id author title date pages extension mime words sentence flesch summary cache txt c247dr2919w Coura Rosalie Diè ne Progress towards the Syntheses of Ambruticin and Its Putative Biosynthetic Intermediate 2010 .txt text/plain 302 12 28 This thesis also highlights the progress towards the synthesis of ambruticin J, a putative biosynthetic intermediate recently proposed by Reeves following the characterization of the PKS gene cluster responsible for the biosynthesis of ambruticin. In light of the limited amount of ambruticin J available biosynthetically, its large scale preparation via organic synthesis was implemented in order to investigate the role of the epoxidase, AmbJ during the post-PKS modifications leading to the production of ambruticins and their analogues. cache/c247dr2919w.txt txt/c247dr2919w.txt