id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
4q77fr0099z	Yini Zhu	Targeting the Cancer-Cell-Intrinsic Mechanisms to Reverse the Immunosuppressive Landscape and Enhance Immunotherapy in Prostate Cancer	2022		.txt	text/plain	493	19	28	Here, we (1) discovered chromatin effector Pygo2, as a driver of PCa and have a significant amplification in PCa patients, induced the de novo resistance to immunotherapy through suppressing cytotoxic T lymphocytes (CTLs) infiltration in the tumor area, and (2) uncovered Speckle-type POZ protein (SPOP) and chromodomain helicase DNA-binding protein 1(CHD1) which frequently mutated and deleted respectively in PCa synergistically protected prostate epithelial cells from DNA damage and implied that the PCa patients with SPOP mutation and CHD1 deletion might be susceptible to poly(ADP-ribose) polymerase inhibitors(PARPi) or DNA-damaging agents and immunotherapy because of the potential higher neoantigen expression. Our results indicated that SPOP and CHD1 could synergistically promote the repair of DNA damage in prostate epithelial cells.	cache/4q77fr0099z.txt	txt/4q77fr0099z.txt