id author title date pages extension mime words sentence flesch summary cache txt 4m90dv1624f Victoria R. Zellmer Tumor-Induced Mammary Niche Alterations Stimulate Upregulation of Stromal STAT1 and Promote Tumorigenesis 1904 .txt text/plain 243 9 26 Furthermore, depletion of STAT1 in CAFs significantly reduced periductal reactive fibrosis and delayed early breast cancer progression in vivo. The tumor microenvironment (TME) – the dynamic tissue space in which the tumor exists – plays a significant role in tumor initiation and is a key contributor in cancer progression; however, little is known about tumor-induced changes in the adjacent tissue stroma. cache/4m90dv1624f.txt txt/4m90dv1624f.txt