The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1074/jbc.M117.782771 Corpus ID: 46747411The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells @article{Chen2017TheRP, title={The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells}, author={J. Chen and J. Martindale and C. Cramer and M. Gorospe and U. Atasoy and P. D. Drew and S. Yu}, journal={The Journal of Biological Chemistry}, year={2017}, volume={292}, pages={14532 - 14543} } J. Chen, J. Martindale, +4 authors S. Yu Published 2017 Biology, Medicine The Journal of Biological Chemistry In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS). Whereas many cytokines and their receptors are potently regulated via post-transcriptional mechanisms in response to various stimuli, how CCR6 expression is post-transcriptionally regulated in Th17 cells is unknown. Here, using RNA-binding protein HuR conditional knock-out (KO) and… Expand View on ASBMB doi.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 14 CitationsBackground Citations 7 Methods Citations 1 Results Citations 1 View All Figures, Tables, and Topics from this paper figure 1 table 1 figure 2 table 2 figure 3 table 3 figure 4 figure 5 figure 6 View All 9 Figures & Tables Th17 Cells Gene Expression Experimental Autoimmune Encephalomyelitis chemokine receptor CCR6 protein, human ELAVL1 wt Allele Promotion (action) Multiple Sclerosis Chemokine CCL22 Parathyroid Hormone Receptor IL8RA wt Allele CNS disorder 14 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression J. Chen, William Adamiak, Ganlei Huang, U. Atasoy, A. Rostami, Shiguang Yu Chemistry, Medicine Scientific Reports 2017 9 PDF Save Alert Research Feed RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation J. Chen, J. Martindale, +5 authors Shiguang Yu Biology, Medicine The Journal of Immunology 2020 1 View 5 excerpts, cites methods, background and results Save Alert Research Feed The retinoic acid receptor drives neuroinflammation and fine tunes the homeostasis of interleukin-17-producing T cells Rasmus Agerholm, John Rizk, Darshana Kadekar, Annie Borch, S. Hadrup, Vasileios Bekiaris Chemistry, Biology 2020 PDF View 1 excerpt, cites background Save Alert Research Feed HuR controls apoptosis and activation response without effects on cytokine 3’ UTRs Fedor V. Karginov Biology, Medicine RNA biology 2019 Save Alert Research Feed Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR) Christopher W. Schultz, R. Preet, Teena Dhir, D. Dixon, J. Brody Biology, Medicine Wiley interdisciplinary reviews. RNA 2020 12 View 1 excerpt, cites background Save Alert Research Feed Unraveling a new player in multiple sclerosis pathogenesis: The RNA-binding protein HuR. Cristiana Pistono, M. C. Monti, +9 authors A. Pascale Medicine Multiple sclerosis and related disorders 2020 1 Save Alert Research Feed Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells. Y. Zhang, Zhiyuan Wei, +6 authors Y. Tian Biology, Medicine RNA biology 2020 Save Alert Research Feed Posttranscriptional regulation of MMP‐9 by HuR contributes to IL‐1β‐induced pterygium fibroblast migration and invasion Yu-Hong Cui, Qingyang Feng, +9 authors Hong-Wei Pan Chemistry, Medicine Journal of cellular physiology 2019 View 1 excerpt, cites background Save Alert Research Feed Post‐transcriptional control of immune responses and its potential application Masanori Yoshinaga, O. Takeuchi Biology, Medicine Clinical & translational immunology 2019 5 View 2 excerpts, cites background Save Alert Research Feed Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene. J. Li, W. Durose, +6 authors K. Ikenaka Biology, Medicine Journal of neurochemistry 2020 Save Alert Research Feed ... 1 2 ... 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