id author title date pages extension mime words sentence flesch summary cache txt p2676t07f3d Raymond Kenney Walters Evaluation of a Two-Stage Statistical Learning Design for Genome-Wide Studies 2013 .txt text/plain 149 6 34 GBM is used as a first stage variable selection screen to substantially reduce the dimensionality of SNP data while maintaining sensitivity to additive, nonlinear, and interaction effects, allowing hypothesis testing with a reduced multiple testing burden in the second stage analysis. Thorough simulations shows the proposed two-stage design can substantially improve power to detect effect SNPs in a wide range of conditions. cache/p2676t07f3d.txt txt/p2676t07f3d.txt