8 10 their their PRON 00000001s0d 8 11 colloidal colloidal ADJ 00000001s0d 8 12 stability stability NOUN 00000001s0d 8 13 and and CCONJ 00000001s0d 8 14 binding binding ADJ 00000001s0d 8 15 affinity affinity NOUN 00000001s0d 8 16 to to ADP 00000001s0d 8 17 both both CCONJ 00000001s0d 8 18 a a DET 00000001s0d 8 19 synthetic synthetic ADJ 00000001s0d 8 20 bone bone NOUN 00000001s0d 8 21 mineral mineral NOUN 00000001s0d 8 22 analog analog NOUN 00000001s0d 8 23 and and CCONJ 00000001s0d 8 24 damaged damaged ADJ 00000001s0d 8 25 bone bone NOUN 00000001s0d 8 26 tissue tissue NOUN 00000001s0d 8 27 . . PUNCT 00000001s0d 9 1 bisphosphonate bisphosphonate NOUN 00000001s0d 9 2 functionalized functionalize VERB 00000001s0d 9 3 au au PROPN 00000001s0d 9 4 nps nps PROPN 00000001s0d 9 5 exhibited exhibit VERB 00000001s0d 9 6 the the DET 00000001s0d 9 7 most most ADV 00000001s0d 9 8 rapid rapid ADJ 00000001s0d 9 9 binding bind VERB 00000001s0d 9 10 kinetics kinetic NOUN 00000001s0d 9 11 and and CCONJ 00000001s0d 9 12 highest high ADJ 00000001s0d 9 13 binding binding ADJ 00000001s0d 9 14 affinity affinity NOUN 00000001s0d 9 15 . . PUNCT 00000001s0d 10 1 bisphosphonate bisphosphonate NOUN 00000001s0d 10 2 functionalized functionalize VERB 00000001s0d 10 3 au au PROPN 00000001s0d 10 4 nps nps PROPN 00000001s0d 10 5 of of ADP 00000001s0d 10 6 varying vary VERB 00000001s0d 10 7 particle particle NOUN 00000001s0d 10 8 diameter diameter NOUN 00000001s0d 10 9 were be AUX 00000001s0d 10 10 also also ADV 00000001s0d 10 11 prepared prepared ADJ 00000001s0d 10 12 to to PART 00000001s0d 10 13 investigate investigate VERB 00000001s0d 10 14 nanoparticle nanoparticle NOUN 00000001s0d 10 15 size size NOUN 00000001s0d 10 16 effects effect NOUN 00000001s0d 10 17 on on ADP 00000001s0d 10 18 x x NOUN 00000001s0d 10 19 - - NOUN 00000001s0d 10 20 ray ray NOUN 00000001s0d 10 21 attenuation attenuation NOUN 00000001s0d 10 22 and and CCONJ 00000001s0d 10 23 deliverability deliverability NOUN 00000001s0d 10 24 . . PUNCT 00000001s0d 11 1 damaged damaged ADJ 00000001s0d 11 2 bone bone NOUN 00000001s0d 11 3 tissue tissue NOUN 00000001s0d 11 4 labeled label VERB 00000001s0d 11 5 by by ADP 00000001s0d 11 6 bisphosphonate bisphosphonate NOUN 00000001s0d 11 7 functionalized functionalize VERB 00000001s0d 11 8 au au PROPN 00000001s0d 11 9 nps nps PROPN 00000001s0d 11 10 was be AUX 00000001s0d 11 11 able able ADJ 00000001s0d 11 12 to to PART 00000001s0d 11 13 be be AUX 00000001s0d 11 14 detected detect VERB 00000001s0d 11 15 using use VERB 00000001s0d 11 16 absorption absorption NOUN 00000001s0d 11 17 edge edge NOUN 00000001s0d 11 18 subtraction subtraction NOUN 00000001s0d 11 19 in in ADP 00000001s0d 11 20 x x NOUN 00000001s0d 11 21 - - NOUN 00000001s0d 11 22 ray ray NOUN 00000001s0d 11 23 tomography tomography NOUN 00000001s0d 11 24 . . PUNCT 00000001s0d 12 1 other other ADJ 00000001s0d 12 2 novel novel NOUN 00000001s0d 12 3 x x NOUN 00000001s0d 12 4 - - NOUN 00000001s0d 12 5 ray ray NOUN 00000001s0d 12 6 imaging imaging NOUN 00000001s0d 12 7 methods method NOUN 00000001s0d 12 8 were be AUX 00000001s0d 12 9 also also ADV 00000001s0d 12 10 investigated investigate VERB 00000001s0d 12 11 to to PART 00000001s0d 12 12 potentially potentially ADV 00000001s0d 12 13 improve improve VERB 00000001s0d 12 14 the the DET 00000001s0d 12 15 detection detection NOUN 00000001s0d 12 16 of of ADP 00000001s0d 12 17 nanoscale nanoscale PROPN 00000001s0d 12 18 contrast contrast NOUN 00000001s0d 12 19 agents agent NOUN 00000001s0d 12 20 . . PUNCT 00000001s0d 13 1 in in ADP 00000001s0d 13 2 summary summary NOUN 00000001s0d 13 3 , , PUNCT 00000001s0d 13 4 the the DET 00000001s0d 13 5 ability ability NOUN 00000001s0d 13 6 to to PART 00000001s0d 13 7 utilize utilize VERB 00000001s0d 13 8 functionalized functionalize VERB 00000001s0d 13 9 gold gold ADJ 00000001s0d 13 10 nanoparticles nanoparticle NOUN 00000001s0d 13 11 as as SCONJ 00000001s0d 13 12 targeted target VERB 00000001s0d 13 13 x x NOUN 00000001s0d 13 14 - - NOUN 00000001s0d 13 15 ray ray NOUN 00000001s0d 13 16 contrast contrast NOUN 00000001s0d 13 17 agents agent NOUN 00000001s0d 13 18 for for ADP 00000001s0d 13 19 microdamage microdamage NOUN 00000001s0d 13 20 in in ADP 00000001s0d 13 21 bone bone NOUN 00000001s0d 13 22 tissue tissue NOUN 00000001s0d 13 23 was be AUX 00000001s0d 13 24 found find VERB 00000001s0d 13 25 be be AUX 00000001s0d 13 26 to to PART 00000001s0d 13 27 feasible feasible ADJ 00000001s0d 13 28 with with ADP 00000001s0d 13 29 improved improved ADJ 00000001s0d 13 30 x x NOUN 00000001s0d 13 31 - - NOUN 00000001s0d 13 32 ray ray NOUN 00000001s0d 13 33 imaging imaging NOUN 00000001s0d 13 34 techniques technique NOUN 00000001s0d 13 35 . . PUNCT