id author title date pages extension mime words sentence flesch summary cache txt dz010p12h95 Parinda Tennakoon Mechanisms of Endocrine Therapy Resistance in Estrogen Receptor Positive Breast Cancer by ZNF217 and ERBB3 Signaling 2023 .txt text/plain 417 20 41 Moreover, by analyzing cell culture media in MCF7 cells ± siRNA ZNF217, I discovered that ZNF217 alters the cytokine/chemokine/growth factor profile secreted by ER+ breast cancer cells. Together, my results suggest that Zfp217 overexpression in ER+ breast cancer cells causes endocrine therapy resistance and that growth factor induction via NRG1 induces non-canonical ER binding to the genome and a ZNF217-dependent gene expression signature. cache/dz010p12h95.txt txt/dz010p12h95.txt