id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
6w924b32f1m	Jaeho Shin	Development of Rationally Engineered Peptide-Targeted Liposomal Nanoparticles to Achieve Enhanced Therapeutic Efficacy with Selectivity and Design of Novel Inhibitors for Allergy	2022		.txt	text/plain	443	18	29	This is accomplished by evaluating the liposomal formulation first in vitro, and then further optimizing it in vivo by adjusting the individual design parameters, such as peptide density, linker length, peptide hydrophilicity, and particle size, to achieve maximal cellular uptake while preserving the selectivity for specific target cancer cells. Furthermore, by taking advantage of multivalency in our design and using weak-to-moderate monovalent affinity ligand peptides as the targeting elements, we are able to achieve selectivity by designing avidity for cancer cells while avoiding healthy cells/tissue.	cache/6w924b32f1m.txt	txt/6w924b32f1m.txt