[PDF] Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1074/jbc.RA118.002934 Corpus ID: 49314626Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature @article{Neill2018EndorepellinRT, title={Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature}, author={T. Neill and E. Andreuzzi and Z. Wang and S. Peiper and Maurizo Mongiat and R. Iozzo}, journal={The Journal of Biological Chemistry}, year={2018}, volume={293}, pages={12137 - 12148} } T. Neill, E. Andreuzzi, +3 authors R. Iozzo Published 2018 Chemistry, Medicine The Journal of Biological Chemistry Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and induces autophagy in endothelial cells. To further investigate this property, we used NanoString, a digital PCR platform for measuring pre-defined transcripts in biological samples to analyze a custom subset of 95 autophagy-related genes in human… Expand View on ASBMB jbc.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 10 CitationsBackground Citations 2 Methods Citations 1 View All Figures and Topics from this paper figure 1 figure 2 figure 3 figure 4 figure 5 figure 6 View All 6 Figures & Tables Heparitin Sulfate Neoplasms Endothelial Cells Autophagy Proteoglycan Transcript Protein Tyrosine Kinase Cleaved cell mitochondrial depolarization PARK2 gene Mitofusin-2 Endothelial Growth Factors KDR gene Growth Factor Receptors Transcriptome TCHP gene Tumor Suppressor Genes Membrane Potentials Reverse Transcriptase Polymerase Chain Reaction Umbilical vein Subgroup 10 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells Aastha Kapoor, C. G. Chen, R. Iozzo Chemistry, Medicine The Journal of Biological Chemistry 2020 4 View 5 excerpts, cites background and methods Save Alert Research Feed Proteoglycan-driven Autophagy: A Nutrient-independent Mechanism to Control Intracellular Catabolism T. Neill, Simone Buraschi, Aastha Kapoor, R. Iozzo Chemistry, Medicine The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2020 2 Save Alert Research Feed Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis. C. G. Chen, Maria A. Gubbiotti, +4 authors R. Iozzo Chemistry, Medicine Matrix biology : journal of the International Society for Matrix Biology 2020 8 PDF Save Alert Research Feed Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology C. G. Chen, R. Iozzo Biology, Medicine The Journal of Biological Chemistry 2020 Save Alert Research Feed Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy. Maria A. Gubbiotti, Simone Buraschi, Aastha Kapoor, R. Iozzo Biology, Medicine Seminars in cancer biology 2019 16 Save Alert Research Feed Extracellular matrix: the gatekeeper of tumor angiogenesis. M. Mongiat, Simone Buraschi, E. Andreuzzi, T. Neill, R. Iozzo Chemistry, Medicine Biochemical Society transactions 2019 9 Save Alert Research Feed Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression S. Brassart-Pasco, S. Brézillon, B. Brassart, L. Ramont, J. Oudart, J. C. Monboisse Chemistry, Medicine Frontiers in Oncology 2020 20 View 1 excerpt, cites background Save Alert Research Feed Role of Extracellular Matrix in Gastrointestinal Cancer-Associated Angiogenesis E. Andreuzzi, A. Capuano, +7 authors M. Mongiat Medicine International journal of molecular sciences 2020 5 PDF Save Alert Research Feed Complexity of matrix phenotypes R. Iozzo, A. Theocharis, T. Neill, N. Karamanos Medicine, Computer Science Matrix biology plus 2020 1 Save Alert Research Feed Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases. N. Karamanos, A. Theocharis, T. Neill, R. Iozzo Biology, Medicine Matrix biology : journal of the International Society for Matrix Biology 2019 101 Save Alert Research Feed References SHOWING 1-10 OF 141 REFERENCES SORT BYRelevance Most Influenced Papers Recency Endorepellin-evoked Autophagy Contributes to Angiostasis * A. Goyal, Maria A. Gubbiotti, Daphney Chery, L. Han, R. Iozzo Biology, Medicine The Journal of Biological Chemistry 2016 28 PDF Save Alert Research Feed Endorepellin Evokes Autophagy in Endothelial Cells* C. Poluzzi, J. Casulli, A. Goyal, Thomas J Mercer, T. Neill, R. Iozzo Biology, Medicine The Journal of Biological Chemistry 2014 57 PDF View 7 excerpts, references background and results Save Alert Research Feed The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy Stephen M. Douglass, A. Goyal, R. Iozzo Biology, Medicine Connective tissue research 2015 48 PDF View 2 excerpts, references background Save Alert Research Feed Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin G. Bix, Jian Fu, +9 authors R. Iozzo Biology, Medicine The Journal of cell biology 2004 184 PDF View 2 excerpts, references background Save Alert Research Feed Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers. C. Poluzzi, R. Iozzo, L. Schaefer Biology, Medicine Advanced drug delivery reviews 2016 55 Save Alert Research Feed Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. A. Nyström, Zabeena P. Shaik, +5 authors R. Iozzo Biology, Medicine Blood 2009 57 View 1 excerpt, references background Save Alert Research Feed Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) A. Goyal, Nutan Pal, +7 authors R. Iozzo Biology, Medicine The Journal of Biological Chemistry 2011 79 PDF View 5 excerpts, references background Save Alert Research Feed Endorepellin, a Novel Inhibitor of Angiogenesis Derived from the C Terminus of Perlecan* M. Mongiat, S. Sweeney, J. S. San Antonio, Jian Fu, R. Iozzo Biology, Medicine The Journal of Biological Chemistry 2003 296 PDF View 3 excerpts, references background Save Alert Research Feed BMP-1/Tolloid-like Metalloproteases Process Endorepellin, the Angiostatic C-terminal Fragment of Perlecan* E. González, C. Reed, +5 authors R. Iozzo Biology, Medicine Journal of Biological Chemistry 2005 166 PDF View 1 excerpt, references background Save Alert Research Feed Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways A. Goyal, C. Poluzzi, +4 authors R. Iozzo Biology, Medicine The Journal of Biological Chemistry 2012 55 PDF Save Alert Research Feed ... 1 2 3 4 5 ... Related Papers Abstract Figures and Topics 10 Citations 141 References Related Papers Stay Connected With Semantic Scholar Sign Up About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. 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