id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
mw22v40853t	Thomas E. Frederick	A New Basis for Signal Transduction in the Staphylococcus aureus Beta-Lactam Sensor Protein BlaR1	1904		.txt	text/plain	349	16	39	Our results suggest a new basis for the BlaR1 signaling mechanism, in which sustained L2-BlaRS contact mediates transmembrane signaling stimulated by changes in BlaRS dynamics upon binding of b-lactam antibiotics. Specifically, binding of b-lactam (penicillin-like) antibiotics to the extracellular sensor domain of BlaR1 (BlaRS) initiates a transmembrane signal that stimulates the production of b-lactamase proteins, which then destroy the b-lactam antibiotics.	cache/mw22v40853t.txt	txt/mw22v40853t.txt