id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
1r66j100r5h	Michael William Handlogten	Design of a Heterobivalent Inhibitor of Allergy and More Physiologically Relevant Allergy Models	2013		.txt	text/plain	348	10	28	These dual targeting HBIs had greater than 120 fold increased affinity for the target IgE compared to the monovalent hapten and prevented mast cell degranulation in a variant of the commonly used DNP/IgEDNP allergy model, however due to the many simplifications of this allergy model a more advanced heterotetravalent allergen (HtTA) model was developed. The HtTA allergy model allowed an integrative approach to study mast cell degranulation by presenting 2 haptens each with a valency of 2 and requiring both hapten specific IgEs to be present on the mast cell surface to stimulate degranulation.	cache/1r66j100r5h.txt	txt/1r66j100r5h.txt