id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
tt44pk0601d	Grant Lee James Keller	Computational Characterization of Peptide-Majorhistocompatibility Complex Antigen Structure	2022		.txt	text/plain	166	5	9	As a consequence of the extreme diversity of peptide-MHC antigens, T cell receptors are paradoxically capable of cross-reacting to chemically and structurally distinct peptide-MHC.Research into the biophysical and structural underpinnings of T cell receptor antigen specificity and cross-reactivity have revealed some correlates and dependence on structural features, however our understanding remains too limited to develop immunotherapeutics intended to recruit T cells to a tumor in a patient-specific manner. A critical component of this is the recognition by T cell receptors of peptide antigen presented on major histocompatibilty complex (MHC) proteins.	cache/tt44pk0601d.txt	txt/tt44pk0601d.txt