id author title date pages extension mime words sentence flesch summary cache txt rj430289g0v Lucas Q. Ton Positional Cloning and RNA Interference Assay Demonstrated Plasmodium-Melanizing Function of a Serine Protease Within the Plasmodium Encapsulation 1 Locus (Pen1) of the Malaria Mosquito Anopheles Gambiae 2007 .txt text/plain 459 17 33 We also show that RNAi knockdown abolishes CLIPB17 gene induction in L35 and significantly reduces refractoriness to both Plasmodium berghei and P. cynomolgi B. Melanotic encapsulation represents the fastest and most important endogenous refractory mechanism against pathogens too large or too numerous for other immune mechanisms to cope with (Vey, 1993). In a selected strain with a fully refractory phenotype (L35 strain), CLIPB17 gene expression is up-regulated at the time of parasite melanization. cache/rj430289g0v.txt txt/rj430289g0v.txt