id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
qz20sq89r9h	Erin Marie Daly	Probing Tubuling Interactions with 14-Methyl Epothilone D Analogues	2011		.txt	text/plain	330	14	21	We have confirmed through computer modeling techniques that (14S)- and (14R)-methyl epothilone D preferentially exist as epoxide/olefinic conformer I and epoxide/olefinic conformer II, correspondingly. Computational methods and high-field NMR experiments on the epothilone pharmacophore have enabled us to distinguish epoxide/olefinic conformer I and epoxide/olefinic conformer II and, subsequently, to determine which most accurately describes the bioactive conformation for this region.	cache/qz20sq89r9h.txt	txt/qz20sq89r9h.txt