id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
k0698625s8t	Nathan J. Alves	Utilization of the Conserved Antibody Nucleotide Binding Site (NBS): From Antibody Purification and Advanced Medical Diagnostics to Next Generation Therapeutics	2013		.txt	text/plain	342	9	6	This method of crosslinking also has implications in the development of next generation pharmaceutical antibodies by providing a site-specific insertion of functional moieties such as: chemotherapeutics, cell penetrating peptides, targeting sequences for bispecific antibody preparation, imaging molecules, and immobilization of antibodies to various nanoparticle drug delivery platforms, without negatively impacting antibody-antigen binding interactions. This dissertation will demonstrate how an underutilized, highly conserved binding domain located on the antibody variable fragment, known as the nucleotide binding site (NBS), can be implemented for antibody purification, advanced medical diagnostic development and for next generation antibody based therapeutics.	cache/k0698625s8t.txt	txt/k0698625s8t.txt