id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
6395w665s12	Samantha K. Atkins	The Hemodynamic Theory of Bicuspid Aortic Valve Disease	1904		.txt	text/plain	552	19	30	This study found that AV tissue responds in a time-dependent manner to BAV leaflet WSS, with acute inflammatory and remodeling expression and activity within 24 hours that begins to decrease after 48 hours, except in the case of pro-inflammatory cytokine BMP-4 and cellular adhesion molecule VCAM-1. Despite increasing evidence for this hemodynamic etiology, the demonstration of the involvement of mechanical abnormalities in the pathogenesis of BAV disease requires the investigation of causality between the blood flow environment imposed on the leaflets and the aortic wall and the local biology, which has been lacking to date.	cache/6395w665s12.txt	txt/6395w665s12.txt