id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
dn39x062k1j	Ian H. Guldner	Characterizing the Brain Metastatic Niche and Elucidating Its Functional Role during Brain Metastasis Outgrowth	2020		.txt	text/plain	399	12	22	Intriguingly, depleting microglia during brain metastasis outgrowth reduced metastasis number, while inhibiting the infiltration of BMDM to metastatic lesions did not change metastasis number, implicating microglia as the main myeloid effector during brain metastasis. Here, leveraging recently developed techniques, we sought to (1) characterize spatial and pseudo-temporal aspects of key components of the metastatic niche, (2) compositionally and transcriptionally profile the myeloid immune component of the brain metastatic niche, and (3) elucidate the functional role of myeloid cells during brain metastasis and the molecular mechanism by which they regulate metastatic outgrowth.	cache/dn39x062k1j.txt	txt/dn39x062k1j.txt