id author title date pages extension mime words sentence flesch summary cache txt 4f16c250f9m Bhavana Palakurthi Maximizing the Anti-Tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-Specific CXCL16 and STAT1 Signaling 2022 .txt text/plain 165 7 29 We found that metronomic chemother- apy (MCT) treatment led to an accelerated T cell exhaustion through CXCL16- mediated recruitment of peripheral immature myeloid cells and expansion of STAT1- driven PD-L1 expressing myeloid cells. Our study leveraged single-cell analyses to dissect the dynamics of breast cancer TIME and provides a pre-clinical rationale to translate the anti-STAT1 plus anti-PD-1 combinatorial immunotherapy regimen to maximize ICB's efficacy. cache/4f16c250f9m.txt txt/4f16c250f9m.txt