id author title date pages extension mime words sentence flesch summary cache txt gb19f477842 Jeanette Young Towards Characterization of the Polyketide Synthase Gene Cluster Responsible for the Production of Gephyronic Acid 2012 .txt text/plain 415 15 31 Our recent total synthesis and structural reassignment of gephyronic acid incorporates a synthetic route that provides a means by which to prepare gephyronic acid efficiently and selectively and has provided significant quantities, thus facilitating further biological evaluation towards identifying gephyronic acids specific mode of action in cancer cells. An in vitro translation assay demonstrated that gephyronic acid is a specific inhibitor of eukaryotic protein synthesis (IC50 66-80 ng/mL). cache/gb19f477842.txt txt/gb19f477842.txt