id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
8s45q813p6k	Miranda Burnette	Advanced Screening and Integrative Analysis for Biotechnology and Disease	1904		.txt	text/plain	259	5	4	This thesis describes several milestone applications that advance the state-of-the art in each field: the generation of the first chemically defined cell culture medium enabling long term culture of a Drosophila cell lines (Chapter 2); building on these results led to unexpected discoveries in the field of developmental biology with the discovery of novel spatiotemporal patterning of polyamines during organogenesis (Chapter 3); the optimization and application of an in vivo tumor screening approach to efficiently identify novel functional targets during secondary metastatic outgrowth in tumors (Chapter 4); and through a close, multidisciplinary collaboration, the characterization of novel compounds through both cytotoxicity and mechanism of action studies, along with the preliminary creation of an ultra-high-content screening platform for structure-activity analysis of compound libraries (Chapter 5). For each application, several avenues are available to further progress the technology, which is discussed in the concluding chapter (Chapter 6).	cache/8s45q813p6k.txt	txt/8s45q813p6k.txt