id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
qz20sq90x3r	Sharif Rahmy	Overcoming Resistance to Immune Checkpoint Blockade Therapy	2022		.txt	text/plain	188	7	19	Here we show evidence that by altering epigenetic regulation using a histone deacetylase inhibitor we can simultaneously increase MHC-I expression on tumor cells and change the differentiation of infiltrating immune cells from immunosuppressive macrophages towards immunostimulatory antigen presenting cells (APCs). ICB therapy is based on reactivating exhausted T-cells (PD-1) and increasing T-cell activation (CTLA-4), one major mechanism of resistance is mediated through downregulation of the Major Histocompatibility Complex I (MHC-I) on cancer cells, as the MHC complex is responsible for presenting antigen to T-cells, and thereby crucial for facilitating T-cell mediated killing.	cache/qz20sq90x3r.txt	txt/qz20sq90x3r.txt