Springer A++ Viewer


PublisherInfo

PublisherName : BioMed Central

PublisherLocation : London

PublisherImprintName : BioMed Central

Tumor suppression by FEZ
ArticleInfo

ArticleID : 4182

ArticleDOI : 10.1186/gb-spotlight-20010821-01

ArticleCitationID : spotlight-20010821-01

ArticleSequenceNumber : 253

ArticleCategory : Research news

ArticleFirstPage : 1

ArticleLastPage :

ArticleHistory :
RegistrationDate : 2001–08–21

OnlineDate : 2001–08–21

ArticleCopyright : BioMed Central Ltd2001

ArticleGrants :

ArticleContext : 130592211

2



Jonathan B Weitzman
Email: jonathanweitzman@hotmail.com

The FEZ1/LZTS1 gene maps to chromosome 8p22, a region lost in many tumors. In the Early Edition
of the Proceedings of the National Academy of Sciences, Hideshi Ishii and colleagues, from Thomas
Jefferson University, Philadelphia, describe a mechanism for FEZ1-mediated growth suppression. They
created an inducible gene-expression system in MCF7 breast cancer cells, in which FEZ1 expression
was controlled by tetracycline. FEZ1 expression inhibited cell growth in vitro (at the S-phase to G2/M
transition in the cell cycle) and tumor formation in vivo. Ishii et al.demonstrated that the FEZ1 protein is
phosphorylated by cAMP-dependent protein kinase (PKA) during the cell cycle. Two-hybrid protein-
protein interaction analysis in yeast showed that FEZ1 interacts with elongation factor EF1γ. Also, FEZ1
is associated with microtubule components and with the p34cdc2 mitotic kinase. FEZ1 appears to
suppress tumor growth by regulating microtubule dynamics and progression through mitosis.

References
1. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in
multiple human tumors.

2. Proceedings of the National Academy of Sciences , [http://www.pnas.org]

3. Thomas Jefferson University , [http://www.tju.edu]

4. FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.,
[http://www.pnas.org/cgi/content/abstract/181222898v1]

This PDF file was created after publication.

http://www.pnas.org
http://www.tju.edu
http://www.pnas.org/cgi/content/abstract/181222898v1

	Tumor suppression by FEZ
	References