id author title date pages extension mime words sentence flesch summary cache txt 0g354f18w6x Nishant Kumar Singh Structural Drivers of Antigen Specificity in T Cell Receptors 2018 .txt text/plain 173 6 27 Overall, our results show that the positions on the CDR loops associated with antigen specificity are broadly distributed among the germline and hypervariable loops, and include interactions with both the peptide and MHC protein, with significant implication for engineering TCRs with novel binding properties. I, in conjunction with our collaborators at University of Illinois and Loyola University, combined structural and functional analysis with deep mutational scanning to gain insight into the encoding of TCR specificity. cache/0g354f18w6x.txt txt/0g354f18w6x.txt