id author title date pages extension mime words sentence flesch summary cache txt t435gb21x6s Thomas Francis Clarke Rare Codon Clusters: Enrichment, Functional Effects, Non-Random Localization and Conservation 2009 .txt text/plain 220 11 54 Rare codon clusters can impede ribosome translation of the rare codon sequence and are not distributed randomly throughout genes: rare codons are enriched at the 5' and 3' termini of genes from E. coli and other prokaryotes. Furthermore, rare codon clusters can be conserved across multiple homologues, indicating additional selective pressures govern the use of synonymous codons, and specifically that local pauses in translation can be beneficial for protein biogenesis. cache/t435gb21x6s.txt txt/t435gb21x6s.txt