id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
r207tm7328m	Jarred Robert Edward Pickering	The Application of Polyketide Natural Product GEX1A to Niemann-Pick Type C Disease	2015		.txt	text/plain	368	12	33	Our laboratory determined that the novel cholesterol activity of GEX1A merited further investigation within the context of Niemann-Pick Type C.Through isolation of natural GEX1A from its producing organism, our laboratory has demonstrated that GEX1A represents a novel therapeutic candidate for Niemann-Pick type C. Specifically, GEX1A restores cholesterol homeostasis in NPC1 mutant cell lines and cells induced with the disease associated phenotype. Histone deacetylase inhibitors, such as trichostatin A and vorinostat, have recently been shown to restore cholesterol homeostasis in Niemann-Pick type C mutant cell lines.	cache/r207tm7328m.txt	txt/r207tm7328m.txt