Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1038/jid.2015.50 Corpus ID: 6804281Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain @article{Andrews2015KeloidPP, title={Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain}, author={Jonathan P. Andrews and J. Marttala and E. Macarak and J. Rosenbloom and J. Uitto}, journal={The Journal of investigative dermatology}, year={2015}, volume={135}, pages={1921 - 1924} } Jonathan P. Andrews, J. Marttala, +2 authors J. Uitto Published 2015 Biology, Medicine The Journal of investigative dermatology Fibronectins (FNs) are high molecular weight glycoproteins present in extracellular connective tissue matrices (ECM) and extracellular fluids, including blood plasma. The human FN gene consists of 45 exons, and the primary mRNA transcripts are alternatively spliced to form up to 20 different mRNA variants (White et al., 2008). The FNs interact with other matrix proteins, such as collagens, glycosaminoglycans and fibrin, as well as cell surface receptors, including integrins α9β1, α5β1 and αvβ3… Expand View on PubMed jidonline.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 22 CitationsBackground Citations 8 View All Figures and Topics from this paper figure 1 Keloid Fibronectins Specimen inorganic phosphate incubated Norepinephrine Buffers Radioimmunoprecipitation Assay Edetic Acid Pulmonary Fibrosis Congenital Abnormality Staining method Transcript Betadine Glycosaminoglycans FN-TGM2 complex Exons Status Epilepticus Fluorides Reducing Agents Extraction Null Value Connective Tissue Molecular Weight nervous system disorder 22 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain. Rhiannon Kelsh-Lasher, A. Ambesi, C. Bertram, P. McKeown-Longo Biology, Medicine The Journal of investigative dermatology 2017 18 PDF Save Alert Research Feed Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases E. Macarak, P. Wermuth, J. Rosenbloom, J. Uitto Medicine, Biology Experimental dermatology 2020 2 Save Alert Research Feed Fibronectin extra domain A (FN-EDA) elevates intraocular pressure through Toll-like receptor 4 signaling A. L. Roberts, T. Mavlyutov, +4 authors C. McDowell Chemistry, Medicine Scientific Reports 2020 3 PDF Save Alert Research Feed Knockdown of fibronectin extra domain B suppresses TGF-β1-mediated cell proliferation and collagen deposition in keloid fibroblasts via AKT/ERK signaling pathway. J. Cui, Zhouna Li, C. Jin, Zhe-Hu Jin Chemistry, Medicine Biochemical and biophysical research communications 2020 1 Save Alert Research Feed EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation. Rhiannon M Kelsh, P. McKeown-Longo, R. Clark Chemistry, Medicine The Journal of investigative dermatology 2015 23 PDF View 2 excerpts, cites background Save Alert Research Feed TLR4 Ligands Selectively Synergize to Induce Expression of IL-8. Lauren M Valenty, Christine M. Longo, Carol Horzempa, A. Ambesi, P. McKeown-Longo Biology, Medicine Advances in wound care 2017 2 PDF View 1 excerpt, cites background Save Alert Research Feed Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways W. Wang, M. Qu, +7 authors Yue-lei Chen Medicine Journal of Molecular Medicine 2016 29 PDF View 1 excerpt, cites background Save Alert Research Feed Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment. Jonathan P. Andrews, J. Marttala, E. Macarak, J. Rosenbloom, J. Uitto Medicine Matrix biology : journal of the International Society for Matrix Biology 2016 110 Save Alert Research Feed Long non-coding RNA expression profiling in the lesional tissue and derived fibroblasts of keloid Chunyu Yuan, Wen-bo Bu, +6 authors H. Gu Medicine Postepy dermatologii i alergologii 2017 3 PDF View 1 excerpt, cites background Save Alert Research Feed Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program J. McKeown-LongoPaula, J. HigginsPaul Biology 2017 5 Save Alert Research Feed ... 1 2 3 ... References SHOWING 1-10 OF 12 REFERENCES SORT BYRelevance Most Influenced Papers Recency New insights into form and function of fibronectin splice variants E. White, F. Baralle, A. Muro Medicine The Journal of pathology 2008 256 View 1 excerpt, references background Save Alert Research Feed The Extra Domain A of Fibronectin Activates Toll-like Receptor 4* Y. Okamura, M. Watari, +5 authors J. Strauss Biology, Medicine The Journal of Biological Chemistry 2001 1,174 PDF Save Alert Research Feed Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan A. Muro, A. Chauhan, +4 authors F. Baralle Biology, Medicine The Journal of cell biology 2003 274 PDF View 1 excerpt, references background Save Alert Research Feed FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-Like Receptor Signaling S. Bhattacharyya, Zenshiro Tamaki, +5 authors J. Varga Biology, Medicine Science Translational Medicine 2014 139 View 1 excerpt, references background Save Alert Research Feed Transforming growth factor β regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts E. Balza, L. Borsi, G. Allemanni, L. Zardi Biology, Medicine FEBS letters 1988 179 View 1 excerpt, references background Save Alert Research Feed Fibronectin (FN) in hypertrophic scars and keloids C. Ward Kischer, MaryJ.C. Hendrix Chemistry, Medicine Cell and Tissue Research 2004 64 Highly Influential View 2 excerpts, references background Save Alert Research Feed Fibronectin gene expression differs in normal and abnormal human wound healing Jill C. Sible, E. Eriksson, Steven P. Smith, N. Oliver Chemistry, Medicine Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 1994 19 Highly Influential View 3 excerpts, references background Save Alert Research Feed The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin I. Charo, L. Nannizzi, J. Smith, D. Cheresh Biology, Medicine The Journal of cell biology 1990 226 Highly Influential PDF View 4 excerpts, references background Save Alert Research Feed Regulation of Fibronectin EDA Exon Alternative Splicing: Possible Role of RNA Secondary Structure for Enhancer Display A. Muro, M. Caputi, R. Pariyarath, F. Pagani, E. Buratti, F. Baralle Biology, Medicine Molecular and Cellular Biology 1999 130 PDF View 1 excerpt, references background Save Alert Research Feed Keloids: current concepts of pathogenesis (review). G. Bran, U. Goessler, K. Hormann, F. Riedel, H. Sadick Medicine International journal of molecular medicine 2009 168 View 1 excerpt, references background Save Alert Research Feed ... 1 2 ... Related Papers Abstract Figures and Topics 22 Citations 12 References Related Papers Stay Connected With Semantic Scholar Sign Up About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. 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