[PDF] Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1074/jbc.M117.791731 Corpus ID: 22558737Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors @article{Ahn2017ComplexIO, title={Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors}, author={K. Ahn and M. Root}, journal={The Journal of Biological Chemistry}, year={2017}, volume={292}, pages={16498 - 16510} } K. Ahn, M. Root Published 2017 Medicine, Biology The Journal of Biological Chemistry The homotrimeric HIV-1 envelope glycoprotein (Env) undergoes receptor-triggered structural changes that mediate viral entry through membrane fusion. This process is inhibited by chemokine receptor antagonists (CoRAs) that block Env–receptor interactions and by fusion inhibitors (FIs) that disrupt Env conformational transitions. Synergy between CoRAs and FIs has been attributed to a CoRA-dependent decrease in the rate of viral membrane fusion that extends the lifetime of the intermediate state… Expand View on ASBMB jbc.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 8 CitationsHighly Influential Citations 1 Background Citations 4 Methods Citations 1 View All Figures, Tables, and Topics from this paper figure 1 table 1 figure 2 figure 3 figure 4 figure 5 figure 6 figure 7 figure 8 View All 9 Figures & Tables chemokine receptor enfuvirtide Membrane Fusion ERVW-1 gene Antiviral Agents fusion inhibitor receptor binding viral membrane HIV Infections Kinetics Affinity Cora (plant) Paper Mentions News Article HIV Drugs: Why Do Some Act Synergistically and Others Not? Technology Networks 9 October 2017 News Article Here's Why HIV Drugs Don't Synergize Medindia 3 October 2017 News Article When HIV Drugs Dont Cooperate Infection Control Today 2 October 2017 News Article When HIV drugs don't cooperate EurekAlert! 2 October 2017 8 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Structural and Thermodynamic Analysis of HIV-1 Fusion Inhibition Using Small gp41 Mimetic Proteins. S. Jurado, Mario Cano-Muñoz, +7 authors F. Conejero-Lara Chemistry 2019 2 Save Alert Research Feed Identification of a glycan cluster in gp120 essential for irreversible HIV-1 lytic inactivation by a lectin-based recombinantly engineered protein conjugate. Bibek R Parajuli, K. Acharya, +6 authors I. Chaiken Chemistry, Medicine The Biochemical journal 2020 Save Alert Research Feed How entry inhibitors synergize to fight HIV G. Melikyan Biology, Medicine The Journal of Biological Chemistry 2017 7 Highly Influenced PDF View 3 excerpts, cites background Save Alert Research Feed Molecular mechanism of HIV-1 resistance to sifuvirtide, a clinical trial–approved membrane fusion inhibitor D. Yu, X. Ding, +6 authors Y. He Chemistry, Medicine The Journal of Biological Chemistry 2018 11 PDF View 1 excerpt, cites background Save Alert Research Feed Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin Alexander Herrmann, M. Roesner, +5 authors R. Brack-Werner Biology, Medicine Scientific Reports 2020 1 PDF Save Alert Research Feed Comparison of null models for combination drug therapy reveals Hand model as biochemically most plausible Mark Sinzger, J. Vanhoefer, C. Loos, J. Hasenauer Computer Science, Biology 2018 PDF View 2 excerpts, cites background Save Alert Research Feed Comparison of null models for combination drug therapy reveals Hand model as biochemically most plausible Mark Sinzger, J. Vanhoefer, C. Loos, J. Hasenauer Computer Science, Medicine Scientific Reports 2019 3 PDF View 2 excerpts, cites methods Save Alert Research Feed The Herbert Tabor Young Investigator Awards: Meet the awardees! L. Gierasch, G. Demartino Sociology, Medicine The Journal of Biological Chemistry 2018 3 PDF View 1 excerpt, cites background Save Alert Research Feed References SHOWING 1-10 OF 80 REFERENCES SORT BYRelevance Most Influenced Papers Recency Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding Kristen M Kahle, H. Steger, M. Root Chemistry, Medicine PLoS pathogens 2009 48 PDF View 25 excerpts, references background and methods Save Alert Research Feed Kinetic Dependence to HIV-1 Entry Inhibition* H. Steger, M. Root Chemistry, Medicine Journal of Biological Chemistry 2006 63 PDF View 5 excerpts, references methods and background Save Alert Research Feed Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics J. Reeves, S. Gallo, +9 authors R. Doms Biology, Medicine Proceedings of the National Academy of Sciences of the United States of America 2002 418 PDF Save Alert Research Feed Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer Mukta D. Khasnis, Konstantine Halkidis, A. Bhardwaj, M. Root Chemistry, Medicine PLoS pathogens 2016 13 PDF View 3 excerpts, references background and methods Save Alert Research Feed Kinetic Factors Control Efficiencies of Cell Entry, Efficacies of Entry Inhibitors, and Mechanisms of Adaptation of Human Immunodeficiency Virus E. Platt, James P. Durnin, D. Kabat Biology, Medicine Journal of Virology 2005 113 PDF View 1 excerpt, references results Save Alert Research Feed Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein M. Root, D. Hamer Biology, Medicine Proceedings of the National Academy of Sciences of the United States of America 2003 36 PDF View 1 excerpt Save Alert Research Feed Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation Kosuke Miyauchi, M. Kozlov, G. Melikyan Biology, Medicine PLoS pathogens 2009 64 PDF View 1 excerpt, references results Save Alert Research Feed Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors. T. Ketas, S. Holuigue, K. Matthews, J. Moore, P. J. Klasse Biology, Medicine Virology 2012 19 View 1 excerpt, references background Save Alert Research Feed Is there a future for antiviral fusion inhibitors? B. Berkhout, D. Eggink, R. Sanders Biology, Medicine Current opinion in virology 2012 64 Save Alert Research Feed HIV-1 gp41 as a target for viral entry inhibition. M. Root, H. Steger Biology, Medicine Current pharmaceutical design 2004 92 View 10 excerpts, references background Save Alert Research Feed ... 1 2 3 4 5 ... Related Papers Abstract Figures, Tables, and Topics Paper Mentions 8 Citations 80 References Related Papers Stay Connected With Semantic Scholar Sign Up About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. 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