Summary of your 'study carrel' ============================== This is a summary of your Distant Reader 'study carrel'. The Distant Reader harvested & cached your content into a collection/corpus. It then applied sets of natural language processing and text mining against the collection. The results of this process was reduced to a database file -- a 'study carrel'. The study carrel can then be queried, thus bringing light specific characteristics for your collection. These characteristics can help you summarize the collection as well as enumerate things you might want to investigate more closely. Eric Lease Morgan May 27, 2019 Number of items in the collection; 'How big is my corpus?' ---------------------------------------------------------- 365 Average length of all items measured in words; "More or less, how big is each item?" ------------------------------------------------------------------------------------ 2241 Average readability score of all items (0 = difficult; 100 = easy) ------------------------------------------------------------------ 59 Top 50 statistically significant keywords; "What is my collection about?" ------------------------------------------------------------------------- 43 PMC 39 Jefferson 24 University 20 Thomas 17 Feed 13 patient 13 Channel 10 Medicine 9 Cancer 9 Bax 8 Virginia 7 mitochondrial 7 Center 6 american 6 OMM 6 New 5 true 5 York 5 VDAC 5 Milton 5 MCU 5 MAC 5 HSCT 5 HLA 5 H2O2 4 ros 4 micu1 4 advertising 4 USA 4 States 4 Sodium 4 OIP106 4 Mitochondrial 4 John 4 HIV-1 4 GRIF1 4 CSI 4 Bak 4 American 3 pulmonary 3 pancreatic 3 european 3 cost 3 artery 3 William 3 Washington 3 VDAC2 3 United 3 Scholar 3 Press Top 50 lemmatized nouns; "What is discussed?" --------------------------------------------- 2298 % 2057 patient 1644 cell 1228 study 893 mitochondrial 868 t 865 o 834 year 831 time 796 case 729 r 717 p 699 i 694 e 621 n 613 datum 593 history 592 group 585 cancer 580 result 574 c 571 analysis 570 author 566 a 561 paper 525 l 519 day 517 use 517 effect 516 article 512 treatment 489 disease 487 protein 475 h 470 letter 455 care 441 fusion 430 role 430 risk 423 site 420 reference 418 tion 416 change 408 model 405 law 404 factor 403 work 400 number 397 therapy 397 activity Top 50 proper nouns; "What are the names of persons or places?" -------------------------------------------------------------- 3709 Jefferson 2125 University 1748 Thomas 1474 e 1379 de 1172 la 1114 al 989 et 966 � 865 J. 839 USA 805 y 755 Medicine 750 New 748 J 669 Philadelphia 661 Research 658 s 644 C 644 American 637 M. 627 t 595 . 581 York 567 Virginia 559 S. 540 m 532 n 502 que 497 R. 486 John 484 M 483 el 483 d 470 o 466 U.S. 452 Center 446 United 440 A 422 States 422 Press 418 C. 417 u 413 Washington 413 MD 411 Medical 411 Journal 395 PA 395 L. 388 h Top 50 personal pronouns nouns; "To whom are things referred?" ------------------------------------------------------------- 1969 we 1827 it 1414 he 885 i 786 they 468 you 431 she 392 them 236 him 148 us 110 her 84 me 83 one 74 itself 69 himself 58 themselves 18 myself 15 ourselves 15 herself 14 bl 13 yourself 9 mine 8 de- 7 hg 6 з 6 ya 6 dy- 6 ce 5 hxk2 4 ours 4 in- 3 ui 3 s 3 je 2 ’s 2 ку 2 концепція 2 yt 2 pik3ca 2 oneself 2 ie 2 http://www.cfr.org/publication.html?id=5772 2 his 2 em 2 day-1 2 au 1 지인과 1 전혀 1 심사필 1 는 Top 50 lemmatized verbs; "What do things do?" --------------------------------------------- 17985 be 4372 have 1367 use 1185 do 894 show 805 include 633 see 617 find 605 make 559 provide 534 follow 517 increase 491 induce 464 report 455 suggest 455 base 433 publish 407 take 386 associate 380 receive 378 compare 354 write 351 know 336 give 323 identify 323 develop 312 require 309 remain 305 note 297 treat 297 lead 293 say 293 bind 291 support 289 contain 273 relate 265 involve 262 become 260 consider 256 continue 254 serve 252 present 246 cite 242 cause 234 perform 234 allow 233 describe 230 appoint 229 determine 228 indicate Top 50 lemmatized adjectives and adverbs; "How are things described?" --------------------------------------------------------------------- 2344 not 979 also 975 other 954 more 750 only 748 - 700 high 661 most 612 first 572 well 539 such 489 however 484 low 483 early 457 american 452 as 448 new 447 clinical 392 many 370 available 365 true 351 large 346 french 337 important 334 specific 328 medical 317 different 314 political 300 great 300 even 296 long 293 significant 285 so 285 same 285 human 283 further 279 then 279 single 266 false 265 free 255 patient 253 old 251 similar 248 out 246 non 245 less 243 thus 242 very 241 up 241 several Top 50 lemmatized superlative adjectives; "How are things described to the extreme?" ------------------------------------------------------------------------- 182 most 136 least 106 good 69 Most 45 high 31 great 30 large 18 low 16 early 12 late 12 bad 9 old 8 strong 6 big 5 simple 4 tight 4 southw 4 manif 4 e 4 clear 4 broad 4 Least 3 northw 3 long 3 eld 3 close 2 young 2 ret 2 rare 2 poor 2 overharv 2 near 2 deep 1 𝑡-t 1 year.2 1 wide 1 warm 1 true 1 slight 1 shown2mmaway 1 short 1 safe 1 rich 1 proud 1 plain 1 pC02 1 ofJNNP 1 new 1 j 1 irAEs Top 50 lemmatized superlative adverbs; "How do things do to the extreme?" ------------------------------------------------------------------------ 479 most 58 least 26 well 3 worst 2 highest 1 vest 1 long 1 fromthe Top 50 Internet domains; "What Webbed places are alluded to in this corpus?" ---------------------------------------------------------------------------- 233 www.cambridge.org 219 dx.doi.org 192 doi.org 107 m 83 www.ncbi.nlm.nih.gov 43 europepmc.org 37 www.karger.com 37 cancerdiscovery.aacrjournals.org 34 creativecommons.org 32 www.cureus.com 32 refhub.elsevier.com 30 www.afb.org 27 science.sciencemag.org 27 cancerres.aacrjournals.org 24 www.neurology.org 22 online.liebertpub.com 21 scholar.google.com 20 www.tandfonline.com 19 www.jabfm.org 18 founders.archives.gov 16 nn.neurology.org 16 n.neurology.org 15 www.sciencemag.org 14 oll.libertyfund.org 12 www.erudit.org 12 www.archives.gov 12 www.a3bs.com 12 muse.jhu.edu 12 crossmark.crossref.org 11 assets.cureus.com 10 www.jstor.org 10 www.gaumard.com 9 www.persee.fr 9 www.british-history.ac.uk 9 www.acgme.org 9 jamanetwork.com 8 neurology.org 7 jcm.asm.org 6 www.loc.gov 6 www.limbsandthings.com 6 www.biomedcentral.com 6 works.bepress.com 6 cureus.com 5 www.upress.virginia.edu 5 www.liebertpub.com 5 www.jco.org 5 www.cdc.gov 5 www 5 spie.org 5 memory.loc.gov Top 50 URLs; "What is hyperlinked from this corpus?" ---------------------------------------------------- 116 http://www.cambridge.org/core/terms 116 http://www.cambridge.org/core 107 http://m 50 http://doi.org/10.1017/S0080440119000069 43 http://europepmc.org/abstract/MED/ 28 http://doi.org/10.1017/S0025727300055290 12 http://www.neurology.org 12 http://www.jabfm.org/ 12 http://creativecommons.org/licenses/by/4.0/ 12 http://cancerdiscovery.aacrjournals.org/ 11 http://science.sciencemag.org/ 10 http://www.sciencemag.org/help/reprints-and-permissions 10 http://www.afb.org/jvib/jvib991108.asp 10 http://doi.org/10.1017/S0898588X13000059 9 http://jamanetwork.com/ 9 http://doi.org/10.1017/S0018268000041856 9 http://cancerres.aacrjournals.org/ 8 http://oll.libertyfund.org/ 8 http://neurology.org/nn 7 http://www.jabfm.org 7 http://online.liebertpub.com/doi/10.1089/pancan.2018.0004 6 http://www.erudit.org/fr/ 6 http://scholar.google.com/scholar?q=intitle:The 6 http://dx.doi.org/10.1159%2F000446271 6 http://doi.org/10.16995/dscn.277 6 http://creativecommons.org/licenses/by/4.0 6 http://cancerdiscovery.aacrjournals.org/cgi/alerts 5 http://www.sciencemag.org/about/terms-service 5 http://www 5 http://refhub.elsevier.com/S0022-5223(13)01321-4/sref11 5 http://jcm.asm.org/ 5 http://creativecommons.org/licenses/by-nc-nd/4.0/ 4 http://www.persee.fr/doc/xvii_0291-3798_2000_num_51_1_1550 4 http://www.pdffactory.com 4 http://www.neurology.org/cgi/content/full/66/4/484 4 http://www.gaumard.com/s550 4 http://www.gaumard.com/s500 4 http://www.cureus.com/users/40273-dimitrios-papanagnou- 4 http://www.cfr.org/publication.html?id=5772 4 http://www.acgme.org/outcome/comp/compHome.asp 4 http://spie.org/app/profiles/default.aspx 4 http://refhub.elsevier.com/S0022-5223(13)01321-4/sref10 4 http://jitc.bmj.com/ 4 http://dx.doi.org/10.1208/s12248-008-9053-4 4 http://dx.doi.org/10.1111/j.1525-1497.2004.30247.x 4 http://dx.doi.org/10.1016/j.radonc.2012.01.003 4 http://doi.org/10.16993/iberoamericana.478 4 http://doi.org/10.1017/S0043887100000332 4 http://doi.org/10.1017/S0034670500043771 4 http://doi.org/10.1017/S0018268000020239 Top 50 email addresses; "Who are you gonna call?" ------------------------------------------------- 8 pubs@aacr.org 4 xzhang09@gmail.com 4 walter.koch@jefferson.edu 4 pweyand@oeb.harvard.edu 4 eafoster@aol.com 4 dabbey1000@aol.com 4 .pubs@aacr.orgd 4 .pubs@aacr.org 3 mon-li.chu@jefferson.edu 2 wkurtz@virginia.edu 2 ttoma@mail.dntis.ro 2 spainr@ohsu.edu 2 scott.waldman@jefferson.edu 2 sapd@ucla.edu 2 robin.casten@jefferson.edu 2 pletsch@forestry.umt.edu 2 maj4@le.ac.uk 2 kuru@jdv.edu.in 2 jvib@afb.net 2 justinvaughn@boisestate.edu 2 ikonomij@musc.edu 2 haidar@fda.hhs.gov 2 gregory.kane@jefferson.edu 2 gbai@jhu.edu 2 erichager777@yahoo.com 2 eileen.maloney@jefferson.edu 2 dirk.deruysscher@maastro.nl 2 bpuaca@cnu.edu 2 bjrottinghaus@uh.edu 2 barry.rovner@jefferson.edu 2 bahriata@gazi.edu.tr 2 aradhak3@jhu.edu 2 anelson@education.wisc.edu 2 afbinfo@afb.net 2 a.m.rostami@jefferson.edu 2 ulrich.rodeck@mail.tju.edu 2 res950@gmail.com 2 nathan.handley@jefferson.edu 2 karinarachel89@gmail.com 2 ernesto.seman@uib.no 2 azzeyn@gmail.com 2 amanda.n.reese@gmail.com 2 alsynnestvedt@gmail.com 1 xiaobo_xy@126.com 1 vreich@stanford.edu 1 thomas.kowalski@jefferson.edu 1 theresa.yeo@jefferson.edu 1 tblumenfeld59@gmail.com 1 syed.o.shah@jefferson.edu 1 support@jstor.org Top 50 positive assertions; "What sentences are in the shape of noun-verb-noun?" ------------------------------------------------------------------------------- 11 c am b 9 d is multifunctional 8 % were caucasian 8 jefferson did not 7 % were female 7 study did not 6 % were male 6 cells showed oscillatory 6 cells were incu- 5 c induced relocation 5 jefferson was not 5 mitochondrial associated bax 5 patients were more 4 % being under- 4 % reporting severe 4 cells were more 4 jefferson did indeed 4 jefferson was there 4 patients did not 4 patients had ecog 4 patients received cyclophosphamide 4 patients using current 4 r are unclear 4 studies has unusually 4 studies have re- 4 studies provide direct 4 study provides evidence 3 cases were con- 3 cells were not 3 jefferson was only 3 patients is substantial 3 patients were able 3 study was exempt 2 % had anoma- 2 % requiring hospitalization 2 % were african 2 % were caucasians 2 % were not 2 cases reported so 2 cases were also 2 cases were hla 2 cells had robust 2 cells is dependent 2 cells is unknown 2 d is declivity 2 jefferson does not 2 jefferson was president 2 jefferson was responsible 2 jefferson wrote directly 2 patients are disease Top 50 negative assertions; "What sentences are in the shape of noun-verb-no|not-noun?" --------------------------------------------------------------------------------------- 2 % had no comorbidities 2 % were not adherent 2 jefferson was no utopian 2 patients requiring no additional 1 cases had no fol- 1 jefferson did not yet 1 jefferson is no exception 1 jefferson made no public 1 jefferson was not directly 1 jefferson was not immune 1 jefferson was not seriously 1 patients had no risk 1 s do no t 1 t is not possible 1 thomas was not able 1 time is not right Sizes of items; "Measures in words, how big is each item?" ---------------------------------------------------------- 30783 work_oj2hcfrsjndy5ceqapggi5jnye 29200 work_f7drlpbeuzc6vp7tmtbbujwmo4 26061 work_5xmswbi4vbcltarsolsbpfkoce 18861 work_jb26bv33fnbgrbkbbfy324nqry 16767 work_i472kap5ejf5rdur3za75zbqia 15772 work_bc4eeq3lwjhlnj2nu6n66f656q 14624 work_ouoelfomejbftnozksouqbcs5y 12730 work_6ljb6ohxbnboxdvv4z3sfn6zsu 12357 work_u6hptdchl5ftja4vpftl5irhp4 10513 work_wkfxqckxubf4row2dc2uboj54a 10367 work_ks3o5n7e5jbg3o5rnyyakcvily 10054 work_bt5xvtxekzetfozjy2mszf6yxy 9538 work_25dcj7duczc3habhr2kdi3m4pq 9297 work_rub6ij7p3bfsniuxaj7ol2tpua 8897 work_i3ya3uetzzdedebpvrojgucbem 8249 work_zvxxhxf3sjdztkkg4qvgyu2jya 7932 work_lxzohfh3w5h65app3cz5xzlcqu 7847 work_z6y5jhaganejpod7he4pgtxiba 7814 work_gycky3uo6bewrdyivudpoxijxa 7394 work_gxbygdbdlzbuhmly7jz7ifnlfm 6835 work_4hjwkfv47rcnpiwrhqqgky5z5y 6571 work_toganz75qrdfzgnrxwrvy4vzbq 6559 work_jcidujmtybar7mpakfqg2ygwmm 6252 work_4b7mg2kk5vf5xn5j3txw3rdklq 5798 work_oqu6gjgzw5aaljenenxgf6an5y 5705 work_nxtajoo3ajhd3lxmxvv5vmw3bu 5703 work_tn7ctpntp5fk3fdrtfm7vmrqm4 5672 work_bgc6ssit5fdnjjgl2sjepjtara 5660 work_ps4t7x5kanbdfj64lkgjcuuavy 5078 work_h6mkrfmi5zfj3kkklfjos5e3ye 5047 work_lzdgmiz55ze7vb4ebwodl6gqfy 5026 work_ht6dow65jvbovcm6xtt4bqakmy 4856 work_qwg4h76wwvbfloo7ikmvegm4te 4820 work_n4usqfb455ggxbynaci4pswvku 4798 work_fq3gijbqezcqfgcxxnzfzglj3q 4565 work_ucr5v4gzqnhu5jr3qkqmfteeya 4496 work_7t6wuhvmvnee3nndlesmclytvq 4470 work_25mhms4zovgqhak6b4pwyzptei 4446 work_sx2mti2acnfqdmxgzyq6o622ku 4372 work_5q6nq6njevazxcs4cezvrjjbzq 4202 work_b62rxd2yenfjpceh22zuvjzqru 4103 work_u2dv6vc2anakrjdmv4l42enoum 3999 work_f2i6belgkzaolg54vnd6ylfkbq 3911 work_qu4j5vmrmvgn3ndf4jugjlvotm 3881 work_p3xvzfb5qnev5mxvfcqon4ggzq 3614 work_zxiop7hzvvbk3pg5uha447xlmu 3589 work_igkr4atmrjaffibtgqagu3cuse 3524 work_2rlajuwylja2lbkwp647j4nnoy 3389 work_yrgkfxaypjhwrcelbejhpmzbnq 3312 work_rxefowy3qbacdjsh7da6wp2eca 3305 work_ecr4eurpube5nnhlofop25u2rm 3227 work_7yf4qwfjmvd5tocqawwezffaju 3214 work_b34uk64ij5hm3hyh2dek5zfbtm 3181 work_7khgf6akzbfntedngeb3b6ed6y 3179 work_anbgrjkyhzf7npnepuuurbrycy 3169 work_7jbkzpspjndzpjsju575jkdoou 3152 work_6fcpsk4s6ffqbbiijqxl644ppm 3100 work_wgf2msbacfaetpobn6pl73o5ui 3046 work_kyngdaqaynbchmtuuhelcjmzvq 3020 work_ncb3aud2g5ebjlpiiax275hz7e 3013 work_bcdkx2x635cq3n2rul6aysbkiu 2961 work_4mhsxy6uzveetlaj6fn3zadkia 2907 work_72ewughxa5fydaj6bqf3lu74pq 2895 work_sr2zxr76qrcrfdmqn3xibcmixq 2884 work_3lfxdqrjqbcffk5deirop3j3mq 2871 work_2imd7rx4qzdqtlbif74rrumclm 2866 work_za5po6cz5zdkxk5sblzd3ws5py 2838 work_xp3xzlhaybhyfdpj2wlkbvgova 2783 work_fp3i33dllna4nhahi6vk6dmtom 2759 work_bqq5zgzm4nd5hdz7mxmon5jnxy 2723 work_l6ilujshwrh6zmjv37za3by6iy 2634 work_veau5scdkratpfqwspftdidgaa 2628 work_il2ytikkcvhktlpwxw46dgflri 2626 work_uc2s5avzwnc6hia5dw7vqm2cru 2550 work_blwyqxj2zjdxphejzl6ng5gs3y 2514 work_ijyhzd6gvfe6ziaas7xm23q4li 2503 work_ea7xhzzxnvghvbbfe7fvnmrg74 2481 work_dayz2iy525aotchtbl2gyobm2a 2481 work_63xqyjlaxbhnhb6c5hu5jlo5xu 2480 work_4jheoe6s5jbc5lxgowinku6jgi 2437 work_ocbnxupirban5l6i2nikb5nkyu 2399 work_2pgqcqsi2bdf5porqgz6zwzj3e 2376 work_26dcccnkargwxlkj3sryto232e 2371 work_knc3kts4s5ak7dfmuw2hwsyfu4 2353 work_ubulcdtip5hanpzapkfyzkfyku 2341 work_xai5uteqojdvlerxixyal7mgqm 2330 work_clhxj3r6pndirghkema3cc6pny 2307 work_6ripg5mayvfq5dtx5vqd6cuxnm 2272 work_knnzct6pkfgc3fx5egkozpsgei 2266 work_tdyzby7r7fgxhgyeyitcd27eka 2239 work_gtx2btazrvfgnayzuyenwoixgi 2235 work_y2yuwf7anjc2jkmyhgbfhuzjea 2220 work_qzi2ceoworejjkvejzljzm6xpi 2209 work_3qtgbd6zv5cp3oxsj4ydrr56tu 2207 work_7srw72wiangpno7oaikrfgta4y 2187 work_cayyxzwg7vag5mih4mex56qifq 2155 work_atj3w6poyvcehgp2shpyuvc2pm 2115 work_kxfbgxp3ofbvng72zikzrcr6zm 2101 work_wxh4ufsvcnaotk63e3xldmrm6m 2093 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MVHR 50 (1963-64): 115; E.James Ferguson, review of The Papers of Alexander Hamilton, vols. ibid.: 119-20; Charles Sellers, review of The Papers of Henry Clay, vol. Levy, review of The Papers of James Madison, vol. 31 Review of The Papers of John Adams, Series III, General Correspondence, vols. 38 Sellers raised the question of time and money in his review of The Papers of Henry Clay, vol. 39 Review of The Papers of James Madison, vols. 39 Review of The Papers of James Madison, vols. 39 Review of The Papers of James Madison, vols. review ofThe Papers of James Madison, vol. 55 Brooke Hindle, review of The Papers of Benjamin Franklin, vols. 55 Brooke Hindle, review of The Papers of Benjamin Franklin, vols. Kerber, review of The Papers of James Madison, vols. work_25mhms4zovgqhak6b4pwyzptei (TJU) developed a pilot training program for senior post-graduate-year three (PGY-3) residents of developing a resident-led, post-Emergency-Department (ED) visit TH follow-up program as integrated into an EM graduate medical education program to describe what patient complaints trained senior residents on the delivery and utility of telehealth in patient care. Residents spent four hours per week performing follow-up visits on patients seen in the ED ED patients suitable for a telehealth follow-up visit were identified by a faculty member, Prior to the TH encounter, residents reviewed the patient''s ED note from their original visit to Data collected from each encounter included the number of patient visits to the ED, chief integrating TH training into a graduate medical education program for senior EM residents is Integrating Telehealth Emergency Department Follow-up Visits into Residency Training TABLE 1: Demographic and Chief Complaint Data of Patients Receiving Telehealth (TH) Follow-Up Visits After Emergency Department Discharge (N=197) work_26dcccnkargwxlkj3sryto232e Examining Possible Influences of the Classics on Early American Leaders Three of the essays focus specifically on Jefferson: Peter Onuf''s "Ancients, Moderns, and the Progress of Mankind: Thomas Jefferson''s Classical World"; Caroline Winterer''s "Classical Taste at Monticello: The Case of Thomas Jefferson''s Daughter and Granddaughters"; and Richard Guy Wilson''s "Thomas Jefferson''s Classical Architecture: An American Agenda." Two prominently In Shalev''s, Jefferson "saw the classics as a comforting Jefferson saw little to be gained from reading the classics because Americans Perhaps because their essays are more specific in their treatments of Jefferson''s use of the classics, Winterer and Wilson find evidence that he borrowed Two additional essays address the influence of the classics on Jefferson less Hutcheson ("Thomas Jefferson and Natural Morality: Classical Moral Theory, for Jefferson, Anglo-Saxon precedents more than those of the classics provided Similarly, Shalev in his essay calculates that, in the run-up to the Revolution, Jefferson was "silent" regarding classical references. work_2d2rjxvulzfp3dxha7fey723vu Zurich Open Repository and University of Zurich CH-8057 Zurich Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-58197 Journal Article The Journal of Urology, 185(4):1447-1448. https://doi.org/10.5167/uzh-58197 https://doi.org/10.1016/j.juro.2010.11.094 https://doi.org/10.1016/j.juro.2010.11.094 Ricardo González Continence Reconstruction Using the Artificial Urinary Sphincter and the Malone Antegrade The Journal of Urology, Volume 185, Issue 4, April 2011, Pages 1444sphincter with simultaneous intestinal surgery (1,2) and 2) the importance of achieving urinary and fecal continence simultaneously (3). enterocystoplalsty since 38% of the patients needed it either to achieve continence or preserve I perform reconstructive procedures for urinary and fecal incontinence in importance of taking a holistic approach to the treatment of urinary and fecal incontinence. González, D.H. Nguyen, N. artificial urinary sphincter. J Urol, 182 (2009), p. J Urol, 182 (2009), p. González, S. González, S. González, S. González, S. J Pediatr Urol, 1 (2005), p. work_2hqf6524kbbnbpxvmkqbghqite supported by funding from the Agenzia Sanitaria e Sociale Regionale, Regione Emilia-Romagna, Italy. Correspondence to: Maurizio Leoni, care of breast cancer patients in Emilia-Romagna, Emilia-Romagna, Italy cancer survivors in one region in Italy. treated women, with incident cases of breast cancer in the years 2002-2005 who were abdominal echogram, bone scans and chest x-rays were estimated from administrative data and compared by Local Health Unit (LHU) of residence. had a bone scan and 5231 (52.2%) had a chest x-ray. echograms, bone scans and chest x-rays were substantially higher in the population of breast cancer survivors than in the general female population. The observed variation in the use of abdominal echograms, bone scans tests in the population of postsurgical breast cancer patients in the Emilia-Romagna We recommend additional review of the methods of follow-up care in breast cancer patients in the LHUs of Emilia-Romagna, with the aim of work_2imd7rx4qzdqtlbif74rrumclm У статті виконано огляд та аналіз ідеї американського просвітника, демократа і президента США Томаса Джефферсона (1743-1826) щодо розвитку Сполучених Штатів Америки Томас Джефферсон, рання історія Сполучених Штатів Америки. Дослідження ідеї аграрного розвитку країни, чинників, котрі вплинули на становлення демократичної теорії Томаса Джефферсона, а також історична присвячені аналізу політичної діяльності лідера Американської революції і Війни за незалежність та третього президента Сполучених Штатів Америки. погляди на діяльність Томаса Джефферсона в контексті ранньої історії Сполучених Штатів Америки. теорії Томаса Джефферсона, його ідеї фермерського розвитку республіки. Метою статті є дослідження та аналіз ідеї фермерського шляху розвитку США в контексті демократичної теорії Томаса Джефферсона. Томас Джефферсон змушений був визнати необхідність промислового розвитку для майбутнього існування держави, хоча до 1805 року застерігав Америку від згубного, на його погляд, впливу промисловості, яка сприяла розвитку корупції та олігархії. шлях розвитку Сполучених Штатів Америки, за яким 5. Заслуга Томаса Джефферсона в історії Сполучених Штатів Америки полягає в утіленні демократичних основ у життя американського суспільства work_2lphv6g3ubdtxbt7wriqoe57xa sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220685566 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:26 If you need further help, please send an email to PMC. Include the information from the box above in your message. 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Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_2pgqcqsi2bdf5porqgz6zwzj3e Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 Knowledge and Use of Low Vision Services Among Persons with Age-related Macular Degeneration JVIB November 2005 work_2qse2rrmnzarlmywqwnmgdnata Background: Small bowel cancers, specifically duodenal cancer, occur at very low rates but require aggressive Case Presentation: We present the unique case of a patient with both duodenal cancer and partial intestinal Conclusion: Understanding of intestinal malrotation and review of the imaging is crucial in preparing for a resection of a duodenal tumor in a patient with this condition. Keywords: pancreaticoduodenectomy; intestinal malrotation; congenital anomaly year.2 Another rare finding in adults is intestinal malrotation (IM). with both duodenal cancer and incidental small bowel apparent structural anomalies, the patient was recommended to undergo surgical resection through a pancreaticoduodenectomy. *Address correspondence to: Deepika Koganti, MD, Department of Surgery, Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, 1015 We present a rare case of a patient with adenocarcinoma intestinal malrotation treated with pancreaticoduodenectomy]. (2018) Duodenal adenocarcinoma in a patient with partial intestinal malrotation, Journal of Pancreatic Cancer 4:1, 30–32, DOI: 10.1089/ work_2rlajuwylja2lbkwp647j4nnoy Source: OAH Magazine of History, Vol. 8, No. 4, Life in Revolutionary America (Summer, on the law to help rule their slaves. which Jefferson translated statutory law concerning slaves show how the law of helped people like Jefferson control the nor customary laws concerning slave gov Dominion law gave owners of "slaves slaves involved both customary law and Jefferson accepted the laws of Virginia, Jefferson and other slave owners had no slave law. who emancipated his slaves; Jefferson also Jefferson lived, on what the laws of his slavery were the wolf, and the law of slavery could not always protect slave Jefferson''s pronouncements about slavery slave owner, he either had to obey the laws Jefferson and the Wolf: The Sage of Monticello Confronts the Law of Slavery [pp. Jefferson and the Wolf: The Sage of Monticello Confronts the Law of Slavery [pp. Jefferson and the Wolf: The Sage of Monticello Confronts the Law of Slavery [pp. work_2siudwnejraqjjci35vkxaxrey sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220682277 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:22 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_2tfrdwufgzeyfjxtw6mjzapiqa HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol HIV-1 membrane fusion is mediated by sequential binding of the viral homotrimeric Env (gp120/gp41) to cellular CD4 and chemokine receptor (CXCR4 or bridges the viral and cellular membranes, and exposes the N-HR and C-HR domains which are targeted by HIV-1 fusion inhibitors T20 and 5-Helix, respectively. Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion a multivalent, D-peptide fusion inhibitor, PIE12-trimer. Viral propagation in increasing inhibitor concentrations produced HIV-1 populations with 50to 100-fold reduced sensitivity cholPIE12-trimer. HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol Dependent Fashion CD4 Binding Induces an Asymmetric Transition of HIV-1 Env from its Native Conformation into the Prehairpin Intermediate State Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion Inhibitor Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion Inhibitor Fusogenic Activity of the HIV-1 Gp41 MPER-TMD Region: Mechanism and Targeting by Immunogens and Inhibitors work_2ufl5n632zge3edm7bwjwo47y4 Jnana-Deepa Vidyapeeth, Pune www.jdv.edu.in Jnanadeepa ("Light of Wisdom" pronounced as Gyanadeepa) is a biannual interdisciplinary journal of religious studies closely associated With Jnana-Deepa Vidyapeeth: Pontificial Institute of Philosophy and Religion, Pune 411 014, India. Jnanadeepa is published biannually, in All correspondence (requests for subscriptions, manuscripts, books for review-two The Editor, Jnanadeepa, Jnana-Deepa Vidyapeeth, Pune 411 014, India Subscriptions could be sent from India either by Money Order or demand Draft. Money Order or Crossed Cheque is preferred. in the name of Jnana Deepa Vidyapeeth. Publisher: Kuruvilla Pandikattu for Jnana Deepa Publications. Thomas Kuriacose Book Review Editor Stephen C. Thomas Malipurathu Thomas Kattathara John Karuvelil Anil Thomas Other Countries (Air Mail) $ 40 (€ 40) $ 100 (€ 100) Paul''s Radical Dissent with the P ast Life S. Stephen Jayard ............................. S. Stephen Jayard ............................. Dissent in Democrac y: Thomas Jefferson kuru@jdv.edu.in jnanadeepa 23.1 jan 2019 dissent in democracy.pdf (p.2-157) work_2xreei2mtfhohlkb72ior62ytu PMS42 THE EFFECT OF LIFESTYLE CHOICES ON THE RISK OF IMPAIRMENT IN RHEUMATOID ARTHRITIS PATIENTS: AN ANALYSIS OF AEROBIC EXERCISE AND CIGARETTE SMOKING The Health Assessment Questionnaire (HAQ) was used to measure functional status (scores 0–3). reported signifi cantly worse scores in morning stiffness, fatigue, pain, and PCS (all CONCLUSIONS: RA patients using current SC biologics still suffer from serious impairments in symptoms, functional status, QoL, and However, patients who discontinued SC biologic therapy have signifi cantly worse symptom scores, physical functioning, and activity impairment compared with those currently being treated. Utility scores correlated signifi cantly with WOMAC™, and patients with high BMI RESULTS: Compared to the general population, our study sample performed poorly with respect to all the SF-36 domains except mental health (MH) and patients who exercise regularly have higher quality of life scores and clinical outcomes. validity of the HUI-3 for deriving utility scores for AS patients. work_33my6o4jcjc6tmenppdwy4muca found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, due to its role in supporting Bak insertion to the OMM for Bak targeting to the OMM and tBid induced cytochrome c release. 1Thomas Jefferson University, Philadelphia, PA, USA, 2Semmelweis heterogeneous distribution of OMM proteins than wild-type cells, and in particular that heterogeneity of pro-apoptotic Bak leads to dysregulation of Biddependent apoptotic signaling. Thus, OMM function depends on mitochondrial fusion BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells Which Domain of VDAC2 is Necessary for Bak Insertion to the Outer Mitochondrial Membrane and tBid Induced Cytochrome C Re ... Outer Mitochondrial Membrane Protein Distribution and Function Depend on Mitochondrial Fusion Mitochondrial Fusion Dynamics in Skeletal Muscle of Healthy and Diseased Rat Mitochondrial Fusion Dynamics in Skeletal Muscle of Healthy and Diseased Rat BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells before and after Hypericin Photodynamic Action work_3dpf3omt4vh4pbjupnuedvfiya Indeed, the report cites the approval of genetically engineered hepatitis B vaccine in 1986 as World''s Vaccines and Immunization;'' lauds recent successful campaigns to deliver vaccines against diseases-including polio, resources for new vaccines. received supplementary doses of polio vaccines during special national immunization the $600-800 million needed for vaccine preserve vaccine activity, and development of the vaccines-plus $14 for program costs. recombinant hepatitis B vaccine has been development costs for vaccines are not all that that of older vaccine products, its effectiveness the first recombinant DTaP vaccine to detoxify the pertussis toxin. wider vaccine development and usage. Program for Vaccines and Immunization. "consortia to bring vaccine prices down and Edible plant vaccines plant-based vaccine could start at the most accessible production method," he says, Even though the potato vaccine will be Even though the potato vaccine will be the first plant-based vaccine in human tri commercial edible plant vaccine will be in work_3etqynfcwrcu3gwpvh2difpbvq patients developed new web formation Topical Mitomycin-C Use in Surgery of the Anterior Commisure anterior glottic web at some point during therapy (Table 1). the AGW following MMC application (Fig 2). An anterior web in one patient Three patients developed new webs One patient with congenital glottic webbing treated cohort more than 80% of the patients treated with MMC demonstrated Six patients underwent surgery at the anterior commisure reports examining MMC in patients developing webs following SCCA patients subjected to instrumentation at the anterior commisure with subsequent application of mitomycin c were included in the study. previously known anterior glottic webs were included. glottic webbing and MMC application to the anterior commisure. MMC is effective in treating anterior glottic webs in more than 1. Edwards, J., Tanna, N., Bielamowicz, S.A. Endoscopic lysis of anterior glottic webs and silicone keel placement. webbing during therapy subsequently cleared the AGW AGW during treatment with MMC. work_3exdxcqlfff2jlbmobd4p4xsyy been used to measure binding affinity of Adnectin-A to the cell surface expressed receptor X to measure the effect of avidity of the multivalent adnectin the channel activation gate; and KChIP4a KID directly interacts with the T1 interaction between the voltage sensing domain and the intracellular activation gate underlies CSI (Bähring & Covarrubias, 2011, J Physiol 589:461studies of structural mechanisms of hERG channel activation by small molecules are truly novel. pharmacophore model for hERG channel openers using PHASE protocol. Pharmacophore model is also combined with previously developed receptorbased homology model of hERG K channel and novel activators are generated A-Type Kv4 Channel Closed-State Inactivation is Modulated by the Tetramerization Domain Interacting with Auxilary KChIP4a Two-in-One: Activation and Inactivation at the Intracellular Gate of a Kv Channel Development and Validation Studies of Universal Pharmacophore Models for hERG Channel Openers Development and Validation Studies of Universal Pharmacophore Models for hERG Channel Openers work_3hb7zo6rtrek3jsst6xfsbl6vm Case Presentation: A 77-year-old female underwent a central pancreatectomy with Roux-en-Y pancreaticojejunostomy and pancreatic stump oversew after presenting with symptoms of hypoglycemia concerning for an Conclusion: Resection of insulinomas is the preferred approach of treatment, and resection by central pancreatectomy is a safe option for benign lesions in the neck of the pancreas. Keywords: central pancreatectomy; CT scan; insulinoma; intraoperative ultrasound; pancreatic neuroendocrine Pancreatic neuroendocrine tumors (PNETs) are rare entities of the endocrine pancreas with poorly understood The patient underwent central pancreatectomy with found that patients with resected insulinomas had a The most common procedure to remove a pancreatic insulinoma is enucleation.1,2 Central pancreatectomy is rarely performed. tumor was localized to the neck of the gland, we performed central pancreatectomy with Roux-en-Y pancreaticojejunostomy to preserve maximal pancreatic Pancreatic insulinoma: Cite this article as: Nagle RT, Takyi VE, Yeo CJ (2017) Central pancreatectomy with pancreaticojejunostomy for an insulinoma: a case work_3jsou4tyqzb6ph6cjv5rlxh64q sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220678642 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:17 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_3lfxdqrjqbcffk5deirop3j3mq Thomas Jefferson and Douwes'' Method for Determining Key words: Jefferson, Douwes, Douwes'' method, latitude determination. science and mathematics and gave Jefferson a good foundation in Latin, Greek, method of calculating latitude using double solar altitudes. The first zone contains data relating to five solar altitude observations taken on February 7, 1811. be given as a fu-st approximation to the true latitude (Jefferson used 37"42''), but To those who are unfamiliar with Douwes'' method and the mathematics involved, the following illustration is offered as a key to understanding the computations that Jefferson dealt with in calculating the latitude of Poplar Forest. reference to the first solar altitude reading taken on February 7, Jefferson subtracted the sine of the lesser altitude (0.39450) from the sine of the greater altitude In "Trigonometry Problems," we are afforded a rare glimpse of Thomas Jefferson doing practical mathematics. The author thanks the University of Virginia Library for permission to reproduce Jefferson''s "Trigonometry Problems." Thomas Jefferson and mathematics. work_3mssctfusjc4td4dj4zjqhfbiy Direct Anterior Approach: Risk Factor for Early Femoral Failure of Cementless Total Hip Arthroplasty A Multicenter Study | Semantic Scholar Corpus ID: 6299470Direct Anterior Approach: Risk Factor for Early Femoral Failure of Cementless Total Hip Arthroplasty A Multicenter Study title={Direct Anterior Approach: Risk Factor for Early Femoral Failure of Cementless Total Hip Arthroplasty A Multicenter Study}, Background: The direct anterior approach for total hip arthroplasty (THA) is marketed with claims of superiority over other approaches. Early Failure of Primary Total Hip Arthroplasty: Is Surgical Approach a Risk Factor? A Comparison of Risk of Dislocation and Cause-Specific Revision Between Direct Anterior and Posterior Approach Following Elective Cementless Total Hip Arthroplasty. Perioperative Fracture Risk and Two-Year Survivorship of a Short Tapered Femoral Stem following Direct Anterior Approach Cementless Total Hip Arthroplasty with a Fracture Table Minimal Incision Surgery as a Risk Factor for Early Failure of Total Hip Arthroplasty work_3phhi5olf5ehbnyeoksqmsdscu We have recently found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, In this study, we evaluated and compared the biophysical properties of mitochondrial Ca2þ uptake in different mouse tissues. from mouse heart, skeletal muscle, liver, kidney, spleen and brown adipose tissue were patch clamped in the whole-mitoplast configuration. Bcl-xL Increases Bax Mitochondrial Localization and Activation in NonApoptotic Cells We report that, in non-apoptotic pro-lymphocyte cells, Bcl-xL induced an increase of the mitochondrial localization of Bax up to the level found in apoptotic cells. mutant of Bcl-xL, that lost its capacity to inhibit Bax-induced release of cytochrome c, still increased the mitochondrial localization of wild-type Bax, thus The Isoform Specific N Terminus of VDAC2 is Dispensable for tBid Induced Cytochrome C Release Patch-Clamp Analysis of Mitochondrial Ca2+ Uniporter in Different Tissues Bcl-xL Increases Bax Mitochondrial Localization and Activation in Non-Apoptotic Cells Bcl-xL Increases Bax Mitochondrial Localization and Activation in Non-Apoptotic Cells work_3qtgbd6zv5cp3oxsj4ydrr56tu PIN24 THE ECONOMIC IMPACT OF METHICILLIN RESISTANCE IN STAPHYLOCOCCUS AUREUS BACTEREMIA IN KOREA regression models adjusting for hospital fixed effects and patient S. aureus infection hospital stays were S. aureus infection on hospital charges and length-of-stay was OBJECTIVES: To identify factors associated with total hospital Demographic, economic, and clinical data, including length-of-stay (LOS), payer types, total costs, and Diagnosis Related Group (DRG) assignments were collected from the hospital cost accounting system. hospitalizations during the study period, 287 cases were confirmed positive for candidemia. weights, as well as age are associated with total hospital costs medical cost and prolonged hospital stay. DIRECT COSTS OF ANEMIA AMONG PATIENTS TREATED of anemia on medical resource use and cost in patients treated RESULTS: Cases included 70 patients with anemia (57 initiating, 13 worsening.) Cases had greater use of medical resources OBJECTIVES: Determine the economic impact and resource utilization of adult HIV and HCV co-infected hemophilia patients work_3tjweo4oardnnnj3kni7maaymi PublisherName : BioMed Central PublisherImprintName : BioMed Central ArticleDOI : 10.1186/gb-spotlight-20010423-01 ArticleCitationID : spotlight-20010423-01 ArticleCopyright : BioMed Central Ltd2001 Active antisense oligonucleotides directed against the insulin-like growth factor type I receptor (IGFIR/AS ODN) have shown potential as an antitumour agent in animal studies. Journal of Clinical Oncology David Andrews and colleagues from Thomas Jefferson University Hospital, Philadelphia, describe their novel implantation of IGF-IR/AS ODN-treated cells in patients studied 12 patients treated by surgery for malignant astrocytoma. collected at surgery were treated ex vivo with an IGF-IR/AS ODN and reimplanted in the rectus sheath Examination of the IGF-IR/AS ODN-treated cells after a 24-hour in situ IGF-IR was down regulated to 10% after ex vivo antisense treatment (J Clin Oncol 2001, suggests that ex vivo IGF-IR/AS ODN treatment of autologous glioma cells can induce apoptosis and an insulin-like growth factor type i receptor in malignant astrocytomas. 2. Thomas Jefferson University Hospital, [http://www.jeffersonhospital.org/show.asp?durki=3858] http://www.jeffersonhospital.org/show.asp?durki=3858 work_42cyhjxu6vfync7gcp7ouwd6gm Severe Mucositis with Bendamustine Etoposide Ara-C and Melphalan (Be-EAM) As Conditioning Regimen in Non-Hodgkin Lymphoma (NHL) Patients Undergoing Autologous Stem Cell Transplantation (AutoSCT) Cause of SCIAR is either the graft (DMSO, cell content, volume, clumping) or Melphalan (Be-EAM) As Conditioning Regimen in NonHodgkin Lymphoma (NHL) Patients Undergoing Autologous Stem Cell Transplantation (AutoSCT) Marrow Transplant and Cell Therapy, Rush University Medical IL; 3 Section of Bone Marrow Transplantation and Cell Therapy, refractory lymphoma pts undergoing autologous stem cell Methods: Data from 22 consecutive patients (pts), undergoing AutoSCT using the Be-EAM [Bendamustine200mg/m2 Conclusion: Bendamustine based conditioning is an effective regimen in patients with NHL undergoing autologous stem cell transplantation as previously reported. achieving a target autologous stem cell dose for patients also compared day 1 stem cell collection in the CTM planned plerixafor is an effective strategy for stem cell mobilization in patients being considered for autologous transplant. Autologous Stem Cell Transplantation work_42oif4ezjbaenocjjlhj7nty3e monitor clinical and patient-reported Initial Results from the CASCADE-FH Registry: CAscade SCreening 1Duke Clinical Research Institute, Durham, NC; 2University of Pennsylvania, Philadelphia, PA; 3University of Kansas, Kansas City, KS; 4Vanderbilt University, Nashville, TN; 5Oregon Health and Science University, Portland, OR; 6Baylor College of Medicine, Houston, TX; 7FH Foundation, South Pasadena, CA; 8UT Southwestern, Dallas, TX; 9Thomas Jefferson University, Philadelphia, PA; 10Rogosin Institute, New York, NY; 11MGH Heart Center, Boston, MA; 12NYU Langone Medical Center, New York, NY; 13UCLA School of Duke Clinical Research Institute Median age, years 53.0 52.0 53.0 Current LDL level (mg/dL) • Clinical events (hospitalizations, • Patient-reported outcomes (QOL, (IQRs) for continuous variables clinical data clinical data between FH patients and clinical researchers who have patterns and outcomes in this high risk patient population Baseline Characteristics of the CASCADE-FH Patient Population Treatment patterns of the CASCADE-FH Patient Population *Among patients treated with statins *Online portal patients only work_4a6d7xpno5e2jna5awvn6p3yfy sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220676998 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:15 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_4b7mg2kk5vf5xn5j3txw3rdklq Recasting the Significant: The Transcultural Memory of Alexander von Humboldt''s Visit to Philadelphia and Washington, D.C. humanities an inflated role in current accounts of the life and work of Alexander von Humboldt. Keywords: Alexander von Humboldt; cultural memory; transcultural memory; Thomas Jefferson; American Humboldt literature is the aforementioned visit to Philadelphia and Washington, D.C. in the from Humboldt''s biography and onto his influence on nineteenth-century American literary culture. that visiting the United States and encountering Thomas Jefferson profoundly affected Humboldt and visiting the United States was no mere fancy for Humboldt on his return journey; indeed, American World." McCullough, like Sachs, begins his account with Humboldt''s arrival in the United States Recent American accounts associate Humboldt''s imperative to visit the United States with his The second work on Humboldt by a European author for an American audience is Andrea Wulf''s In the field of cultural memory studies, an element such as Alexander von Humboldt is best work_4bguvjbq6jcvfj6htarzqm43bu sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220685220 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:25 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_4hjwkfv47rcnpiwrhqqgky5z5y The history of slavery in the United States is burgeoning with stories like Celia''s of sexual exploitation and victimization at the hands of predatory white men white male slave owners took advantage of the power discrepancy between themselves and their enslaved property in order to sexually harass, exploit, and assault the women and girls under their charge. work "''Prematurely Knowing of Evil Things'': The Sexual Abuse of Africans American Girls and Young Women in Slavery and Freedom," suggests: "Hammond''s introspection gives readers pause and may explain within the institution of slavery, the sexual exploitation and victimization of black women and girls was not only accepted but the cultural save black women and girls from sexual exploitation and victimization Even Brown, who effectively and emotionally described the sexual exploitation and victimization of enslaved women and girls in Clotel, voiced similar sentiments work_4jfcpmjx5jcnlpnhvqfratbv64 The anecdote came to mind after watching an exchange between host Tom Brokaw and President-elect Barack Obama on see that no-smoking rules are obeyed in his White House. you would like to bring to the White House? what we want to do is to open up the White House and… Yes, we''re going to have an education local schools into the White House. the White House where people are talking about traveling the White House so that, once again, we appreciate this possible in the White House. Scientific lectures at the White House. the White House, we have some obvious choices. president should hear Rita Colwell''s ( University of Maryland the White House lectures. directly to douglas.mccormick@ informausa.com. whom the People of the United States should invite to lecture at the People''s House, what we should ask them to talk about, 2. "To the Editor," molecularbiology.forums.biotechniques.com. the White House social calendar. We ask BioTechniques'' readers: work_4jheoe6s5jbc5lxgowinku6jgi largely pediatric patients performed at Duke and using mostly red cell table below shows the day 42 neutrophil engraftment cumulative incidence (ANC500) and graft failure probability (GF) comparisons of the CALCINEURIN-INHIBITOR FREE GVHD PROPHYLAXIS IN UNMANIPULATED HAPLOIDENTICAL STEM CELL TRANSPLANTATION (SCT) We tested this hypothesis in haploidentical peripheral blood stem cells SCT without (HR) match rate using real patient unrelated donor (URD) searches in HLA match rates and can be used to inform patients searching A 2 STEP APPROACH TO MYELOABLATIVE HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANATION (HSCT): REPORT OF A PHASE II UNMANIPULATED HAPLOIDENTICAL STEM CELL TRANSPLANTATION alternative donor sources in stem cell transplantation (SCT). the controllable GVL effect by T cells, we have performed unmanipulated haploSCT using myeloablative or reduced intensity preconditioning regimen accompanied with intensified GVHD prophylaxis. A 2 Step Approach To Myeloablative Haploidentical Hematopoietic Stem Cell Transplanation (Hsct): Report Of A Phase Ii Trial ... Unmanipulated Haploidentical Stem Cell Transplantation Using Myeloablative Or Reduced-Intensity Preconditioning Regimen work_4lq2rfmffjgwbgrjnrz2mf3a4m the identification of the viral proteins that have potent that the viral protein LMP1 activates NFkB in epithelial Recent studies of the viral protein LMP2 have shown between the effects of expression of viral proteins in Editor of Journal of Virology and Cancer Research and serves on the editorial boards of Virology, Molecular years studying the molecular virology of polyomaviruses, including SV40 and JCV in the Laboratory Molecular Virology under the direction of the late Dr the identification of a novel viral-encoded protein Molecular Biology and the Jefferson Institute of Molecular Medicine at Thomas Jefferson University. Section of the Jefferson Institute of Molecular Medicine. His research focused on the molecular pathogenesis of reactivation of JCV in immunocompromised individuals, regulation of HIV-1 in brain cells, and molecular of human neurotropic viruses (JCV, HIV), gene expression, and replication in the CNS cells. factors in the CNS, interaction of viral proteins with work_4mhsxy6uzveetlaj6fn3zadkia John Heysham Gibbon, Jr, 41st President of The American Professor John Heysham Gibbon, Jr. EDUCATION AND SURGICAL TRAINING Gibbon pursued a research fellowship position in Dr Churchill''s laboratory and in 1930 After an internship and clinical fellowships at the Pennsylvania Hospital, Dr Gibbon became a faculty member Although Dr Gibbon will always be known as the inventor of the cardiopulmonary bypass machine, he also made It was Dr Gibbon who was given the responsibility to assess her clinically and to document her pulse, respiratory rate, and blood pressure every 15 minutes starting Frank Allbritten (right) performing the first successful open heart surgery Dr Gibbon''s heart–lung bypass machine was used on an Fifty years of open-heart surgery. during the early years of open-heart surgery with the Gibbon heart–lung machine. Gibbon JH Jr. The road ahead for thoracic surgery. Historical perspectives of The American Association for Thoracic Surgery: John H. Historical perspectives of The American Association for Thoracic Surgery: John H. work_4nsmiln6bzdulde6nvnslzr5lm A 2 Step Approach To Myeloablative Haploidentical Hematopoietic Stem Cell Transplanation (Hsct): Report Of A Phase Ii Trial With 18 Months Of Follow-Up For All Patients in HLA match rates and can be used to inform patients searching A 2 STEP APPROACH TO MYELOABLATIVE HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANATION (HSCT): REPORT OF A PHASE II alternative donor sources in stem cell transplantation (SCT). the controllable GVL effect by T cells, we have performed unmanipulated haploSCT using myeloablative or reduced intensity preconditioning regimen accompanied with intensified GVHD prophylaxis. Patients under 45 years old underwent myeloablative preconditioning regimen consisting of FLU/CA/CY/ SCT) underwent reduced intensity preconditioning regimen consisting of FLU/(CA)/BU/ATG or FLU/(CA)/MEL/ATG (haplo-mini, n There is no difference in survival rate among patients'' diseases. A 2 Step Approach To Myeloablative Haploidentical Hematopoietic Stem Cell Transplanation (Hsct): Report Of A Phase Ii Trial ... Unmanipulated Haploidentical Stem Cell Transplantation Using Myeloablative Or Reduced-Intensity Preconditioning Regimen work_4q3yxfwxczas5mirr5goi5ia2a games:science:science_magazine_1920-1939:root:data:science_1920-1939:pdf:1929_v069_n1790:p1790_0410.pdf [Ganino] GANINO User Tools Site Tools Search Tools Register Register Log In Log In Recent Changes Recent Changes Media Manager Media Manager Sitemap Sitemap Trace: games:science:science_magazine_1920-1939:root:data:science_1920-1939:pdf:1929_v069_n1790:p1790_0410.pdf This topic does not exist yet You''ve followed a link to a topic that doesn''t exist yet. If permissions allow, you may create it by clicking on Create this page. Page Tools Show pagesource Show pagesource Old revisions Old revisions Backlinks Backlinks work_4ui5vgmtyfaqzfxowstezuv7re Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment. Corpus ID: 207550788Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment. title={Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment.}, author={Janice L. This issue was addressed by creating a clinically relevant epithelial ex vivo injury-repair model based on cataract surgery. In this culture model, the response of the lens epithelium to wounding can be followed live in… Expand View 3 excerpts, cites methods and background Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_5lqkdolxbng6fou5xq2sbaxdz4 PMH27: THE IMPACT OF DEPRESSION ON HEALTH-RELATED QUALITY OF LIFE (HRQL) adult and geriatric patients with schizophrenia treated Health status was measured by the SF-36 at time of admission and at three (geriatric) or six months (adult) THE IMPACT OF DEPRESSION ON HEALTHRELATED QUALITY OF LIFE (HRQL) health-related quality of life (HRQL) utilizing the SF-36 The scores of patients with depression were compared to age and gender matched US population norms and contrasted to results of similar research the adult and geriatric depression groups. scores for the adult and geriatric depression groups were both the adult and geriatric groups of depressed patients Adult inpatients with depression had similar scores on all domains However, geriatric patients with depression had lower scores on HRQL across all domains versus geriatric patients with other psychiatric illnesses. with both adult and geriatric patients'' perceived HRQL. on mental health domains, but also scored significantly health-related quality of life (HRQoL) of transformed work_5mn5cp6umffwhnphooi2wcpjgu different effects of mutations of individual asparagines on the channel activation, inactivation, and drug sensitivity. Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: We use Molecular Dynamics simulations to identify the binding sites for a hydrophobic general anesthetic isoflurane, on voltage gated bacterial sodium channel NaChBac. Apart from the NavAb was published (Payandeh et al (2011) Nature 475, 353), giving an unambiguous picture of the structure of the sodium channel selectivity filter (SF) Experimental ion selectivity determination from pore-only constructs of a sodium channel with the same SF sequence Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: Structure and Accessibility of Distinct Interaction Sites Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: Structure and Accessibility of Distinct Interaction Sites A Key Gating Charge Interaction Required for Slow Inactivation of the Navab Bacterial Sodium Channel Polymodal, High Affinity Actions of μ-Conotoxins on a Bacterial Voltage-Gated Sodium Channel work_5q6nq6njevazxcs4cezvrjjbzq resident trainees identify reportable patient safety priorities. in the Patient Safety Escape Room study as part of their residency orientation (June 2018). room, tasked with identifying a predetermined set of serious patient safety hazards, and The escape room patient-safety activity allowed interns to actively engage in an innovative Gamification to Incorporate Patient Safety Priorities Through a Simulated ''Escape Room'' Experience. Teaching patient safety and error reporting to the Graduate Medical Education (GME) Jefferson intern and resident physicians to better identify potential patient safety priorities and TABLE 1: Equipment and materials required for the patient safety escape room during the activity, as well as discussing patient safety hazards noted in the rooms. Error reporting documentation (35); the escape room experience (16); confusion on the The escape room patient-safety activity was well received by incoming resident physicians at TABLE 1: Equipment and materials required for the patient safety escape room simulation cases work_5xk6a6kxbvbz3kou7apjucxcky We have recently found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, In this study, we evaluated and compared the biophysical properties of mitochondrial Ca2þ uptake in different mouse tissues. Bcl-xL Increases Bax Mitochondrial Localization and Activation in NonApoptotic Cells We report that, in non-apoptotic pro-lymphocyte cells, Bcl-xL induced an increase of the mitochondrial localization of Bax up to the level found in apoptotic cells. mutant of Bcl-xL, that lost its capacity to inhibit Bax-induced release of cytochrome c, still increased the mitochondrial localization of wild-type Bax, thus The Isoform Specific N Terminus of VDAC2 is Dispensable for tBid Induced Cytochrome C Release Patch-Clamp Analysis of Mitochondrial Ca2+ Uniporter in Different Tissues SR-Mitochondrial Ultrastructure in the Heart of Normal and Ethanol-Fed Rats SR-Mitochondrial Ultrastructure in the Heart of Normal and Ethanol-Fed Rats Bcl-xL Increases Bax Mitochondrial Localization and Activation in Non-Apoptotic Cells work_5xmswbi4vbcltarsolsbpfkoce During this period, one other French privateering case was also entered onto the Supreme Court French privateering cases occupied a very substantial portion of the Supreme Court docket during this courts decided dozens of French privateering cases in the period from 1794 to 1797, and the executive related to the French privateering cases, including the Supreme Court papers in the referenced above, as well as some other French privateering cases that never reached the Supreme Court. French privateer obtained a valid judgment from a prize court before selling the captured ship to the British owners filed an in rem action in federal court, alleging that the capture was illegal because the ship the last French privateering case.129 During this period, the Supreme Court decided 23 captured by French privateers.171 In 14 of those cases, the courts at all three levels – French privateering cases for lack of jurisdiction, and before the Supreme Court issued its decision in Glass work_63xqyjlaxbhnhb6c5hu5jlo5xu All patients received physician directed smoking cessation counseling. recommended the book quit smoking, although this difference was not significant, p Smoking cessation rates did not appear to be impacted by reading Allen Carr''s The convincing patients to quit smoking is the best-selling self-help book The Easy Way Way to Stop Smoking by Allen Carr in achieving smoking cessation in patients being Way to Stop Smoking by Allen Carr in achieving smoking cessation in patients being recommendation to purchase the book The Easy Way to Stop Smoking by Allen Carr. read the book at all had the highest percentage of smoking cessation that patients would quit smoking, although it was not a significant cancer diagnosis was the major reason for their smoking cessation, and Identifying patients who are ready or motivated to quit smoking may patients may be more likely to successfully quit smoking. work_65jszt6plbfc3j47pcixap6yl4 PHP23 A COMPARATIVE ANALYSIS OF THE FINANCING, PRICING AND REIMBURSEMENT SYSTEMS FOR PRESCRIPTION DRUGS IN THE NORDIC COUNTRIES OBJECTIVES: To elicit similarities and differences in the policies and practices for financing, pricing and reimbursing prescription drugs in the often perceived similar Nordic countries Nordic countries all have a national health care system financed To give a systematic overview of the current state of the European pharmaceutical market as a whole. CONCLUSIONS: The future of the actors in the European pharmaceutical market is not clear. conditions and assesses related health service use and costs in the Individuals were classified as having a chronic condition in 2000, and we examined pharmacy and hospital use/costs RESULTS: We identified five highly prevalent chronic conditions: cardiovascular diseases (N = 824,190, 20.8% of the population); rheumatologic CONCLUSIONS: Interestingly, one-fourth of the population with selected chronic conditions accounted for large proportions of cost and use of health work_65l7v34ahfh7nk3are5b6izqia Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 on mitochondrial motility and its inhibition by agonist-induced cytoplasmic [Ca2þ] ([Ca2þ]c) signals in H9c2 cells. In OIP106 and GRIF1 overexpressing cells, elongated mitochondria with varied degree of aggregation were Mitochondrial contribution to cell signaling and function relies on the association and local communication of mitochondria with the ER and the plasma the kinetics and short-term effects of the linkage formation, we have now devised fluorescent protein pairs targeted to the OMM and ER or PM containing formation between the ER and mitochondria was followed by a decrease in mitochondrial motility (>40% in 15 min) and by sensitization of mitochondria to MEFs lack tBid induced complete cyto c release and loss of MEFs and also supported the tBid-induced cyto c release. Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 work_6f7jxz3anbh5pjfuasfakmg76a sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220680894 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:20 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_6fcpsk4s6ffqbbiijqxl644ppm The objective of this study was to evaluate soil erosion vulnerability in the southern region of the Meia Ponte watershed, Goias, Brazil, considering two situations: natural and anthropic cover conditions. used remote sensing data represented by several parameters: lithology, soil class, slope, rain intensity, vegetation index, vicinity For each variable, we established a scale of weights according to erosive susceptibility information in the analysis of erosive susceptibility, was used through the relationship between soil use and land occupation. southern part of the Meia Ponte River watershed, the anthropic factor showed greater influence. susceptibility were soil use and occupation, low vegetation index, and high slope. presents medium natural erosive susceptibility in most of the study area. 85Soil erosion vulnerability in the southern part of the Meia Ponte watershed, Goias, Brazil 85Soil erosion vulnerability in the southern part of the Meia Ponte watershed, Goias, Brazil use of soil, which increases erosive susceptibility. work_6gv6nnxc3nfdjefnwob632qulq Calcium-Induced ROS Generation during Ischemia Triggers mPTPDependent Cell Death during Reperfusion Impairment of mitochondrial function is a central event of ischemiareperfusion (I/R) injury leading to tissue damage and cell death. 1, ROS generation with Mito-Sox Red, mPTP opening as mitochondrial calcein ROS with superoxide dismutase mimetic MnTBAP or antioxidant Trolox prevented reperfusion-induced cell death. We conclude that mPTP-dependent cell death during reperfusion is mediated by Ca2þdependent ROS generation during ischemia. These probes, targeted to the ER lumen, ER membrane (cytosolic face), cytosol, mitochondrial matrix and outer membrane (OMM) and the IP3-receptor, of the ER membrane, bulk cytosol and mitochondrial matrix and OMM. It was found that the mitochondrial surface in close association with ER was significantly reduced in the chronic ethanol-fed condition as Calcium-Induced ROS Generation during Ischemia Triggers mPTP-Dependent Cell Death during Reperfusion Dynamic Measurement of Ca2+-Induced Changes in Organelle-Specific Redox Microdomains Dynamic Measurement of Ca2+-Induced Changes in Organelle-Specific Redox Microdomains work_6i2iwigggrfblefghe5hbmdfsu patients with neovascular AMD treated with anti-VEGF Mean age in the non-VMA group A 79-year-old man with neovascular AMD in the left eye was treated with one intravitreal bevacizumab injection A 79-year-old man with neovascular AMD in the left eye was treated with one intravitreal bevacizumab injection the non-VMA group (63% at year 2 compared with 54%, Patients in the non-VMA group The clinic utility of treating VMA associated with neovascular AMD was recently explored by Novack and coworkers12 as they investigated the use of intravitreal ocriplasmin 100 patients with VMA and wet AMD to compare combination therapy (ocriplasmin plus anti-VEGF) versus sham treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. Influence of the vitreomacular interface on outcomes of ranibizumab therapy in neovascular age-related macular degeneration. Influence of vitreomacular interface on anti-VEGF therapy using treat and extend treatment work_6ljb6ohxbnboxdvv4z3sfn6zsu For 200 years, historians have written that Thomas Jefferson and his fellow patriots brought a second printer into the colony Broader civic discourse spurred by commercial competition helped to develop new revolutionary ideals, including the concept of a constitutional protection for a free press, which ultimately was expressed in the First Thomas Jefferson has long been credited with bringing a printer to Virginia in 1765, introducing print competition to a colony that until then had only one printing press, Act and colonial printers, Thomas'' eyewitness account provided invaluable details regarding American printing, and, a great diminution of the last, provoked their united zealous opposition." While Schlesinger repeated Thomas'' claims, he also suggested the new, second printer in Virginia was not influenced by The first printer, William Parks, began his newspaper publishing with an overt recognition of the limits of press freedom and work_6qly7u7urvgsfgfh7d5cwvlinm The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells | Semantic Scholar Corpus ID: 46747411The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells title={The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells}, In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS). RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation View 5 excerpts, cites methods, background and results View 10 excerpts, references background, results and methods By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_6ripg5mayvfq5dtx5vqd6cuxnm will therefore want to teach constitutional law in the most effective is a welcome trend to offer constitutional law as a two-semester sequence, a trend reflected by text Constitution and, second, that students need a foundation in constitutional powers before they can understand constitutional rights. constitutional law teaching is simple: students learn the material better if rights issues are taught first. questions are more intuitive to students than constitutional powers rules of contract formation, questions of constitutional powers are contract, constitutional rights questions are quite familiar and understandable to students, exposed as before students step into a constitutional law classroom, few, if any, constitutional powers/rights dichotomy. rights in American political culture Thomas Jefferson put the Declaration at the top of his required reading list for government and law students (Hellenbrand 1990, 164). Reordering American Constitutional Law Teaching Reordering American Constitutional Law Teaching Hence, my rationale for teaching constitutional rights work_6vs5fvkrdfhtplqeqtlhi4k7zu G protein–coupled receptor kinase 5 in pathological cardiac hypertrophy, providing a first mechanistic target for this indication.1 kinase 5 (GRK5) is unique in hypertrophy or is redundant with other "GRK5 has been shown to be increased in heart failure," Koch Koch said that prior to aortic banding "the hearts of the GRK5 Previous work by others had also shown increased nuclear localization of GRK5 in a rat model of cardiac hypertrophy. GRK5 played a direct role in pathological hypertrophy via transcriptional regulation of genes responsible for this condition. Koch acknowledged that the effects of GRK5''s role in hypertrophy Researchers contacted by SciBX agreed that Koch''s team had identified an important mechanism in the development of cardiac hypertrophy, but they disagreed over whether the findings would easily pathological cardiac hypertrophy," he said. redundant with other class II HDAC kinases, Koch said the team is Koch said another study by the team targets GRK5 with a GRK5 work_72ewughxa5fydaj6bqf3lu74pq found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, due to its role in supporting Bak insertion to the OMM Outer Mitochondrial Membrane Protein Distribution and Function heterogeneous distribution of OMM proteins than wild-type cells, and in particular that heterogeneity of pro-apoptotic Bak leads to dysregulation of Biddependent apoptotic signaling. protein Opa1 or ethanol exposure caused suppression of fusion, which is followed by mitochondrial dysfunction and late onset myopathies. that wild-type Bcl-xL increased the mitochondrial localization of Bax; but that To understand the mechanisms involved in the control and regulation of mitochondrial reactive oxygen species (ROS) levels, a two-compartment computational Mitochondrial Energetic-Redox (ME-R) model accounting for energetic, Which Domain of VDAC2 is Necessary for Bak Insertion to the Outer Mitochondrial Membrane and tBid Induced Cytochrome C Re ... Outer Mitochondrial Membrane Protein Distribution and Function Depend on Mitochondrial Fusion Identification of Mitochondrial Proteins regulated during Activation of GPER1-Leading to Cardioprotection work_74iwhjx3kreepaep3xrq5aygky companies that support LED application markets. Attendees were offered a pleasing scenario of interesting papers on industry technology, operating factors and market growth. The growth of high brightness light emitter applications categories and their related markets (HB LEDs and some lasers) LED application area of cell phone and followed by the other large growth market segments, such as out door and indoor device HB LED market showed spectacular This degree of market growth is quite the HB LED market on a value basis, back lighting growth was also supported For the future, LED back lighting is also large unit market, but most of the HB LEDs tend not to be included in the market values. growth in most market segments, including autos, for which the first forward lighting market segment, because significant price competition is expected to result of all this HB LED growth will be an Small LED, spectacular growth work_776pakjkc5gg5gmhbtv2kr52ci and discussion of important issues related to the advancement of science, including the presentation of minority or conflicting points of view, rather than by publishing only material Accordingly, all articles published in Science-including editorials, news and News Editor: Barbara J. Research News: Roger Lewin, deputy editor; Deborah M. Adapting this observation to the new biotechnology industry, we might say that we are the problems of science to the needs of health and the economy, however, Louis Pasteur is application that is the hallmark of the current biotechnology industry. In Pasteur''s early studies he pursued the academic problem of optical antipodes, The modem technology industry parallels in uncanny ways the approach of Louis Basic research in academia leads to applications in industry. Questions posed by industrial problems generate new academic initiatives. people''s plants" that may provide more new bases for industrial crops than the 20 species on ARTICLE TOOLS http://science.sciencemag.org/content/232/4756/1313.citation http://science.sciencemag.org/content/232/4756/1313.citation work_7a6y3eyjobechkz4m2squs2x5q Conclusions: 1) Clinically significant, sustained ARRHY occurred in ~1/5 of patients in this medical-cardiologic ARRHY occurred while there were signs of inflammation P211 Transthoracic cardioversion with damped biphasic waveform shocks The objective of this prospective study was to evaluate the clinical efficacy of biphasic waveforms for cardioversion of atrial fibrillation. biphasic waveform with a delivered energy of ≤195 J was 2. Vostrikov V et al.: Resuscitation, 1998, 3(2):S42,(O–16). P212 Evaluation of transesophageal atrial pacing in the prone and lateral position Introduction: Transesophageal atrial pacing (TEAP) is placement in the prone or laterally positioned intubated patients in the supine position. heart rate and the current output on the pulse generator current was gradually increased until atrial capture was The PES was then withdrawn 1 cm at a time and pacing thresholds were redetermined for each DOI from 44 to 25 cm inclusive. data collection in the supine position, each patient was the same manner after the patients'' position was changed. work_7jbkzpspjndzpjsju575jkdoou Previous studies have shown that risk attitudes and tolerance for uncertainty are significant risk profile of EM residents using a widely available risk tolerance and attitude assessment tool. Our pilot assessment of risk types in EM residents highlighted shifts across the years of attitude that was the prominent domain for resident risk tolerance. https://www.cureus.com/users/40273-dimitrios-papanagnouKeywords: risk, risk tolerance, wellness, risk attitude, risk type, emergency medicine, graduate medical RTi scores are reported as means with 95% CIs. Differences in risk tolerance based on PGYtraining level were assessed. evaluation of risk attitudes and risk tolerance in emergency medicine. When it comes to risk attitudes, PGY-one residents were most risk tolerant with regards to the PGY-two residents were most risk tolerant with regards to PGY-three residents, who were most risk tolerant when it came to their own health and safety. An Evaluation of Risk Attitudes and Risk Tolerance in Emergency Medicine Residents work_7khgf6akzbfntedngeb3b6ed6y A trend towards higher-grade cervical intraepithelial neoplasia in the follow-up of detected HPV 16/18 was noted. follow-up results for both reflex and cotesting were observed in the 3 HPV assays. test approved by the FDA to replace the Pap test for primary screening of cervical cancer [6] . Assays for HPV DNA testing in our practice have included Digene Hybrid Capture 2 (HC 2) ® approved by A 3-month (January to March) follow-up of cases with detected HR HPV was performed for 2008 HC 2 ® , for 2011 Cervista ® , In addition, HR HPV positivity of various cytologic interpretations in Pap specimens and follow-up biopsies were obtained. Total Pap tests, ThinPreps and HR HPV testing including reflex and cotesting for the years 2003 – 2015. Table 3 shows the follow-up of HR HPV detected cases in both reflex and cotesting categories for the same ASCUS reflex HPV test by Roche Cobas®, 1-year follow-up work_7l7j377kxjcmjab3p5kfecznsy HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol HIV-1 membrane fusion is mediated by sequential binding of the viral homotrimeric Env (gp120/gp41) to cellular CD4 and chemokine receptor (CXCR4 or bridges the viral and cellular membranes, and exposes the N-HR and C-HR domains which are targeted by HIV-1 fusion inhibitors T20 and 5-Helix, respectively. Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion Viral propagation in increasing inhibitor concentrations produced HIV-1 populations with 50to 100-fold reduced sensitivity cholPIE12-trimer. HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol Dependent Fashion CD4 Binding Induces an Asymmetric Transition of HIV-1 Env from its Native Conformation into the Prehairpin Intermediate State CD4 Binding Induces an Asymmetric Transition of HIV-1 Env from its Native Conformation into the Prehairpin Intermediate State Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion Inhibitor Fusogenic Activity of the HIV-1 Gp41 MPER-TMD Region: Mechanism and Targeting by Immunogens and Inhibitors work_7m6zc6spovasjimzwz5gqgd3pu Despite calls by family medicine organizations to build research capacity within the discipline, few family physicians report research activity. Policy that supports efforts in family medicine research and increases awareness of opportunities for primary care research in the practice setting is essential for family medicine to expand its scholarly foundations. Of American Board of Family Medicine Maintenance of Certification Examination candidates Family Medicine and Primary Care, Washington, DC (AWB, Family Medicine, which contracts annually for health policy/health services research conducted by the Robert Graham Center for studies related to maintenance of certification and quality. Family Medicine and Primary Care, 1350 Connecticut Percentage of family physicians reporting time devoted to research in 2007–2009. into primary care requires more family physicians to be trained as researchers and translators. support to build research capacity and push family physicians to incorporate scholarly activity family physicians dedicating sufficient time to important research endeavors. work_7rvkaayel5eg3hn7v2rpikuv6i sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220679185 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:18 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_7srw72wiangpno7oaikrfgta4y Target Value-Tailored Apheresis Can Improve Prediction of Product Hematopoietic Progenitor Cells Prior to Autologous Transplantation Hematopoietic Stem Cell Collection in Poor Mobilizers: Background: The collection of a minimum number of hematopoietic stem cells (HSC), generally defined as 2 x 106 When used to unselected patients undergoing a first mobilization attempt, plerixafor plus GCSF allows more CD34+ The proportion lf patients in whom a minimum of 2 x 106 CD34+ cells/kg was collected ranged from 37 Methods: We conducted a retrospective study of all peripheral blood HPC apheresis collections performed at the The median pre-collection peripheral blood CD34+ cell achieve the minimum number of HPCs. The median apheresis volume for day 1 collections was 20 (range 3.6 e 24) L. stem cell mobilization using either CHM (16 patients) with cells/kg dose collection and the median number of apheresis A Plerixafor-Based Strategy Allows Adequate Hematopoietic Stem Cell Collection in Poor Mobilizers: Results from the Canadia ... work_7t6wuhvmvnee3nndlesmclytvq Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations The prevalence of hypothyroidism in our patients with pancreatic cancer was To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1. hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion (𝑃 < 0.05). We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer. argue that high levels of thyroid hormones induce cancer cell cancer, hypothyroid patients on thyroid hormone supplementation were found to have significantly (𝑃< 0.05) higher Figure 2: Effects of exogenous thyroid hormone treatment on PDAC cells proliferation, migration, and invasion (𝑃< 0.05). hormones and cancer: clinical studies of hypothyroidism in work_7ts2owjawrazrntibpl76m4yye mtDNA T8993G Mutation-Induced Mitochondrial Complex V Inhibition Augments Cardiolipin-Dependent Alterations of Mitochondrial Dynamics During Oxidative, Ca2+ and Lipid Insults in NARP Cybrids: A Potential Therapeutic Target study investigated how mtDNA T8993G (NARP)-induced inhibition of mitochondrial complex V altered mitochondrial dynamics in association with a protective mitochondrial phospholipid, cardiolipin (CL), as a potential therapeutic a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca2þ and lipidstress. Intriguingly, melatonin, by differentially preserving CL during various stresses (oxidation > Ca2þ > lipid), rescuesdifferentially CL-altered mitochondrial dynamics and cell death (oxidation > CL to prevent its oxidization and/or depletion and, therefore, it exerts great potential in rescuing CL-dependent mitochondrial dynamics-associated mitochondrial pathologies for treatment of NARP-induced pathologies and diseases. MICU1 in mitochondrial Ca2þ uptake, we used wild type HeLa cells (Ctrl), mtDNA T8993G Mutation-Induced Mitochondrial Complex V Inhibition Augments Cardiolipin-Dependent Alterations of Mitochondria ... Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells work_7xy45yhdu5aobmtarqtbrnvlme We have recently found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, In this study, we evaluated and compared the biophysical properties of mitochondrial Ca2þ uptake in different mouse tissues. Bcl-xL Increases Bax Mitochondrial Localization and Activation in NonApoptotic Cells We report that, in non-apoptotic pro-lymphocyte cells, Bcl-xL induced an increase of the mitochondrial localization of Bax up to the level found in apoptotic cells. mutant of Bcl-xL, that lost its capacity to inhibit Bax-induced release of cytochrome c, still increased the mitochondrial localization of wild-type Bax, thus The Isoform Specific N Terminus of VDAC2 is Dispensable for tBid Induced Cytochrome C Release Patch-Clamp Analysis of Mitochondrial Ca2+ Uniporter in Different Tissues Patch-Clamp Analysis of Mitochondrial Ca2+ Uniporter in Different Tissues SR-Mitochondrial Ultrastructure in the Heart of Normal and Ethanol-Fed Rats Bcl-xL Increases Bax Mitochondrial Localization and Activation in Non-Apoptotic Cells work_7yf4qwfjmvd5tocqawwezffaju The report, in a letter to the editor of the New England Journal of Medicine published on April 28, described a two-week period in which five patients between the ages of 33 and 49 presented to the Mount Sinai Health System with new-onset symptoms of large vessel ischemic stroke. Some stroke neurologists at other hospitals around the country told Neurology Today they are seeing a similar trend, consistent with an increased risk of clots forming in other organ systems; they are now recommending that all patients with COVID-19 be treated with heparin or other therapy as a preventive measure. In just the two weeks since the Mount Sinai letter was submitted to the New England Journal of Medicine, three additional cases of large-vessel stroke in young patients with COVID-19 have presented to the hospital there, according to the letter''s first author and neurologist Thomas J. work_7yswwxefmrhphbkznullcq4pxy PublisherName : BioMed Central PublisherImprintName : BioMed Central ArticleDOI : 10.1186/gb-spotlight-20010308-01 ArticleCitationID : spotlight-20010308-01 ArticleCopyright : BioMed Central Ltd2001 Measuring tumour levels of the protein BAG-1 can predict which women with localised breast cancer with early stage breast cancer. immunostaining for BAG-1 a protein that inhibits apoptosis was greater in 79 of 122 invasive breast Interestingly, 82% of women who had tumours that contained high levels of BAG-1 had a longer contained low levels of the protein. predicting survival (J Clin Oncol 2001, 19:992-1000). Patients with tumours containing low levels of BAG-1 may benefit from more aggressive cancer 1. Turner BC, Krajewski S, Krajewska M, et al:BAG-1: A novel biomarker predicting long-term survival in early-stage breast cancer. J Clin Oncol 2001, 19:992-1000., [http://www.jco.org/cgi/content/ 2. Thomas Jefferson University, [http://www.tju.edu/] http://www.jco.org/cgi/content/abstract/19/4/992 http://www.jco.org/cgi/content/abstract/19/4/992 http://www.tju.edu/ BAG-1 can predict survival from breast cancer BAG-1 can predict survival from breast cancer work_7zhzmidivndmtmmiztjyird4d4 Int J Gynecol Pathol 1994;13:127–30. and HSP90 in endometrial carcinomas: correlation with histologic parameters to progesterone receptor status in endometrial adenocarcinoma. Prognostic significance of hormone receptors in endometrial cancer. Endometrial carcinoma. Gastrointestinal Pathology Plus on CDROM, Philadelphia, Lippincott Williams & The second edition of Gastrointestinal Pathology The electronic version contains an expanded text and more illustrations. mind that Windows prefers to self-manage virtual memory for most applications. The production disk contains 270 MB of data, with approximately 85% of the space devoted to pictures and are bundled together to run this reference work. There are shortcuts to individual text items and exporting images are available in The text and illustrations have been revised for the second edition, and references are updated through 1995 (some through 1996). The combination of content, search capabilities, and the ability to print text and export images makes this CD a powerful reference work. could produce higher quality microscopic images. work_a2cjqdaoizd7ndi6mef7egqr7a Score (DSS) for characterization of femoropopliteal arterial lesions. Methods: We evaluated 44 lesion and patient characteristics in our Results: We identified 1329 femoropopliteal lesions in 675 patients. Statistical analysis by multivariable Cox proportional hazards model identified 16 variables that impact patency: seven lesion characteristics (Table I) most impact were a chronic total occlusion (DSS 16), lesion length �100 Patient characteristics that impact patency after endovascular CAD, Coronary artery disease; CHF, congestive heart failure; CI, confidence interval; HR, hazard ratio. with bypass surgery for critical limb ischemia (CLI) with tissue loss and Methods: A retrospective review (2004 to 2010) of patients undergoing ET for tissue loss (Rutherford class 5 and 6) provided data for loss, ET permits sustained limb salvage in patients at high risk for bypass Midterm Results of Limb Salvage and Stent Patency with Popliteal limb salvage and stent patency in patients undergoing popliteal artery collected database, identifying all patients undergoing popliteal artery work_a65bezft35bbxhk75quup2bjte [PDF] Yellow nail syndrome chylous pleural effusions: defective lymph valves involved? Corpus ID: 49313853Yellow nail syndrome chylous pleural effusions: defective lymph valves involved? title={Yellow nail syndrome chylous pleural effusions: defective lymph valves involved?}, We believe that dynamic parameters such as stroke volume variation are currently the best markers of volume responsiveness.1 While the models of Guyton and Starling are magnificent in their simplicity, therapeutic interventions based on these principles may lead to therapeutic errors in complex critically ill patients. This is demonstrated by the fact that no clinical study (of which we are aware) has shown central venous pressure to be a reliable tool in the fluid management of critically ill… Expand Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_a7fmx72kmvdtzm4tcoliesrj5u Calcium-Induced ROS Generation during Ischemia Triggers mPTPDependent Cell Death during Reperfusion Impairment of mitochondrial function is a central event of ischemiareperfusion (I/R) injury leading to tissue damage and cell death. 1, ROS generation with Mito-Sox Red, mPTP opening as mitochondrial calcein ROS with superoxide dismutase mimetic MnTBAP or antioxidant Trolox prevented reperfusion-induced cell death. We conclude that mPTP-dependent cell death during reperfusion is mediated by Ca2þdependent ROS generation during ischemia. of the ER membrane, bulk cytosol and mitochondrial matrix and OMM. It was found that the mitochondrial surface in close association with ER was significantly reduced in the chronic ethanol-fed condition as Calcium-Induced ROS Generation during Ischemia Triggers mPTP-Dependent Cell Death during Reperfusion Dynamic Measurement of Ca2+-Induced Changes in Organelle-Specific Redox Microdomains Mitochondrial Nm23-H4/NDPK-D is Multifunctional: Intermembrane Cardiolipin Transfer Linked to Apoptosis Mitochondrial Nm23-H4/NDPK-D is Multifunctional: Intermembrane Cardiolipin Transfer Linked to Apoptosis work_ae6tqkbfibckbal42dbebzlayy physician-legislators were more the representatives of their local constituencies than of their medical and health related legislation that the doctors generally supported. legislation as the 1892 law on the practice of medicine and the 1902 public health law. in his collective description of the physician-legislators to show which characteristics were relatively small niche in the history of modern medicine and politics, but the author fills it well. of the first school of osteopathy, in Kirksville, Missouri, the author manages to avoid the Drawing effectively on recent work in the history of popular science and medicine, as accomplishing her book''s other main mission, to fill in the narrative gaps left in Still''s seemingly central question of how Still came by his practice of bone-setting, for example, history of osteopathy. to inquire into either the local or the national practice of bone-setting during the 1880s and available at https://www.cambridge.org/core/terms. https://www.cambridge.org/core/terms https://www.cambridge.org/core work_agdkvpyizbajfn6malakdgbvtm PPN12: DEVELOPMENT OF TWO INSTRUMENTS TO CAPTURE EASE-OF-CARE OUTCOMES IN HEALTH-CARE PROVIDERS WHO CARE FOR PATIENTS TREATED WITH PCA DELIVERY SYSTEMS of therapy was 183 days, with 40% of patients receiving narcotic analgesics for greater than 120 days. DEVELOPMENT OF AN INSTRUMENT TO CAPTURE EASE-OFCARE OUTCOMES IN PATIENTS TREATED WITH PCA Patient Controlled Analgesia (PCA) is a common method of postsurgical pain management. optimal in terms of overall convenience, ease of use, and effectiveness of managing pain from a patient''s perspective has not patients who use PCA delivery systems for post-operative pain RESULTS: The final Patient Ease-of-Care Questionnaire consists of 28 items and covers seven aspects associated instrument to capture "ease-of-care" outcomes among patients The instrument is currently being used in clinical trials comparing two PCA delivery systems. OBJECTIVES: To develop questionnaires to measure "ease-ofcare" outcomes from the perspective of nurses and physical therapists who manage the care of patients treated for acute pain work_anbgrjkyhzf7npnepuuurbrycy Janiceps Conjoined Twins: A Case Report 4. Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran million births (8,9) ; it refers to twins with fused head in a longitudinal and transverse approach in early pregnancy, cephalothoracopagus may raise for conjoined cephalothoracopagus twinning in case of finding a single presence of two separate fetal hearts in early pregnancy. Keywords: Cephalothoracopagus janiceps, Conjoined Twins, Ultrasonographic Mahboobeh Shirazi, Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran . ultrasound diagnosis of cephalothoracopagus CTs was Two separate beating heart at 13-14 weeks of pregnancy; D. of conjoined twinning in early pregnancy. The next step after diagnosis of conjoined twinning conjoined cephalothoracopagus twinning in case of two separate fetal hearts in early pregnancy. 30 Ultrasonographic Misdiagnosis of Conjoined Twins 30 Ultrasonographic Misdiagnosis of Conjoined Twins Prenatal sonographic diagnosis of conjoined twins in Cephalothoracopagus Janiceps Conjoined Twins: A Case Report. work_apnylbxnyrhfjhyhiaeg6cfx3e A Scoring System Predicting Outcome After Unrelated Donor Stem Cell Transplantation In Primary Refractory Acute Myeloid Leukemia stem cell transplantation can result in long term survival most patients lack a matched family donor and are destined to die of refractory disease. of patients with PREF AML in whom allografting is technically feasible but the outcome of unrelated donor transplantation in this of patients with PREF AML who are likely to benefit from unrelated donor transplantation. HLA DISPARITY AND RAPID IMMUNE RECONSTITUTION DO NOT OVERCOME PROPENSITY TO RELAPSE IN PATIENTS UNDERGOING HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT) WITH PA; 6Thomas Jefferson University Hospital, Philadelphia, PA We examined relapse rates based on the number of antigen mismatches at A, ANTI-HLA ANTIBODIES PREDICT GRAFT FAILURE, TIME TO ENGRAFTMENT AND UMBILICAL CORD UNIT DOMINANCE IN DOUBLE UMBILICAL A Scoring System Predicting Outcome After Unrelated Donor Stem Cell Transplantation In Primary Refractory Acute Myeloid Leu ... work_aqo3mgd4ejhudiv23mifu7snuu the collected essays focus on the impact of the Napoleonic Empire on the Napoleonic studies in France have been largely limited to the impact of the Napoleonic Empire in Europe. the chronological framework of Napoleonic studies and of Atlantic history the quasi-disappearance of the French Atlantic empire with the failure to demonstrate that the impact of the Napoleonic regime endured after his The book''s Napoleonic Empire thus has no colonial or postcolonial dimension: no chapter is of the Napoleonic regime on Latin American independence movements half the contributions focusing on Central America, Gran Colombia, Cuba, following Napoleon''s model, in the political field (Mónica Ricketts); and the impact of the Napoleonic Code (John Savage). In fact, Childs''s essay on the little-known riots of free people of color Napoleonic laws in the nineteenth-century Atlantic world. scholars interested in Napoleonic Empire, Atlantic Revolutions, Latin work_ar3mit5djrdthm2kfoxw45ptw4 CD3/8 T-Cell Responses to CMV Reactivation and Association with Overall Survival in T-Cell Replete Haploidentical Transplants: A Retrospective Analysis Figure 3: Comparison of Th2+Th17 cTFH (Left) and (Th2+Th17)/Th1 cTFH ratio (Right) in patients without cGVHD (N¼38) and with cGVHD (N¼33). (Right) Frequencies of cTFH in the CD4+ T-cell gate beginning 2 months after HSCT. Increased representation of Th2 and Th17 cTFH subsets CD3/8 T-Cell Responses to CMV Reactivation and CMV reactivation has been associated with increased nonrelapse mortality(NRM) and improved earlyrelapse incidence cell numbers, especially in CD3/8 counts, was associated with CMV reactivation in many patients treated with this approach. The median CD3/8 count for the group, 125 cells/ul, 43% patients reactivated CMV prior to D90. CMV reactivation, disease at HSCT and higher HCT analysis, patients with acute GVHD/CD8H had superior OS Higher CD3/8 counts in CMV-R patients 1 Pediatric Blood and Marrow Transplant, University of Graft failure (GF) after hematopoietic cell transplant (HCT) work_atenkq4jzrbw5hg7vwfm6y6gnm Fatal Massive Hemoptysis in a Patient on Low-Dose Oral Prednisone: Chronic Necrotizing Pulmonary Aspergillosis We report a case of chronic necrotizing aspergillosis in a 74-year-old man with chronic lung disease, described in 1981 by Gefter et al,1 who described 5 patients with locally invasive pulmonary aspergillosis. Massive hemoptysis is a rare and potentially fatal complication of chronic necrotizing pulmonary aspergillosis. We describe a case of chronic necrotizing pulmonary aspergillosis that was misdiagnosed as bacterial pneumonia Chronic necrotizing pulmonary aspergillosis was suspected, and the patient was started on lipid with chronic necrotizing pulmonary aspergillosis (Fig. 2). Chronic necrotizing pulmonary aspergillosis is defined Chronic necrotizing pulmonary aspergillosis is usually Diagnosing chronic necrotizing pulmonary aspergillosis Massive hemoptysis is a potentially fatal complication of chronic necrotizing pulmonary aspergillosis. S. Chronic necrotizing pulmonary aspergillosis in pneumoconiosis: Chronic necrotizing pulmonary aspergillosis following cryptococcal infection of the lung. work_atj3w6poyvcehgp2shpyuvc2pm not generally known that the Cherokee actually preserved documents in their national archives before the American Revolution. Preserved in the Cherokee archives were wampum strings and Cherokee by Indian Superintendent John Stuart, Lord Dunmore, from Stuart to the Great Warrior of June, 1773, in which the superintendent suggested that the chief persuade a British trader to read Campbell to Jefferson, June 20, 1781, Papers of the Continental Congress, No. 71, Vol. 11, Lib. Cong. Attakullakulla Willinanan and the other Head Chiefs of the Cherokee Nation. and the Chiefs of the Cherokee Nation of Indians. Creek & Cherokee Indians to their Traders at a Congress of the principal Warriors of the Cherokee Nation at Chote." A.D.S. 2pp. other Chiefs of the Cherokee Nation. other Chiefs of the Cherokee Nation. Commissioners of Virginia and the Chiefs of that part of the Cherokee Nation called the Overhill Indians. work_axjs4ovfxncgtpmebbsnyt46iy 1Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, USA; 2Center for Value-Based Care Research , the original study''s findings. empathy and diabetes outcomes was consistent in all multivariable and sensitivity analyses. replicate studies. It may be true that empathy was associated with diabetic control among patients of 29 Family Medicine conclusion that "physician empathy is an important factor associated with clinical competence and patient outcomes" is Finally, the authors cite our "error in judgment" for acknowledging that the two studies that found correlations between empathy and diabetes outcomes were conducted by the same Research shows even when studying investigators that are professionally invested in a specific field authors are required to disclose financial conflicts of interest, stake in the outcome of this study. the impact of empathy on patient outcomes. Value-Based Care Research Cleveland Clinic, Cleveland, OH, USA https://doi.org/ Primary study authors of significant http://dx.doi.org/10.1371/journal.pmed.0020124 http://dx.doi.org/10.1371/journal.pmed.0020124 Physician Empathy and Diabetes Outcomes Physician Empathy and Diabetes Outcomes work_axpx5sds4nendlaof4shbcinwu PPN11: DEVELOPMENT OF AN INSTRUMENT TO CAPTURE EASE-OFCARE OUTCOMES IN PATIENTS TREATED WITH PCA DELIVERY SYSTEMS of therapy was 183 days, with 40% of patients receiving narcotic analgesics for greater than 120 days. DEVELOPMENT OF AN INSTRUMENT TO CAPTURE EASE-OFCARE OUTCOMES IN PATIENTS TREATED WITH PCA Patient Controlled Analgesia (PCA) is a common method of postsurgical pain management. optimal in terms of overall convenience, ease of use, and effectiveness of managing pain from a patient''s perspective has not patients who use PCA delivery systems for post-operative pain RESULTS: The final Patient Ease-of-Care Questionnaire consists of 28 items and covers seven aspects associated instrument to capture "ease-of-care" outcomes among patients The instrument is currently being used in clinical trials comparing two PCA delivery systems. OBJECTIVES: To develop questionnaires to measure "ease-ofcare" outcomes from the perspective of nurses and physical therapists who manage the care of patients treated for acute pain work_axwn4pddrvgcjhmssabchdx2ly Estimate of the Relative Risk of Succinylcholine for Triggering Malignant Hyperthermia | Semantic Scholar Corpus ID: 13261377Estimate of the Relative Risk of Succinylcholine for Triggering Malignant Hyperthermia title={Estimate of the Relative Risk of Succinylcholine for Triggering Malignant Hyperthermia}, BACKGROUND:Facilities with volatile anesthetic agents stock dantrolene for the treatment of malignant hyperthermia (MH). We considered the stocking of dantrolene at facilities with succinylcholine alone (i.e., where volatile anesthetics are not available), by using registry data and estimates of the frequency… Expand Sort by Most Influenced Papers Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review Larach, Thomas T Klumpner, +46 authors R. Malignant hyperthermia: current strategies for effective diagnosis and management Prevalence of Malignant Hyperthermia Due to Anesthesia in New York State, 2001–2005 Malignant Hyperthermia: A Review of Published Cases Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. work_b34uk64ij5hm3hyh2dek5zfbtm 1 Letter dated April 23, 1861, Draper-Wisconsin Historical Society Correspondence. Before he became in 1854 the first director of the Society, a position to which he devoted most of his time and energy until his retirement 32 years later, he had acquired the most significant portions of his collection, including nearly all of the original records In the Draper Collection, therefore, are manuscripts, usually military in nature, that might perhaps have been found in State and National archives if more such These include, among the papers of William Preston, the correspondence, muster rolls, receipts for pay and provisions, and courtmartial records for the militia of Augusta County, Virginia, in the Most of the original manuscripts in the Draper Collection relate the remaining material he believed would probably comprise between 50 and 100 more volumes.11 When the State Historical Society received the collection 16 years later, very few additional manuscripts had been arranged or bound. work_b62rxd2yenfjpceh22zuvjzqru analyze 29,479 hospitalizations spanning from 2002 to 2018 at Philadelphia healthcare institutions where the primary diagnosis for admission was diverticulitis or diverticular bleeding. were collected for patients hospitalized with diverticular bleeding, diverticulitis, and diverticulitis complications. by hemorrhage were more similar demographically to patients admitted with diverticular bleeding than those admitted with other forms of that demographic differences between diverticular bleeding and diverticulitis suggest distinct etiologies, we conclude that hemorrhage Complicated Diverticulitis or Exacerbation of Diverticular Bleeding? Philadelphia with primary diagnosis of diverticular bleeding or diverticulitis. bleeding, diverticulitis, or diverticular complications and the general There was no significant difference in gender distribution between diverticular bleeding and diverticulitis or any of its complications, all of which showed a female in etiology to diverticular bleeding than diverticulitis based on patient protocols for diverticular bleeding rather than complicated diverticulitis, patients may receive more appropriate treatment while avoiding Treatment of patients with acute colonic diverticulitis complicated by abscess formation: A systematic review. work_b7h2klfpdjgxrnshzwcumdcsme [PDF] Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors | Semantic Scholar Corpus ID: 22558737Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors title={Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors}, The homotrimeric HIV-1 envelope glycoprotein (Env) undergoes receptor-triggered structural changes that mediate viral entry through membrane fusion. This process is inhibited by chemokine receptor antagonists (CoRAs) that block Env–receptor interactions and by fusion inhibitors (FIs) that disrupt Env conformational transitions. Sort by Most Influenced Papers Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics View 3 excerpts, references background and methods View 3 excerpts, references background and methods View 3 excerpts, references background and methods By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_bc4eeq3lwjhlnj2nu6n66f656q En segundo lugar, exponemos la posición de Hannah Arendt respecto de la Revolución americana como réplica del republicanismo clásico, en que realiza Hannah Arendt de la Revolución americana, como réplica del republicanismo clásico, en desmedro de la la protección de los derechos y las libertades individuales del gobierno tiránico. amenaza potencial a los derechos individuales17, Jefferson vinculaba estrechamente ambas circunstancias, por lo que en sí mismo, y entiende que esta perspectiva es compatible con las ideas del propio Jefferson adaptó estas ideas convenientemente para su batalla ideológica por la independencia de las colonias, inclusive al Fundaremos esta apreciación que vincula a Thomas Jefferson con las ideas del las libertades de los individuos para participar en políticas de gobierno que afectaran su propiedad privada (taxation). que una usurpe los derechos de las otras: que se protejan los derechos y las libertades de cada una. work_bcdkx2x635cq3n2rul6aysbkiu that ROS target mito-motility to control mitochondrial function. at birth (Nguyen et al., 2014) and fibroblasts (MEFs) derived from Miro1 KO embryos show abnormal mitochondrial distribution, but the calcium-dependent inhibition of motility is unaffected and the respiratory and calcium buffering Imaging in perfused whole heart ex vivo, showed considerable mitochondrial continuity and fusion activity in ventricular CM. Higher Mitochondrial Membrane Potential Induces ROS Production in the mitochondrial function in human iPS cells from a patient of FTDP-17 carrying the 10þ16 MAPT mutation. mitochondrial metabolism low levels of ROS, primarily superoxide, are produced at complexes I and III in the electron transport chain. Reactive Oxygen Species (ROS) Suppress Mitochondrial Motility Reactive Oxygen Species (ROS) Suppress Mitochondrial Motility Higher Mitochondrial Membrane Potential Induces ROS Production in the Familiar Form of Frontotemporal Dementia with MAPT Mu ... The Role of Complex I in Mitochondrial Reactive Oxygen Species Formation in Cochlear Sensory and Supporting Cells during Ot ... work_bfhqcqpcerajtc77gcsjfs7wjm Which Domain of VDAC2 is Necessary for Bak Insertion to the Outer Mitochondrial Membrane and tBid Induced Cytochrome C Release? Mitochondrial Membrane and tBid Induced Cytochrome C Release? found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, due to its role in supporting Bak insertion to the OMM for Bak targeting to the OMM and tBid induced cytochrome c release. 1Thomas Jefferson University, Philadelphia, PA, USA, 2Semmelweis heterogeneous distribution of OMM proteins than wild-type cells, and in particular that heterogeneity of pro-apoptotic Bak leads to dysregulation of Biddependent apoptotic signaling. BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells Which Domain of VDAC2 is Necessary for Bak Insertion to the Outer Mitochondrial Membrane and tBid Induced Cytochrome C Re ... Outer Mitochondrial Membrane Protein Distribution and Function Depend on Mitochondrial Fusion BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells before and after Hypericin Photodynamic Action work_bg6tl67zsbhk5k7ks2moqxsule The timely diagnosis of early disseminated Lyme disease presenting as multiple secondary erythema rash and flu-like symptoms led to several laboratory tests with no specific diagnosis. Lyme disease in the list of diagnoses pertaining to diffuse skin rashes in the febrile patient. This case describes a patient with secondary erythema migrans (EM) associated with early disseminated LD. occurs at the site of a tick bite.1 Primary EM lesions Salzman, MD, Department of Family and Community Medicine, Division of Geriatrics, Thomas Jefferson University, Philadelphia, PA Secondary EM lesions of early disseminated LD Patients with secondary EM may have more constitutional symptoms than those with primary EM lesions alone.5 Upper respiratory tract and gastrointestinal symptoms are typically absent.1 The differential diagnosis for a diffuse, patchy, erythematous rash associated with flu-like symptoms can patient''s rash spared the palms and soles, unlike of patients with early disseminated LD. Early Lyme disease. function in early Lyme disease. work_bgc6ssit5fdnjjgl2sjepjtara We assessed the relationship of RNFL loss with disease duration in subjects with untreated MS and determined if Expanded Disability Status Scale, multiple sclerosis, neurodegeneration, optic nerve diseases, optical coherence tomography, rehabilitation, retinal nerve fiber layer, visual acuity. coherence tomography, ON = optic neuritis, OU = oculus uterque (both eyes), RNFL = retinal nerve fiber layer, RNFLt = Optical coherence tomography (OCT) is under evaluation as an outcome measure of axonal degeneration for use in clinical macular volumes and foveal thicknesses, did not demonstrate superior correlations with disease duration compared with the RNFLt (Table 2). (a) Retinal nerve fiber layer thickness (RNFLt) of both eyes correlates with disease duration. Thickness of retinal nerve fiber layer correlates with disease duration in parallel with corticospinal tract dysfunction in untreated multiple sclerosis Thickness of retinal nerve fiber layer correlates with disease duration in parallel with corticospinal tract dysfunction in untreated multiple sclerosis work_bgzhh3zlczfkrhoapbpoh2fgzi Schuirmann,2 Terry Hyslop,3 Barbara Davit,1 Dale Conner,1 The affiliations listed in the PDF and online version of this Schuirmann3 and Terry Hyslop1 were (3) Office of Biostatistics, CDER/FDA, 10903 New Hampshire Ave, Silver Spring, Maryland, USA The online version of the original article can be found at http://dx.doi. 1 Office of Generic Drugs, CDER/FDA, 7519 Standish Place, 2 Office of Biostatistics, CDER/FDA, 10903 New Hampshire Ave, Silver Spring, MD, USA. 1015 Chestnut St., Suite M100, Philadelphia, PA, USA. (e-mail: Sam. haidar@fda.hhs.gov) http://dx.doi.org/10.1208/s12248-008-9053-4 http://dx.doi.org/10.1208/s12248-008-9053-4 /AutoPositionEPSFiles true /CalRGBProfile (sRGB IEC61966-2.1) /sRGBProfile (sRGB IEC61966-2.1) /PassThroughJPEGImages true /EmbedAllFonts true /EmbedJobOptions true /LockDistillerParams true /ParseDSCCommentsForDocInfo true /PreserveDICMYKValues true /PreserveOverprintSettings true /AlwaysEmbed [ true /NeverEmbed [ true /DownsampleColorImages true /CropGrayImages true /EncodeGrayImages true /DownsampleMonoImages true /EncodeMonoImages true I documenti PDF creati possono essere aperti con Acrobat e Adobe Reader 5.0 e versioni successive.) De gemaakte PDF-documenten kunnen worden geopend met Acrobat en Adobe Reader 5.0 en hoger.) work_blwyqxj2zjdxphejzl6ng5gs3y Ž .analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms AAA , one individual with polymorphism between 168 alleles from AAA patients and 102 control alleles. Keywords: Aortic aneurysms; Connective tissue; Direct sequencing; Intracranial aneurysms; Polymorphism DNA sequencing of 50 aortic aneurysm patients Ž .tissue inhibitors of metalloproteinases TIMPs in tissue conditions inhibiting the expression or mutations in the primary structure of the TIMP genes. TIMP2 in patients with AAA andror IA to determine The TIMP2 sequence variants were polymorphisms with minor allele frequencies of 0.049 and difference between controls and AAA patients was and TIMP2 genes in aneurysm patients. The differences in allele frequencies of nt 573 TIMP2 polymorphism between the control and AAA groups are interesting preliminary findings that need further follow-up Sequence of human tissue inhibitor of characterization of the human tissue inhibitor of metalloproteinases-2 gene. Expression and sequence of the gene for tissue work_bn4i2xcp2je6vhlo2mqowj6qqi PINI6 COST-UTILITY OF CHRONIC HEPATITIS “Câ€? Index claims were outpatient or emergency department visits in 1999–2001 by individuals aged 25–64 with a primary diagnosis of pneumonia, Exclusion criteria: antibiotic prescription, pneumonia diagnosis, or hospitalization in prior 30-days; initial therapy stay (LOS) attributable to complicated skin and soft tissue infections (cSSI) for patients admitted to Thomas Jefferson University discharges in 2003, 1,883 (5.5%) included one of the cSSI diagnosis codes; these encompassed 225 DRGs. The mean cost for DRGs, mean cost of cSSI added $42,563 onto the cost for cases COST-UTILITY OF CHRONIC HEPATITIS "C" TREATMENT OBJECTIVE: To estimate cost-utility of the following alternatives in the treatment of chronic hepatitis C (CHC) in the of life and costs of health care institutions. RESULTS: Triple therapy (peginterferon plus ribavirin plus thymosin alpha-1) was dominant over the rest of alternatives costing OBJECTIVES: This study investigated the effect of using different utilities for a cost-utility analysis comparing peginterferon work_bqq5zgzm4nd5hdz7mxmon5jnxy physical activity (PA) as very important aspects of health and wellness patient-centered fitness and nutrition class on participants'' attitudes, knowledge, and self-efficacy regarding their health. METHODS: An urban line dancing class and brief healthy eating intervention Pre/postsurveys were administered to assess attitudes and confidence toward physical activity and healthy lifestyles. RESULTS: Participants'' self-assessment of health and levels of physical activity improved. decrease in participants'' physical activity gratification was observed. Participants'' confidence improved in reading food labels for health, but confidence CONCLUSIONS: A resident-led fitness and nutrition class, tailored to perceived community needs, generated significant interest and sustained participation. addressing health, nutrition, and overall fitness, and the results reflect opportunities and challenges of engaging communities in physical fitness. There were no significant changes in self-assessment of one''s overall health, physical fitness, ability Participants'' overall self-assessment of health and level of physical fitness trended positively. health and participation in exercise. work_brr6dmmhfrfbnogbtek33ffnum Robbinsdale, MN 55422, U.S.A. Perhaps unlike any other field of science, paleontology is dependent upon the training is completely immaterial to making great scientific discoveries in paleontology. Historically, Earth Science is replete with giants who had little or no academic discovered by amateurs and commercial collectors, not degreed professionals. The history of commercial fossil collecting is long and honorable. before the advent of geologic sciences or such things as museums. commercially traded fossils for centuries. The contributions of commercial fossil collecting have not been small. specimen of Archaeopteryx, arguably one of the most important fossil species known, is the result of collection by commercial groups. Tyrannosaurus rex was found by a commercial party which, incidentally has discovered rex specimens than any other group, public or private. commercial shop to thank for his discovery of baby dinosaurs that launched him to the front of dinosaur science. work_bt5xvtxekzetfozjy2mszf6yxy the Thomas Jefferson Papers (Washington: Library of Congress, 1976). included the records of the Virginia Company of London (1619-24), materials relating to the General Assembly, and other colonial records, as well as notes and commentaries on such subjects as history, philosophy, and the law.9 In addition, Randolph prepared and edited four volumes entitled Memoir, Correspondence, and letters and papers, never before published, as were thought to throw light on Mr. Jefferson''s character."13 The result of Tucker''s research was The Life of Thomas of the Joint Committee on the Library, was the removal of the Jefferson manuscripts from the District of Columbia to Williamsburg.21 Washington was determined to maintain his full schedule of academic duties at the College of William In addition to editing Jefferson''s papers for publication, however, Washington had also These Jefferson papers were sent to the Joint Committee on the Library, with others, upon work_btzleucjbzh7vhgrlbrxm4mevq Physics development of web-based tools for use in hardware clusters Jefferson Lab and MIT are developing a set of web-based tools within the Lattice Hadron Physics Collaboration to allow lattice QCD theorists to treat the computational facilities located at the two sites as a single meta-facility. The prototype Lattice Portal provides researchers the ability to submit jobs to the cluster, browse data caches, the present system to include job submissions at the meta-facility level (shared queue), as well as multi-site file routing mechanism to provide users with the ability to run jobs at one of several sites according At the present time, JLab and MIT have developed an initial set of web-based tools and utilities The current capabilities of the present system allow users at either the JLab or MIT sites At both the MIT and JLab sites, only the execution queues have been configured in the batch work_byy4mwoflffxhdhlvwzel3ncbe We investigated the kinetics of MAC inhibition in mitochondria from wild type, Bak, and Bax knockout cell lines using Mitochondrial Ca2þ has a critical role for balancing cell survival and death. Here we show that adrenergic signaling induces MCU tyrosine phosphorylation and accelerates mitochondrial Ca Pyk2 and MCU, which subsequently accelerates mitochondrial Ca2þ uptake via confirmed that only two tyrosine sites were phosphorylated in response to adrenergic stimulation in situ using cell lines stably expressing MCU-YFs. In addition, overexpression of these MCU-YFs failed to increase mitochondrial Ca is required for activation of Akt survival pathways and mitochondrial function. At embryonic day (E) 9.5, mitochondrial ETC activity and oxidative phosphorylation (OXPHOS) are not coupled, Initiation of Electron Transport Activity and a Decrease of Oxidative Stress Occur Simultaneously during Embryonic Heart De ... The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver work_c4l5ipinsbgshki4bhxzahuxsi formed in mitochondrial outer membranes (OM) of apoptotic cells or in synthetic membranes by Bax and related proteins/peptides, using electron microscopy (EM), atomic force microscopy and x-ray diffraction. MAC function was induced through staurosporine treatment and microinjection of tBid or cytochrome c. apoptosis signals MAC formation, while pDsRed-2 expression shows mitochondrial structure as red fluorescence. microinjection with tBid or cytochrome c induced relocation of Bax and collapse of the mitochondrial network. cleaved by caspase-8 and other enzymes forming tBid that induce mitochondrial outer membrane (OMM) permeabilization and cytochrome c (cyto-c) release. coordinated cyto-c release and also inhibited tBid-induced cell death. The mammalian GRIF1 and OIP106, and the drosophila Milton are kinesinbinding proteins that form a complex with the Miro GTPase, an outer mitochondrial membrane EF-hand protein, to support the movement of mitochondria Mechanism of the Mitochondrial Cytochrome C Release Wave in Bid-Induced Apoptosis work_c5iz6tmtc5gnxdobgqhwyl5nhq William Howard Adams, The Paris Years of Thomas Jefferson. William Howard Adams, The Paris Years of Thomas Jefferson. d''études anglo-américaines des XVIIe et XVIIIe siècles. du confort de l''habitat, avec la généralisation des parcours séparés pour La rencontre de Jefferson avec Paris est bien autre chose qu''un classique et des beaux-arts, non pas seulement pour leur valeur élégante ou détaillée du Paris des années 1780 (ch. L''étude restitue l''exigence intellectuelle d''un homme qui a su affronter les (297) qui en viendra à regarder comme prix à payer pour elle les morts en L''étude constate l''importance politique que Jefferson a toujours accordée à l''éducation, celle aussi des relations personnelles, y compris dans artistique, pour l''évolution de la théorie politique (liens avec les journalistes, traducteurs, imprimeurs) que pour les choix politiques des "Jefferson à Paris," qui fourmille de références précises pour pousser plus loin l''enquête, porte, en fait, sur "Jefferson et Paris" et montre que cette work_c5k5k5nry5cytm2hgfefux36yy mitochondrial membranes which result in the dramatic increase of their permeability. study investigated how mtDNA T8993G (NARP)-induced inhibition of mitochondrial complex V altered mitochondrial dynamics in association with a protective mitochondrial phospholipid, cardiolipin (CL), as a potential therapeutic a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca2þ and lipidstress. Intriguingly, melatonin, by differentially preserving CL during various stresses (oxidation > Ca2þ > lipid), rescuesdifferentially CL-altered mitochondrial dynamics and cell death (oxidation > CL to prevent its oxidization and/or depletion and, therefore, it exerts great potential in rescuing CL-dependent mitochondrial dynamics-associated mitochondrial pathologies for treatment of NARP-induced pathologies and diseases. MICU1 in mitochondrial Ca2þ uptake, we used wild type HeLa cells (Ctrl), mtDNA T8993G Mutation-Induced Mitochondrial Complex V Inhibition Augments Cardiolipin-Dependent Alterations of Mitochondria ... Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells work_c67qbifkfzfg3anuu52tufchua sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220676662 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:15 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_cayyxzwg7vag5mih4mex56qifq patient''s ECMO flow rate, arterial blood gas, and blood pressure all remained stable. Concurrent use of HFOV with VV ECMO using an Avalon cannula may result in a shunt that the venous and arterial lumens of the Avalon cannula, increasing the ECMO flow rate appeared Keywords: high-frequency oscillatory ventilation (hfov), acute respiratory distress syndrome (ards), extracorporeal membrane oxygenation (ecmo), avalon cannula lung protective ventilation and ECMO, high-frequency oscillatory ventilation (HFOV) should be observed in an Avalon cannula and treated with an increase of ECMO flow. from the Avalon extracorporeal membrane oxygenation (ECMO) cannula (yellow arrow), suggesting (approximately 240 mmHg assuming an ECMO flow of 4.5 L/min with an Avalon cannula size 27 use of HFOV and high-flow ECMO, however. concurrent use of HFOV with VV ECMO via an Avalon cannula, it is likely that an increase in Shunting of Oxygenated Blood to the Venous System in the Avalon® Cannula on Venovenous Extracorporeal Membrane Oxygenation with High-frequency Oscillatory Ventilation work_cbmac3ctmbde5g2ulr4nw6cdjm Česky / English Informace a služby Pro autory Informace pro autory English Historik Jaroslav Čechura se v předkládané monografii zaměřuje na období třicetileté války. Obě témata se prolínají v závěrečné části věnované kronice Chronicon Aulae Regiae. Katalog jaro 2021 Novinky Nakladatelství Karolinum na období jaro/léto 2021 naleznete v našem novém katalogu. Světla a stíny husitství (Události – osobnosti – texty – tradice) Čornej, Petr Gecko, Tomáš Fašismus Křížková, Věra Kloudová, Věra Koptík, Tomáš Prášek, Petr Témata Témata Témata AUC INTERPRETATIONES AUC INTERPRETATIONES AUC KINANTHROPOLOGICA AUC KINANTHROPOLOGICA AUC THEOLOGICA AUC THEOLOGICA AUC THEOLOGICA AUC GEOGRAPHICA AUC GEOGRAPHICA AUC PHILOLOGICA AUC PHILOLOGICA AUC PHILOLOGICA AUC PHILOLOGICA Informace o akcích a nových titulech nakladatelství. Fašismus podle Rogera Griffina V edici Politeia vychází již druhá kniha jednoho z největších odborníků na fašismus, britského profesora moderních dějin a politického teoretika na Oxford Brookes University Rog... Nakladatelství Karolinum Nakladatelství Karolinum Nakladatelství Kontakt a služby © Karolinum 2021 work_cdb3mgp56nhutjnqc54ksdhrjm formation and fusion, we used organelle-targeted fluorescent proteins, including photoactivatable GFP, which allow tracking of individual mitochondria. Strikingly, 80-90% of the physical contacts between adjacent mitochondria did not result in fusion events. ionophore that induces matrix swelling evoked a decrease in mitochondrial motility leading to fewer contacts among mitochondria but the number of fusion Here we evaluated mitochondrial fusion dynamics in human skeletal muscle cells (HUSMC). Mitochondrial fusion events were evaluated by confocal imaging of cells expressing mitochondria matrix targeted DsRed and Recent studies have suggested that type 3 IP3Rs (IP3R3) are particularly important for mediating the Ca2þ transfer at the ER-mitochondrial interface. in the mitochondrial Ca2þ transfer we used two point mutants of the IP3R1, each IP3R isoform can support local ER-mitochondrial Ca2þ transfer and their Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells work_cfyfq74hmffxxlzoylpypk2lwq Acute fibrinous and organizing pneumonia is a newly recognized pattern of lung injury. male with acute fibrinous and organizing pneumonia caused by decitabine. Key words: acute respiratory distress syndrome, ARDS, acute lung injury, ALI, decitabine, myelodysplastic syndrome, drug induced pneumonitis, acute fibrinous and organizing pneumonia. The diagnosis of acute fibrinous and organizing pneumonia secTajender S Vasu MD, Rodrigo Cavallazzi MD, Amyn Hirani MD, Paul Acute fibrinous and organizing pneumonia was first described by Beasley et al2 in 2002. several conditions associated with acute fibrinous and organizing pneumonia, including collagen-vascular disease, Recently, acute fibrinous and organizing pneumonia has also Patients with acute fibrinous and organizing pneumonia this is the first case describing acute fibrinous and organizing pneumonia pattern of lung injury secondary to decitabine. involvement in acute fibrinous and organizing pneumonia fibrinous and organizing pneumonia: a histological pattern of lung Acute fibrinous and organizing pneumonia Acute fibrinous and organizing pneumonia work_cgsg5sxyqzagnonqf7rsp6nrau sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220686374 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:27 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_cl5yercisrfz3oqpznagusz6ni Thomas Jefferson''s alleged paternity of Eston Hemings Jefferson, the last child of data at hand in interpreting their results. No mention was made of Thomas Jefferson''s brother Randolph (1757–1815), or of know Thomas Jefferson was there, but how it is possible that Thomas Jefferson''s father, even at that time to be Thomas Jefferson''s Eston Hemings Jefferson. son of Thomas Jefferson''s brother Randolph, might have been the father of one or Isham was reared by Thomas Jefferson; he Monticello at that time, whereas it is documented that Thomas Jefferson was. as Thomas Jefferson to have fathered Eston DNA data that Thomas Jefferson can neither A. Jr Thomas Jefferson and his Unknown a mammal of the same body size and aerobic power. mammals of the same size and aerobic inactive flight muscles are only half as large aerobic mammals of their size, using lungs Why rheas have an aerobic power that work_clhxj3r6pndirghkema3cc6pny From Individualized Treatment of Sickle Cell Pain to Precision Medicine: A 40-Year Journey In the 1970s, sickle cell pain was treated with trial and error approach Keywords: Sickle cell disease; Pain; Individualized treatment; Personalized medicine; Precision medicine An infliction in the life expectancy figure of patients with sickle cell disease (SCD) occurred around the middle of the 1970s opioids as ligands that bind to stereospecific and saturable receptors in the central nervous system and other tissues [3, 4]. by binding to receptors, opioids initiate a series of biochemical events including activation of G proteins, inhibition of Life expectancy of patients with sickle cell disease from 1900 through 2010. where life expectancy of patients with sickle cell disease began to increase. Treatment of pain in adults with sickle cell Management Evolution of Sickle Cell Pain J Clin Med Res. 2016;8(5):357-360 Management Evolution of Sickle Cell Pain J Clin Med Res. 2016;8(5):357-360 work_cqxfdwye7nbwxkzuxjopxzpi2q If you ask the average ten year old in America what a scientist looks like, they almost always describe high school students, they''re likely to allows students to engage in real, live science education has become a adequate resources to allow students to University Science Outreach Program education of students between the stereotypes of science by recruiting young scientists. Abbreviations: TJU, Thomas Jefferson University; TJUSOP, Thomas Jefferson University Science Outreach Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America. science education, promote interest in future participation in biologyrelated fi elds, and allow all students TJUSOP educators assist the teachers over 2,000 students and 75 teachers all teachers and students at no cost the quality of its science education. experiments allows students and the seventh-grade unit, the students 4 and 7 and "Student Scientists" in A Philadelphia Student Uses the TJUSOP allows student participants National Science Foundation. National Science Foundation. work_cwe6fr2dqfedxhgqautpxjrst4 Indirect treatment comparison of interventions for Neovascular (WET) age-related macular degeneration (WET AMD) METHODS: All patients who stayed on the same active treatment for 52 weeks were included. percentage of PASI-75/90/100 and DLQI-0/1 (no impact on patient quality of life) Pharmacy students on the use of skin whitening product. METHODS: A selfadministered questionnaire on the use of skin whitening product was distributed to IIUM Kuantan Undergraduate Pharmacy students at IIUM Kuantan degeneration and dePreSSive SymPtomS: baSeline reSultS from the study, about one third of patients reported depression and/or psychotropic medication treatment. OBJECTIVES: To undertake a network meta-analysis (NMA) to assess the effectiveness of licensed interventions (aflibercept 2q8, ranibizumab PRN, pegaptanib and Identified studies often reported results at multiple time of ranibizumab and aflibercept at any time point: mean difference at 12 months CONCLUSIONS: Aflibercept and ranibizumab are effective treatments PreServative-free fixed combination for the treatment of oPenangle glaucoma and oht; interPreting reSultS from a large work_d4tgumenobhibegkxcxfiw5hge sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220685956 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:26 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_dayz2iy525aotchtbl2gyobm2a All patients received physician directed smoking cessation counseling. recommended the book quit smoking, although this difference was not significant, p Smoking cessation rates did not appear to be impacted by reading Allen Carr''s The convincing patients to quit smoking is the best-selling self-help book The Easy Way Way to Stop Smoking by Allen Carr in achieving smoking cessation in patients being Way to Stop Smoking by Allen Carr in achieving smoking cessation in patients being recommendation to purchase the book The Easy Way to Stop Smoking by Allen Carr. read the book at all had the highest percentage of smoking cessation that patients would quit smoking, although it was not a significant cancer diagnosis was the major reason for their smoking cessation, and Identifying patients who are ready or motivated to quit smoking may patients may be more likely to successfully quit smoking. work_dfm6ta6pibft7j2h2ycubcxaje Re: Evaluation of an Ongoing Diabetes Group Medical Visit in a Family Medicine Practice Re: Evaluation of an Ongoing Diabetes Group Medical Visit in a Family Medicine Practice similar patient demographic using diabetes shared medical appointments (SMAs). hour two is group diabetes self-management education. SMA model that incorporates medical care (directed group to share SMA models and experiences across Evaluation of an Ongoing Diabetes Group Medical Visit in a S. Specialty diabetes group medical visits improve access to Diabetes Group Medical Visit in a Family Ganetsky, PharmD, BCPS and for their response to our article1 evaluating a diabetes group medical visit (GMV) and for sharing their experience implementing a diabetes shared medical appointment (SMA). visits that incorporate medical care and group self-management education.2,3 While our program has a different In addition, we agree with the authors'' call for national best practices for group visits, a national working of an ongoing diabetes group medical visit in a family work_drjkecmfvzhefakvkih2gwjpci A diagnosis of dysthyroid eye disease was made and the patient crowding of the orbital apex suggestive of dysthyroid eye disease. follicular cell that stimulates antibody production which cross reacts with extraocular tissue. Rarely, however, do features of a metastatic lesion indicate the primary origin of the Figure 1 Fundus photograph of the right eye showing three orange choroidal metastases Figure 2 Fundus photograph of the left eye showing a single orange choroidal lesion nasal to A diagnosis of multiple metastatic uveal carcinoid tumour was Choroidal metastases from carcinoid tumour fluorescein angiogram of the right eye showing the right eye showing continued hyperfluorescence the right eye showing isofluorescence of the three primary carcinoid tumour and uveal metastases may be as long as 15 years (mean 7 Support provided by the Eye Tumor Research Foundation, Philadelphia, PA, USA. Uveal metastases from carcinoid tumor. carcinoid tumor metastatic to the eye and orbit. work_dt3ivtkrsvhc7gsuxbfwh4vuzi With a focus in Latin American cultural production over and social changes, the author explores senses (feeling, polity, its ambivalent relation with technological transformations, and the cultural production reflecting (and "A Politics of Perception", the author dissects the penetrating and prescient ideas of León Rozitchner about politics, American truth of the body as the locus of a prolific relation between politics and violence. Politics and Culture in Latin America. Iberoamericana – Nordic Journal of Latin American and Caribbean Studies, Perception, Politics and Culture in Latin America. Perception, Politics and Culture in Latin America. Perception, Politics and Culture in Latin America. Keywords: Latin American culture; Democracy; History of senses; Literature; Modernity in Latin America Democracy moves one step further from Masiello''s previous work about the Latin American polity. long history of that power in Latin America. OPEN ACCESS Iberoamericana – Nordic Journal of Latin American and Caribbean Studies is a work_e2b3k7zzv5gn7n46rawinygrza formed in mitochondrial outer membranes (OM) of apoptotic cells or in synthetic membranes by Bax and related proteins/peptides, using electron microscopy (EM), atomic force microscopy and x-ray diffraction. MAC function was induced through staurosporine treatment and microinjection of tBid or cytochrome c. apoptosis signals MAC formation, while pDsRed-2 expression shows mitochondrial structure as red fluorescence. microinjection with tBid or cytochrome c induced relocation of Bax and collapse of the mitochondrial network. cleaved by caspase-8 and other enzymes forming tBid that induce mitochondrial outer membrane (OMM) permeabilization and cytochrome c (cyto-c) release. coordinated cyto-c release and also inhibited tBid-induced cell death. The mammalian GRIF1 and OIP106, and the drosophila Milton are kinesinbinding proteins that form a complex with the Miro GTPase, an outer mitochondrial membrane EF-hand protein, to support the movement of mitochondria Mechanism of the Mitochondrial Cytochrome C Release Wave in Bid-Induced Apoptosis work_e445yejrxfggfonsb2nhyd7exy ISSN: 0142-159X (Print) 1466-187X (Online) Journal homepage: https://www.tandfonline.com/loi/imte20 Medical student perceptions of hospital discharge To cite this article: Beth Careyva, Danielle Snyderman & Gretchen Diemer (2013) Medical student perceptions of hospital discharge transitions in care, Medical Teacher, 35:11, 967-967, DOI: https://www.tandfonline.com/action/showCitFormats?doi=10.3109/0142159X.2013.786821 https://www.tandfonline.com/doi/mlt/10.3109/0142159X.2013.786821 https://www.tandfonline.com/doi/mlt/10.3109/0142159X.2013.786821 Medical student perceptions Thirdyear medical students are frequently involved in discharges Students'' self-assessed competency in transitional care perceptions of transitional care following an educational Students identified a patient and completed a semistructured telephone interview within 3–5 days after discharge to assess patients'' adherence with discharge instructions. guiding the students to: assess the patient''s understanding of Several students also highlighted continuity of care and patient relationships as the Toward safe hospital discharge: A transition in care curriculum for medical students. effective transitions of care at hospital discharge: A review of key issues Australian health care is provided through either publicallyfunded teaching hospitals, or privately provided services in work_ea7xhzzxnvghvbbfe7fvnmrg74 Background: Physician feelings of ineffectiveness and family-related barriers hamper childhood obesity Methods: In this feasibility study, we evaluated physician-level counseling of 9to 12-year-old children and their parents/caretakers using Fitwits MD (Carnegie Mellon University School of Design, Pittsburgh, PA), a brief, structured intervention with flashcards and take-home games. Residency-based physicians in three lowto mid-level socioeconomic urban offices provided self-report data over 8 months Conclusions: Fitwits MD improved residency-based physician self-efficacy and emphasized important health education topics regarding office-based childhood obesity discussions with preadolescents and Keywords: Body Mass Index, Communication, Health Literacy, Obesity, Portion Size widely known, not all physicians and families discuss childhood obesity in a forthright, understandable way. barriers: time pressure; insufficient training for nutrition-based and body mass index (BMI) counseling; treatment futility; home and neighborhood Physicians completed open-ended comment cards after each office visit intervention. MD intervention improved residency-based physicians'' comfort and competence levels and reduced help physicians assess and discuss obesity with work_ecr4eurpube5nnhlofop25u2rm A segmental hypoplastic anterior tibial artery coexisting with an hypertrophied perforating fibular artery a case report and which one of the 3 terminal branches of the popliteal artery (PPA), the anterior tibial artery (ATA) of good caliber size at origin became artery (PTA) when it is weak or absent by a strong communicating branch or, reinforcing a weak ATA and dorsalis pedis artery (DPA) by A segmental hypoplastic anterior tibial artery coexisting with an hypertrophied perforating fibular artery a case report and clinical implications. A segmental hypoplastic anterior tibial artery coexisting with an hypertrophied perforating fibular artery a case report and clinical implications. A segmental hypoplastic anterior tibial artery coexisting with an hypertrophied perforating fibular artery a case report and clinical implications. A segmental hypoplastic anterior tibial artery coexisting with an hypertrophied perforating fibular artery a case report and clinical implications. work_egxvuzl27zcyhirkg3ca5l6id4 Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain | Semantic Scholar Corpus ID: 6804281Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain title={Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain}, Fibronectins (FNs) are high molecular weight glycoproteins present in extracellular connective tissue matrices (ECM) and extracellular fluids, including blood plasma. Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin''s EDA Domain. Knockdown of fibronectin extra domain B suppresses TGF-β1-mediated cell proliferation and collagen deposition in keloid fibroblasts via AKT/ERK signaling pathway. View 1 excerpt, cites background View 1 excerpt, cites background View 1 excerpt, cites background View 1 excerpt, cites background Fibronectin gene expression differs in normal and abnormal human wound healing By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_eijaspg7cnatfndvfydrqd4pim ASMscience | Branches: ASM Activity at the Local Level:Dinner and a Show? 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Open access content Subscribed content About ASM Public Access Policy Publications Individual Member Journal Subscriptions Journal of Microbiology & Biology Education® Journal of Microbiology & Biology Education® Please enter a valid email address Approval was partially successful, following selected items could not be processed due to error work_ellbtzc6yvc6jpygzzkvdligbe ND4 IMPACT OF TOPIRAMATE FOR MIGRAINE PROPHYLAXIS ON WORKPLACE PRODUCTIVITY: RESULTS FROM TWO U.S. RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER TRIALS IMPACT OF TOPIRAMATE FOR MIGRAINE PROPHYLAXIS ON WORKPLACE PRODUCTIVITY: RESULTS FROM TWO U.S. RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, OBJECTIVE: To compare the impact of topiramate 100 mg/day versus placebo on workplace productivity among individuals with migraine, using data from two six-month randomized, Total lost productivity was the sum of A The mean monthly (28-day) rate of lost productivity per RESULTS: A total of 449 subjects were enrolled in the trials (226 lost productivity at baseline (162 topiramate, 163 placebo). At baseline, the mean rates of total lost productivity were 10.4 hours/28 days for topiramate 100 mg/d and 10.1 hours/28 days for placebo (not significant). productivity hours/28 days for topiramate 100 mg/d versus Our findings suggest that topiramate 100 mg/day may be associated with improvements in productivity among individuals with migraine. work_esxlj4aprfd4dbj7mevibd6gey sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220677512 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:16 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_expiur4zyzfb5nc3pvdk2vsuri formation and fusion, we used organelle-targeted fluorescent proteins, including photoactivatable GFP, which allow tracking of individual mitochondria. Strikingly, 80-90% of the physical contacts between adjacent mitochondria did not result in fusion events. ionophore that induces matrix swelling evoked a decrease in mitochondrial motility leading to fewer contacts among mitochondria but the number of fusion Here we evaluated mitochondrial fusion dynamics in human skeletal muscle cells (HUSMC). Mitochondrial fusion events were evaluated by confocal imaging of cells expressing mitochondria matrix targeted DsRed and Recent studies have suggested that type 3 IP3Rs (IP3R3) are particularly important for mediating the Ca2þ transfer at the ER-mitochondrial interface. in the mitochondrial Ca2þ transfer we used two point mutants of the IP3R1, each IP3R isoform can support local ER-mitochondrial Ca2þ transfer and their Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells work_f2i6belgkzaolg54vnd6ylfkbq Catheter-associated urinary tract infections (CAUTIs) can be fatal, and are a source of avoidable expense for indwelling catheter days decreased, while overall intensive care patient days increased. Introduction of a FEUC was associated with a statistically significant decrease in CAUTI rate among female complications including catheter-associated urinary tract infections (CAUTIs) [1]. that this would prevent CAUTIs. As our outcome measure, we compared CAUTI rates in female ICU patients before and after the product days, and hospital-acquired pressure injury (HAPI) rates, male patients were excluded. In the year prior to FEUC introduction, there were 23 CAUTIs in female ICU patients, a rate of 3.14 per 1000 CAUTI = catheter associated urinary tract infection. collection does include device-associated pressure injuries, which are a useful balancing measure for FEUC TABLE 2: Female HAPI and Device-Associated Pressure Injury Prevalence Before and After FEUC TABLE 2: Female HAPI and Device-Associated Pressure Injury Prevalence Before and After FEUC work_f2y4ko3pr5g4hktkr2mzntfh6i Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous-Cell Carcinoma: An Enigmatic Entity with Complex Pathogenesis from it has been suggested to be indispensable for the development of squamouscell carcinomas (SCCs) in patients affected by recessive dystrophic epidermolysis bullosa (RDEB). develop in RDEB patients lacking expression of collagen VII altogether. affected patients develop severe mutilating scarring and are at high risk of developing squamous-cell carcinomas (SCCs) frequently observed, predicting expression of truncated collagen VII, including VII expression for SCC development in that 2 of 11 patients investigated developed SCC in the absence of collagen VII RDEB patients, expression of collagen VII of collagen VII alone is not likely to provide a reliable diagnostic tool to identify patients at risk of SCC development. like RDEB-associated SCCs. These parallels raise the question of whether, regardless of collagen VII/NC1 expression status, chronic wound healing represents Harvey-ras mutations are rare events in nonmelanoma human skin cancer. work_f7drlpbeuzc6vp7tmtbbujwmo4 appointed Marbury prior to leaving office?2 If he had, Jefferson and Secretary of State Madison arguably violated Marbury''s rights by denying him a Adams''s midnight appointments as nullities, without regard to whether commissions were delivered, on the theory that all of the non-Article III appointees served at his pleasure. This rule is subject to the exceptions found in the Constitution, namely the President''s ability to appoint during a Senate''s recess,109 and Congress''s ability to vest act of appointment?"131 Another critic claimed that because the Constitution said that the President must commission "all the officers," it implied that Looking to early practice, some of President George Washington''s letters discussed appointment as occurring after Senate consent but before signing any commission. Moreover, on his second day of office, President Jefferson issued a commission to James Madison which read, "I have nominated, and . Washington (nomination, appointment, commissioning),162 President Jefferson''s 1807 delivery theory contemplates a different sequence: nomination, work_fa54luwm7jd2rm7jvdrasrcfze sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220682734 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:22 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_fcgzjfsfcrbq5f3dhotyqr4soa ayda bir yayımlanan Türk Kütüphaneciliği Komitesi ile birlikte, bu yıl da olağanüstü bir "Bilgi" giderek artan biçimde bir provision of library and information Ekonomik kalkınma ile bilgi erişim eden ülkeler kütüphane ve bilgi merkezlerini Bir gün "bilgi Ekonomik kalkınma ile bir ülkedeki bilgi teknolojisi araçlarının varlığı arasında ile demokrasi arasında da bir ilişki olduğu the availability of information access and library and information centers with fairly of library and information professionals to retrieval of information sources available in libraries and information centers, cinema ekonomik kalkınma ile bilgi teknolojisi ve dijital kütüphanelere ve bilgi destruction of libraries and archives in BosniaHerzegovina," Middle East Studies Association Türk Kütüphaneciliği*nin IFLA''95 information and support their libraries access to information and democracy, Library and information centers, kalmanızı ve verimli bir IFLA Konferansı about the IFLA''95 ISTANBUL Special Issue libraries, Turkish archival studies, destruction of libraries and archives in BosniaHerzegovina," Middle East Studies Association Bulletin work_fjin73vz5rb2lmpfswdww3n7r4 In the mass region above 1.5 GeV many overlapping baryon states are present and some There are also many baryon resonances predicted to be in this mass range which have never been observed. properties of baryon structure, the nucleon excitation spectrum must be measured in In this paper, we present results on the reactions ep → In the two-pion channel, the data show resonant structures not visible in known N∗ and ∆ states fail to match our results. In the η channel, results from CLAS Now we present results from the an order of magnitude over a wider range in Q2 than any previous experiment. We also observe structure in the differential cross section that is not predicted by current phenomenological models. baryon resonances[2] or a significant revision of the properties of known states in the Thompson, et al., (The CLAS Collaboration), Phys. Rev. Lett. Rev. C59 (1999) 3002. work_fp3i33dllna4nhahi6vk6dmtom Keywords: Inventory models, conjugate duality, generalized geometric programming. theory and has been instrumental in the solution of many nonlinear optimization problems occurring in such diverse areas as marketing, Balachandran and Gensch [1], water pollution management, Ecker and McNamara [4] production engineering, Petropoulos [8], transportation planning, Jefferson and Scott [9], and machine maintenance, Cheng [2]. The dual problem, taken in the geometric programming sense (i) the dual problem is optimized over the polar to the cone constraints (ii) the constraints in the primal problem are absorbed into the dual objective function. In this way, while the primal program may have nonlinear constraints, the dual may be simply an optimization over a polyhedral set. means a finite dimensional convex programming problem with the constraint set being a cone. this case, the minimal cost is 20798.15 with optimal dual variables ν = and the geometric dual is a discrete time optimal control problem. work_fq3gijbqezcqfgcxxnzfzglj3q Upper limits were set on the production cross section as serve as checks of our analysis procedure, e.g., by comparing their production cross sections with the world data. The resulting nK� invariant mass distribution is shown in Fig. 3. an upper limit on the �� production cross section taking 4. The 95% C.L. upper limit on the total cross section as a 4. The 95% C.L. upper limit on the total cross section as a The mass position and width of the measured peaks are indicated. derive the 95% C.L. upper limit on the ���1540� differential cross section d�=d cos� �K The 95% C.L. upper limit on the number of �� events at a mass of the photon energy was limited to 2.6 GeV, only events Search for Theta(+)(1540) pentaquark in high-statistics measurement of gamma p ->(K)over-bar(0)K(+)n at CLAS Search for Theta(+)(1540) pentaquark in high-statistics measurement of gamma p ->(K)over-bar(0)K(+)n at CLAS work_frcctd5wlbecpfh34kd3fi5hgq Abbreviations: chronic obstructive pulmonary disease, COPD; alpha-1-antitrypsin deficiency, AATD; human immunodeficiency virus, HIV; hypocomplementemic urticarial vasculitis syndrome, HUVS; alpha-1-antitrypsin protein, AAT; erythrocyte sedimentation rate, ESR; Images in COPD: idiopathic emphysema in a never smoker. Images in COPD: idiopathic emphysema in a never smoker. development of chronic obstructive pulmonary 10% of patients with emphysema have either rarely Thomas Jefferson University Hospital, Philadelphia, Pennsylvania alpha-1-antitrypsin protein (AAT) level of 141 mg/dL emphysema, in a never smoker patient, other potential 3% of cases of emphysema.2 The rate of decreased lung suspected if the patient presents with emphysema at a Intravenous drug use has been associated with early onset development of emphysema. decades, HIV-associated emphysema develops over a vasculitis.10 Emphysema in HUVS has been thought risk for developing emphysema.11,12 Emphysema in nonsmokers: alpha injection of talc-containing drugs intended for oral use. Long-term risk of emphysema in fibrosis and emphysema in patients exposed to agrochemical work_frhyilnjgve23ol4blynsvsgcq However, there is an eccentric, crescent-shaped hyperintense signal encasing the anterior aspect of the left internal carotid artery on T1and T2-weighted MRI images, which This finding is characteristic of a subintimal hematoma related to left internal carotid artery other complication from her internal carotid artery dissection. carotid or vertebral arteries is an important cause of neck artery dissection presented with a painful Horner syndrome. An MRI is commonly ordered to evaluate neck pain, suspect arterial dissection and dedicated vascular imaging (P) demonstrate left internal carotid artery dissection. a–c Crescentshaped bright signal caused by sub-intimal blood products (arrowhead) draped over the black left internal carotid artery flow void internal carotid artery sub-intimal hematoma (arrowhead) conspicuous. ''''flow voids'''' on MRI that appear a black signal along the patient maintains a flow void in her left internal carotid internal carotid artery is diagnostic of a sub-intimal carotid artery dissection. work_fsqmoqxrv5g7tjxig2yts3oina he founders of American independence included the study of mathematics and science in the late carried out experiments in electricity, such as his celebrated he was fascinated by magic squares, and constructed a column, or 4 9 4 sub-square, have the same sum. Thomas Jefferson (1743–1826), the third president of the United States, extolled the virtues of science and wrote of the Interested in classical architecture, he designed his home, Monticello, and the rotunda of the University of Virginia. France, and strongly advocated decimalising the American coinage, but it was not until 1866 that the United States Congress passed a law legalising the use of metric measurements. Benjamin Banneker (1731–1826) was a self-taught mathematician and astronomer. In later life he constructed accurate astronomical Benjamin Franklin Thomas Jefferson Franklin''s lightning experiment Virginia rotunda Banneker and Washington Benjamin Banneker � Column editor''s address: Robin Wilson, Mathematical Institute, 96 THE MATHEMATICAL INTELLIGENCER � 2017 Springer Science+Business Media New York work_fu4vzyvcpjgdrnuvgv2bma7z4i [PDF] Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature | Semantic Scholar Corpus ID: 49314626Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature title={Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature}, Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and induces autophagy in endothelial cells. Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy. Endorepellin Evokes Autophagy in Endothelial Cells* The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_fxjatxsmnfflhpit7sbqcl6hfi PMS43 IS THE HEALTH UTILITIES INDEX VALID AND RESPONSIVE IN ASSESSING PATIENTS WITH ANKYLOSING SPONDYLITIS? The Health Assessment Questionnaire (HAQ) was used to measure functional status (scores 0–3). reported signifi cantly worse scores in morning stiffness, fatigue, pain, and PCS (all CONCLUSIONS: RA patients using current SC biologics still suffer from serious impairments in symptoms, functional status, QoL, and However, patients who discontinued SC biologic therapy have signifi cantly worse symptom scores, physical functioning, and activity impairment compared with those currently being treated. Utility scores correlated signifi cantly with WOMAC™, and patients with high BMI RESULTS: Compared to the general population, our study sample performed poorly with respect to all the SF-36 domains except mental health (MH) and patients who exercise regularly have higher quality of life scores and clinical outcomes. validity of the HUI-3 for deriving utility scores for AS patients. work_fzaeb7iocrgfnnra3xfwtwupjq different effects of mutations of individual asparagines on the channel activation, inactivation, and drug sensitivity. Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: We use Molecular Dynamics simulations to identify the binding sites for a hydrophobic general anesthetic isoflurane, on voltage gated bacterial sodium channel NaChBac. Apart from the NavAb was published (Payandeh et al (2011) Nature 475, 353), giving an unambiguous picture of the structure of the sodium channel selectivity filter (SF) Experimental ion selectivity determination from pore-only constructs of a sodium channel with the same SF sequence for PIIIA when the NavAb channel is occupied by 2 sodium ions. Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: Structure and Accessibility of Distinct Interaction Sites A Key Gating Charge Interaction Required for Slow Inactivation of the Navab Bacterial Sodium Channel Volatile General Anesthetic Interactions with a Bacterial Sodium Channel Polymodal, High Affinity Actions of μ-Conotoxins on a Bacterial Voltage-Gated Sodium Channel work_g3pt6scrhfb6niwzlyojtfv5ha Anatomic anomalies of the infrarenal aorta and iliac arteries are rare. aorta bifurcated immediately inferior to the main renal arteries, at the level of the second lumbar vertebrae. vascular anomalies included a common superior mesenteric artery/celiac axis plus multiple renal arteries. main renal arteries, with a dominant left common iliac The right common iliac artery traveled in a circuitous route Reprint requests: Eric Hager, MD, Thomas Jefferson University Hospital, In addition to the nonbranching right iliac artery (Fig 3, a) and high a common celiac axis-superior mesenteric artery trunk (Fig 3, b); retroperitoneal course of the right common iliac artery. of the left common iliac artery, the patient demonstrates bifurcation of the aorta and sweeping right common iliac artery. Congenital anomaly of the external iliac artery: a case report. Congenital anomalies of the external iliac artery: case report and review of the literature. of the right common iliac artery with no branches, work_gb5rlsphfjehhkepox5hejbplu We have recently found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, In this study, we evaluated and compared the biophysical properties of mitochondrial Ca2þ uptake in different mouse tissues. Bcl-xL Increases Bax Mitochondrial Localization and Activation in NonApoptotic Cells We report that, in non-apoptotic pro-lymphocyte cells, Bcl-xL induced an increase of the mitochondrial localization of Bax up to the level found in apoptotic cells. mutant of Bcl-xL, that lost its capacity to inhibit Bax-induced release of cytochrome c, still increased the mitochondrial localization of wild-type Bax, thus The Isoform Specific N Terminus of VDAC2 is Dispensable for tBid Induced Cytochrome C Release The Isoform Specific N Terminus of VDAC2 is Dispensable for tBid Induced Cytochrome C Release Patch-Clamp Analysis of Mitochondrial Ca2+ Uniporter in Different Tissues Bcl-xL Increases Bax Mitochondrial Localization and Activation in Non-Apoptotic Cells work_gen7vzxntfgfxhtxqokbwsnvd4 sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220678009 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:17 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_gewu5p6lcvepvfwrwrwkxnnwci mitochondrial membranes which result in the dramatic increase of their permeability. study investigated how mtDNA T8993G (NARP)-induced inhibition of mitochondrial complex V altered mitochondrial dynamics in association with a protective mitochondrial phospholipid, cardiolipin (CL), as a potential therapeutic a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca2þ and lipidstress. Intriguingly, melatonin, by differentially preserving CL during various stresses (oxidation > Ca2þ > lipid), rescuesdifferentially CL-altered mitochondrial dynamics and cell death (oxidation > CL to prevent its oxidization and/or depletion and, therefore, it exerts great potential in rescuing CL-dependent mitochondrial dynamics-associated mitochondrial pathologies for treatment of NARP-induced pathologies and diseases. of an outer mitochondrial membrane protein. Tunde Golenar1, Gyorgy Csordas1, Fabiana Perocchi2, Vamsi K. MICU1 in mitochondrial Ca2þ uptake, we used wild type HeLa cells (Ctrl), mtDNA T8993G Mutation-Induced Mitochondrial Complex V Inhibition Augments Cardiolipin-Dependent Alterations of Mitochondria ... Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells work_ggna7lxt5bdnrnvac7lrj2t2ja Medical School Anatomy and Pathology Workshops for High School Students Enhance Learning and Provide Inspiration for Careers in Medicine | Semantic Scholar Corpus ID: 6342378Medical School Anatomy and Pathology Workshops for High School Students Enhance Learning and Provide Inspiration for Careers in Medicine title={Medical School Anatomy and Pathology Workshops for High School Students Enhance Learning and Provide Inspiration for Careers in Medicine}, Fenderson, +2 authors Tracey Wojdon-Smith "Anatomy and Pathology Workshop" is a cadaver-based outreach program that models medical education to large groups of high school students. This study was designed to evaluate the impact of this program on students'' knowledge of anatomy and interest in biomedical science. Anatomy of a successful K–12 educational outreach program in the health sciences: Eleven years experience at one medical sciences campus By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_gj4t6vwnwzfgdduyvrmzq3wbxy DOI: 10.3892/mmr.2017.7698 structure and remodeling following myocardial infarction JIANSHU GAO, XIAOQIANG LIU3, BINGJIAN WANG, HAIYAN Mol Med Rep 16: 673-679, 2017; DOI: 10.3892/mmr.2017.6643 Following the publication of this article, an interested reader drew to our attention that we had incorrectly reported (in the Materials and methods section, ''Western blot analysis'', on p. 674) that the anti-farnesoid X receptor (FXR) antibody of used in this study to probe for FXR. of Dr Xin-Liang Ma at Thomas Jefferson University (Philadelphia, PA, USA), as referenced in the following article: Koch W, Xin-Ma XL and He B: Cardiomyocyte-expressed the western blotting analysis was raised against the C-terminus of FXR (C-20; cat. We sincerely apologize for this mistake, and thank the reader of our article who drew this matter to our attention. error made in our incorrect referencing of the antibody did not affect the conclusions reported in this study. regret the inconvenience that this mistake caused. work_glckmfmdcfca7ctqfycvzyzznm sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. 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Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_gltaeczlxjfebk7eg54uv3t3iy sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220685139 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:25 If you need further help, please send an email to PMC. Include the information from the box above in your message. 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Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_gmgx6h6rtfgn5jzhb3v54fp5xq work_gtx2btazrvfgnayzuyenwoixgi CRT-130 Gender Difference on Procedural and 30-day Outcomes in Patients Treated with Orbital Atherectomy for De-Novo, Severely Calcified Coronary Lesions: Results from the ORBIT II Trial Background: In prior studies, patients with previous coronary artery bypass grafting 30-day outcomes in patients with and without a history of previous CABG in the ORBIT Kaplan Meier at 30-days, patients had similar low rates of MACE (previous CABG: Methods: ORBIT II patients with severely calcified coronary lesions treated with the Orbital Atherectomy for De-Novo, Severely Calcified Coronary Lesions: Results from the analysis, we evaluate the procedural and 30-day outcomes of male and female patients females treated with orbital atherectomy for severely calcified coronary arteries Comparing the Procedural and 30-Day Outcomes in Patients with or without a History of Coronary Artery Bypass Graft When Tre ... Gender Difference on Procedural and 30-day Outcomes in Patients Treated with Orbital Atherectomy for De-Novo, Severely Calc ... work_gvvrew3nqrambfetplnlmrcgvi found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, due to its role in supporting Bak insertion to the OMM for Bak targeting to the OMM and tBid induced cytochrome c release. 1Thomas Jefferson University, Philadelphia, PA, USA, 2Semmelweis heterogeneous distribution of OMM proteins than wild-type cells, and in particular that heterogeneity of pro-apoptotic Bak leads to dysregulation of Biddependent apoptotic signaling. Here we applied mitochondria matrix-targeted DsRed and photoactivable GFP to study mitochondrial fusion in rat FDB SM fibers. BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells Which Domain of VDAC2 is Necessary for Bak Insertion to the Outer Mitochondrial Membrane and tBid Induced Cytochrome C Re ... Outer Mitochondrial Membrane Protein Distribution and Function Depend on Mitochondrial Fusion BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells before and after Hypericin Photodynamic Action BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells before and after Hypericin Photodynamic Action work_gwgr6itufngmrheyg7pjmcv3ca sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. 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Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_gxbygdbdlzbuhmly7jz7ifnlfm Nucleon form factor data available before the start of Elastic electron scattering has provided most of our information on the spatial distributions of the quarks in the using a different approach to model-independent analysis [3] of nucleon form factors. data will provide further insight and sensitivity for completing our understanding of how to construct nucleons Neutron radial charge distribution (top) and the polarization term contribution to the proton radial charge distribution (bottom) as inferred from an analysis using phenomenological models [2] of the world nucleon form factor data. Nucleon strange form factor data from parity-violating the energy and momentum of the final state proton measured in coincidence with the inelastically scattered electron, it is straightforward to infer the missing mass associated with the decay of the excited state (see fig. the pion cloud and of the value of measuring the transition form factors for nucleon excitation is the Roper work_gycky3uo6bewrdyivudpoxijxa KEYWORDS • Thomas Jefferson; John Locke; Private Property; Declaration of Independence; Republicanism. to harm another in his Life, Health, Liberty, or Possessions." Albeit in the Declaration of Independence Thomas Jefferson (1743-1826) omitted Locke''s mention of property and replaced it with That America could lose its soul and become that kind of aggregate of private properties denounced by Hegel represented, in fact, Jefferson''s worst nightmare. nearly the socialist conception that living labor has claims superior to any property rights." Jefferson, Lynd''s argument continued, "seemed to imply that, in the absence of remedial state action, On Jefferson considering property of land sanctioned by the "laws of civil society" for the encouragement of industry (also shorn of any moral reprobation), see TJ to Thomas Earle, 24 Sept. 22 Yarbrough, "Jefferson and Property Rights," 68; TJ to James Madison, 28 Oct. 1785, PTJ, 8:682. work_gzgrjss2mbd27cam4ru6vqoesy Background: Pancreatic neuroendocrine tumors (PNETs) are relatively rare, and data guiding management of neuroendocrine tumor (PNET) resected through distal pancreatectomy and splenectomy who developed recurrent and fine-needle aspiration may have had a role in seeding the posterior gastric wall, highlighting the risk of performing this diagnostic procedure in the setting of suspected pancreatic malignancy. Keywords: metastatic pancreatic neuroendocrine tumor; PNET prognosis than pancreatic ductal adenocarcinoma, hepatic metastases are observed in more than 50% of patients with PNETs and are associated with a 5-year Surgical pathology revealed a pancreatic neuroendocrine carcinoma in the gastric wall and adrenal gland pancreatic neuroendocrine neoplasm recurrence potentially from needle-tract seeding. endoscopic ultrasound-guided fine needle aspiration for pancreatic cancer. recurrent metastatic pancreatic neuroendocrine tumor with gastric invasion: consequences of potential needle-tract seeding from fineneedle aspiration, Case Reports in Pancreatic Cancer 2:1, 58–61, DOI: PNETs ¼ pancreatic neuroendocrine tumors Zheng et al.; Case Reports in Pancreatic Cancer 2016, 2.1 work_h2titnoefvb5rmyy46zvbyosfm Developing and Sustaining a Web-Based Library Newsletter 1990''s, Scott Library, like most others, used printed newsletters to inform users about new resources and the Forum seemed like a good time to look back at its in developing and sustaining a library newsletter. ■ Library news and information (primary focus) participation of Library and AISR staff members University and Hospital faculty and staff to contribute ■ Ability to search content (including current issue Information Services and Research (AISR)—with JEFFLINE, The first issue of the JEFFLINE Forum, October 1999. A contents page containing links to articles and at least one http://jeffline.jefferson.edu/Education/forum/ ■ Establishing ties with library staff to contribute ■ Recruiting non-library staff to contribute articles "how to" articles and "tips." features to each article ■ Readers like the flash demos created using Camtasia and ■ We recognize that the Forum is time consuming to non-Jeffersonians subscribe to the JEFFLINE Forum Scott Memorial Library work_h6mkrfmi5zfj3kkklfjos5e3ye Three other Jefferson collections, at the Virginia State Library The Rare Book and Manuscript Division of the University of Virginia Library has attempted to trace all surviving letters to and from 1 Two index volumes in the Jefferson Papers, Library of Congress. collected editions of Jefferson''s writings, and printed items in historical journals and other publications. Randolph, who published a Memoir, Correspondence, and Miscellanies, from the Papers of Thomas Jefferson (4 vols., Charlottesville, of Congress received 178 drafts of Jefferson''s letters on the University of Virginia, and some years earlier Wilson Cary Nicholas Randolph had presented to the University of Virginia 62 of Jefferson''s sketches and plans of its original buildings.20 The Library of Congress added 121 "inedited letters" to its collection at a sale in Philadelphia, and has since acquired other Jefferson Early History of the University of Virginia as contained in letters of Thomas Jefferson work_hgjwyqyucfca7b24az4mge2hye ISSN: 1532-5008 (Print) 1532-5016 (Online) Journal homepage: https://www.tandfonline.com/loi/uemp20 Boldea (2013) In Memoriam: Jim Cathey, Electric Power Components To link to this article: https://doi.org/10.1080/15325008.2013.805632 https://www.tandfonline.com/action/journalInformation?journalCode=uemp20 https://www.tandfonline.com/action/journalInformation?journalCode=uemp20 https://www.tandfonline.com/loi/uemp20 https://www.tandfonline.com/action/showCitFormats?doi=10.1080/15325008.2013.805632 https://www.tandfonline.com/action/authorSubmission?journalCode=uemp20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=uemp20&show=instructions https://www.tandfonline.com/doi/mlt/10.1080/15325008.2013.805632 https://www.tandfonline.com/doi/mlt/10.1080/15325008.2013.805632 With sadness, the electrical engineering community learned that Professor Jim Cathey from University of Kentucky, Editor-in-Chief for more than a decade of Electric Power Jim joined the faculty at University of Kentucky decades ago, when I was there Coming from industry, Jim had remarkable practical electrical His textbook on electric machinery is an excellent demonstration of teaching talent: depth, balance, clarity, practicality, and impeccably worked-out More than a decade ago, Jim took over this journal from its founding editor, Professor as a service to the worldwide electrical engineering community. in Kentucky and around the globe through Electric Power Components and Systems. Electric Power Components and Systems Electric Power Components and Systems Electric Power Components and Systems work_hnrimwptxzfnpmx3yggmifmb7i sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220680266 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:19 If you need further help, please send an email to PMC. Include the information from the box above in your message. 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Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_hpmg75ruwjcxdnjrjw3qc36lzq sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220686314 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:27 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_ht6dow65jvbovcm6xtt4bqakmy the outcomes that patients deem most important for their quality of life and overall health. assess patient expectations with regard to seeking spine care, we conducted a prospective study Conclusions: It is possible that current outcomes measures for spine surgery, including the VAS, patient-specific outcomes measures in spine surgery. Patient-Centered Outcomes in Spine Surgery. Analogue Scale of Spinal Pain (VAS), Oswestry Disability Index (ODI), Short Form Health Survey Spine surgery serves as an appropriate model for patient centered outcomes in neurosurgery as it Current validated measures for patient outcomes in spine surgery include the VAS [13], ODI [14In this survey, the majority of patients seeking evaluation at a spine surgery center did so for http://scholar.google.com/scholar?q=intitle:The Patient Protection and Affordable Care Act: implications for public health policy and practice TABLE 4: Validated measures for patient outcomes in spine surgery TABLE 4: Validated measures for patient outcomes in spine surgery work_ht6shvqfizdfzodjbtjxqypg4i [PDF] A Basic Probe of the Beale Cipher as a Bamboozlement | Semantic Scholar Corpus ID: 5468494A Basic Probe of the Beale Cipher as a Bamboozlement title={A Basic Probe of the Beale Cipher as a Bamboozlement}, Methods Citations Citation Type Citation Type Cites Methods Sort by Most Influenced Papers View 1 excerpt, cites methods View 1 excerpt, cites background View 1 excerpt, cites background Authorship Attribution Authorship Attribution Psychology, Computer Science The Beale Cipher as a Bamboozlement Part II The Beale Cipher: a Dissenting Opinion Philosophy, Computer Science The Beale cipher: A dissenting View 1 excerpt, references background View 1 excerpt, references background Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License ACCEPT & CONTINUE work_hwxx5didljd2lk5lo4bevhxtza Voltage-activated potassium (Kv) channels open an intracellular gate in response to changes in transmembrane voltage, allowing K N-terminus of the protein acting as a blocking particle, binding at the intracellular cavity of the channel and physically obstructing the permeation pathway. results suggest that despite being tethered to a particular subunit, the single inactivation particle has sufficient freedom to interact with position 470 of each from the solution; from the gate it repels an ion in the channel pore cavity into Water Structure at the Potassium Channel Gate: The Importance of the Gating Interactions between the Cytoplasmic T1 Domain and Pore of a Kv Channel Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Water Structure at the Potassium Channel Gate: The Importance of the Prolines in the PVPV Sequence, as Shown by Computation ... work_i2uc4p4zq5cw3jp7kacmhysxje Mennonites, Amish, and the American Civil War (review) Mennonites, Amish, and the American Civil War (review) Big Bone Lick State Park Museum and should remain a standard resource The Ohio State University Mennonites, Amish, and the American Civil War. By James O. Ohio and Indiana paid a $200 commutation fee or hired substitutes to avoid (Kent, Ohio: Kent State University Press, 2008. With his biography of Martin Davey, Frank Vazzano sets out to tell the "good Davey''s terms as governor, all of which appeared in Ohio History. Davey''s life and times during his formative years and early career during the Vazzano captures the transformation of Davey during changing times as he turns Although one of Ohio''s most successful politicians in the twentieth century who served multiple terms as mayor, in Congress, and as governor of Ohio, Davey remains elusive as a political leader. Vazzano documents Davey''s work_i3ya3uetzzdedebpvrojgucbem Expanding human populations may have important effects on the availability of timber from private lands in the South. examine the effects of development on timber supply, we compared the density of populations and various site variables with expert opinions on the future location of commercial timberland for a study site in Virginia. predictor of commercial timberland and resulting probability equations provide a method for adjusting timber inventories. Findings indicate that the transition between rural and urban land use occurs where population density is between 20 and 70 Population effects reduce commercial inventories between 30 and 49% in the study area. effect may be the reduced investment in timber production in areas of moderate population density as total effect of population density on timberland area population density of 45 people psm and the probability of commercial forestry is >0.75 at ca. lands and adjusting forest area for population effects work_i472kap5ejf5rdur3za75zbqia Keywords: Murine model, intervertebral disc, nucleus pulposus, annulus fibrosus, spine. SMAD-3 knockout Spinal malformations and kyphosis, changes in CEP structure, and decreased IVD proteoglycan and collagen content. Defective notochord sheath, deformed NP, cell death, and reduced SHH signalling; secondary impairment of dorsalventral neural tube patterning. MCT4 knockout Disc degeneration with increased aggrecan degradation, MMP13, and type X collagen levels. Shhcre; Hif-1αfl/fl Notochordal cell loss and severely prominent fibrosis of the disc by 1 month of age. SOX5/6 double knockout Defective notochord sheath formation, apoptosis of notochord cells, and spine lacking NP. Ercc1 deficiency Advanced age-related degenerative changes in the vertebral bodies and intervertebral discs, including reduced proteoglycan content, increased apoptosis, and increased p16. Note: while perlecan is referred to as an HS-proteoglycan, intervertebral disc cells synthesise gene in notochord-derived cells results in ageassociated degeneration of IVDs, decreased levels COL9A1 knockout Premature degeneration associated with physical impairment and degenerative changes in the disc including the CEP. work_i7txrd33offu3juanxc33aoyti Abstract: A recent article by Joseph Buschman regrets that democratic theory is an unfinished The argument appears to assume an essential relationship between library information science (LIS) and democratic theory. In his article "Democratic theory in Library Information Science: Toward an Information Science (LIS) "democratic theory is an unfinished, truncated idea remaining at its chronic collective failure to develop "democratic theory" in LIS, and concludes with a forceful the technology is deployed, so library service would be democratic only accidentally through the It is widely accepted that accessible public libraries with liberal collection development point, effective library services are also important for non-democratic political regimes. always pervades library service and it is not necessarily democratic. There are, I submit, two reasons for the lack of democratic theories of LIS. Democratic theory in Library Information Science. Democratic theory in Library Information Science. Democratic theory in Library Information Science. Library services in theory and context. work_icfhfj4xybadbm3jdjwfc2wyz4 sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220678172 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:17 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_icg7osjckbgrtm5x5jc7r4ihfe sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220677342 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:16 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_icsipe3itza57oc7ahgvt4fxwi The voltage dependent anion channel (VDAC) is involved in regulation of metabolite flux across the mitochondrial outer membrane (MOM). G6P, which is known to cause HXK2 detachment from the MOM, fully reverses the inhibition of tubulin-VDAC binding. Thus we propose a novel mechanism of mitochondrial respiration control in cancer cells through the competition between HXK2 and tubulin for VDAC binding. matrix [Ca2þ] response in permeabilized shMICU1 cells. MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca of MICU1 in HeLa cells causes lower threshold and decreased cooperativity of Silencing of MICU1 caused a leftward-shifted dose response and decreased cooperativity of mitochondrial Novel Mechanism of Mitochondrial Respiration Control through Competition between Hexokinase-2 and Tubulin for VDAC Binding Reprogramming of Mitochondrial Ca2+ Handling in MICU1-Deficient HeLa Cells MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca2+ Uptake in the Liver MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca2+ Uptake in the Liver work_ie3uvlhknza3pen3zjqo22ywy4 sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220680289 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:19 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_igkr4atmrjaffibtgqagu3cuse Thomas Jefferson, Poplar Forest, First Floor Plan. Poplar Forest is of brick construction and octagonal in plan, containing a central 8, the construction is scaled to Jefferson''s plan for Poplar Forest. The square locates the center room of the Poplar Forest plan (fig. Jefferson''s preliminary sketches for Pantops/Poplar Forest, before 1804, produce octagonal Thomas Jefferson''s Poplar Forest: Symmetry and Proportionality in a Thomas Jefferson''s Poplar Forest: The Mathematics of an Ideal Villa. Jefferson''s Poplar Forest. Thomas Jefferson''s Designs for the University of Virginia. Constructing Optimism: Thomas Jefferson''s Poplar Forest. 498 Rachel Fletcher – Thomas Jefferson''s Poplar Forest 498 Rachel Fletcher – Thomas Jefferson''s Poplar Forest 498 Rachel Fletcher – Thomas Jefferson''s Poplar Forest 498 Rachel Fletcher – Thomas Jefferson''s Poplar Forest 498 Rachel Fletcher – Thomas Jefferson''s Poplar Forest 498 Rachel Fletcher – Thomas Jefferson''s Poplar Forest Thomas Jefferson''s Architectural Drawings. Thomas Jefferson''s Poplar Forest Thomas Jefferson''s Poplar Forest Thomas Jefferson''s Poplar Forest work_iidvjzadlzdhnno6xgicblnkwe sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220678373 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:17 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_ijti7doz7fbzngzzfhtoejlsgm Adequate and Predictable Stem Cell (SC) Collection and Low Incidence of Neutropenic Fever (NF) with Cyclophosphamide (C) and G-CSF Mobilization in Multiple Myeloma (MM) : A Single Center Analysis Three patients received plerixafor prior to day 2 collection. There was no significant difference in CD34 yield, neutropenia, or NF hospitalization in patients >70 years. Methods: A retrospective chart review examining outcomes in patients with MCL who underwent either autologous or allogeneic peripheral blood HSCT at Thomas Results: A total of 12 patients with MCL underwent HSCT In the allogeneic HSCT group, median One of 5 patients had residual disease prior to HSCT. autologous HSCT group, the median number of prior therapies was 1. Post autologous HSCT 2/7 patients relapsed Our patients who underwent autologous HSCT were transplanted earlier (08/ Autologous HSCT for patients with MCL can also provide outcome of patients with t(4;14) after high-dose chemotherapy and autologous hematopoietic stem cell transplant work_ijyhzd6gvfe6ziaas7xm23q4li Acquisition, analysis, or interpretation of data: Radhakrishnan, Nowak, Parker, Hospital Risk of Data Breaches Hospital Risk of Data Breaches the Department of Health and Human Services (HHS) to examine what type of hospitals face a higher risk of data breaches. The Department of Health and Human Services publishes the submitted data breach incidents on 4859) affected individuals per breach; 33 hospitals that had Broad access to health information, essential for hospitals'' quality improvement efforts and research and education needs, inevitably increases risks for data The evolving landscape of breach activity, detection, management, and response requires hospitals to continuously evaluate their risks and apply best data security practices. Aventura Hospital and Medical Center FL 2 Cincinnati Children''s Hospital Medical Center OH 60 998 Reid Hospital & Health Care Services IN 22 001 Author Contributions: Dr Bai had full access to all of the data in the study and Data breaches of protected health information in work_il2ytikkcvhktlpwxw46dgflri Anti-Hla Antibodies Predict Graft Failure, Time To Engraftment And Umbilical Cord Unit Dominance In Double Umbilical Cord Blood Transplantation stem cell transplantation can result in long term survival most patients lack a matched family donor and are destined to die of refractory disease. of patients with PREF AML in whom allografting is technically feasible but the outcome of unrelated donor transplantation in this of patients with PREF AML who are likely to benefit from unrelated donor transplantation. HLA DISPARITY AND RAPID IMMUNE RECONSTITUTION DO NOT OVERCOME PROPENSITY TO RELAPSE IN PATIENTS UNDERGOING HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT) WITH ANTI-HLA ANTIBODIES PREDICT GRAFT FAILURE, TIME TO ENGRAFTMENT AND UMBILICAL CORD UNIT DOMINANCE IN DOUBLE UMBILICAL Methods: 73 patients with banked pre-transplant sera who underwent DUCBT using 4/6 or better allelic HLA-matched UCB RECIPIENTS OF MATCHED UNRELATED ADULT DONOR (MUD) PERIPHERAL BLOOD STEM CELL TRANSPLANTATION (PBSCT) PRELIMINARY RESULTS OF DAY 100 TRM, IMMUNE RECONSTITUTION (IR), PTLD, work_ipo4o4umibfzdeyg77wumg3yam and included Group 1 (n�24) with a placental edge-to-internal os distance of 1-10 OBJECTIVE: To assess the relationship between umbilical artery acid-base status and major neurodevelopmental disability at age 6 years among very preterm CONCLUSION: The risk of long-term major neurodevelopmental disability associated with abnormal cord pH and base excess remains considerably increased OBJECTIVE: To determine whether the increased rate of preterm birth (PTB) among women in a methadone treatment program is associated with supplementation of methadone with additional substances. No. of "supplements" to methadone Preterm birth OR (95% CI) vaginal delivery were recruited as control group and patients( n�15) who underwent c sections due to NRFHRP were recruited as study group. After vaginal dinoprostone application there was statistically significant increase in uterine arteryRI(uaRI) in study CONCLUSION: Increased uaRI more than 0.11 after sustained release of dinoprostone in postterm pregnancies may allow earlier prediction of development of work_iy4z2dwpb5bkflxs7rs2aqkrly [PDF] Patient Perceptions of Telehealth Primary Care Video Visits | Semantic Scholar Corpus ID: 4288476Patient Perceptions of Telehealth Primary Care Video Visits title={Patient Perceptions of Telehealth Primary Care Video Visits}, Our objective is to describe patient experiences with video visits performed with their established primary care clinicians. METHODS We constructed semistructured, in-depth qualitative interviews with adult patients following video visits with their primary care clinicians at a single academic medical center. Patient Perceptions of Telehealth Primary Care Video Visits [Original Research] New research shows patients value the convenience of telehealth Sort by Most Influenced Papers Patient Perceptions of Video Visits Using Veterans Affairs Telehealth Tablets: Survey Study Physicians'' experiences of video consultation with patients at a public virtual primary care clinic: a qualitative interview study Acceptability, benefits, and challenges of video consulting: a qualitative study in primary care Patients'' Satisfaction with and Preference for Telehealth Visits work_j2jgmfw46bhgflssy62y3za3wa sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. 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Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_j5aijqasyrddfbomfe6hwyykea sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220684119 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:24 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_jai4xhsisbdg3j4xhyntxar3sm We investigated the kinetics of MAC inhibition in mitochondria from wild type, Bak, and Bax knockout cell lines using Mitochondrial Ca2þ has a critical role for balancing cell survival and death. Here we show that adrenergic signaling induces MCU tyrosine phosphorylation and accelerates mitochondrial Ca Pyk2 and MCU, which subsequently accelerates mitochondrial Ca2þ uptake via confirmed that only two tyrosine sites were phosphorylated in response to adrenergic stimulation in situ using cell lines stably expressing MCU-YFs. In addition, overexpression of these MCU-YFs failed to increase mitochondrial Ca is required for activation of Akt survival pathways and mitochondrial function. At embryonic day (E) 9.5, mitochondrial ETC activity and oxidative phosphorylation (OXPHOS) are not coupled, Initiation of Electron Transport Activity and a Decrease of Oxidative Stress Occur Simultaneously during Embryonic Heart De ... The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver work_jb26bv33fnbgrbkbbfy324nqry and why." Rinaldi chose to depict Jefferson and the Monticello community through the eyes of a house slave who enjoys privileges alien historical evidence than the novel provides may question whether Jefferson deserves Harriet''s pity-provoking depiction of him: this essay Despite the four historical inaccuracies that this essay will examine later, and despite Harriet''s relatively privileged slave status, the Before discussing these four historical inaccuracies and why they matter, this section examines Rinaldi''s choice of Harriet rather than Sally whom Harriet had to contend" (Thomas Jefferson and Sally Hemings 31). In Rinaldi''s novel, Martha complains to Harriet, "There are altogether too many Hemings on this place to suit me." She refers to herself Rinaldi''s narrative purpose: Harriet''s efforts to please Jefferson are on Rinaldi''s depiction of Jefferson in this scene with Harriet conflicts with the speculates that Beverly may have eased Harriet''s transition to Washington''s white culture (Thomas Jefferson and Sally Hemings 33). work_jcidujmtybar7mpakfqg2ygwmm Exclusion of Breast Cancer as an Integral Tumor of Hereditary Nonpolyposis breast tumors from three women who were carriers of MMR gene mutations from HNPCC families. None of these three breast tumors displayed MSI nor was the expression of MMR proteins altered in these tissues from �80% of patients with an HNPCC syndrome (Amsterdam or Bethesda Criteria) and 100% of patients with verified germline alterations of the hMSH2 or hMLH1 gene display MSI-H (8, 34, (Lynch II) syndrome comes from MSI analysis of single breast tumors To clarify the involvement of breast cancer in HNPCC, we examined the tumors from patients with synchronous and metachronous between breast cancer, MSI, and HNPCC, the results of Risinger et al. EXCLUSION OF BREAST CANCER AS TUMOR OF HNPCC EXCLUSION OF BREAST CANCER AS TUMOR OF HNPCC EXCLUSION OF BREAST CANCER AS TUMOR OF HNPCC EXCLUSION OF BREAST CANCER AS TUMOR OF HNPCC work_jmqxlacsvvbzvefkps76c7t6pq chromosome recruited male-line descendants of Thomas''s paternal uncle Field Jefferson, since Thomas had Another unwelcome revelation was the fact that one of the tested descendants carried a different Y-chromosome type from his putative of the Jefferson study relied upon non-paternity being the non-paternity frequency; when a test is done, there''s DNA-based kinship analysis is also used in the controversial practice of familial searching, where a crimescene DNA profile is used to search a database for profiles sufficiently similar to derive from close relatives; suspects from crime-scene DNA, by predicting their surnames from a large database of Y-STR profiles and associated names [12]. allows us to calculate an average non-paternity frequency of 1-4% per generation. 5. Macintyre S, Sooman A: Non-paternity and prenatal genetic screening. 7. Brock DJH, Shrimpton AE: Non-paternity and prenatal genetic screening. of familial searches in DNA databases. Thomas Jefferson''s Y chromosome belongs to a rare European lineage. work_jmzkjxptivdavglzf5qks52dfu been used to measure binding affinity of Adnectin-A to the cell surface expressed receptor X to measure the effect of avidity of the multivalent adnectin the channel activation gate; and KChIP4a KID directly interacts with the T1 interaction between the voltage sensing domain and the intracellular activation gate underlies CSI (Bähring & Covarrubias, 2011, J Physiol 589:461studies of structural mechanisms of hERG channel activation by small molecules are truly novel. pharmacophore model for hERG channel openers using PHASE protocol. Pharmacophore model is also combined with previously developed receptorbased homology model of hERG K channel and novel activators are generated A-Type Kv4 Channel Closed-State Inactivation is Modulated by the Tetramerization Domain Interacting with Auxilary KChIP4a A-Type Kv4 Channel Closed-State Inactivation is Modulated by the Tetramerization Domain Interacting with Auxilary KChIP4a Two-in-One: Activation and Inactivation at the Intracellular Gate of a Kv Channel Development and Validation Studies of Universal Pharmacophore Models for hERG Channel Openers work_jqgc6awppzcsxbcycaukophyde Self-plagiarism, also known as recycling fraud, occurs when an author reuses 3 text in subsequent writings without attributing the previous publication.1-3 4 themselves.5 In the US, copyright protection extends for the life of the author 21 Authors of technical articles are often asked to assign copyright to a 1 5. Have authors been legally sanctioned for violating copyright on their own 6 that "authors have special rights to their words not withstanding copyright."3 10 6. If copyright law has not been enforced against authors repeating themselves, 12 plagiarism ever easier to detect, 7 the JAAD urges all authors to promote 19 Self-plagiarism or fair use? Available at: http://www.plagiary.org/2007/song-from-myself.pdf. http://www.copyright.gov/title17/circ92.pdf. Copyright Term and the Public Domain in the United States. http://www.copyright.cornell.edu/training/Hirtle_Public_Domain.htm. Self-plagiarisim: Dellavalle, Banks, and Ellis-6 Self-plagiarisim: Dellavalle, Banks, and Ellis-6 Self-plagiarisim: Dellavalle, Banks, and Ellis-6 Self-plagiarisim: Dellavalle, Banks, and Ellis-6 Self-plagiarisim: Dellavalle, Banks, and Ellis-6 Self-plagiarisim: Dellavalle, Banks, and Ellis-6 work_jws3vkqayjgmbb6tbfyjs6jezi formed in mitochondrial outer membranes (OM) of apoptotic cells or in synthetic membranes by Bax and related proteins/peptides, using electron microscopy (EM), atomic force microscopy and x-ray diffraction. MAC function was induced through staurosporine treatment and microinjection of tBid or cytochrome c. apoptosis signals MAC formation, while pDsRed-2 expression shows mitochondrial structure as red fluorescence. microinjection with tBid or cytochrome c induced relocation of Bax and collapse of the mitochondrial network. cleaved by caspase-8 and other enzymes forming tBid that induce mitochondrial outer membrane (OMM) permeabilization and cytochrome c (cyto-c) release. coordinated cyto-c release and also inhibited tBid-induced cell death. The mammalian GRIF1 and OIP106, and the drosophila Milton are kinesinbinding proteins that form a complex with the Miro GTPase, an outer mitochondrial membrane EF-hand protein, to support the movement of mitochondria Mechanism of the Mitochondrial Cytochrome C Release Wave in Bid-Induced Apoptosis work_k6raqhvelffzrawxhq7f3ygnve 가 연구한 행복감과 삶의 영역별 만족도에 영향을 미치는 요인을 근거로 한국인의 행복감 에 영향을 미치는 결정요인을 검증하고자 하였다. 분석결과 한국인의 행복감은 행복을 둘러 인과적 영향을 미치는 요인은 모형마다 차이가 있지만 공통적으로 주관적 계층의식이 유의 미한 영향을 미치는 것으로 나타났으며, 영역별 만족도 가운데 가정생활만족도가 특히 더 많은 영향을 미치는 것으로 나타났다. 는가 하는 심리적 요인이 행복에 중요한 인과적 영향을 미치고 있으며, 우리가 살면서 행복 핵심용어: 한국종합사회조사, 행복감, 영역별 만족도, 일, 가정생활, 고 천명하고, 자유권, 평등권과 더불어 행복추구권을 국민의 가장 중요한 기본권의 하나로 명시 행복추구권에서 전제되는 행복은 객관화되기 어렵고 단지 추구만 할 수 있는 권리로 행복을 측정하는 초기의 지표들은 모두 객관적으로 나타날 수 있는 경제적인 것이었다. 회발전을 측정하는 중요한 지표로 활용된 GDP는 국민의 물질적 수준을 보여준다는 점에서 한 Easterlin(1974; 1995)은 후진국과 선진국, 사회주의와 자본주의 등 30개 나라의 행복감을 측정 (Easterlin Paradox)''을 주장하고 GDP 한계를 지적한 바 있다. 지만 국민의 행복감이나 사회발전 수준 등 보다 근본적인 부분에 대해서는 제대로 파악할 수 work_kmfxoxz3xnh4fbgnnwpmikxmni Score (DSS) for characterization of femoropopliteal arterial lesions. Methods: We evaluated 44 lesion and patient characteristics in our Results: We identified 1329 femoropopliteal lesions in 675 patients. Statistical analysis by multivariable Cox proportional hazards model identified 16 variables that impact patency: seven lesion characteristics (Table I) most impact were a chronic total occlusion (DSS 16), lesion length �100 Patient characteristics that impact patency after endovascular CAD, Coronary artery disease; CHF, congestive heart failure; CI, confidence interval; HR, hazard ratio. with bypass surgery for critical limb ischemia (CLI) with tissue loss and Methods: A retrospective review (2004 to 2010) of patients undergoing ET for tissue loss (Rutherford class 5 and 6) provided data for loss, ET permits sustained limb salvage in patients at high risk for bypass Midterm Results of Limb Salvage and Stent Patency with Popliteal limb salvage and stent patency in patients undergoing popliteal artery collected database, identifying all patients undergoing popliteal artery work_knc3kts4s5ak7dfmuw2hwsyfu4 Results: Female applicants to VS integrated programs increased �20Vascular Iliac Stents in the Treatment of TASC A, B, C and D Iliac Lesions included 325 patients, of which 190 presented with TASC A or B lesions and data were comparable for all TASC patient groups. The long-term survival rate was 65% in the endovascular patients (mean follow up, 33.9 months) and 80.8% in the surgical patients Methods: We evaluated 44 lesion and patient characteristics in our Results: We identified 1329 femoropopliteal lesions in 675 patients. Statistical analysis by multivariable Cox proportional hazards model identified 16 variables that impact patency: seven lesion characteristics (Table I) Patient characteristics that impact patency after endovascular Methods: A retrospective review (2004 to 2010) of patients undergoing ET for tissue loss (Rutherford class 5 and 6) provided data for Midterm Results of Limb Salvage and Stent Patency with Popliteal limb salvage and stent patency in patients undergoing popliteal artery work_knnzct6pkfgc3fx5egkozpsgei Diagnosing Mr. Jefferson: Retrospectives on developmental disabilities at Monticello. Diagnosing Mr. Jefferson: Retrospectives on developmental disabilities at In his book Diagnosing Jefferson: Evidence of a Condition That Guided His Beliefs, Behavior, and Personal Associations, Ledgin (2000) wrote with certainty that Thomas Jefferson was a support his argument that Jefferson had this developmental disability. According to Ledgin (2000), Jefferson actually referred to the University as "a The second characteristic of Jefferson described by Ledgin (2000) as being indicative of autism Ledgin (2000) also ascribed several of Jefferson''s personal relationship difficulties to autism. Jefferson was the sibling of a sister and a brother with disabilities. Randolph Jefferson who fathered Sally Hemings'' children and that Thomas was not involved In a book published by the Thomas Jefferson Heritage Society, Coates (2001) was age 51 when Eston [a child claimed to be the son of Thomas Jefferson and Sally Hemings] Thomas Jefferson. work_kr7qhnzdv5f6jnndny4kztgj5e CORR Insights®: Tendon Collagen Crosslinking Offers Potential to Improve Suture Pullout in Rotator Cuff Repair: An Ex Vivo Sheep Study : Tendon Collagen Crosslinking Offers Potential to Improve Suture Pullout in Rotator Cuff Repair: An Ex Vivo Sheep Study genipin, to augment tendon repairs. (ex vivo) sheep model, allows us to strength is enhanced after tendon incubation in genipin for 24 hours when strength of tendons repaired using a genipin has any real clinical utility. Future in-vivo rotator cuff animal article ''''Tendon Collagen Crosslinking Offers Potential to Improve Suture Pullout in Rotator Cuff Repair: An Ex Vivo Sheep Study'''' by � The Association of Bone and Joint Surgeons1 2016 A Publication of The Association of Bone and Joint Surgeons® in vivo of the genipin at the time of CORR Insightsreg: Tendon Collagen Crosslinking Offers Potential to Improve Suture Pullout in Rotator Cuff Repair: An Ex Vivo Sheep Study work_ks3o5n7e5jbg3o5rnyyakcvily obliterate real events that took place between the years of 1649 and 1660 on the island of Great Separate kingdoms of England and Scotland having a shared king. In the real world of 1649, England became a republic, and then, three years later, Scotland began already been crowned in Scotland as ''King of Great Britain'' institution which holds the real power in today''s United Kingdom of England, Scotland and Northern Queen Anne became the last monarch in line from Charles II, to rule separately over England and Scotland, England, tried to imply that their ''Union of Crowns'' was their authority to claim title as ''King of Great Britain'', According to the official nunc pro tunc version of current history, Scotland politically united with England in http://abcconn.org/history/index.php?title=American_Baptist_Historical_Society http://www.heritage.org/initiatives/first-principles/primary-sources/jefferson-s-letter-to-the-danbury-baptists http://www.abc-usa.org/what_we_believe/our-history http://www.monticello.org/site/research-and-collections/jeffersons-gravestone http://www.british-history.ac.uk/report.aspx?compid=74904&strquery=john%20lilburne 1776 Declaration of Independence, and noted that the reigning King George III of Great Britain had work_ks7qmlfaynb7zezlfptluf435e Pulmonary sequestration is an uncommon congenital pulmonary sequestration is only rarely associated with other This case report describes a patient with an intralobar sequestration on the right side who also had a left-sided segment of the right lower lobe, and the pulmonary vessels two segmental divisions-an isomerism of the left-sided Disease, Thomas Jefferson University Hospital, Philadelphia, PA pulmonary bronchial isomerism was made. thoracotomy showed a bilobed right lung, the upper lobe An intralobar sequestration was located in the medial portion of the right lower lobe The sequestrated lung segment was Intralobar pulmonary sequestrations constitute 0-2-6 4% 400 cases of intralobar pulmonary sequestration Savic et al do other reports of pulmonary sequestration"9 mention Intralobar pulmonary sequestration in conjunction with bronchial isomerism Intralobar pulmonary sequestration in conjunction with bronchial isomerism congenital anomalies of the lung, gut, abdominal viscera, Lung sequestrations: report of seven cases and review aortic arch associated with pulmonary sequestration. work_kwvyudrv4zalznxpzztokxrdee PHP24 A SYSTEMATIC REVIEW OF THE EUROPEAN PHARMACEUTICAL MARKET AND THE IMPACT OF EUROPEAN UNION REGULATION AND JURISDICTION OBJECTIVES: To elicit similarities and differences in the policies and practices for financing, pricing and reimbursing prescription drugs in the often perceived similar Nordic countries Nordic countries all have a national health care system financed To give a systematic overview of the current state of the European pharmaceutical market as a whole. CONCLUSIONS: The future of the actors in the European pharmaceutical market is not clear. conditions and assesses related health service use and costs in the Individuals were classified as having a chronic condition in 2000, and we examined pharmacy and hospital use/costs RESULTS: We identified five highly prevalent chronic conditions: cardiovascular diseases (N = 824,190, 20.8% of the population); rheumatologic CONCLUSIONS: Interestingly, one-fourth of the population with selected chronic conditions accounted for large proportions of cost and use of health work_kxfbgxp3ofbvng72zikzrcr6zm PIN21 THE CLINICAL AND ECONOMIC BURDEN OF COMPLICATED SKIN AND SKIN STRUCTURE INFECTIONS DUE TO STAPHYLOCOCCUS AUREUS: FINDINGS FROM A NATIONAL DATABASE RESULTS: The estimated unit cost of gargling was 49.2 yen. treatment costs and the costs of patients'' hospital stay. second group (ceftriaxone); the cost of hospital stay amounted In the breakdown of expenditure on treatment of community-acquired pneumonia with levofloxacin, patients'' hospital stay accounted for patients'' hospital stay amounted to 40% and that on drug treatment—to 60%. thus indicated that when using a more cost-effective drug (levofloxacin) for the treatment of one patient compared to a less (cSSSIs) are a common complication among hospitalized patients. S. aureus infection hospital stays were S. aureus infection on hospital charges and length-of-stay was Demographic, economic, and clinical data, including length-of-stay (LOS), payer types, total costs, and Diagnosis weights, as well as age are associated with total hospital costs work_kyngdaqaynbchmtuuhelcjmzvq Sosyal Bilgiler Eğitiminde İyi Bir Örnek: ABD Kongre Kütüphanesi tarafından yürütülen Amerikan Hafıza Projesi ve sosyal bilgiler eğitimine Bilindiği gibi kütüphaneler bir kurum olarak, sosyal bilgiler eğitiminin çok ABD''de çevrim içi birinci elden kaynak hizmeti veren pek çok kurum bulunmaktadır. Makalemi daha çok dijital tarih ve kültür materyallerini içeren Amerikan Hafızası milyon birinci elden tarihsel kaynak dijital ortama aktarılarak arşivlenmiş ve bir yılları arasında "Yorganlar ve Yorgancılık" ile ilgili bir koleksiyon da bulunmaktadır. Kongre Kütüphanesi, 1997-2001 arasında Amerikan Hafıza Bursiyer (Fellows) Pek çok eyalette sosyal bilgiler ve tarih öğretmenlerine yönelik birinci ve ikinci ortama aktarılması olarak özetlenebilecek olan Amerikan Hafıza Projesi ile önemli bir Sosyal Bilgiler Eğitiminde İyi Bir Örnek: ABD Kongre Kütüphanesinin Amerikan Hafıza Projesi Sosyal Bilgiler Eğitiminde İyi Bir Örnek: ABD Kongre Kütüphanesinin Amerikan Hafıza Projesi Sosyal Bilgiler Eğitiminde İyi Bir Örnek: ABD Kongre Kütüphanesinin Amerikan Hafıza Projesi Sosyal Bilgiler Eğitiminde İyi Bir Örnek: ABD Kongre Kütüphanesinin Amerikan Hafıza Projesi work_l65hqnshcvdmlkuyg44ouupb7e sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220679024 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:18 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_l6ilujshwrh6zmjv37za3by6iy *Department of Therapeutic Radiology, Yale University School of Medicine, Smilow Cancer Hospital, New Haven, Education radiation oncology training program directors (PD) and their chairs was performed. endowed chair assignment, National Institutes of Health (NIH) funding, and Hirsch index evaluating leadership trends over time and comparing academic radiation oncology with chairs of academic departments with training programs, for the combined Harvard Radiation Oncology Training Program), 7; that trained 62% of the chairs at the time of the study: Harvard Oncology Training Program), 13; National Cancer Institute, 6; former Joint Center Program, now the combined Harvard Radiation Oncology Training Program), 13 chairs/7 PD; University of Institution Chairs Program directors evaluated for faculty at radiation oncology training programs in A Profile of Academic Training Program Directors and Chairs in Radiation Oncology A Profile of Academic Training Program Directors and Chairs in Radiation Oncology Chair and program director institution of training Chair and program director institution of training work_lbteoujornfovnyuetg2t5hycm Hla Disparity And Rapid Immune Reconstitution Do Not Overcome Propensity To Relapse In Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant (Hsct) With Persistent Disease At The Time Of Transplant stem cell transplantation can result in long term survival most patients lack a matched family donor and are destined to die of refractory disease. of patients with PREF AML in whom allografting is technically feasible but the outcome of unrelated donor transplantation in this of patients with PREF AML who are likely to benefit from unrelated donor transplantation. HLA DISPARITY AND RAPID IMMUNE RECONSTITUTION DO NOT OVERCOME PROPENSITY TO RELAPSE IN PATIENTS UNDERGOING HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT) WITH ANTI-HLA ANTIBODIES PREDICT GRAFT FAILURE, TIME TO ENGRAFTMENT AND UMBILICAL CORD UNIT DOMINANCE IN DOUBLE UMBILICAL A Scoring System Predicting Outcome After Unrelated Donor Stem Cell Transplantation In Primary Refractory Acute Myeloid Leu ... work_ljgpbu32hbeodo3bwxpwgyym64 We investigated the kinetics of MAC inhibition in mitochondria from wild type, Bak, and Bax knockout cell lines using Mitochondrial Ca2þ has a critical role for balancing cell survival and death. Here we show that adrenergic signaling induces MCU tyrosine phosphorylation and accelerates mitochondrial Ca Pyk2 and MCU, which subsequently accelerates mitochondrial Ca2þ uptake via confirmed that only two tyrosine sites were phosphorylated in response to adrenergic stimulation in situ using cell lines stably expressing MCU-YFs. In addition, overexpression of these MCU-YFs failed to increase mitochondrial Ca is required for activation of Akt survival pathways and mitochondrial function. At embryonic day (E) 9.5, mitochondrial ETC activity and oxidative phosphorylation (OXPHOS) are not coupled, Initiation of Electron Transport Activity and a Decrease of Oxidative Stress Occur Simultaneously during Embryonic Heart De ... The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver work_ljteiyih6zfthmopdebx5fzyym (page number not for citation purposes) Mental health courts – a human rights perspective This presentation analyzes specialised mental health justice system, from a human rights (HR) perspective. MHCs and relating to PMIs essential dignity rights as well through respecting PMIs'' rights to services and fulfilling society''s duty to provide same, and not through MHCs, will PMIs be afforded the full rights that democratic states fundamental commonalities in approaches to the problems faced by MDOs provide a general societal and judicial context for an analysis of MHCs and a related HR provisions of the European Convention on Human Rights Coercive Treatment in Psychiatry: A Comprehensive Review

Thomas W Kallert, John Monahan, Juan E Mezzich Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-224X-7-S1-info.pdf This abstract is available from: http://www.biomedcentral.com/1471-244X/7/S1/S101 © 2007 Kerr; licensee BioMed Central Ltd. http://www.biomedcentral.com/ http://www.biomedcentral.com/ http://www.biomedcentral.com/info/about/charter/ work_llf466pvuvdodmoj5zxkxdwxmm Final proof that scientists can work with the research, the BBC programme The Experiment attempts to recreate aspects of a 1971 psychology study by Stanford University acting as guards were so brutal to the prisoners University who planned the experiment with and divided into 6 guards and 9 prisoners. more psychological stress than the prisoners. Reality TV show recreates famed social study Thomas Jefferson''s descendants have decided nearly 800 descendants of Jefferson''s Sally Hemings''s children bore a likeness to children by Hemings, who was a slave at Jefferson''s descendants have always descended from Sally Hemings''s son Eston with other evidence, indicated a "high probability that Thomas Jefferson fathered Eston father of all six of Sally Hemings''s children". But Jefferson''s descendants remain Sally Hemings," says Nathaniel Abeles, the Monticello Association''s president. Monticello, home of Thomas Jefferson, where Jefferson''s descendants continue to deny slave link Jefferson''s descendants continue to deny slave link work_ltqf5n3zyjbbxofsbhpjyeifx4 sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220685605 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:26 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_luaxo5mksvaqzoiflczn7iakxu HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol HIV-1 membrane fusion is mediated by sequential binding of the viral homotrimeric Env (gp120/gp41) to cellular CD4 and chemokine receptor (CXCR4 or bridges the viral and cellular membranes, and exposes the N-HR and C-HR domains which are targeted by HIV-1 fusion inhibitors T20 and 5-Helix, respectively. Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion Viral propagation in increasing inhibitor concentrations produced HIV-1 populations with 50to 100-fold reduced sensitivity cholPIE12-trimer. HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol Dependent Fashion CD4 Binding Induces an Asymmetric Transition of HIV-1 Env from its Native Conformation into the Prehairpin Intermediate State Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion Inhibitor Fusogenic Activity of the HIV-1 Gp41 MPER-TMD Region: Mechanism and Targeting by Immunogens and Inhibitors Fusogenic Activity of the HIV-1 Gp41 MPER-TMD Region: Mechanism and Targeting by Immunogens and Inhibitors work_lxzohfh3w5h65app3cz5xzlcqu public; including the ''Notes on Virginia.'' " To this Jefferson sent Commission called for the assembling of the entire Jefferson documentation in photofacsimile form; and the agreement with The which enabled us to obtain paper prints of the documents in the about one third the number of documents (17,000) that the Jefferson is planned to embrace in fifty volumes of text. of Jefferson''s "official papers" (the term is a very loose one) became the property of the United States in 1848 and, since the beginning of this century, has been in the custody of the Library of A page from Jefferson''s Index to Letters Written and Received (Epistolary Record), An estimated 5,000 Jefferson documents have been located known or likely sources of Jefferson material. the whole body of printed source materials, from Jefferson''s time is being gradually segregated for printing in a classified series, assumed to be volumes 41 to 50, which will embrace, first, Jefferson''s larger published and unpublished writings and papers (the work_lzdgmiz55ze7vb4ebwodl6gqfy Founders Online: Early Access: Reflections on Open Access, Crowd Sourcing, and Metadata Standards Keywords: Founders Online; Open Access; transcription; metadata; crowd Founders Online, a digital initiative of the National Historical Publications and Founders Online, a digital initiative of the National Historical Publications and digitally, I helped to manage the Early Access portion of the project from 2012 staff and in working with a variety of editing projects with different editorial policies This emphasis on the nonacademic user sets Founders Online apart from other digital projects (Ivy Group Access project was created to transcribe and proofread these documents, which My experience in Founders Online: Early Access not only convinced me of the Founders Online: Early Access was a complex, digital project with a large paid WK was a paid project manager working on Founders Online: Early Access from 2012 http://www.marklogic.com/blog/founders-online-lessonperformance/. http://www.marklogic.com/blog/founders-online-lesson-performance/ http://www.marklogic.com/blog/founders-online-lesson-performance/ http://aotus.blogs.archives.gov/2015/02/05/what-have-you-found-in-founders-online/ http://aotus.blogs.archives.gov/2015/02/05/what-have-you-found-in-founders-online/ http://aotus.blogs.archives.gov/2015/04/27/thomas-jefferson-prize-for-founders-online/ http://aotus.blogs.archives.gov/2015/04/27/thomas-jefferson-prize-for-founders-online/ http://www.upress.virginia.edu/2013/06/12/founders-online-launches http://www.upress.virginia.edu/2013/06/12/founders-online-launches work_m27to4kogvdfbebem7ztznmfpi ShieldSquare Captcha We apologize for the inconvenience... ...but your activity and behavior on this site made us think that you are a bot. 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Please solve this CAPTCHA to request unblock to the website You reached this page when trying to access https://iopscience.iop.org/article/10.1086/125905/pdf from April 06 2021, 01:59:25 UTC work_m6x5yc4ydjdkppx6ts5nwslhqa sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220678441 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:17 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_mbbjhpzvbnbrxjmvjp272kl5m4 [PDF] Steroids in patients with septic shock. Corpus ID: 8561349Steroids in patients with septic shock. title={Steroids in patients with septic shock.}, The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article. Citation Type Citation Type Sort by Most Influenced Papers View 1 excerpt, cites background View 1 excerpt, cites background Hydrocortisone therapy for patients with septic shock. In patients undergoing cardiac surgery, thoracic epidural analgesia combined with general anaesthesia results in faster recovery and fewer complications but does not affect length of hospital stay. Intensive insulin therapy in critically ill patients. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_mcz426tsfzavhiwnqssv62worm Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 on mitochondrial motility and its inhibition by agonist-induced cytoplasmic [Ca2þ] ([Ca2þ]c) signals in H9c2 cells. In OIP106 and GRIF1 overexpressing cells, elongated mitochondria with varied degree of aggregation were Mitochondrial contribution to cell signaling and function relies on the association and local communication of mitochondria with the ER and the plasma the kinetics and short-term effects of the linkage formation, we have now devised fluorescent protein pairs targeted to the OMM and ER or PM containing formation between the ER and mitochondria was followed by a decrease in mitochondrial motility (>40% in 15 min) and by sensitization of mitochondria to MEFs lack tBid induced complete cyto c release and loss of MEFs and also supported the tBid-induced cyto c release. Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 work_mfwwzfe3sjgejlmtkh3yuopici PMT34: ASSESSING PHYSICIAN PRACTICE PROFITABILITY USING AN ACTIVITY BASED COSTING MODEL translation process in each target country using the following methodology: 1) two forward translations by professional, native speaking translators of the target language fluent in English; 2) comparison and reconciliation model was developed using activity-based costing principles and included direct (drug acquisition, supplies, clinical labor time, office visits) and indirect (malpractice insurance, office rent) expenses. amount from payers, including: drug reimbursement; office visits for physician evaluation, injections, end of RESULTS: Practice profitability is inversely proportional to the number of low complexity office visits profitability for in-office services, with Medicare reimbursements generally resulting in a net loss for practices (�5 loss per office visit for the lowest complexity services) and typical managed care reimbursements providing only small profits (approximately 4 per low complexity visit). OBJECTIVE: To determine the non-workplace productivity costs (NWPC) for migraineurs using the human work_mjwbu5u4gbh5zkf4xswmmm2xja been used to measure binding affinity of Adnectin-A to the cell surface expressed receptor X to measure the effect of avidity of the multivalent adnectin the channel activation gate; and KChIP4a KID directly interacts with the T1 interaction between the voltage sensing domain and the intracellular activation gate underlies CSI (Bähring & Covarrubias, 2011, J Physiol 589:461studies of structural mechanisms of hERG channel activation by small molecules are truly novel. pharmacophore model for hERG channel openers using PHASE protocol. Pharmacophore model is also combined with previously developed receptorbased homology model of hERG K channel and novel activators are generated Slow deactivation of hERG1 (Kv 11.1) potassium channels maintains IKr during final repolarization of the cardiac action potential and opposes asynchronous early depolarization. A-Type Kv4 Channel Closed-State Inactivation is Modulated by the Tetramerization Domain Interacting with Auxilary KChIP4a Two-in-One: Activation and Inactivation at the Intracellular Gate of a Kv Channel Development and Validation Studies of Universal Pharmacophore Models for hERG Channel Openers work_mliiwjj35ff2jkrxobbdx6idq4 Benjamin Franklin et Thomas Jefferson : Aux sources de l''amitié francoaméricaine 1776-1808. 1 Spécialiste des relations franco-américaines, Nicole Fouché propose une comparaison porté sur Franklin et Jefferson, c''est qu''ils furent les deux premiers ministres depuis la guerre de Sept Ans, qui opposa la France et l''Angleterre sur le sol américain tour à tour de Franklin puis de Jefferson — l''auteur remarque que les missions des deux C''est ce qui ressort des trois chapitres suivants où sont décrits les Jefferson, comme Franklin, entretint des liens amicaux étroits avec les l''amitié franco-américaine amorcée d''une façon tout à fait remarquable par son que Franklin lors de son séjour en France, Jefferson est défini par N. deux ministres en France, ou qui cherchent à en savoir plus sur le contexte des Lumières et sur la place de Franklin et de Jefferson dans les cercles français de Benjamin Franklin et Thomas Jefferson : Aux sources de l''amitié franco-américaine 1776-1808. work_morbzh2emfck5ftpbbjrliyp4m PIN23 DETERMINANTS OF TOTAL HOSPITAL COSTS AMONG INPATIENTS WITH CANDIDEMIA (cSSSIs) due to Staphylococcus aureus among hospitalized LENGTH-OF-STAY IN U.S. HOSPITALS aureus infection on hospital S. aureus infection hospital stays were significantly more likely among male, older patients, stays that S. aureus infection on hospital charges and length-of-stay was DETERMINANTS OF TOTAL HOSPITAL COSTS AMONG OBJECTIVES: To identify factors associated with total hospital Demographic, economic, and clinical data, including length-of-stay (LOS), payer types, total costs, and Diagnosis Related Group (DRG) assignments were collected from the hospital cost accounting system. hospitalizations during the study period, 287 cases were confirmed positive for candidemia. LOS was 43.3 days and the average inpatient cost for candidemia significantly positively correlated with total hospital costs. patients with higher relative DRG weights were associated with weights, as well as age are associated with total hospital costs aureus bacteremia in Korea, where MRSA is endemic in majority of hospitals. work_msjla3r7c5eirav6o54scpozuq [PDF] Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: A review of the randomised data | Semantic Scholar Corpus ID: 6635635Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: A review of the randomised data title={Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: A review of the randomised data}, Sort by Most Influenced Papers Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. Superficial chest wall recurrences of breast cancer: prognostic treatment factors for combined radiation therapy and hyperthermia. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_mtrqpwo2gjec7bt5vdvtbuwnhm Randall was an accomplished clinical microbiol-ogist when the field was still developing its identity. Randall was a distinguished clinical microbiologist even before knowledge of infectious microorganisms." Her contributions included research in bacteriology, the clinical care that her laboratories performed, and, perhaps foremost, her educational work After her studies, Dr. Randall became director of the microbiology laboratory at Thomas Jefferson University Hospital and was 3476 jcm.asm.org Journal of Clinical Microbiology p. Dr. Randall was also the president of the Illinois Society for Microbiology. She started a master''s degree program in clinical microbiology in Philadelphia, PA. effect on the quality of clinical microbiology in Philadelphia." Dr. Randall and Dr. Morello taught a traveling workshop on staphylococci and streptococci sponsored by the ASM, and Dr. Morello Dr. Randall was a mentor to those interested in clinical microbiology. Dr. Randall published over 30 articles, mainly in clinical bacteriology. clinical microbiology. work_my7tiiqme5buzanmep7jacgdl4 Acute verses Chronic Stroke: Strong evidence supports the use of motor imagery for individuals with acute and chronic stroke to improve upper o Statistically significant results for use of motor imagery for patients Protocol: Motor Imagery with Relaxation: Strong evidence supports the use Protocol: Motor Imagery with Graded Performance: Strong evidence delivered motor imagery to improve upper extremity function; moderate evidence supports the use of therapist delivered motor imagery; o Video, Audio, & Therapist Scripted: 1 article (Level I) (not statistically o Video & Therapist Delivered: 1 article (Level I) (not statistically Clinical Effectiveness of Motor Imagery Post Stroke: Motor imagery in physical therapy practice. Mental practice with motor imagery in stroke recovery: Effect of imagery perspective on occupational performance after stroke: A randomized controlled trial. Mental practice in chronic stroke: Results of a randomized, placebo-controlled trial. Effects of mental practice on affected limb use and function in chronic stroke. work_n2yncwhgunbdvdozglhf427ryq As oncologists in the era of coronavirus disease 2019 (COVID-19), we are taskedwith caring for patients who are at high risk for adverse effects from the novel more susceptible to infection with SARS-CoV-2.2 During this pandemic, a new vulnerability has arisen: how can patients receive life-sustaining treatment for cancer tenuous patients at risk for nosocomial infection, high-quality cancer care requires a Although important during a pandemic, cancer care at home can also have a lasting impact when healthcare returns to "normal operations." This commentary describes home-based approaches for clinic visits, chemotherapy, and acute care; models, home-based chemotherapy has been safe, was preferred by patients, and single-site cancer center in Europe, recently described "Christie at Home," a model demonstration program called "Cancer Care at Home" (CC@H). with a new proposed patient-determined quality indicator for cancer care: days at Accelerating the Delivery of Cancer Care at Home During the The oncology hospital at home: health care utilization work_n3y54yonyne7hahximdipafmam Correction to: 2019 Neurocritical Care Latorre2 and Neurocritical Care Society Survey Working Group Members © 2020 Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society The original article had a typo in Table 2, the "N" for males and females should be switched. for Neuroscience, Thomas Jefferson University, 909 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA The original article can be found online at https ://doi.org/10.1007/s1202 https://doi.org/10.1007/s12028-020-01032-z https://doi.org/10.1007/s12028-020-01032-z https://doi.org/10.1007/s12028-020-01032-z https://doi.org/10.1007/s12028-020-01032-z https://doi.org/10.1007/s12028-020-01032-z https://doi.org/10.1007/s12028-020-01032-z for Neuroscience, Thomas Jefferson University, 909 Walnut Street, 3rd Floor, Table 2 Median incomes Practice setting Academic/university faculty 171 $251,000–$275,000 Salary plus bonus 73 $301,000–$325,000 Salary plus productivity 60 $251,000–$275,000 Salary plus productivity and bonus 34 $301,000–$325,000 Share of total practice income 5 $276,000–$300,000 Correction to: 2019 Neurocritical Care Survey: Physician Compensation, Unit Staffing and Structure Correction to: 2019 Neurocritical Care Survey: Physician Compensation, Unit Staffing and Structure Correction to: Neurocrit Care (2020) 33:303–307 https:doi.org10.1007s12028-020-01032-z work_n4usqfb455ggxbynaci4pswvku attitudes of political science presidency experts about presidential greatness. Presidential Greatness Survey Rank and Knowledge presidential greatness and how impressions of presidents have view presidential greatness as well as our greatest presidents The least great president was James Buchanan, followed by Warren Harding, Andrew Johnson, Franklin Pierce, and about overall greatness ratings and rankings for each president, of years was included because it balances several studies to average across with a consistent grouping of presidents in each past six scholarly surveys, we could compare the political science perspective, as captured in the 2014 PEP study, with an Of the modern presidents, Bill Clinton earned the highest overall greatness rating and George W. Lincoln was included in a respondent''s Top 5 list 148 times, followed by Franklin Delano Roosevelt (131), George Washington Bush was included in the list of most polarizing presidents 93 times, Our survey of political scientists regarding presidential greatness work_n6whn7qwkreafgdclhcqvt5fve at the Mayo Graduate School and received his PhD there in at the University of Tennessee Health Science Center and received additional training at Washington University. us with an excellent review of West Nile Virus pathogenesis. Jayasri Das Sarma received her early training in India and She received her PhD from Drexel (MCP Hahnemann) School of Medicine and postdoctoral fellowship at her PhD from the University of Iowa College of Medicine. Julie spent additional training at Northwestern University. provides a review about the innate immune response to viral Karin received her PhD from the University of Missouri Medical School. RML as a postdoctoral fellow, studying retrovirus pathogenesis in the CNS. Karin provides a review of La Crosse virus pathogenesis in the CNS and innate contributions to disease. virus contribute to the pathogenesis. exciting work on the role of dendritic cells in the pathogenesis Tufts University and Harvard Medical School, he is work_n7mskm6yvrhljfuzwccq5defxe sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220682626 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:22 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_ncb3aud2g5ebjlpiiax275hz7e The voltage dependent anion channel (VDAC) is involved in regulation of metabolite flux across the mitochondrial outer membrane (MOM). Thus we propose a novel mechanism of mitochondrial respiration control in cancer cells through the competition between HXK2 and tubulin for VDAC binding. found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, due to its role in supporting Bak insertion to the OMM Thus, OMM function depends on mitochondrial fusion Here we applied mitochondria matrix-targeted DsRed and photoactivable GFP to study mitochondrial fusion in rat FDB SM fibers. Novel Mechanism of Mitochondrial Respiration Control through Competition between Hexokinase-2 and Tubulin for VDAC Binding Reprogramming of Mitochondrial Ca2+ Handling in MICU1-Deficient HeLa Cells MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca2+ Uptake in the Liver Which Domain of VDAC2 is Necessary for Bak Insertion to the Outer Mitochondrial Membrane and tBid Induced Cytochrome C Re ... work_ncdyx2h4xjan3kdfbm3zhzuo7i [PDF] A Randomized Controlled Comparison of Flushing Protocols in Home Care Patients With Peripherally Inserted Central Catheters | Semantic Scholar Corpus ID: 22134851A Randomized Controlled Comparison of Flushing Protocols in Home Care Patients With Peripherally Inserted Central Catheters title={A Randomized Controlled Comparison of Flushing Protocols in Home Care Patients With Peripherally Inserted Central Catheters}, In a 2002 study of 50 000 home care patients, catheter dysfunction with loss of patency was the most common complication and occurred in 29% of the peripherally inserted central catheters (PICCs) tracked. Sort by Most Influenced Papers normal saline flush to maintain the patency of central venous catheter among adult patients: A systematic review and meta-analysis Normal saline versus heparin for patency of central venous catheters in adult patients a systematic review and meta-analysis Central venous catheters in home infusion care: outcomes analysis in 50,470 patients. work_newopgrnrzfqbeyqnf4pqkzeka EP-1199: The identification of putative biomarkers of radioresistance in rectal cancer tissue using antibody microarray radioresistance in rectal cancer tissue using antibody 1University of Hull, Cancer Biology Proteomics Group, Hull, to improve therapy regimens, rectal cancer remains as one of this study is to identify putative protein biomarkers of radiotherapy resistance using rectal cancer tissue biopsy cancer biopsy samples (radioresistant versus radiosensitive) Analysis (IPA) which mapped these DEPs onto their most Results: The antibody microarray analysis of the clinical involved in the extrinsic pathway (death receptor) apoptotic radiotherapy and this pathway. Conclusions: Antibody microarray analysis of rectal cancer routine clinical management of cancer patients. Validation of a rectal cancer outcome prediction model in 1Shanghai Medical College Fudan University, Radiation Maastricht University Medical Centre, Radiation Oncology Radiation Oncology Department, Philadelphia, USA and overall survival of locally advanced rectal cancer after validate these prediction models in a routine clinical Chinese work_nhpxexcujfgffidq5ul5ucxzoi PMS41 AN ASSESSMENT OF SELF REPORTED OUTCOMES IN A NATIONALLY REPRESENTATIVE SAMPLE OF ELDERLY PERSON DIAGNOSED WITH RHEUMATOID ARTHRITIS The Health Assessment Questionnaire (HAQ) was used to measure functional status (scores 0–3). reported signifi cantly worse scores in morning stiffness, fatigue, pain, and PCS (all CONCLUSIONS: RA patients using current SC biologics still suffer from serious impairments in symptoms, functional status, QoL, and However, patients who discontinued SC biologic therapy have signifi cantly worse symptom scores, physical functioning, and activity impairment compared with those currently being treated. Utility scores correlated signifi cantly with WOMAC™, and patients with high BMI RESULTS: Compared to the general population, our study sample performed poorly with respect to all the SF-36 domains except mental health (MH) and patients who exercise regularly have higher quality of life scores and clinical outcomes. validity of the HUI-3 for deriving utility scores for AS patients. work_noavfquljbfbzcqdy6nlswjrm4 is most often reduction or change of habitat and isolation of wildlife populations. be attributed to increases in human population and percapita consumption. People unmoved on the population issue with conservation arguments may be moved As the human population grew, wildlife conservation and management developed as an applied scientific discipline with a focus on reducing or controlling consumption by humans and increasing production of wildlife. but the human population increases by higher rates, what Population growth is not the only factor causing increases in regulations, but we believe it to be other freedoms, a tyranny of population growth. that human population growth is the cause of most of our conservation issues are unaffected by human population Increased human population equals increased pressure for regulation. that human population growth is a grave threat to individual freedom and to all that we as conservationists hold The human population problem: educating and work_np5pvgfmgrefnljyoljhka6xt4 Pancreatic Cancer in Lynch Syndrome: A Case Report | Semantic Scholar Corpus ID: 57762060Pancreatic Cancer in Lynch Syndrome: A Case Report title={Pancreatic Cancer in Lynch Syndrome: A Case Report}, journal={Case Reports in Pancreatic Cancer}, Intenzo, +2 authors A. Case Reports in Pancreatic Cancer Abstract Background: In the literature, pancreatic cancer is not frequently acknowledged among the tumors that are considered a part of Lynch Syndrome. Figures and Topics from this paper Pancreatic Cancer Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications Risk of Pancreatic Cancer in Families With Lynch Syndrome View 3 excerpts, references background View 3 excerpts, references background Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License ACCEPT & CONTINUE work_nrm5owbwvrefllt3jqmbr5gafi Researchers knock down gene to stop HIV in its tracks Researchers knock down gene to stop HIV in its tracks The HIV-resistant bone marrow donor in HIV attach and infect healthy cells (N. pluripotent stem cells (Hum. Gene Ther. disrupt CCR5 expression in human T cells, The gene therapy lowered viral loads and expression of the CCR5 gene with zinc fingers, same gene therapy tactic in bone marrow. marrow stem cell therapy has the advantage therapy aimed at T cells, which must be "We do not lack ways to attack HIV," says A potential obstacle to CCR5-based gene cell for its normal functions than CCR5," says Ramesh Akkina, who studies HIV gene therapy an HIV gene therapy technique involving three month, Zaia''s team showed that patients modified genes in their blood and showed no Gene therapy against HIV "is now within cheap medicines from online Canadian pharmacies work_nxtajoo3ajhd3lxmxvv5vmw3bu Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor–producing Th1 cells in CNS neuroinflammation To study the immunomodulatory effect of dimethyl fumarate (DF) on granulocyte macrophage colony-stimulating factor (GM-CSF) production in CD4+ T cells in experimental autoimmune encephalomyelitis (EAE) and human peripheral blood mononuclear cells human cells and ameliorates inflammatory responses.3,4 In addition, EAE mice treated with DF show a significant reduction in GM-CSF–producing CD4+ T cells can effectively induce EAE by passive transfer, and lack of GM-CSF in Th1 DF = dimethyl fumarate; EAE = experimental autoimmune encephalomyelitis; GM-CSF = granulocyte macrophage colonystimulating factor; MNC = mononuclear cell; RRMS = relapsing-remitting MS; WT = wild type. (E) Flow cytometry analysis demonstrated that DF significantly reduced GM-CSF production in IFN-γ–producing CD4+ (Th1) cells. Figure 3 The suppressive effect of DF on GM-CSF depends on IFN-γ in murine cells DF treatment significantly decreased GM-CSF in CD4+ T cellsfromWTbut not CD4+ T cells from IFN-γ−/− mice. work_nz5rlndysbg43csd2naujiigry [PDF] Social Determinants of Methadone in Pregnancy: Violence, Social Capital, and Mental Health | Semantic Scholar Corpus ID: 732544Social Determinants of Methadone in Pregnancy: Violence, Social Capital, and Mental Health title={Social Determinants of Methadone in Pregnancy: Violence, Social Capital, and Mental Health}, journal={Issues in Mental Health Nursing}, The purpose of this article is to describe the contextual risks experienced by drug abusing mothers in order to direct further research and policy changes that protect their children. Sort by Most Influenced Papers Contributions of psychology to research, treatment, and care of pregnant women with opioid use disorder. View 1 excerpt, cites background View 1 excerpt, cites background View 1 excerpt, cites background View 1 excerpt, cites background View 1 excerpt, cites background Low-Income Women''s Use of Substance Abuse and Mental Health Services View 6 excerpts, references methods and background View 5 excerpts, references background View 5 excerpts, references background work_oafkbjhmubc65dwmsql3evlcqe Student Perspectives With a High-Utilizing Patient | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar''s Logo Corpus ID: 11963984Student Perspectives With a High-Utilizing Patient title={Student Perspectives With a High-Utilizing Patient}, It could have been any time, on any day, in any doctor''s waiting room, but today was different. Today, I was sitting with Mrs Murphy and she was scared. The analog clock on the wall ticked to 2:27 PM. We were waiting for a 2:30 PM appointment to see Dr Green. He was the first doctor that Paula told us about when we met. Topics from this paper About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License ACCEPT & CONTINUE work_ocbnxupirban5l6i2nikb5nkyu Case 1-A 53-year-old hypertensive woman receiving hydrochlorothiazide 50 mg daily was prescribed captopril 12-5 mg thrice daily in addition; Case 2-During a research study a 54-year-old man with essential hypertension received enalapril 20 mg twice daily. additional weeks of treatment with captopril the symptoms persisted and have been reported during captopril treatment,35 the symptom described by our patients has not, to our knowledge, been previously Clinical pharmacology and therapeutic applications of the new oral angiotensin converting enzyme inhibitor, captopril. referred at 25 weeks'' gestation after ultrasonography showed a hydropic fetus. Initial serology for cytomegalovirus on maternal sera showed an antibody normal range for a fetus of this gestation as stated by Alford et al.4 Radioimmunoassay for cytomegalovirus IgM showed that the fetal serum had a showed a titre of 800 in the serum taken at 21 weeks'' gestation, but such IgM specific IgM on fetal cord serum obtained at 25 weeks'' gestation was work_oj2hcfrsjndy5ceqapggi5jnye Chapter 2: The Rhetors – The Thomas Jefferson Memorial Commission and Franklin rhetorical formation and consequence of a single (and highly motivated) public memory space, whilst Jefferson Memorial Commission (TJMC) and its most senior and energetic patron, President Franklin provided the rhetorical mechanics for the Thomas Jefferson Memorial Commission to engineer a Thomas Jefferson Memorial Commission embarked upon a series of purposeful and recontextualizing Underlined section indicates the text used in the Thomas Jefferson Memorial Panel intervention, the Thomas Jefferson Memorial Commission was established by an Act of Congress to ''Thomas Jefferson Memorial''" (TJMC-4). work of the Thomas Jefferson Memorial Commission, the process of inscription selection and The Thomas Jefferson Memorial Commission: General Records, 1934-1943. The Thomas Jefferson Memorial Commission: General Records, 1934-1943. References relating to the papers of the Thomas Jefferson Memorial Commission (TJMC) are The Thomas Jefferson Memorial (American Symbols). Appendix B: The Inscriptions of the Thomas Jefferson Memorial work_om6o7y5ktradjd46oq3e7oxlha PMT33: LINGUISTIC VALIDATION OF THE VASCULAR QUALITY OF LIFE QUESTIONNAIRE (VASCUQOL) IN 8 LANGUAGES translation process in each target country using the following methodology: 1) two forward translations by professional, native speaking translators of the target language fluent in English; 2) comparison and reconciliation model was developed using activity-based costing principles and included direct (drug acquisition, supplies, clinical labor time, office visits) and indirect (malpractice insurance, office rent) expenses. amount from payers, including: drug reimbursement; office visits for physician evaluation, injections, end of RESULTS: Practice profitability is inversely proportional to the number of low complexity office visits profitability for in-office services, with Medicare reimbursements generally resulting in a net loss for practices (�5 loss per office visit for the lowest complexity services) and typical managed care reimbursements providing only small profits (approximately 4 per low complexity visit). OBJECTIVE: To determine the non-workplace productivity costs (NWPC) for migraineurs using the human work_oo6w7juhcrgg7mbyyg7vrizjnm Smallpox vaccination: an early start of modern medicine in America | Semantic Scholar Corpus ID: 20702504Smallpox vaccination: an early start of modern medicine in America title={Smallpox vaccination: an early start of modern medicine in America}, ABSTRACT Smallpox was eradicated by the World Health Organization in 1980. Smallpox Vaccine Sort by Most Influenced Papers Edward Jenner and the History of Smallpox and Vaccination Smallpox in Washington''s Army: Strategic Implications of the Disease During the American Revolutionary War View 1 excerpt, references background View 1 excerpt, references background View 1 excerpt, references background View 1 excerpt, references background Vaccines for preventing smallpox. Vaccines for preventing smallpox. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License work_oodexbsunzh3renuliohib4bcu Brain researchers have detected improvements in cognition and differences in how meditation and prayer affect the brains of those not only were the brain images in a study of people who meditated Hospital and an assistant professor in psychology at Harvard Medical School, "the ability of your brain to change, to grow and adapt" in of Medicine, reported that the brain chemical GABA, a neurotransmitter associated with control of anxiety, peaked in experienced yoga brain chemistry associated with yoga," Streeter said. yoga was associated with improved sleep, increased positivity, and In contexts involving meditation and prayer, brain scans show believes in God, said Andrew Newberg, director of research at the Newberg also discussed brain chemistry changes associated with Neuroscientists describe improvements in cognition and mood at AAAS event yoga report changes in brain Meditation and yoga associated with changes in brain Meditation and yoga associated with changes in brain Meditation and yoga associated with changes in brain ARTICLE TOOLS http://science.sciencemag.org/content/358/6362/461 work_op4vb6uwtjaifahhytqes4npaq Papers Presented at the Annual Meetings of the Knee Society The Papers Presented at the Annual Meetings of the Knee the 2009 Members Meeting of the Knee Society held in symptomatic patellar crepitus after total knee arthroplasty. fail an initial attempt at irrigation, débridement, and component retention for deep prosthetic infection around a total relative risks and on the rates of success/failure after irrigation, débridement, and component retention. efforts to control infection in those patients who fail an reimplantation total knee arthroplasty than is the typical fluid analysis of late deep prosthetic infection and suggested synovial white blood cell counts of 1500 cells/lL or The high quality of these papers reaffirms the commitment of the Knee Society to advancing the international Papers Presented at the Annual Meetings of the Knee Society: Editorial Comment Created PDF documents can be opened with Acrobat and Adobe Reader 5.0 and later.) work_oqu6gjgzw5aaljenenxgf6an5y Pride of Place es la historia del modo en que una Gran parte de la obra de Jefferson debería verse, hablando metafóricamente, como una lucha entre el pasado fijo europeo y el futuro dos edificios, Monticello —la casa que Thomas Jefferson construyó para sí mismo en Virginia— y Taliesin —la casa y estudio de Frank Lloyd Wright en La decisión de construir encima de una colina, a pesar de los numerosos problemas prácticos que esto suponía, incluida de modo que los terrenos alrededor del edificio una casa un lugar "elevado y alegre".N5 Jefferson, que además de la influencia general de Palladio, Scully señala como fuente específica para los proyectos originarios de Monticello una planta tomada del libro del la que diferencia Monticello de otra casa, el Taliesin en este sentido, deseaba que la casa pareciese literalmente parte de la colina: "La relación con la naturaleza no era ya una de analogía, mediada por las work_ouoelfomejbftnozksouqbcs5y Bibliography of Published Works Relating to the Upper Canada Rebellion, 1837-1838 Bibliography of Published Works Relating to the Upper Canada The only published comprehensive bibliography of works related to the Canadian Rebellions of 1837"Political History of Upper Canada to chapter VII of Life in Canada (Toronto: W. Canada Rebellion (Toronto: C. Street (Toronto: Ontario Historical Society, Upper Canada," chapter of Rebellions Rebellion in Upper Canada," Journal at Toronto in Upper Canada (Albany, New Canada (New York: William H. New York from the Canada State Prisoners, Upper Canada Rebellion of 1837 (Toronto: Upper Canada Rebellion of 1837 (Toronto: Western Upper Canada," in Canadian State the Upper Canadian Rebellion," Ontario from Canada," Canadian Historical Review, the Rebellion in Upper Canada," Canadian of 1837 in Upper Canada," Canadian Papineau Rebellion," New York History, 15 Papineau Rebellion," New York History, 15 Canada in the 1830s," Canadian Historical Canadian Rebellion (Toronto: McLeod & work_oyhev7rbtbclbmwatepng3q4u4 Reply to the Letter to the Editor: Symptomatic Pulmonary Embolus After Joint Arthroplasty: Javad Parvizi MD, FRCS, Ronald Huang MD, recently published article entitled After Joint Arthroplasty: Stratification 1. Parvizi J, Huang R, Raphael IJ, Arnold WV, Rothman RH. Symptomatic pulmonary embolus after joint arthroplasty: stratification of risk factors. (RE: Parvizi J, Huang R, Raphael IJ, Arnold embolus after joint arthroplasty: stratification Clin Orthop Relat Res. 2014;472:903–912.) Clin Orthop Relat Res. 2014;472:903–912.) authors and Clinical Orthopaedics and Related Research editors and board members Orthopaedic Surgery at the Rothman Institute, Thomas Jefferson University Philadelphia, PA 19107, USA Orthopaedic Research at the Rothman Institute, Thomas Jefferson Hospital, � The Association of Bone and Joint Surgeons1 2014 Clin Orthop Relat Res (2014) 472:2554 / DOI 10.1007/s11999-014-3718-3 A Publication of The Association of Bone and Joint Surgeons® Reply to the Letter to the Editor: Symptomatic Pulmonary Embolus After Joint Arthroplasty: Stratification of Risk Factors work_p2e5y7zvhrfzfhueyp4c4zsiqu sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220682490 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:22 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_p3xvzfb5qnev5mxvfcqon4ggzq Temporal Expression of Mutant TDP-43 Correlates with Early Amyotrophic Lateral Sclerosis Phenotype and Motor Weakness Method: Transgenic rats were established that express mutant human TDP-43 (M337V substitution) in neurons, then a Tet-off system was used to regulate its expression. Keywords: Amyotrophic Lateral Sclerosis (ALS), TAR DNA-binding protein 43, motor neurons, transgenic rats, CAG, Tetresponsive transactivator. function in ALS rats expressing the causative gene in neurons and muscles, indicating that the motor neuron degeneration is partially reversible [10]. double transgenic rats were deprived of Dox to activate mutant TDP gene. To examine whether mutant TDP-43 expressed in neurons could induce ALS-like phenotypes, we chose the regulatory promoter of CAG gene to control the activation of of CAG-tTA/TRE-TDP-43M337V double transgenic rats suffered from progressive weakness after Dox (Fig. 1A, B). Mutant human TDP-43 expressed on 30 days causes shorter onset and induces more severe paralysis in transgenic rats. work_p7na4rdetfclfoifgtupzbkiyq Calcium-Induced ROS Generation during Ischemia Triggers mPTPDependent Cell Death during Reperfusion Impairment of mitochondrial function is a central event of ischemiareperfusion (I/R) injury leading to tissue damage and cell death. 1, ROS generation with Mito-Sox Red, mPTP opening as mitochondrial calcein ROS with superoxide dismutase mimetic MnTBAP or antioxidant Trolox prevented reperfusion-induced cell death. We conclude that mPTP-dependent cell death during reperfusion is mediated by Ca2þdependent ROS generation during ischemia. These probes, targeted to the ER lumen, ER membrane (cytosolic face), cytosol, mitochondrial matrix and outer membrane (OMM) and the IP3-receptor, of the ER membrane, bulk cytosol and mitochondrial matrix and OMM. It was found that the mitochondrial surface in close association with ER was significantly reduced in the chronic ethanol-fed condition as Calcium-Induced ROS Generation during Ischemia Triggers mPTP-Dependent Cell Death during Reperfusion Calcium-Induced ROS Generation during Ischemia Triggers mPTP-Dependent Cell Death during Reperfusion Dynamic Measurement of Ca2+-Induced Changes in Organelle-Specific Redox Microdomains work_pbdkjh4zizeipkmp7id74ukldy HP8 FDA REGULATORY ACTIONS AGAINST MISLEADING OR UNSUBSTANTIATED ECONOMIC AND QUALITY-OF-LIFE CLAIMS: AN ANALYSIS OF WARNING LETTERS AND NOTICES OF VIOLATION ADVERTISING SPENDING AND DRUG PRICING direct-to-consumer (DTC) advertising spending on drug advertising spending would be added to drug prices (b) OBJECTIVE: Explore the relationship of DTC advertising spending and drug pricing for the top twenty drugs of the drug; (b) the percent changes in the DTC advertising spending and drug price. advertising spending and drug price for a year was CONCLUSION: Results indicate a very weak relationship between DTC advertising spending and drug prices. factors associated with consumers'' seeking various information sources about medications sought in response to MEASURES OF ASTHMA SEVERITY: PATIENTPERCEIVED, SYMPTOM DERIVED, AND FEV1 rely on methods such as frequency of self-reported symptoms and patient perceived severity. severity determined by patient-reported information. Symptom-derived Severity (NSS) were determined from between FEV1-DS and each patient-reported severity work_phkk6ubq5rf57gu4ktuh5f5ef4 Neurocritical Care Research Conference. The most important outcome of the First Neurocritical Care Research Neurocritical Care Research Conference took place in approaches to multifaceted therapeutic bundles in neurocritical care followed by five scientific sessions: (1) Global Care Research Conference: (1) the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care, a collaboration between Division of Vascular Neurology and Neurocritical Care, and discussions that followed during this Second Neurocritical Care Research Conference. Acknowledgments The Second Neurocritical Care Research Conference was funded by the National Institutes of Health (NINDS) CAC, Zaidat OO, for the First Neurocritical Care Research The Neurocritical Care Research Network: NCRN. The Neurocritical Care Research Network: NCRN. Monitoring in Neurocritical Care: a statement for healthcare 336 Neurocrit Care (2015) 22:335–336 336 Neurocrit Care (2015) 22:335–336 336 Neurocrit Care (2015) 22:335–336 336 Neurocrit Care (2015) 22:335–336 The Second Neurocritical Care Research Conference The Second Neurocritical Care Research Conference work_pjqor5x3wfg6zgy3hs34ijyb4i At first glance, five years seems like a long time. American Journal of Pathology. Scientific Editor position to increasing Reviews and other pathology journals, the AJP received a 2006 Impact Factor of 5.917, placing it again in the first position for general pathology journals.1 We believe this rebound is sustainable, as the AJP continues to be the most-frequently cited journal in the field, receiving over 32,000 citations in extremely well among Pathology journals. While Impact Factor is important to the perceived success of the Journal, our real success lies in publishing the Together with our Editors, the Editorial Board represents the The American Society for Investigative Pathology, our Publisher, has for decades selected its editors The American Journal of Pathology, Vol. 172, No. 6, June 2008 Copyright © American Society for Investigative Pathology an honor to serve The American Journal of Pathology. thank our authors, reviewers, and readers for having work_plxw75kbjnf67jxff35u6rekxm Potent Inhibition of Human Immunodeficiency Virus Type 1 in Primary T Cells and Alveolar Macrophages by a Combination Anti-Rev Strategy Delivered in an Adeno-Associated Virus Vector Binding of Intracellular Anti-Rev Single Chain Variable Fragments to YONG WU, LINGXUN DUAN, MINGHUA ZHU, BAOCHENG HU, SATOSHI KUBOTA, OMAR BAGASRA, Hamilton Laboratories, Center for Human Retrovirology, Division of Infectious Diseases, Department of Medicine, FARIDA SHAHEEN, LINGXUN DUAN, MINGHUA ZHU, OMAR BAGASRA, AND ROGER J. Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Potent Inhibition of Human Immunodeficiency Virus Type 1 in Primary T Cells The heavy chain of the D8 anti-Rev single-chain variable fragment (SFv) has been reanalyzed and demonstrated to be an It should also be noted that the function of the aberrant heavy chain in the D8SFv is not known. There was noted to be rather minimal binding data for the D8SFv available to be reevaluated at this time, including only a single work_pmttktycljehfpug4w3ijuqg3i sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220686645 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:27 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_pmxkrqafqrfzrfusjhr227kpqm sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220681314 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:21 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_pohvxbpaozbehnf47slmrrzylm [PDF] Testing the information-theoretic approach | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar''s Logo Search Corpus ID: 36568446Testing the information-theoretic approach title={Testing the information-theoretic approach}, author={Hillary E. Hillary E. Save to Library Create Alert Figures from this paper Use of anthrax vaccine in the United States: recommendations of the Advisory Committee on Immunization Practices. Journal of toxicology. Medicine Medicine Vaccination against Anthrax with Attenuated Recombinant Strains of Bacillus anthracis That Produce Protective Antigen Biology, Medicine Save Save Save Alert Alert Alert Research Feed Research Feed Research Feed 4 References 4 References Stay Connected With Semantic Scholar About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License ACCEPT & CONTINUE work_ps4t7x5kanbdfj64lkgjcuuavy Instant messaging, virtual reference services, Ask a determine the nature of questions patrons asked reference librarians and A more recent 2004 Pew Study, "How Americans Use Instant Messaging," posited that 62% of Internet users ages 18 to 27 have used IM. In the fall of 2006, Cleveland and Philbrick conducted a study to determine current trends in virtual reference services in academic health • IM offers reference departments an additional means of communication for users to ask questions. • An online survey was sent to IM users who asked questions. of Library Chat." Reference Services Review 30, no.3 (2002): 183-97. Analysis and Lessons Learned Instituting an Instant Messaging Reference Service at an Academic Health Sciences Library Analysis and Lessons Learned Instituting an Instant Messaging Reference Service at an Academic Health Sciences Library Analysis and Lessons Learned Instituting an Instant Messaging Reference Service at an Academic Health Sciences Library: The First Year work_ptfyrurjzvd7nit6kqbpsr2ab4 Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: We use Molecular Dynamics simulations to identify the binding sites for a hydrophobic general anesthetic isoflurane, on voltage gated bacterial sodium channel NaChBac. Apart from the NavAb was published (Payandeh et al (2011) Nature 475, 353), giving an unambiguous picture of the structure of the sodium channel selectivity filter (SF) Experimental ion selectivity determination from pore-only constructs of a sodium channel with the same SF sequence for PIIIA when the NavAb channel is occupied by 2 sodium ions. Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: Structure and Accessibility of Distinct Interaction Sites A Key Gating Charge Interaction Required for Slow Inactivation of the Navab Bacterial Sodium Channel A Key Gating Charge Interaction Required for Slow Inactivation of the Navab Bacterial Sodium Channel Polymodal, High Affinity Actions of μ-Conotoxins on a Bacterial Voltage-Gated Sodium Channel work_qicnzj2zuzbyhezjrtiqlk4pby ipheral arteries in vivo, with resultant expression of gene approach can be used for localized gene transfer into coronary Vessel wall injury in either acute coronary smdromes or during coronary angiaplasty is associated with increased assess plasma levels of tissue plasminogen activator experimental vessel wall injury (INS). atherosclerotic rabbits, IN9 was produced by angioplasty of iliac arteries IPL 18, while 8 rabbits with no 1N.l Histology in 9 rabbits from INJ group revealed medial INJ in all enimals. t-PA levels were not different between C and INJ groups. following deep vascular wall injury as a result of an AXIOPLASTY: A STUDY IN THE ATHEROSCLEROTIC RABBIT. performed a study in 17 NZW rabbits with bilateral focal Rabbits plasminogen activator (tPA), 3mg/kg, or saline (S). after lnfuslon: 108 59 in tPA VS. measured 28 days after A changed from 1.2 L 0.1 to 1.7 f. decreased serum fibrinogen by about 60% resulted in a work_qo5umel66bddlnm4c5gcj2efvu PublisherName : BioMed Central PublisherImprintName : BioMed Central ArticleDOI : 10.1186/gb-spotlight-20010821-01 ArticleCitationID : spotlight-20010821-01 ArticleCopyright : BioMed Central Ltd2001 The FEZ1/LZTS1 gene maps to chromosome 8p22, a region lost in many tumors. Jefferson University, Philadelphia, describe a mechanism for FEZ1-mediated growth suppression. created an inducible gene-expression system in MCF7 breast cancer cells, in which FEZ1 expression FEZ1 expression inhibited cell growth in vitro (at the S-phase to G2/M transition in the cell cycle) and tumor formation in vivo. Ishii et al.demonstrated that the FEZ1 protein is suppress tumor growth by regulating microtubule dynamics and progression through mitosis. 1. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in 2. Proceedings of the National Academy of Sciences , [http://www.pnas.org] 3. Thomas Jefferson University , [http://www.tju.edu] 4. FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis., http://www.pnas.org http://www.tju.edu http://www.pnas.org/cgi/content/abstract/181222898v1 http://www.pnas.org/cgi/content/abstract/181222898v1 Tumor suppression by FEZ Tumor suppression by FEZ work_qtqqrsqrpvamhiqbdnq2mvvkze sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220680976 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:20 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_qu4j5vmrmvgn3ndf4jugjlvotm Two tulip poplars (Liriodendron tulipifera L.) growing at Monticello, the home of Thomas Jefferson''s writings express his interest in tulip poplars and suggest that he may have planted investigated the ages of both trees (referred to as northwest and southwest). A.D. 1852 and those of the upper and lower sections of the northwest tree dated to 1822 and 1808, the conclusion that the northwest tree and likely the southwest tree were Jefferson era, but the evidence two large tulip poplar trees recently removed from the west lawn of Monticello date to the Jefferson Crossdated ring-width measurements from northwest and southwest tulip poplars sampled in this study. northwest and southwest tulip poplars growing on the west lawn at Monticello. support the interpretation that Jefferson intentionally planted the northwest tree, as tulip poplars Tulip Poplars at Thomas Jefferson''s Monticello 47 Tulip Poplars at Thomas Jefferson''s Monticello 47 Tulip Poplars at Thomas Jefferson''s Monticello 47 work_qwg4h76wwvbfloo7ikmvegm4te activated cells expressing iNOS in the MS brain we have 1. Identification of cells expressing iNOS mRNA in MS brain tissue. RT-IS-PCR for iNOS mRNA (green) and a panel of cell-specific reagents (redyorange). In Fig. 1D, oligodendrocytes stained with anti-CNPase antibody (orange) are distinguished from cells identified as iNOS mRNA-positive cells association of iNOS mRNA-positive cells with accumulations of nitrotyrosine in an MS plaque (B). iNOS mRNA-positive mononuclear cells (green), evidently Clinical symptoms of EAE in SWXJ-14 mice immunized with treatment, the first clinical signs of EAE developed, progressing into significant disease over the next few days (Fig. 3). level of NO in brain tissue of c-PTIO-treated mice was Effect of the Peroxynitrite Scavenger Uric Acid on EAE. day of uric acid can delay the onset of clinical signs of EAE plaques contained few if any iNOS mRNA-positive cells and Effect of administration of uric acid on brain and spinal cord NO levels in EAE work_qzi2ceoworejjkvejzljzm6xpi A number of published case reports in the literature have detailed various neoplasms that have caused an intussusception isolated to the duodenum. We present here a case of duodeno-duodenal intussusception secondary to a leiomyoma. Case: A 65-year-old Caucasian male presented with intermittent bloody stools and syncope over a 9-month period secondary to a duodenal leiomyoma causing intussusception, which was treated through a pancreaticoduodenectomy. Conclusion: Intussusception of the duodenum is an uncommon entity and the diagnosis of a leiomyoma should Key words: leiomyoma; duodeno-duodenal intussusception; gastrointestinal bleed GI bleeding secondary to duodeno-duodenal intussusception caused by a leiomyoma. found in less than 10% of the population with intussusception.2 More commonly, patients present with nonspecific symptoms including intermittent abdominal duodeno-duodenal intussusception secondary to a small Rare presentation of pancreatitis secondary to intussusception of duodenal duplication cyst, a pediatric case report. lead: a case report of a leiomyoma causing duodeno-duodenal intussusception and review of literature, Case Reports in Pancreatic work_r2l5qw4fd5bpjmlyph3rqxjw4e PIN15 IMPACT OF COMPLICATED SKIN AND SOFT TISSUE INFECTIONS ON INPATIENT COSTS FOR AN ACADEMIC MEDICAL CENTER Index claims were outpatient or emergency department visits in 1999–2001 by individuals aged 25–64 with a primary diagnosis of pneumonia, Exclusion criteria: antibiotic prescription, pneumonia diagnosis, or hospitalization in prior 30-days; initial therapy stay (LOS) attributable to complicated skin and soft tissue infections (cSSI) for patients admitted to Thomas Jefferson University discharges in 2003, 1,883 (5.5%) included one of the cSSI diagnosis codes; these encompassed 225 DRGs. The mean cost for COST-UTILITY OF CHRONIC HEPATITIS "C" TREATMENT OBJECTIVE: To estimate cost-utility of the following alternatives in the treatment of chronic hepatitis C (CHC) in the of life and costs of health care institutions. RESULTS: Triple therapy (peginterferon plus ribavirin plus thymosin alpha-1) was dominant over the rest of alternatives costing OBJECTIVES: This study investigated the effect of using different utilities for a cost-utility analysis comparing peginterferon work_r3rqkgtqxjfufcktlht2ja5xdm Massive pulmonary embolism is associated with a mortality of up to 65% acutely.1 We present a patient who had a negative multidetector computed tomography (CT) angiogram but was nevertheless thrombolysed for acute pulmonary embolism. Urvashi Vaid MD and Michael Baram MD are affiliated with the Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania. high clinical probability of acute pulmonary embolism, he An emergency brain CT revealed recent left middle and posterior cerebral artery infarctions, with a 15-mm midline shift (Fig. 2), confirmed Pressure overload from pulmonary embolism, resultant myocardial ischemia, poor left-ventricular filling Notably, 40% of patients with a high clinical probability of pulmonary embolism had a negative CT acute pulmonary embolism resulted in high right-side Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. THROMBOLYTIC THERAPY IN A PATIENT WITH SUSPECTED PULMONARY EMBOLISM THROMBOLYTIC THERAPY IN A PATIENT WITH SUSPECTED PULMONARY EMBOLISM work_r732j5wz3fefjhn3j7r7nin4ym USABMJPrimary Care Medicine for the American Physician BMJ USA is published monthly by Tri-County Family Medicine Medical Director Clinical Professor of Family Medicine Center for Senior Health Rural Health Dept of Family & Community Medicine University of South Alabama School of Medicine College of Medicine University of California, Davis Mount Sinai School of Medicine University of Virginia Publishing, LLC, 100 Avenue of the Americas, New York, NY 10013-1678. POSTMASTER: Send address changes to BMJ USA, Jobson Publishing, LLC, The high disease rates and poor health care experienced by Native Americans are not unique but appear to The public health histories of New Zealand''s illicit drug use remain higher among Native Americans One out of every 5 Native American youths has not been 20% of Native Americans. 20% of Native Americans. heart of these disparities if, as Jefferson wrote, we "consider them as part of ourselves, and cherish with sincerity work_rcfrokwx6nhlzcz5cqa3mzu3si Thomas Jefferson''s alleged paternity of Eston Hemings Jefferson, the last child of data at hand in interpreting their results. No mention was made of Thomas Jefferson''s brother Randolph (1757–1815), or of know Thomas Jefferson was there, but how it is possible that Thomas Jefferson''s father, even at that time to be Thomas Jefferson''s Eston Hemings Jefferson. son of Thomas Jefferson''s brother Randolph, might have been the father of one or Isham was reared by Thomas Jefferson; he Monticello at that time, whereas it is documented that Thomas Jefferson was. as Thomas Jefferson to have fathered Eston DNA data that Thomas Jefferson can neither A. Jr Thomas Jefferson and his Unknown a mammal of the same body size and aerobic power. mammals of the same size and aerobic inactive flight muscles are only half as large aerobic mammals of their size, using lungs Why rheas have an aerobic power that work_rijjzjpiljdcrnb7y6qcj2k2li Voltage-activated potassium (Kv) channels open an intracellular gate in response to changes in transmembrane voltage, allowing K N-terminus of the protein acting as a blocking particle, binding at the intracellular cavity of the channel and physically obstructing the permeation pathway. results suggest that despite being tethered to a particular subunit, the single inactivation particle has sufficient freedom to interact with position 470 of each from the solution; from the gate it repels an ion in the channel pore cavity into Water Structure at the Potassium Channel Gate: The Importance of the Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Water at the Potassium Channel Gate: Quantum Calculations Show an Oscillation in Water Structure Water at the Potassium Channel Gate: Quantum Calculations Show an Oscillation in Water Structure Water Structure at the Potassium Channel Gate: The Importance of the Prolines in the PVPV Sequence, as Shown by Computation ... work_rjraolcx6valtp2jzhrztorzhq CORR Insights®: Custom Acetabular Cages Offer Stable Fixation and Improved Hip Scores for Revision THA With Severe Bone Defects : Custom Acetabular Cages that Paprosky IIIB defects occurred in custom acetabular cages (or triflange acetabular reconstruction using a gritblasted titanium custom cage. acetabular defects, which used other cages, or custom triflange cups. article ''''Custom Acetabular Cages Offer Revision THA With Severe Bone Defects'''' Revision THA With Severe Bone Defects'''' Clin Orthop Relat Res (2016) 474:741–743 / DOI 10.1007/s11999-015-4649-3 reported on 78 acetabular reconstructions performed with a custom acetabular defect with metal or as in when a custom implant is needed. acetabular defect volume [9]. cage, the custom implant as described by with the use of custom implants, without and surgical reconstruction in revision acetabular defect classification. acetabular defect classification. CORR Insightsreg: Custom Acetabular Cages Offer Stable Fixation and Improved Hip Scores for Revision THA With Severe Bone Defects work_rmzyhwo4bjgbzjwk7a45hlohea sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220682965 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:23 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_rnbibsv7xzd27bcqdvf6f6wv7a in mouse liver versus heart mitochondria, and a 4.5 fold higher MICU1 to heart mitochondria displayed a decreased threshold and lesser cooperativity nanodomain which developes into a H2O2 transient following IP3 receptormediated ER Ca2þ release and mitochondrial Ca2þ uptake. Pharmacological inhibition showed that the transient was dependent upon ER Ca2þ, mitochondrial as both a messenger and regulator of calcium signaling and are particularly relevant for the control of mitochondrial function. that ROS target mito-motility to control mitochondrial function. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial at birth (Nguyen et al., 2014) and fibroblasts (MEFs) derived from Miro1 KO embryos show abnormal mitochondrial distribution, but the calcium-dependent inhibition of motility is unaffected and the respiratory and calcium buffering Imaging in perfused whole heart ex vivo, showed considerable mitochondrial continuity and fusion activity in ventricular CM. adult CM lose mitochondrial fusion activity. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial Movement work_roybhvkbrngajpjhz3lftua2mi sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220684943 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:25 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_rtzaiwhknbdu7oxw5my7fcskhi Voltage-activated potassium (Kv) channels open an intracellular gate in response to changes in transmembrane voltage, allowing K N-terminus of the protein acting as a blocking particle, binding at the intracellular cavity of the channel and physically obstructing the permeation pathway. results suggest that despite being tethered to a particular subunit, the single inactivation particle has sufficient freedom to interact with position 470 of each from the solution; from the gate it repels an ion in the channel pore cavity into Water Structure at the Potassium Channel Gate: The Importance of the Access Constraints and Binding Energetics of a Potassium Channel Inactivation Gate Access Constraints and Binding Energetics of a Potassium Channel Inactivation Gate Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Water Structure at the Potassium Channel Gate: The Importance of the Prolines in the PVPV Sequence, as Shown by Computation ... work_rub6ij7p3bfsniuxaj7ol2tpua spinal cord injury and affirm the importance of the multicenter, randomized clinical trial to test rehabilitation strategies. interventions for walking: BWSTT vs a similar intensity of a defined control (CONT) program of overground mobility training. factor, a repeated-measure time factor (onset of SCI to randomization), and the primary endpoint (FIM-L or walking speed) for The baseline characteristics of the BWSTT and CONT groups revealed no differences in age, gender, race, days since injury, or spinal level. A comparison of BWSTT and CONT for walking speed in ASIA C and D subjects who were able to the BWSTT and CONT groups reached functional walkTable 2 Baseline measurements for UMN and LMN subjects in intention-to-treat analyses CONT � defined over-ground mobility control group; FIM-L � Functional Independence Measure locomotor; LEMS � lower extremity ASIA � American Spinal Injury Association Impairment Scale; BWSTT � step training using body weight support on a treadmill work_rxefowy3qbacdjsh7da6wp2eca The Zoom activity requires a team of learners to organize a set of sequential images, baseline teamwork skills of first-year medical students through an immersive gaming medical school were enrolled in the Zoom Team Building Activity as part of their orientation. complete the Zoom game was 24 minutes, and all the teams successfully placed the pictures in and team-building training should begin at the undergraduate medical education setting, The Zoom Team Building Activity is a well-regarded game based on a picture book, "Zoom", by leadership training activity and assessing the baseline teamwork skills for first-year medical The Zoom activity game is an interactive and easily accessible team-building exercise that can Zoom Team Building Activity. The Zoom Picture Book Game: A Creative Way to Promote Teamwork in Undergraduate Medical Education TABLE 1: JTOG assessment of the Zoom activity for first-year medical students TABLE 1: JTOG assessment of the Zoom activity for first-year medical students work_s2u7d2vi4vcubebfpmoha7t7ia Ca2þ uptake shows tissue specific differences and interestingly, mRNA level in mouse liver versus heart mitochondria, and a 4.5 fold higher MICU1 to heart mitochondria displayed a decreased threshold and lesser cooperativity nanodomain which developes into a H2O2 transient following IP3 receptormediated ER Ca2þ release and mitochondrial Ca2þ uptake. Pharmacological inhibition showed that the transient was dependent upon ER Ca2þ, mitochondrial that ROS target mito-motility to control mitochondrial function. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial at birth (Nguyen et al., 2014) and fibroblasts (MEFs) derived from Miro1 KO embryos show abnormal mitochondrial distribution, but the calcium-dependent inhibition of motility is unaffected and the respiratory and calcium buffering Imaging in perfused whole heart ex vivo, showed considerable mitochondrial continuity and fusion activity in ventricular CM. more directly the role of CM''s contractile activity in mitochondrial fusion, adult CM lose mitochondrial fusion activity. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial Movement work_s64wlochtbh2vfjqkrdoyu35ye The voltage dependent anion channel (VDAC) is involved in regulation of metabolite flux across the mitochondrial outer membrane (MOM). The 15 amino acid N-terminal sequence of HXK2 is responsible for mitochondrial binding and, when G6P, which is known to cause HXK2 detachment from the MOM, fully reverses the inhibition of tubulin-VDAC binding. Thus we propose a novel mechanism of mitochondrial respiration control in cancer cells through the competition between HXK2 and tubulin for VDAC binding. matrix [Ca2þ] response in permeabilized shMICU1 cells. MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca of MICU1 in HeLa cells causes lower threshold and decreased cooperativity of Silencing of MICU1 caused a leftward-shifted dose response and decreased cooperativity of mitochondrial Novel Mechanism of Mitochondrial Respiration Control through Competition between Hexokinase-2 and Tubulin for VDAC Binding Reprogramming of Mitochondrial Ca2+ Handling in MICU1-Deficient HeLa Cells MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca2+ Uptake in the Liver work_s7amzuolybcupif4bcx5qftid4 sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. 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Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_sf3vowvzk5edrpmongt2vzh5dm perience, renal images noted during bone scan accurately imaged during bone scanning with this or total-body scanning including kidneys and bladder polyphosphate bone scanning showed abnormal renal kidney ( 1 ) , hydronephorosis, hydroureter (2) , renal Bone scan is normal Posterior scan shows poor visualization of left kidney and intravenous pyelogram confirms poorly functioning left left with poor renal function on right is apparent. shows discrete defect in upper pole of left kidney and increased of left kidney confirmscyst (arrows) in upper pole. who had a bone scan because of pain in the left hip pole of the left kidney (Fig. 4) and a renal cyst was lesion in the upper pole of the right kidney on a 36PARK, GLASSMAN, THOMPSON, AND MATA labeled polyphosphate as a skeletal imaging agent. Selected papers of all aspects of Nuclear Medicine. 536 JOURNAL OF NUCLEAR MEDICINE 536 JOURNAL OF NUCLEAR MEDICINE work_sfmkavggdvbapnfcbamrorp2he Diseases; Cincinnati, OH USA Conventional Drug Delivery Strategy: Perfuse entire vasculature with drug Ultrasound-mediated drug delivery: Ultrasound-mediated drug delivery: 1. Target drug/bubbles to pathologic tissue. Drive drug penetration Drug Delivery, 2013. • Treatment: I.V. recombinant tissue-type plasminogen activator (rt-PA) • Progress: sonothrombolysis to expedite clot lysis Drug Penetration = Lysis – 1 cycle, 120 kHz sinusoidal excitation – Homogenous acoustic pressure in MCA Does clot retraction affect Barrier Permeability 8 Sutton et al., UMB. Ex Vivo Thrombosis System – Drug loading Echogenic Liposome (ELIP) drug drug Drug Targeting & Image-Guidance: Drug Targeting & Image-Guidance: Cardiovascular Drug Delivery: Cardiovascular Drug Delivery: Expert Opinion in Drug Delivery. PRESSURE PRESSURE Drug penetration Form: BEV-ELIP – circulatory stability of drug carriers – tissue targeting Developing/assessing novel drug carrier & US contrast agent (ELIP) drug penetration into tissue & resulting bioeffect • fibrinolytic enzymes, bevacizumab, nitric oxide CVD Drug Delivery: CVD Drug Delivery: work_sgiz4sep3bf3dfefalgamj4egu Researchers knock down gene to stop HIV in its tracks Researchers knock down gene to stop HIV in its tracks The HIV-resistant bone marrow donor in HIV attach and infect healthy cells (N. pluripotent stem cells (Hum. Gene Ther. disrupt CCR5 expression in human T cells, The gene therapy lowered viral loads and expression of the CCR5 gene with zinc fingers, same gene therapy tactic in bone marrow. marrow stem cell therapy has the advantage therapy aimed at T cells, which must be "We do not lack ways to attack HIV," says A potential obstacle to CCR5-based gene cell for its normal functions than CCR5," says Ramesh Akkina, who studies HIV gene therapy an HIV gene therapy technique involving three month, Zaia''s team showed that patients modified genes in their blood and showed no Gene therapy against HIV "is now within cheap medicines from online Canadian pharmacies work_shabcmg6vnavfnvaiun2x4ifu4 in mouse liver versus heart mitochondria, and a 4.5 fold higher MICU1 to heart mitochondria displayed a decreased threshold and lesser cooperativity nanodomain which developes into a H2O2 transient following IP3 receptormediated ER Ca2þ release and mitochondrial Ca2þ uptake. Pharmacological inhibition showed that the transient was dependent upon ER Ca2þ, mitochondrial that ROS target mito-motility to control mitochondrial function. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial at birth (Nguyen et al., 2014) and fibroblasts (MEFs) derived from Miro1 KO embryos show abnormal mitochondrial distribution, but the calcium-dependent inhibition of motility is unaffected and the respiratory and calcium buffering Imaging in perfused whole heart ex vivo, showed considerable mitochondrial continuity and fusion activity in ventricular CM. adult CM lose mitochondrial fusion activity. likely provide some factors to support mitochondrial fusion activity. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial Movement Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial Movement work_sj6aftvnsrd7ziz2jhbaczobuu PND19 DEVELOPING A MIGRAINE QUALITY OF CARE MEASUREMENT SET Ratio (MPR) was estimated as proxy for adherence to PD medications, with a threshold of 0.80 indicating adherence. between medication adherence and PD symptom progression. of study population was not adherent to their PD medications Subjects adherent to their PD medications (MPR >= medication use 6 months before index date. migraine ED visit 12 months after index date. OBJECTIVES: To develop a migraine quality of care measurement set at the health plan level, in order to begin measuring and leaders in migraine care and quality improvement; and 4) assembly of a national advisory board consisting of prominent leaders within migraine care, quality measurement and managed care. These measures capture information on: migraine diagnosis and prevalence; use of preventive and therapeutic medications; and, primary care, specialist, emergency, diagnostic CONCLUSION: Development of an evidence-based set of quality measures for migraine work_smuwlc7darc3hbfj6reacs6m7e sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220681544 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:21 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_sr2zxr76qrcrfdmqn3xibcmixq apoptosis signals MAC formation, while pDsRed-2 expression shows mitochondrial structure as red fluorescence. cleaved by caspase-8 and other enzymes forming tBid that induce mitochondrial outer membrane (OMM) permeabilization and cytochrome c (cyto-c) release. The mammalian GRIF1 and OIP106, and the drosophila Milton are kinesinbinding proteins that form a complex with the Miro GTPase, an outer mitochondrial membrane EF-hand protein, to support the movement of mitochondria ionophore that induces matrix swelling evoked a decrease in mitochondrial motility leading to fewer contacts among mitochondria but the number of fusion Here we evaluated mitochondrial fusion dynamics in human skeletal muscle cells (HUSMC). Mitochondrial fusion events were evaluated by confocal imaging of cells expressing mitochondria matrix targeted DsRed and each IP3R isoform can support local ER-mitochondrial Ca2þ transfer and their Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells work_stxbniasv5h5bjd2twyq3y4ace mitochondrial membranes which result in the dramatic increase of their permeability. study investigated how mtDNA T8993G (NARP)-induced inhibition of mitochondrial complex V altered mitochondrial dynamics in association with a protective mitochondrial phospholipid, cardiolipin (CL), as a potential therapeutic a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca2þ and lipidstress. Intriguingly, melatonin, by differentially preserving CL during various stresses (oxidation > Ca2þ > lipid), rescuesdifferentially CL-altered mitochondrial dynamics and cell death (oxidation > CL to prevent its oxidization and/or depletion and, therefore, it exerts great potential in rescuing CL-dependent mitochondrial dynamics-associated mitochondrial pathologies for treatment of NARP-induced pathologies and diseases. of an outer mitochondrial membrane protein. Tunde Golenar1, Gyorgy Csordas1, Fabiana Perocchi2, Vamsi K. MICU1 in mitochondrial Ca2þ uptake, we used wild type HeLa cells (Ctrl), mtDNA T8993G Mutation-Induced Mitochondrial Complex V Inhibition Augments Cardiolipin-Dependent Alterations of Mitochondria ... Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells work_su6zfttle5hq7fxccg3nnnccwa formation and fusion, we used organelle-targeted fluorescent proteins, including photoactivatable GFP, which allow tracking of individual mitochondria. Strikingly, 80-90% of the physical contacts between adjacent mitochondria did not result in fusion events. ionophore that induces matrix swelling evoked a decrease in mitochondrial motility leading to fewer contacts among mitochondria but the number of fusion Here we evaluated mitochondrial fusion dynamics in human skeletal muscle cells (HUSMC). Mitochondrial fusion events were evaluated by confocal imaging of cells expressing mitochondria matrix targeted DsRed and Recent studies have suggested that type 3 IP3Rs (IP3R3) are particularly important for mediating the Ca2þ transfer at the ER-mitochondrial interface. in the mitochondrial Ca2þ transfer we used two point mutants of the IP3R1, each IP3R isoform can support local ER-mitochondrial Ca2þ transfer and their Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells Mitochondrial Fusion Dynamics in Human Skeletal Muscle-Derived Cells work_sveky7445vfatkdfpzvurqbhza HP5 THE RELATIONSHIP OF DIRECT-TO-CONSUMER ADVERTISING AND CLINICIAN BEHAVIORAL INTENTIONS RESULTS: The data set included 959 acute care hospitals, representing inpatient pharmacy cost information on a valid and reliable quality appraisal instrument applicable to economic evaluations in the pediatric population. exposure of a patient to direct-to-consumer advertising (DTCA), and the likelihood of clinician behavioral intentions to provide information and medications. ADVERTISING SPENDING AND DRUG PRICING direct-to-consumer (DTC) advertising spending on drug OBJECTIVE: Explore the relationship of DTC advertising spending and drug pricing for the top twenty drugs (a) the total DTC advertising spending and per unit price of the drug; (b) the percent changes in the DTC advertising spending and drug price. advertising spending and drug price for a year was CONCLUSION: Results indicate a very weak relationship between DTC advertising spending and drug prices. factors associated with consumers'' seeking various information sources about medications sought in response to result of direct to consumer advertising. work_sx2mti2acnfqdmxgzyq6o622ku The impact of risk factors on gastroparesis at an urban medical with respect to the epidemiology of patient comorbidities and their effect on gastric emptying. Methods We examined the medical records of all patients diagnosed with gastroparesis at a these patients, 29.4% had evidence of medication-associated gastroparesis, 29.0% had diabetesassociated gastroparesis, and 31.7% had idiopathic disease. comorbid conditions that serve as risk factors for the development of gastroparesis, including and severity of gastroparesis; in particular, African American patients are more likely to have diabetic gastroparesis than patients of other races. Keywords Delayed gastric emptying, diabetes mellitus, narcotic medications African American, 64.1% of patients with diabetes-associated having diabetes-associated gastroparesis than females, patients medication-associated gastroparesis than patients with a lower the number of major risk factors and the severity of a patient''s Table 4 Risk factors and severity of delayed gastric emptying risk for diabetic gastroparesis than patients of Gastric emptying in patients work_szqldxk4hzbepgvd2edzmbatbi Final proof that scientists can work with the research, the BBC programme The Experiment attempts to recreate aspects of a 1971 psychology study by Stanford University acting as guards were so brutal to the prisoners University who planned the experiment with and divided into 6 guards and 9 prisoners. more psychological stress than the prisoners. Reality TV show recreates famed social study Thomas Jefferson''s descendants have decided nearly 800 descendants of Jefferson''s Sally Hemings''s children bore a likeness to children by Hemings, who was a slave at Jefferson''s descendants have always descended from Sally Hemings''s son Eston with other evidence, indicated a "high probability that Thomas Jefferson fathered Eston father of all six of Sally Hemings''s children". But Jefferson''s descendants remain Sally Hemings," says Nathaniel Abeles, the Monticello Association''s president. Monticello, home of Thomas Jefferson, where Jefferson''s descendants continue to deny slave link Jefferson''s descendants continue to deny slave link work_t4n2y6uk45dvhe6k77gvcxkciq Rawool: Ultrasound of the hand has become an extremely practical tool, allowing both diagnosis and treatment of various musculoskeletal disorders. According to the authors, this book aims at being a "cookbook" for busy clinicians, including hand surgeons, Designed to allow clinicians to find information quickly includes bullet-point text, informative figures, and detailed selected chapters have video to demonstrate the techniques. The editors are: John R Fowler Jr, Assistant Professor, Medical Center, Pittsburg, Pennsylvania, USA, and Nandkumar M Rawool, Associate Professor, Department of Radiologic Sciences, Thomas Jefferson University, Philadelphia, All the figures (photographs, anatomical drawings, and ultrasound images) are To sum up, this practical step-by-step guide may be greatly helpful for all physicians, seniors and residents, aiming to integrate musculoskeletal ultrasound in their clinical 1 University of Lorraine, CHU Nancy, Nancy, France Rawool: Ultrasound of the hand and upper extremity. Rawool: Ultrasound of the hand and upper extremity. work_t7aihbs6dzbjhf5u6aidukppcu PHP25 USING AN ITALIAN POPULATION DATABASE TO PROFILE PREVALENCE AND COSTS OF CHRONIC CONDITIONS OBJECTIVES: To elicit similarities and differences in the policies and practices for financing, pricing and reimbursing prescription drugs in the often perceived similar Nordic countries METHODS: A review of the four countries'' authorities'' stated Nordic countries all have a national health care system financed To give a systematic overview of the current state of the European pharmaceutical market as a whole. CONCLUSIONS: The future of the actors in the European pharmaceutical market is not clear. conditions and assesses related health service use and costs in the Individuals were classified as having a chronic condition in 2000, and we examined pharmacy and hospital use/costs RESULTS: We identified five highly prevalent chronic conditions: cardiovascular diseases (N = 824,190, 20.8% of the population); rheumatologic CONCLUSIONS: Interestingly, one-fourth of the population with selected chronic conditions accounted for large proportions of cost and use of health work_tdyzby7r7fgxhgyeyitcd27eka Sites of Slavery: Citizenship and Racial Democracy in the Post-Civil Rights Imagination by Salamishah Tillet (review) Sites of Slavery: Citizenship and Racial Democracy in the Post-Civil Rights In Sites of Slavery: Citizenship and Racial Democracy in the Post-Civil Rights Imagination, Salamishah Tillet explores the way in which post-civil rights African Americans return to "sites of slavery"—"the objects, texts, figures, places and narratives from the American slavery"—in order to produce a "democratic aesthetic" which responds to the "civic estrangement" of contemporary African American citizenship in the United States (5). defines "civic estrangement" as "the paradox post-civil rights African Americans experience slavery in the civic sphere [achieved by returning, as the figures in Tillet''s book do, to sites reads Gordon-Reed''s books both as illustrating African American civic estrangement''s at how post-civil rights African American writers and artists return to Uncle Tom''s Cabin Tillet pushes to consider the contradictions she sees in heritage tourism: the clash of desires of African Americans to imagine work_tkkbec2p3baufn3gfwmukixnhi sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220686202 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:26 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_tlo6aod7wnbpbjs4drrdojsh5a 1. Chair, Delaware Institute of Medical Education and Research Board The Delaware Institute for Medical Education and Research (DIMER) was founded in 1969, medical education for Delaware residents in the absence of such a school. entire Delaware healthcare together to focus on medical education and provider workforce. DIMER provides one of the best medical education While DIMER''s charge is to ensure access to quality medical education for Delaware residents, practicing physicians as well as representatives from all our medical education partners and DIMER is not only focused on providing medical education opportunities for Delawareans but The Delaware Branch Campus provides medical students clinical residency; DIMER''s relationships thus extend beyond its education partners and into Delaware''s As of 2019, 229 DIMER students have returned to practice in Delaware. DIMER has been a successful model of Delaware''s medical education program, focusing on 2. Delaware Institute for Medical Education and Research. work_tlzzi4yogbajbdxgzyx3vltsmu inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. this notion is that PPT-resistant cells are resistant to PPP (3). between IGF-IR expression and sensitivity to PPT/PPP was reported Eleven cell types expressing IGF-IR were found sensitive to PPP, and three cell types lacking IGF-IR expression were resistant in vitro C. Shoshan reexamined PPT/PPP effects on IGFIR–deficient R� cells, which were reported resistant to 15 Amol/L ( from Dr. Girnita, Department of Oncology-Pathology, Karolinska Both cell types were equally sensitive; PPP reduced viability of Both drugs induced sub-G1 debris in R� cells, indicative of cell death (PPT, 64% of total counts; PPP, 56%; controls, 6%). Gupta reexamined PPT/PPP effects on HepG2 cells, which were reported resistant to >15 Amol/L PPT/PPP (1). PPT and PPP induce loss of viability and cell death in IGF-IR–deficient Stig Linder, Maria C. Access the most recent version of this article at: work_tn7ctpntp5fk3fdrtfm7vmrqm4 pancreas and related periampullary cancers, premalignant lesions, and nonaffected family members (NAFMs). The ultimate goals of the JPTR are to provide a link between family history, gene mutations, and precision medicine therapy, and to identify high-risk NAFMs for potential surveillance screening. Keywords: cancer registry; family history; pancreatic cancer; risk factors; quality of life be recorded by cancer registries include personal identification, gender, date of birth, address, ethnic group, the quality of life of participants.1The Jefferson Pancreas Tumor Registry ( JPTR), a voluntary, hospital1Department of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, as one or more first degree relative with PC in addition to the index case),3 (b) sporadic pancreatic cancer Banking study, JPTR data have attempted to associate single nucleotide polymorphisms (SNPs) with pathological features or family history of cancers and/or Familial risk of pancreatic cancer. work_to5ccbotbncm7gigcqjc46huy4 Yet, no court has ever granted a community organization''s motion to intervene as a matter of right in police reform, consent decree cases initiated by the Department of Justice. This Note presents an original argument regarding a significant and recurring issue within commercial contract law: efforts clauses. The new top editor of Georgetown''s flagship law journal is ''undocumented and unafraid'' The Georgetown Law Journal editor in chief Agnes Lee''s activism for undocumented immigrants has continued throughout her time at Georgetown University. Lee is believed to be the first openly undocumented student elected to lead a flagship journal at a top U.S. law school. For the first time ever, all Editors-in-Chief for the top sixteen law schools in the country are women. Volume 109, Issue 3 (February 2021) Volume 109, Issue 3 (February 2021) Volume 109, Issue 3 (February 2021) work_toganz75qrdfzgnrxwrvy4vzbq 토머스 제퍼슨의 버지니아대학교 식물원 구상 배경과 내용† This paper examines the background and content of Thomas Jefferson''s botanical garden plan for the University of Also, Jefferson''s perspective on botany, his plan, and botanical gardens are reviewed. 본 연구는 토머스 제퍼슨의 버지니아대학교 식물원 구상의 배경과 내용을 고찰한다. 여 동시대 식물원과 비교하여 버지니아대학교 식물원 구상의 특징을 짚어내고자 하였다. 식물원 구상안을 검토하며 버지니아대학교 식물원을 당대 사례와 비교 검토하였다. 본 연구는 버지니아대학교 식물원 구상을 사례로 19세기 전후 식물원의 역사와 문화에 대한 이해의 폭을 넓히는 때 제퍼슨의 버지니아대학교 식물원 계획은 19세기 전후 미국 버지니아대학교 식물원 계획에 담긴 제퍼슨의 역할을 조명한 1826년 제퍼슨의 버지니아대학교 식물원 구상을 논하기에 렴한, 공립학교를 위한 식물원 계획(Plan for a Botanic Garden 본 연구는 코레아와 제퍼슨의 버지니아대학교 식물원 조성 Letter form Thomas Jefferson to John Patton Emmet, April 27, Fox-Bruguiere, L.(2010) An Uncultivated Legacy: Jefferson''s Botanical Garden at the University of Virginia. Jefferson''s botanical garden at the University of Virginia. work_u2dv6vc2anakrjdmv4l42enoum A novel biosimulation task trainer for the deliberate practice of resuscitative hysterotomy Resuscitative hysterotomy is a daunting and rarely performed procedure in the emergency department (ED). hands-on practice and the development of a novel, tissue-based simulation task trainer. Resuscitative hysterotomy is a high-stakes, lowfrequency procedure that demands provider practice and confidence. Keywords: Resuscitation, Resuscitative hysterotomy, C-section, Emergency medicine, Rapid cycle deliberate practice, intervention, resuscitative hysterotomy is an ideal candidate for simulation-mediated deliberate practice. innovation, the authors sought to (1) enhance procedural training of resuscitative hysterotomies; (2) integrate a realistic simulation model for hands-on, rapid cycle deliberate practice (RCDP) with EM residents; and (3) compare the efficacy of our task trainer with similar hysterotomy models for resident learners. high-fidelity, tissue-based task-trainer models were constructed and tested on a convenience sample of 14 EM Table 1 Biosimulation resuscitative hysterotomy model materials and cost tissue-based simulation task trainer (43% of resident responses). http://www.gaumard.com/s2200-victoria-childbirth-simulator work_u3qvh3es3nbipgsrz6dsngq5bi Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 on mitochondrial motility and its inhibition by agonist-induced cytoplasmic [Ca2þ] ([Ca2þ]c) signals in H9c2 cells. In OIP106 and GRIF1 overexpressing cells, elongated mitochondria with varied degree of aggregation were Mitochondrial contribution to cell signaling and function relies on the association and local communication of mitochondria with the ER and the plasma the kinetics and short-term effects of the linkage formation, we have now devised fluorescent protein pairs targeted to the OMM and ER or PM containing formation between the ER and mitochondria was followed by a decrease in mitochondrial motility (>40% in 15 min) and by sensitization of mitochondria to MEFs lack tBid induced complete cyto c release and loss of MEFs and also supported the tBid-induced cyto c release. Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 work_u6hptdchl5ftja4vpftl5irhp4 In , Thomas Jefferson proposed the use of nose-cutting to punish of Jefferson''s attempt to rationalise the Virginian law code in line with eighteenth-century reform principles. Jefferson drew on British laws from the AngloSaxon period to the Coventry Act for his bill, but his proposals contrast strikingly crimes and punishments in the law codes Jefferson examined, and compares the by Jefferson in his proposed overhaul of capital offences in Virginian criminal law seem strange and anachronistic for a man thought preoccupied Kathryn Preyer, ''Two Enlightened Reformers of the Criminal Law: Thomas Jefferson which concealed contests of authority and justice. Scholars of colonialism have complicated the modernising narrative of crime and punishment by highlighting ways in which penal practices followed different became known as the Coventry Act. This formed the basis of all subsequent colonial disfigurement statutes, including Jefferson''s revision. which met application of the Act and its capital punishment are commensurate with Jefferson''s rescinding of the death penalty. work_ubulcdtip5hanpzapkfyzkfyku Director, University Center for Health Professions Studies; Director, College of Arts & Sciences medical schools and other health profession programs. students across all colleges who wanted to pursue careers in the health professions. The Center for Health Profession Studies supports and encourages students from all majors who advisement and referral services to a growing community of pre-health profession students in all Professions Living Learning Community for freshmen students interested in pre-health Students have the opportunity to participate in exciting health profession medical internship their medical, veterinary, and public health professional programs of study on the island of considered for admission to medical, dental, or other health profession schools. The Center for Health Profession Studies strives to expand services to students and alumni not University of Delaware Center for Health Profession Studies University of Delaware Center for Health Profession Studies University of Delaware Center for Health Profession Studies work_uc2s5avzwnc6hia5dw7vqm2cru in rates of oxygen uptake while the birds mM) matched values reported for mammals running at speeds above their aerobic (the maximum aerobic metabolic rate Previous avian values do not provide evidence of being upper limits; they are probably below species'' maxima, but to unknown The structural basis of the rheas'' aerobic power indicates that respiratory mammals, achieve maximal high rates of The trends in cirrus ''amount when present'' over the previously defined regions of The combination of a large positive trend in cirrus occurrence associated resting minimum for rheas and athletic mammals at Health Science Center, University of Colorado, son of Thomas Jefferson''s brother Randolph, might have been the father of one or as Thomas Jefferson to have fathered Eston DNA data that Thomas Jefferson can neither a mammal of the same body size and aerobic power. aerobic mammals (Table 1). aerobic mammals of their size, using lungs work_ucr5v4gzqnhu5jr3qkqmfteeya Clinical Trials in Metastatic Uveal Melanoma: Current Status standard of care therapy is available for patients with metastatic uveal melanoma. We conducted a search for active clinical trials available worldwide for metastatic uveal melanoma on November 26, 2019, clinical trials for metastatic uveal melanoma discussed in this review are summarized in Table 1. NCT02768766 Intermittent selumetinib for uveal melanoma recruiting I Columbia University Medical Center; Memorial Sloan in metastatic uveal melanoma patients who have not received prior MEK inhibitor therapy (NCT02768766), targets the mitogen-activated protein kinase (MAPK) pathway, regardless of tumor mutational status. randomized phase 2 trial compared selumetinib to chemotherapy in 101 metastatic uveal melanoma patients virus is a phase 1 study of VSV-IFNbetaTYRP1 in patients with metastatic uveal or cutaneous melanoma phase 1 clinical trial available for uveal melanoma patients with leptomeningeal disease involves the administration of intrathecal nivolumab with intravenous available for metastatic uveal melanoma, trials were largely limited to "recruiting" status. work_ud5c46rj3vgpdkbz3vagzy2sue Managing Editor: Monica M. Abelson (Engineering and Applied Sciences); John I. Assistant Managing Editor: Dawn Bennett Associate Editors: Gilbert J. Theuring, Assistant Editor; Susan Randolph, Editorial Assistant Editorial Support: Sherryf Farmer, Supervisor; Linda News Editor: Colin Norman Features Editor: John M. Deputy News Editors: Tim Appenzeller, Joshua Fischman, Holly Bishop, Graphics Associate; Elizabeth Carroll, Graphics Assistant Senior Editor: Richard B. Associate Editor: Jeffrey Williams News Editor: Daniel Clery Science Editorial Board Dr. Noitall, you are one of the great political scientists of all time, the man career of Thomas Jefferson, statesman, scientist, diplomat, inventor, activist, revolutionary, He was always a great supporter of science and considered that the three greatest men in the world at the time (whose pictures he hung on the walls of his house) were Isn''t there one small problem, namely, that Jefferson is dead? ARTICLE TOOLS http://science.sciencemag.org/content/261/5119/275.citation 1993 by the American Association for the Advancement of Science http://science.sciencemag.org/content/261/5119/275.citation http://science.sciencemag.org/ http://science.sciencemag.org/ work_ue76oit4evgajksqdlgboiyy6y 222 Increased PD-L1 tumor expression correlates with high rate of response to PD-1 inhibitors in patients with unresectable, recurrent, and metastatic cutaneous squamous cell carcinoma Patients were grouped in good performance status 1.8–4.6) in patients with poor performance status (p<0.001). The median overall survival (OS) for patients with good performance status was 30 months (95% CI 16.6–42.3) and 4 months (95% CI 3.2–8.1) in patients with poor PS (figure 1). Abstract 221 Figure 1 Progression free survival (PFS) and overall Results Fourteen patients with CSCC treated with PD-1 ICI present in tumor in all tested patients and in blood in 6 RENAL CELL CARCINOMA (MRCC) PATIENTS MANAGED In this paper, we investigated differences in clinical outcomes between African American (AA) and Caucasian mRCC patients treated with ICI Methods We performed a retrospective study of 198 patients Conclusions In this group of mRCC patients treated with ICI, work_ujl43oknrraqpoxo6infx3yhkm Water Structure at the Potassium Channel Gate: The Importance of the Prolines in the PVPV Sequence, as Shown by Computational Mutations, and the Role of a Histidine in Gating Voltage-activated potassium (Kv) channels open an intracellular gate in response to changes in transmembrane voltage, allowing K N-terminus of the protein acting as a blocking particle, binding at the intracellular cavity of the channel and physically obstructing the permeation pathway. results suggest that despite being tethered to a particular subunit, the single inactivation particle has sufficient freedom to interact with position 470 of each from the solution; from the gate it repels an ion in the channel pore cavity into Water Structure at the Potassium Channel Gate: The Importance of the Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Water Structure at the Potassium Channel Gate: The Importance of the Prolines in the PVPV Sequence, as Shown by Computation ... work_uoyvkququrgtzn3rtylbkbcptu Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 on mitochondrial motility and its inhibition by agonist-induced cytoplasmic [Ca2þ] ([Ca2þ]c) signals in H9c2 cells. In OIP106 and GRIF1 overexpressing cells, elongated mitochondria with varied degree of aggregation were Mitochondrial contribution to cell signaling and function relies on the association and local communication of mitochondria with the ER and the plasma the kinetics and short-term effects of the linkage formation, we have now devised fluorescent protein pairs targeted to the OMM and ER or PM containing formation between the ER and mitochondria was followed by a decrease in mitochondrial motility (>40% in 15 min) and by sensitization of mitochondria to MEFs lack tBid induced complete cyto c release and loss of MEFs and also supported the tBid-induced cyto c release. Regulation of Mitochondrial Motility by Milton-like Proteins, OIP106 and GRIF1 work_utfs6p7p4vh4lmfw6nejtqtgpy Try again or register an account. Lippincott Journals Subscribers, use your username or email along with your password to log in. Register for a free account Registered users can save articles, searches, and manage email alerts. Advanced Practice Nursing Critical Care Nursing Internal/General Medicine Internal/General Medicine Residency Oncology Nursing Oncology Surgery Orthopedics/Spine/Sports Medicine Surgery Primary Care/Family Medicine/General Practice Critical Care Medicine Dentistry, Oral Surgery & Medicine Internal Medicine Radiology, Nuclear Medicine & Medical Imaging Sport Medicine/Science may email you for journal alerts and information, but is committed Be sure to verify your new user account in the next 24 hours, by checking your email and clicking the "verify" link. This article has been saved into your User Account, in the Favorites area, under the new folder "". Other articles in this journal by BERNARD BERELSON, Ph.D. Get new journal Tables of Contents sent right to your email inbox Get New Issue Alerts work_uusmrix3bnbkdjrc7dk2scjmg4 Tobias Frederico · Giovanni Salmè · Michele Viviani This special issue of Few-Body Systems collects original efforts of the community in the field of "Relativistic Description of Twoand Three-body Systems in Nuclear Physics" (October 19–23, 2009, ECT∗). the conferences on few-body physics. The research activity for extending the realm of investigation of the accurate non relativistic approaches, His interests covered a wide range of topics, from the calculations of the three-body From this short description of the scientific life of Tjon, one can immediately realize that the few-body ECT∗ Conference are just the continuation of the original ideas laid out by John in his seminal works. In view of this, the compelling motivation for organizing the ECT∗ Conference has been to set up an appropriate place for both discussions and cross-fertilizations between the non relativistic Few-Body community and Created PDF documents can be opened with Acrobat and Adobe Reader 5.0 and later.) work_v5yffxroyfapbogtcxlwqw5nxa Preserving today''s scientific record for tomorrow | The BMJ News & Views At a glance The BMJ Collections Three studies of links in peer reviewed journals all found their useful life to be a few … BMA Member Log In BMA Member Log In If you have a subscription to The BMJ, log in: Subscribe and get access to all BMJ articles, and much more. Please note: your email address is provided to the journal, which may use this information for marketing purposes. If you have registered for alerts, you should use your registered email address as your username Download this article to citation manager Add article to BMJ Portfolio NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. BMJ Opinion BMJ in the USA BMJ in South Asia BMJ Careers BMJ Journals BMJ Student work_v6x4vgpm2vd5dklp5xmbnayvqu advises the Journal of the American Board of Family currently Assistant Professor of Family and Community Medicine at the University of California, Assistant Professor of Family Medicine in Medicine and Director of Student Health at Weill Cornell Medical College in New York City. residency at the Family Medicine Residency Program at New York Presbyterian Hospital—Columbia University Medical Center. He obtained his medical and doctorate degrees from Keio University School of Medicine in residency in family medicine at the Thomas Jefferson University in Philadelphia. Michigan Family Medicine residents in hospital published in national family medicine and cancer Family Medicine supplement from the American Board of Family Medicine''s symposium celebrating the American Board of Family Practice (now the American Board of Family Medicine) was approved forefront of innovation as it became the first medical specialty board to issue time-limited certificates Board of Family Medicine articles and online readership for 2009. work_vcz5sf2ko5bfpcfabvre4zg4mu Calcium-Induced ROS Generation during Ischemia Triggers mPTPDependent Cell Death during Reperfusion Impairment of mitochondrial function is a central event of ischemiareperfusion (I/R) injury leading to tissue damage and cell death. 1, ROS generation with Mito-Sox Red, mPTP opening as mitochondrial calcein ROS with superoxide dismutase mimetic MnTBAP or antioxidant Trolox prevented reperfusion-induced cell death. We conclude that mPTP-dependent cell death during reperfusion is mediated by Ca2þdependent ROS generation during ischemia. These probes, targeted to the ER lumen, ER membrane (cytosolic face), cytosol, mitochondrial matrix and outer membrane (OMM) and the IP3-receptor, of the ER membrane, bulk cytosol and mitochondrial matrix and OMM. It was found that the mitochondrial surface in close association with ER was significantly reduced in the chronic ethanol-fed condition as Calcium-Induced ROS Generation during Ischemia Triggers mPTP-Dependent Cell Death during Reperfusion Dynamic Measurement of Ca2+-Induced Changes in Organelle-Specific Redox Microdomains Mitochondrial Nm23-H4/NDPK-D is Multifunctional: Intermembrane Cardiolipin Transfer Linked to Apoptosis work_veau5scdkratpfqwspftdidgaa TOTAL DONOR CHIMERISM IN THE DAY 21 BONE MARROW PREDICTS By contrast, only 87% of the 15 patients \ 100% total donor engrafted [median day to ANC $ 0.5 31 stem cell transplantation can result in long term survival most patients lack a matched family donor and are destined to die of refractory disease. of patients with PREF AML in whom allografting is technically feasible but the outcome of unrelated donor transplantation in this HLA DISPARITY AND RAPID IMMUNE RECONSTITUTION DO NOT OVERCOME PROPENSITY TO RELAPSE IN PATIENTS UNDERGOING HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT) WITH ANTI-HLA ANTIBODIES PREDICT GRAFT FAILURE, TIME TO ENGRAFTMENT AND UMBILICAL CORD UNIT DOMINANCE IN DOUBLE UMBILICAL The T-Cell Epitope (Tce) Algorithm For Classifying Hla-Dpb1 Mismatches Does Not Predict Clinical Outcomes In Hsct The T-Cell Epitope (Tce) Algorithm For Classifying Hla-Dpb1 Mismatches Does Not Predict Clinical Outcomes In Hsct work_vjkdzyrh5jevxevf5l3h4jqmea The voltage dependent anion channel (VDAC) is involved in regulation of metabolite flux across the mitochondrial outer membrane (MOM). G6P, which is known to cause HXK2 detachment from the MOM, fully reverses the inhibition of tubulin-VDAC binding. Thus we propose a novel mechanism of mitochondrial respiration control in cancer cells through the competition between HXK2 and tubulin for VDAC binding. matrix [Ca2þ] response in permeabilized shMICU1 cells. MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca of MICU1 in HeLa cells causes lower threshold and decreased cooperativity of Silencing of MICU1 caused a leftward-shifted dose response and decreased cooperativity of mitochondrial Novel Mechanism of Mitochondrial Respiration Control through Competition between Hexokinase-2 and Tubulin for VDAC Binding Novel Mechanism of Mitochondrial Respiration Control through Competition between Hexokinase-2 and Tubulin for VDAC Binding Reprogramming of Mitochondrial Ca2+ Handling in MICU1-Deficient HeLa Cells MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca2+ Uptake in the Liver work_vjqj5ffffbbr3jcl46wgx4wsea Background: Acinar cell cystadenoma is a rare pancreatic cyst that has been described in several case reports. Case Presentation: A previously healthy 14-year-old male presented with abdominal pain. have a pancreatic cystic lesion on ultrasound and cross-sectional imaging. Conclusion: Acinar cell cystadenoma is a rare pancreatic cyst whose true malignant potential is unknown. Key words: acinar cell cystadenoma; pancreas; pancreatic cyst pancreatic cyst that has been described in several case reports.1–3 ACA typically arise from a background of normal multilocular acinar cell cystadenoma who underwent successful cyst excision. however, pancreatic acinar cell cystadenoma has been Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions Acinar cell cystadenoma of the pancreas in a 9-year-old boy. rare case of acinar cell cystadenoma in a 14-year-old adolescent: a ACA ¼ acinar cell cystadenoma Cosgrove et al.; Case Reports in Pancreatic Cancer 2016, 2.1 Cosgrove et al.; Case Reports in Pancreatic Cancer 2016, 2.1 work_vmdxaujmhvgf5flffh53jzsdzm 1. President, Delaware Academy of Medicine / Delaware Public Health Association; Editor-inChief, Delaware Journal of Public Health 2. Executive Director, Delaware Academy of Medicine / Delaware Public Health Association This is truly a milestone moment for the Delaware Academy of Medicine / Delaware Public Immediately before Dr. Heymann''s presentation, we recognized the extraordinary work of the Holloway Community Program at Christiana Care Health System. thanked in particular, for her 40 years of advocacy, care, and education. see: https://news.christianacare.org/2019/05/william-j-holloway-program-honored-by-delawareacademy-of-medicine/ The timing of this issue on Communicable Disease could therefore not be better. day-long Holloway Infectious Disease Symposium and the spectacular events and awards above. Philadelphia medical school partners for nearly 50 years. To those of you who have read the Delaware Journal of Public Health from the start in 2015, you''ll notice a change in the layout and readability of this issue. In this Issue: Communicable Disease In this Issue: Communicable Disease work_vqtj2lpl6rcfdg7vrmqbrjfcxu asking for drug information and medications, but their ADVERTISING SPENDING AND DRUG PRICING direct-to-consumer (DTC) advertising spending on drug advertising spending would be added to drug prices (b) OBJECTIVE: Explore the relationship of DTC advertising spending and drug pricing for the top twenty drugs of their DTC advertising spending (source: Competitive (a) the total DTC advertising spending and per unit price of the drug; (b) the percent changes in the DTC advertising spending and drug price. advertising spending and drug price for a year was with an increase in the DTC advertising spending. change in DTC advertising spending decreased and the percent change in drug price increased. CONCLUSION: Results indicate a very weak relationship between DTC advertising spending and drug prices. factors associated with consumers'' seeking various information sources about medications sought in response to consumers seek information from different sources as a result of direct to consumer advertising. work_vr5p4ez5gjhl3gquctrvk746ua different effects of mutations of individual asparagines on the channel activation, inactivation, and drug sensitivity. Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: We use Molecular Dynamics simulations to identify the binding sites for a hydrophobic general anesthetic isoflurane, on voltage gated bacterial sodium channel NaChBac. Apart from the NavAb was published (Payandeh et al (2011) Nature 475, 353), giving an unambiguous picture of the structure of the sodium channel selectivity filter (SF) Experimental ion selectivity determination from pore-only constructs of a sodium channel with the same SF sequence for PIIIA when the NavAb channel is occupied by 2 sodium ions. Binding of Isoflurane to a Bacterial Voltage-Gated Sodium Channel: Structure and Accessibility of Distinct Interaction Sites A Key Gating Charge Interaction Required for Slow Inactivation of the Navab Bacterial Sodium Channel Volatile General Anesthetic Interactions with a Bacterial Sodium Channel Polymodal, High Affinity Actions of μ-Conotoxins on a Bacterial Voltage-Gated Sodium Channel work_vrypc6gohzcqrhzznjcend3erm (figure 1) was admitted for video-EEG monitoring. interictal EEG was suggestive of a left temporal focus (figure 2); however, the ictal EEG was poorly localized and the overall localization was not determined. The dancing semiology is not typical of temporal are suggestive of frontal lobe epilepsy.1 Dancing is Complex partial seizures of frontal lobe onset: statistical analysis Figure 2 Interictal EEG reprint requests to Dr. John 200, Philadelphia, PA 19107 Disclosure: Dr. Skidmore has the following conflicts of interest to disclose for research support: UCB Pharma, Ortho McNeil, Schwarz, left frontal and right anterior Ritu Bagla, John S. Khoury and Christopher Skidmore Video/ EEG use in epilepsy Epilepsy semiology All Epilepsy/Seizures Information about reproducing this article in parts (figures,tables) or in Information about ordering reprints can be found online: Online ISSN: 1526-632X. http://n.neurology.org/content/72/22/e114.full http://n.neurology.org/content/72/22/e114.full http://n.neurology.org/content/suppl/2009/05/29/72.22.e114.DC1 http://n.neurology.org/content/suppl/2009/05/29/72.22.e114.DC1 http://n.neurology.org/content/72/22/e114.full#ref-list-1 http://n.neurology.org/content/72/22/e114.full#ref-list-1 http://n.neurology.org/cgi/collection/all_epilepsy_seizures http://n.neurology.org/cgi/collection/all_epilepsy_seizures http://n.neurology.org/cgi/collection/eeg_ http://n.neurology.org/cgi/collection/eeg_ http://n.neurology.org/cgi/collection/epilepsy_semiology http://n.neurology.org/cgi/collection/epilepsy_semiology http://n.neurology.org/cgi/collection/video__eeg_use_in_epilepsy http://n.neurology.org/cgi/collection/video__eeg_use_in_epilepsy http://www.neurology.org/about/about_the_journal#permissions http://www.neurology.org/about/about_the_journal#permissions http://n.neurology.org/subscribers/advertise http://n.neurology.org/subscribers/advertise work_vyaeyb4xnfebxnjngrkgkbzb7y sys_1000 wp-p1m-38.ebi.ac.uk wp-p1m-38.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220677276 (wp-p1m-38.ebi.ac.uk) Time: 2021/04/06 02:59:16 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_vyjsmor3bzbadn4ygxiq4gqdka Big Bone Lick: The Cradle of American Paleontology (review) Big Bone Lick: The Cradle of American Paleontology (review) The bulk of these interviews represent a generation of Delawares who grew up without knowing many of their cultural Big Bone Lick: The Cradle of American Paleontology. Kentucky''s first tourist attraction, Big Bone Lick has long deserved a modern account such as Stanley Hedeen provides. canoe-load of specimens from Big Bone Lick to Redstone Old Fort.1 Some at the Big Bone Lick."2 What became of these specimens remains unknown, of three Paleo-Indian points "collected" at Big Bone Lick. written that these were discovered in the lowest level of the Big Bone deposits during William Clark''s 1807 excavations for Thomas Jefferson and are associated Paleo-Indian artifacts and megafauna at Big Bone Lick should Big Bone Lick State Park Museum and should remain a standard resource The Ohio State University 4. Stanley Hedeen, Natural History of the Cincinnati Region. work_w4eggqecoregfoka7vcap5sq74 HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol HIV-1 membrane fusion is mediated by sequential binding of the viral homotrimeric Env (gp120/gp41) to cellular CD4 and chemokine receptor (CXCR4 or bridges the viral and cellular membranes, and exposes the N-HR and C-HR domains which are targeted by HIV-1 fusion inhibitors T20 and 5-Helix, respectively. Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion a multivalent, D-peptide fusion inhibitor, PIE12-trimer. Viral propagation in increasing inhibitor concentrations produced HIV-1 populations with 50to 100-fold reduced sensitivity cholPIE12-trimer. HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol Dependent Fashion HIV Fusion Peptide Perturbs Membrane Structure in a Cholesterol Dependent Fashion CD4 Binding Induces an Asymmetric Transition of HIV-1 Env from its Native Conformation into the Prehairpin Intermediate State Evolution of HIV-1 Resistance to a Cholesterol-Linked D-Peptide Fusion Inhibitor Fusogenic Activity of the HIV-1 Gp41 MPER-TMD Region: Mechanism and Targeting by Immunogens and Inhibitors work_w5eevjyfzjbm3ia7t6xmo3jhtq Revolutionary Conceptions: Women, Fertility and Family Limitations in America, 1760ÂŒ1820 the WHIs Women''s Health Initiative. Women''s Health Initiative (WHI) study. Initiative hormone therapy study. postmenopausal hormone therapy: annual trends and Differences in menopausal hormone therapy use among Trends in hormone therapy use before and after publication of the Women''s Health Initiative trial: 10 hormone replacement therapy among postmenopausal women postmenopausal women treated by hormone therapy in Hormone replacement therapy: Patterns of hormone therapy Ann Intern Med coronary heart disease: the role of time since menopause and hormone therapy and coronary heart disease. Menopausal hormone therapy and the Postmenopausal hormone therapy and risk hormone therapy in younger and older women. The Women''s Health Initiative could not have Postmenopausal hormone therapy: of combined postmenopausal hormone therapy: detection bias discontinue postmenopausal hormone therapy. Postmenopausal hormone therapy for disease Hormone replacement therapy in epidemiologic Mortality associated with hormone replacement therapy in J Gen Intern Med 2004; 19: work_w6ibsksa2jgylbbn7njzehv7zi The voltage dependent anion channel (VDAC) is involved in regulation of metabolite flux across the mitochondrial outer membrane (MOM). G6P, which is known to cause HXK2 detachment from the MOM, fully reverses the inhibition of tubulin-VDAC binding. Thus we propose a novel mechanism of mitochondrial respiration control in cancer cells through the competition between HXK2 and tubulin for VDAC binding. matrix [Ca2þ] response in permeabilized shMICU1 cells. MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca of MICU1 in HeLa cells causes lower threshold and decreased cooperativity of Silencing of MICU1 caused a leftward-shifted dose response and decreased cooperativity of mitochondrial Novel Mechanism of Mitochondrial Respiration Control through Competition between Hexokinase-2 and Tubulin for VDAC Binding Reprogramming of Mitochondrial Ca2+ Handling in MICU1-Deficient HeLa Cells Reprogramming of Mitochondrial Ca2+ Handling in MICU1-Deficient HeLa Cells MICU1-dependent Threshold and Cooperativity of Mitochondrial Ca2+ Uptake in the Liver work_wgf2msbacfaetpobn6pl73o5ui We investigated the kinetics of MAC inhibition in mitochondria from wild type, Bak, and Bax knockout cell lines using Mitochondrial Ca2þ has a critical role for balancing cell survival and death. Here we show that adrenergic signaling induces MCU tyrosine phosphorylation and accelerates mitochondrial Ca Pyk2 and MCU, which subsequently accelerates mitochondrial Ca2þ uptake via confirmed that only two tyrosine sites were phosphorylated in response to adrenergic stimulation in situ using cell lines stably expressing MCU-YFs. In addition, overexpression of these MCU-YFs failed to increase mitochondrial Ca elevation by thapsigargin, whereas wildtype MCU transfection dramatically accelerates mitochondrial Ca2þ uptake Mitochondrial Ca2þ uptake is central to oxidative metabolism and cell death The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver work_whsxjmpdbneuphtgnym6ryfc7q Initiation of Electron Transport Activity and a Decrease of Oxidative Stress Occur Simultaneously during Embryonic Heart Development We investigated the kinetics of MAC inhibition in mitochondria from wild type, Bak, and Bax knockout cell lines using Here we show that adrenergic signaling induces MCU tyrosine phosphorylation and accelerates mitochondrial Ca Pyk2 and MCU, which subsequently accelerates mitochondrial Ca2þ uptake via confirmed that only two tyrosine sites were phosphorylated in response to adrenergic stimulation in situ using cell lines stably expressing MCU-YFs. In addition, overexpression of these MCU-YFs failed to increase mitochondrial Ca is required for activation of Akt survival pathways and mitochondrial function. At embryonic day (E) 9.5, mitochondrial ETC activity and oxidative phosphorylation (OXPHOS) are not coupled, Initiation of Electron Transport Activity and a Decrease of Oxidative Stress Occur Simultaneously during Embryonic Heart De ... The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver work_wkfxqckxubf4row2dc2uboj54a white." As evidence, Jacobson reported that, during the late 19th and 20th centuries, selfidentified American Anglo-Saxons classified immigrants from the Catholic and Jewish parts Italians were governed by a half-dozen rival states, American tourists travelling abroad saw The range and tenor of American ideas about Southern Italians that developed Short''s letters – the first extensive travel letters written by an American in Southern Italy – Irving indeed wrote "The Italian Banditti," a series of Southern Italy-based short stories American travel writers pondered the nature of Southern Italian national character and of Southern Italians presented by Irving, Dwight''s Journal depicts Neapolitans as a servile The negative stereotypes about Southern Italians generated by American travelers like century Anglo-Americans perceived in Southern Italians were composed of a litany of slurs Americans attached to Southern Italians included their Roman Catholic faith, peasant is when and how the stereotypes of Italian criminality first took root in American culture. work_wn6awlddpbeztpigfwaxuan4au PMS40 UTILITY AND QUALITY OF LIFE OF PATIENTS WITH OSTEOARTHRITIS TREATED WITH THE CYCLOOXYGENASE INHIBITING NITRIC OXIDE DONATOR (CINOD) NAPROXCINOD The Health Assessment Questionnaire (HAQ) was used to measure functional status (scores 0–3). reported signifi cantly worse scores in morning stiffness, fatigue, pain, and PCS (all CONCLUSIONS: RA patients using current SC biologics still suffer from serious impairments in symptoms, functional status, QoL, and However, patients who discontinued SC biologic therapy have signifi cantly worse symptom scores, physical functioning, and activity impairment compared with those currently being treated. Utility scores correlated signifi cantly with WOMAC™, and patients with high BMI RESULTS: Compared to the general population, our study sample performed poorly with respect to all the SF-36 domains except mental health (MH) and patients who exercise regularly have higher quality of life scores and clinical outcomes. validity of the HUI-3 for deriving utility scores for AS patients. work_wnkdukmw3vfu7cmzbik3ziyx5m found that specifically the VDAC2 isoform is needed for tBid-induced cytochrome c release, due to its role in supporting Bak insertion to the OMM for Bak targeting to the OMM and tBid induced cytochrome c release. 1Thomas Jefferson University, Philadelphia, PA, USA, 2Semmelweis heterogeneous distribution of OMM proteins than wild-type cells, and in particular that heterogeneity of pro-apoptotic Bak leads to dysregulation of Biddependent apoptotic signaling. Thus, OMM function depends on mitochondrial fusion Here we applied mitochondria matrix-targeted DsRed and photoactivable GFP to study mitochondrial fusion in rat FDB SM fibers. BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells Which Domain of VDAC2 is Necessary for Bak Insertion to the Outer Mitochondrial Membrane and tBid Induced Cytochrome C Re ... Outer Mitochondrial Membrane Protein Distribution and Function Depend on Mitochondrial Fusion Outer Mitochondrial Membrane Protein Distribution and Function Depend on Mitochondrial Fusion BCL-2 Proapoptotic Proteins Distribution in U-87 MG Glioma Cells before and after Hypericin Photodynamic Action work_wpfqqt6ihvgz3k3f2zviqucqgq in molecular genetics to neurological practice. The Neurological Management series will also be published as a book in These changes will not deflect the journal from its main task of publishing the best papers in clinical neurological, neurosurgical, and neuropsychiatric science. your national Neurological Society entitles you to an Neurological stamp Casper Wistar (1760-1818) Caspar Wistar obtained his medical education at the University of the State of Pennsylvania in the United States and at Edinburgh University in the United Kingdom, where he was twice president of a student organisation, The Royal Medical Society. assisted in organising a natural history society. Chemistry, later Professor of Anatomy, Surgery, and Midwifery, and then Professor of Anatomy. Wistar members of the American Philosophical Society to which, in 1787, he succeeded Thomas Jefferson as Wisteria, a high-climbing, woody vine of the pea ornithologist Thomas Nuttal. 1986 shows the wisteria vine (Stanley Gibbons 1052, work_wqyqe4jx2bcd7av7nch3lhrbm4 PMH26: CHANGE IN HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH SCHIZOPHRENIA TAKING ANTIPSYCHOTIC AGENTS The MSQ is an effective tool in assessing migraine-related quality of life across different cultures. RESULTS: Schizophrenic patients from both adult and geriatric groups had significantly lower scores (P � .001) on Both groups of schizophrenics scored lower (P � .001) on mental health domains when compared to CHF patients. Adult schizophrenics scored higher in the physical health domains adult and geriatric patients with schizophrenia treated health-related quality of life (HRQL) utilizing the SF-36 The scores of patients with depression were compared to age and gender matched US population norms and contrasted to results of similar research scores for the adult and geriatric depression groups were both the adult and geriatric groups of depressed patients lower scores on HRQL across all domains versus geriatric patients with other psychiatric illnesses. with both adult and geriatric patients'' perceived HRQL. work_wt2k4uqy7ze2jfz4p53fe4qpiq [PDF] Adherence to Positive Airway Pressure Therapy in Hospitalized Patients with Decompensated Heart Failure and Sleep-Disordered Breathing. Corpus ID: 3820314Adherence to Positive Airway Pressure Therapy in Hospitalized Patients with Decompensated Heart Failure and Sleep-Disordered Breathing. title={Adherence to Positive Airway Pressure Therapy in Hospitalized Patients with Decompensated Heart Failure and Sleep-Disordered Breathing.}, Figures, Tables, and Topics from this paper Influence of obstructive sleep apnea on mortality in patients with heart failure. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. work_wxh4ufsvcnaotk63e3xldmrm6m 105 A third-generation human GUCY2C-targeted CAR-T cell for colorectal cancer immunotherapy 104 BCMA-TARGETING CAR-T CELLS EXPANDED IN IL-15 Background Chimeric antigen receptor-T (CAR-T) cells that target B cell maturation antigen (BCMA-CARs) have emerged vivo efficacy and persistence of BCMA-CARs.1 The development of unfavourable differentiation or T cell dysfunction, such as exhaustion and senescence, during the ex vivo expansion of the BCMA-CARs could be limiting their therapeutic CAR-T CELL FOR COLORECTAL CANCER receptor (CAR)-T cell directed towards the extracellular that human GUCY2C CAR-T cells can selectively kill GUCY2C-expressing colorectal cancer cells in vitro and produce inflammatory cytokines in response to antigenic CAR-T cells can selectively target GUCY2C-expressing cancer We hypothesize that GUCY2C-directed CAR-T cells 106 INCREASING AMPK ACTIVITY IN HUMAN T CELLS whose activity increases in memory cells, is a key regulator of human T cells, which significantly increased AMPK activity Abstract 106 Figure 1 AMPK-transduced T cells increase expression work_wybpxozcj5aixfzywxsudwgdja People in Political Science his friends, colleagues, students, and and political commitment to preserving and enhancing all human life. Donnell, Oklahoma State political science, 86, died on November 2. For 25 years he taught politics then called North Texas State Teachers College in Denton, after which, and doctoral degrees from the University of Texas in Austin. political science faculty at Oklahoma political science department, which view of academic political science. His election to serve on the university''s Faculty Council testified to Oklahoma State University Cecelia Marie Kenyon (Cele as she remained a member of the Smith faculty until she retired in 1984. American political theory, and most marking the birthday of Thomas Jefferson, one of her heroes. her colleagues and those college presidents who served while Cele was and the government and politics of political science at the University Jack always had time for his students, colleagues, and friends. kindness to students was well-known work_x42ohdxpvra6jdv7woynmtpjda [PDF] Linear relation between structure and function. Corpus ID: 35513578Linear relation between structure and function. title={Linear relation between structure and function.}, journal={Investigative ophthalmology & visual science}, The functional change after an acute event such as anterior ischemic optic neuropathy (AION) is immediate, but there is a delay before the anatomic changes take place. Optic Neuropathy, Ischemic Nonarteritic anterior ischemic optic neuropathy (NAION) Retinal nerve fiber structure versus visual field function in patients with ischemic optic neuropathy. Optic disc morphology in open-angle glaucoma compared with anterior ischemic optic neuropathies. Investigative ophthalmology & visual science Investigative ophthalmology & visual science Investigative ophthalmology & visual science Medicine, Biology Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License ACCEPT & CONTINUE work_x6jdhnufs5avnbjuvgst4qeehy Another explanation is that choroidal involvement occurred after the vitelliform lesions with the dissemination of the metastatic melanoma. Northern California Retina Vitreous Associates, Mountain View (Drs Khurana, Wieland, and Boldrey); and Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison (Drs Lewis and Albert). Paraneoplastic vitelliform retinopathy associated with metastatic choroidal melanoma. Autoantibodies against bestrophin in a patient with vitelliform paraneoplastic retinopathy and a metastatic choroidal malignant melanoma. development of cutaneous halo nevi or vitiligo in adulthood can occur following treatment of cutaneous melanoma and correlates with decreased morbidity, presumably due to activation of a systemic immune response.5 There have been rare reports of vitiligo and/or cutaneous halo nevi development following enucleation for uveal uveal melanoma who developed a halo ring around numerous pigmented cutaneous nevi following plaque radiotherapy for uveal melanoma. are not aware of other cases of cutaneous halo nevi developing after plaque radiotherapy for uveal melanoma. halo nevi occurring in two patients with choroidal melanoma. work_xai5uteqojdvlerxixyal7mgqm Engraftment and Immune Recovery (IR) in Good Risk Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT): Comparison of Two Different Approaches Using Cyclophosphamide (CY) for T-Cell Tolerization patients (214, 83%) received antiviral therapy within a median of 3 days (range, 0d e 28d) after onset of first symptom. Methods: Case series study for thalassemia and hemoglobinopathy patients undergoing HCT at Bangkok Hospital We developed a 2 step haploidentical HSCT where 76 patients received myeloablative or reduced intensity regimens occurrence of day 0 in the 2 step group, the median time to STEM CELL Transplant Patients: A Case Series occurs in approximately one-half of patients following allogeneic hematopoietic stem cell transplant (HSCT). Engraftment and Immune Recovery (IR) in Good Risk Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT): Compa ... END Organ Disease in the Context of Human Herpes VIRUS 6 Viremia in Pediatric Allogeneic Hematopoietic STEM CELL Transplant ... work_xelmcenf7zgljaobwaxeokbkle related to the advancement of science, including Accordingly, all articles published in Science-including editorials, news and comment, and book reviews Managing Editor: ROBERT V. News Editor: DANIEL S. Advertising Sales Manager: RICHARD L. Sales: NEw YORK, N.Y. 10036: Robert S. EDITORIAL CORRESPONDENCE: 1515 Massachusetts Ave., NW, Washington, D.C. 20005. The obsolescence of education in rapidly developing fields of knowledge has become about equal in rate to the obsolescence of an automobile. every third year, might be an acceptable new pattern. of cramming the educational years of life into adolescence and early case, programs of continuing education for all professional people must The obsolescence of education differs only in degree in the several to alter our pattern of education to cope with them. Education Adapted from The Timely and the Timeless (Basic Books, New York, 1970). ARTICLE TOOLS http://science.sciencemag.org/content/170/3962/1041.citation is a registeredScienceAdvancement of Science, 1200 New York Avenue NW, Washington, DC 20005. http://science.sciencemag.org/content/170/3962/1041.citation http://science.sciencemag.org/ http://science.sciencemag.org/ work_xhpp75npwfftrjwbot3ik4nm3m Production of High Power Femtosecond Terahertz Radiation Most sources of short pulse THz radiation utilize excitation of biased semiconductors or electro-optic crystals by high peak power lasers. For example, this was done by using an undoped InAs wafer irradiated by a femtosecond free-electron laser (FEL) at the Thomas Jefferson National Accelerator Microwatt levels of THz radiation were detected when excited with FEL pulses at 1.06 µm wavelength and 10 W Recently substantially higher powers of femtosecond THz pulses produced by synchrotron emission were Calculations and measurements confirm the production of coherent broadband THz radiation from relativistic electrons with an average power of nearly 20 watts, a world record in this wavelength range by a producing coherent THz radiation from accelerated Calculated and measured spectral power. The spectral content of the emitted THz light was The spectral onset of the superradiant enhancement of the THz light is clearly seen THz radiation work_xlxecryqn5bv7jy5ffmcgpyxui formed in mitochondrial outer membranes (OM) of apoptotic cells or in synthetic membranes by Bax and related proteins/peptides, using electron microscopy (EM), atomic force microscopy and x-ray diffraction. MAC function was induced through staurosporine treatment and microinjection of tBid or cytochrome c. apoptosis signals MAC formation, while pDsRed-2 expression shows mitochondrial structure as red fluorescence. microinjection with tBid or cytochrome c induced relocation of Bax and collapse of the mitochondrial network. cleaved by caspase-8 and other enzymes forming tBid that induce mitochondrial outer membrane (OMM) permeabilization and cytochrome c (cyto-c) release. coordinated cyto-c release and also inhibited tBid-induced cell death. The mammalian GRIF1 and OIP106, and the drosophila Milton are kinesinbinding proteins that form a complex with the Miro GTPase, an outer mitochondrial membrane EF-hand protein, to support the movement of mitochondria Mechanism of the Mitochondrial Cytochrome C Release Wave in Bid-Induced Apoptosis work_xp3xzlhaybhyfdpj2wlkbvgova Pisake Lumbiganon,1 Elizabeth Zell,6 Tsungai Chipato,7 Aye Aye Win,8 Mindy J. and Gynecology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok,2 Thailand; Department of Clinical Epidemiology, University of the Philippines, Manila, The Philippines3; Coombe Women''s Hospital, Dublin, Ireland4; We evaluated the Strep B optical immunoassay (OIA; ThermoBiostar, Inc.) for detecting light and heavy Compared to culture, the sensitivity of OIA for detecting OIA sensitivity and specificity were 50.0 and 97.6%, respectively, compared with culture on blood agar and 26.8 and 98.4% compared with Lim broth. GBS colonization compared with that of culture was low, although the sensitivity of OIA in detecting heavy or dense Minority and Women''s Health, Centers for Disease Control and Prevention, Atlanta, Ga.; USAID; INCLEN; and Thomas Jefferson University for technical support on this project. Diagnostic performance of OIA for detection of vaginal carriage of GBS compared to culture in women with light, heavy, and work_xrtxepuisjaghorh76e463kfxe The Relationship Between Different Types of Sharps Containers and C. difficile Infections Rates in Acute Care Hospitals The potential for sharps containers to become a source of To describe the use of different types of sharps containers in single-use sharps containers and rates of C. difficile infection rates as identified by ICD-9 codes. difficile infection rates between hospitals single-use sharps containers examined 539 hospitals provided data on the type of sharps containers Participating hospitals were predominantly non-for-profit The majority of hospital utilized reusable sharps containers reusable sharps containers differed In bivariate regression, hospitals using single use sharps hospitals using reusable sharps containers single-use sharps containers and lower C. environmental contamination of reusable sharps disposal the role that sharps containers may play in pathogen Geographic Region Ownership Status South 217 (40.3) Government 65 (12.1) difficile infection rates Single Use Sharps Container† -0.1395 0.0474 0.003 0.870 Bacterial and viral contamination of reusable sharps containers in a community work_xuhc2rtekzcknbwcjbro6xyloi HP6 RELATIONSHIP OF DIRECT-TO-CONSUMER ADVERTISING SPENDING AND DRUG PRICING FOR THE TOP TWENTY DRUGS FROM 1997 TO 2000: AN EXPLORATORY STUDY asking for drug information and medications, but their ADVERTISING SPENDING AND DRUG PRICING direct-to-consumer (DTC) advertising spending on drug advertising spending would be added to drug prices (b) OBJECTIVE: Explore the relationship of DTC advertising spending and drug pricing for the top twenty drugs of their DTC advertising spending (source: Competitive (a) the total DTC advertising spending and per unit price of the drug; (b) the percent changes in the DTC advertising spending and drug price. advertising spending and drug price for a year was with an increase in the DTC advertising spending. percent change in drug price increased. CONCLUSION: Results indicate a very weak relationship between DTC advertising spending and drug prices. factors associated with consumers'' seeking various information sources about medications sought in response to result of direct to consumer advertising. work_xwwqofa75bh6joq2ifmq6uirjm Complications of Spine Surgery Radcliff MD, Alexander Vaccaro MD, PhD � The Association of Bone and Joint Surgeons1 2012 Spine surgery, like other methods of invasive intervention, that may occur in the normal course of treatment. an acute awareness of treatment adverse events or complications will allow institution of appropriate remedial This symposium reports original research on the potential complications of spine surgery to inform the orthopaedic and neurosurgical The articles in this symposium encompass the spectrum Complication rate and common complications are explored in basic science and clinical We believe study of complications is essential to improving the ultimate outcome of spine care. We hope readers enjoy this symposium. Fig. 1 Dr. Radcliff is shown. Fig. 2 Dr. Vaccaro is shown. Orthopaedics and Related Research editors and board members are Clinical Orthopaedics A Publication of The Association of Bone and Joint Surgeons® Complications of Spine Surgery: Editorial Comment work_y2yuwf7anjc2jkmyhgbfhuzjea The new 14,000-square-feet Brind-Marcus Center of Integrative Medicine in Villanova, PA, represents a major expansion of integrative health services at Jefferson, which Brind-Marcus Center of Integrative Medicine will provide new as well as similar services as the main campus including: oneon-one consultations with integrative medicine experts; extensive integrative medicine programming; advanced diagnostics capabilities with the new PET-MRI scanner; and an Vice President and Director of Jefferson''s Myrna Brind Center of Integrative Medicine and Brind-Marcus Center of Integrative Medicine stated: "Our executive health Integrative Medicine is the new PET-MRI scanner which was The Brind-Marcus Center of Integrative Medicine, in Villanova, Pennsylvania. The Brind-Marcus Center of Integrative Health will also offer Positron emission tomography–magnetic resonance imaging scanner at the Brind-Marcus Center of Integrative Medicine. of the new Brind-Marcus Center of Integrative Medicine. Myrna Brind Center of Integrative Medicine, Myrna Brind Center of Integrative Medicine, Brind-Marcus Center of Integrative Medicine, Brind-Marcus Center of Integrative Medicine, work_y3lt2rzwubejrmwgl2a2arfa7a sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220682905 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:22 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_yewiultrazhgdb2xhcy3lujz4y Editor''s Letter | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar''s Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1177/2374373518780827 Corpus ID: 49702837Editor''s Letter @article{Boissy2018EditorsL, title={Editor''s Letter}, author={Adrienne R. journal={Journal of Patient Experience}, year={2018}, volume={5}, pages={71 71} Adrienne R. Boissy Boissy Published 2018 Medicine Journal of Patient Experience View on SAGE journals.sagepub.com Save to Library Create Alert Cite Launch Research Feed Share This Paper Related Papers Related Papers Stay Connected With Semantic Scholar Sign Up About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. DatasetsSupp.aiAPIOpen Corpus Terms of Service•Privacy Policy The Allen Institute for AI By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License ACCEPT & CONTINUE work_yh2pzhqm6feztb3ejf5gcp34ca PND18 DETERMINANTS OF EMERGENCY DEPARTMENT UTILIZATION FOR MIGRAINE CARE between medication adherence and PD symptom progression. RESULTS: The study population (N = 470 patientyears) had mean MPR score of 0.49 (±0.38). of study population was not adherent to their PD medications Subjects adherent to their PD medications (MPR >= medication use 6 months before index date. migraine ED visit 12 months after index date. OBJECTIVES: To develop a migraine quality of care measurement set at the health plan level, in order to begin measuring and leaders in migraine care and quality improvement; and 4) assembly of a national advisory board consisting of prominent leaders within migraine care, quality measurement and managed care. These measures capture information on: migraine diagnosis and prevalence; use of preventive and therapeutic medications; and, primary care, specialist, emergency, diagnostic CONCLUSION: Development of an evidence-based set of quality measures for migraine work_ynnlban46ndsvo6vb56iybocpu Voltage-activated potassium (Kv) channels open an intracellular gate in response to changes in transmembrane voltage, allowing K N-terminus of the protein acting as a blocking particle, binding at the intracellular cavity of the channel and physically obstructing the permeation pathway. results suggest that despite being tethered to a particular subunit, the single inactivation particle has sufficient freedom to interact with position 470 of each Water at the Potassium Channel Gate: Quantum Calculations Show an from the solution; from the gate it repels an ion in the channel pore cavity into Water Structure at the Potassium Channel Gate: The Importance of the Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Water Structure at the Potassium Channel Gate: The Importance of the Prolines in the PVPV Sequence, as Shown by Computation ... work_ynzjaxwrf5adfpxrtap5gsrpvu been used to measure binding affinity of Adnectin-A to the cell surface expressed receptor X to measure the effect of avidity of the multivalent adnectin the channel activation gate; and KChIP4a KID directly interacts with the T1 interaction between the voltage sensing domain and the intracellular activation gate underlies CSI (Bähring & Covarrubias, 2011, J Physiol 589:461studies of structural mechanisms of hERG channel activation by small molecules are truly novel. pharmacophore model for hERG channel openers using PHASE protocol. Pharmacophore model is also combined with previously developed receptorbased homology model of hERG K channel and novel activators are generated A-Type Kv4 Channel Closed-State Inactivation is Modulated by the Tetramerization Domain Interacting with Auxilary KChIP4a Two-in-One: Activation and Inactivation at the Intracellular Gate of a Kv Channel Two-in-One: Activation and Inactivation at the Intracellular Gate of a Kv Channel Development and Validation Studies of Universal Pharmacophore Models for hERG Channel Openers work_yoi4qmggkrablnle6sfzui5v5i Background: Pancreatic neuroendocrine tumors (PNETs) are rare, and metastases when present are most commonly found in the liver or the peripancreatic lymph nodes. metastatic PNET in the liver in the setting of multiple concomitant autoimmune disorders, including pernicious Case presentation: The patient is a 70-year-old woman with a history of Hashimoto''s thyroiditis, thymoma, gastric carcinoid tumors, and autoimmune atrophic gastritis with pernicious anemia. Our patient developed a metastatic PNET in the setting of multiple autoimmune disorders, including pernicious anemia. Keywords: atrophic gastritis; gastric carcinoid syndrome; hypergastrinemia; pancreatic neuroendocrine tumor; are associated with pernicious anemia, likely stimulated by the associated hypergastrinemia.2 Our patient additionally had a history of gastric carcinoid Final pathology confirmed metastatic neuroendocrine tumor in the liver and a primary PNET. of gastric carcinoid tumor formation.2 Pernicious anemia and the resulting achlorhydria and hypergastrinemia are one such cause for the development of G cell PNET ¼ pancreatic neuroendocrine tumor work_yrgkfxaypjhwrcelbejhpmzbnq Jefferson Scale of Patient''s Perceptions of Physician Empathy: Preliminary patient ratings form and with selected items from other relevant instruments measuring physicians'' humanistic behavior and the appraisal of we used The American Board of Internal Medicine patient rating form intended to measure aspects of physician communication skills, humanistic qualities, and professionalism in medicine Scale of Patient''s Perceptions of Physician Empathy, 5 criterion measures, and 9 for the American form for the items of Jefferson Scale of Patient''s Perception of Physician Empathy* Correlations between each item of the Jefferson Scale of Patient''s Perceptions of Physician Empathy and the total scores of the American Board of Internal Medicine patient rating Jefferson Scale of Patient''s Perceptions of Physician Empathy and the average scores of the Jefferson Scale of Patient''s Perceptions of Physician Empathy and the selected items from the *The Jefferson Scale of Patient''s Perceptions of Physician Empathy items were work_ys5urha6kbb6ldw5artjbtpsci Lessons in empowerment: Transparency Lessons in empowerment: Transparency This editorial discusses the issues of transparency. A culture of transparency is essential for research. The results section of a paper is arguably the most important section. We expect that the results presented Alter the results or there is statistical significance. A culture of transparency is also important for a There needs to be clarity of expectations. area where transparency is not used is with review of reviewers need keep confidential the manuscripts they review, and papers are frequently reviewed "blind"; that an experienced reviewer can often discern the laboratory where the work was done. A culture of transparency is critically important for I would argue for a culture of transparency in a university, a company, a government laboratory, and in society as a whole. Thomas Jefferson stated that, "Whenever the people are well-informed, they can be trusted trust their own government." work_yu4rqhmrpzbvjifxrvgk4rsc6e in mouse liver versus heart mitochondria, and a 4.5 fold higher MICU1 to heart mitochondria displayed a decreased threshold and lesser cooperativity nanodomain which developes into a H2O2 transient following IP3 receptormediated ER Ca2þ release and mitochondrial Ca2þ uptake. Pharmacological inhibition showed that the transient was dependent upon ER Ca2þ, mitochondrial as both a messenger and regulator of calcium signaling and are particularly relevant for the control of mitochondrial function. that ROS target mito-motility to control mitochondrial function. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial at birth (Nguyen et al., 2014) and fibroblasts (MEFs) derived from Miro1 KO embryos show abnormal mitochondrial distribution, but the calcium-dependent inhibition of motility is unaffected and the respiratory and calcium buffering Imaging in perfused whole heart ex vivo, showed considerable mitochondrial continuity and fusion activity in ventricular CM. adult CM lose mitochondrial fusion activity. Miro1 is Dispensable for Calcium-Mediated Inhibition of Mitochondrial Movement work_yxi4shkzr5d65mldzmjmq4eurm Workshop on Applications of Coherent Infrared Synchrotron Radiation A workshop focused on scientific applications of and plans for a coherent far-infrared (FIR) synchrotron source at the ALS was convened on October 11, 2002 as part of the synchrotron radiation (CSR) presents an opportunity to create a source with intensities The workshop then turned towards recent CSR source developments starting with a talk and can be avoided in the design of a dedicated CSR source. achievement of powerful, steady-state coherent THz synchrotron radiation at BESSY II. The workshop concluded with a presentation by Martin on the current state of plans for a dedicated coherent FIR storage ring at the ALS. ALS booster ring, and would be designed specifically for creating and using CSR in the Drawing showing the main ALS storage ring and a proposed dedicated coherent farinfrared (FIR) ring (in color) located on top of the shielding for the ALS booster ring. work_z24idgywdjawhfxcwa2dukaln4 games:science:science_magazine_1895-1919:root:data:science_1895-1919:pdf:1903_v017_n436:p0436_0752.pdf [Ganino] GANINO User Tools Site Tools Search Tools Register Register Log In Log In Recent Changes Recent Changes Media Manager Media Manager Sitemap Sitemap Trace: games:science:science_magazine_1895-1919:root:data:science_1895-1919:pdf:1903_v017_n436:p0436_0752.pdf This topic does not exist yet You''ve followed a link to a topic that doesn''t exist yet. If permissions allow, you may create it by clicking on Create this page. Page Tools Show pagesource Show pagesource Old revisions Old revisions Backlinks Backlinks work_z2xafw5wvzfxpiqnx2uhvugf5m based on a phylogeny implying close affiliation of apicomplexan cox2a and cox2b genes with ciliate cox2 homologues; a 900-bp insertion that separates the corresponding domains in ciliate mitochondrial cox2 genes; Affiliation of ciliates and apicomplexans previously noted in mitochondrial sequence The presence of an insertion in the mitochondrial cox2 genes of ciliates does not necessarily imply kinship with apicomplexan fragmented cox2a and cox2b genes. Ciliates also exhibit an insertion in cox1 and a fragmented mitochondrial common origin of ciliate COXII and apicomplexan COXIIA and COXIIB sequences. genes from chlorophytes and apicomplexans (blue), the conserved residues in these domains (yellow), the conserved residues found only in chlorophytes and ampicomplexans (black background), the corresponding region of the 300-residue insertion in ciliate mitochondrial COXII (gray), gene or apicomplexan COXIIA and COXIIB and cox2b genes of green origin in apicomplexans must be considered whenever the Soledad Funes, Edgar Davidson, Adrián Reyes-Prieto, Susana Magallón, Pascal Herion, Michael P. work_z6y5jhaganejpod7he4pgtxiba Thomas Jefferson''s five years in Paris as American ambassador (1784-1789) saw a ''Health-care and hospital-building in eighteenth-century France: reform proposals of Du Pont de Nemours Medlin, ''Thomas Jefferson, Andre Morellet and the French version of the Notes on the State of Virginia'', architectural debates in Paris over the plans for the new hospital of the H6tel-Dieu, which called for a B. O''Neal, Jefferson''s buildings at the University of Virginia: the rotunda, Charlottesville, Jefferson''s plan compares strikingly with the pavilion hospitals of the Paris Thomas Jefferson''s University of Virginia and the Paris Hospitals Thomas Jefferson''s University of Virginia and the Paris Hospitals Thomas Jefferson''s University of Virginia and the Paris Hospitals Thomas Jefferson''s University of Virginia and the Paris Hospitals Thomas Jefferson''s University of Virginia and the Paris Hospitals Thomas Jefferson''s University of Virginia and the Paris Hospitals Thomas Jefferson''s University of Virginia and the Paris Hospitals work_za5po6cz5zdkxk5sblzd3ws5py a Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center, The Netherlands; b International Network for Cancer Treatment and Research, Oxford; to build enough proton therapy facilities with interest in research to further improve the treatment and for rare indications such as childhood cancer, the gain from introducing proton therapies into clinical practice remains controversial. recent X-ray based techniques, the gain from proton therapy is confined to a reduction in dose to organs away from the target region. such as non-small cell lung cancer are comparable to, or even superior to, that of protons therapy delivered with passive scattering leads to a lack of evidence to support funding and further development of proton beam therapy in state-of-the-art treatment centres effectiveness of radiotherapy with photons, protons and carbon-ions for nonsmall cell lung cancer: a meta-analysis. Is proton beam therapy cost effective in the radiotherapy and proton beam therapy in patients with lung and liver cancer. work_zjkcoxpmprgxtktvomijhjpodu sys_1000 wp-p1m-39.ebi.ac.uk wp-p1m-39.ebi.ac.uk exception exception Params is empty Params is empty Params is empty if (typeof jQuery === "undefined") document.write(''[script type="text/javascript" src="/corehtml/pmc/jig/1.14.8/js/jig.min.js"][/script]''.replace(/\[/g,String.fromCharCode(60)).replace(/\]/g,String.fromCharCode(62))); // // // window.name="mainwindow"; .pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-nobrand.png);background-size: auto, contain} .print-view{display:block} Page not available Reason: The web page address (URL) that you used may be incorrect. Message ID: 220678276 (wp-p1m-39.ebi.ac.uk) Time: 2021/04/06 02:59:17 If you need further help, please send an email to PMC. Include the information from the box above in your message. Otherwise, click on one of the following links to continue using PMC: Search the complete PMC archive. Browse the contents of a specific journal in PMC. Find a specific article by its citation (journal, date, volume, first page, author or article title). http://europepmc.org/abstract/MED/ work_zq5ugciffjh6bj5ipsf5jitp2u Copyright © Canadian Society for Eighteenth-Century Studies / Société canadienne d''étude du dix-huitième siècle, 2012 Ce document est protégé par la loi sur le droit d''auteur. Cet article est diffusé et préservé par Érudit. Travaux choisis de la Société canadienne d''étude du dix-huitième siècle Canadian Society for Eighteenth-Century Studies / Société canadienne d''étude https://www.erudit.org/fr/revues/lumen/ https://www.erudit.org/fr/revues/lumen/ C''est à St. John''s, Terre-Neuve, que s''est déroulé du 14 au 16 octobre Lady Mary Wortley Montagu, Isobel Grundy est tombée sur le personnage de Philocles : « a vision of male charms […] a feminised man of rôle pourtant essentiel dans la détermination des frontières par les pionniers : arpenteur (Thomas Jefferson, dit-on, était issu d''une longue Memorial de Terre-Neuve, ainsi que son prédécesseur, Chris Loomis, Parker et Rebeccah Hearn, pour m''appuyer dans le travail d''édition congrès, il y a soixante-dix ans. Jay est décédée le 21 mars 2012 à Ce volume lui est dédié. work_zteptygh7ra3zkoyv3ba4zla4y 24 The Open Nuclear Medicine Journal, 2009, Volume 1 Dedication Wolfgang Becker MD, PhD, passed away. Medicine and then in 1995 to the University of Göttingen as the Chair of the His qualities in life, creativity, and hard work to accomplish his goals, brought him many more friends and admirers. 2002 term, he was elected as the President of European Association of Nuclear Medicine (EANM), the challenge he sought to serve nuclear medicine community and the field, beyond his own university and country. He worked with his counterparts in other Nuclear Medicine organizations and worked with them for common goals. and conclusive, and as a leader, he was persuasive and decisive. Helmut Sinzinger has chosen to dedicate this journal to Wolfgang. as a friend, witnessed him as a leader, and heard him as a scientist. to pay my respect, once again, to Wolfgang Becker, MD, PhD. work_zvxxhxf3sjdztkkg4qvgyu2jya La Révolution de Haïti vue par deux personnages contemporains: Le scientifique prussien Alexander von Humboldt et l''homme d''état américain Thomas Jefferson du Nouveau Monde et observé les différentes sociétés coloniales, dont certaines possèdent des caractéristiques critiquables, Humboldt était intrigué par car l''expédition de Humboldt était justement réalisée dans les années qui correspondent à la proclamation de liberté et d''indépendance de l''état de Haïti On voit dans ces deux citations que Humboldt considérait les incidents en Haïti Dans le cas de Thomas Jefferson, son attitude au sujet des événements de Haïti dans le contexte et en relation avec ses intérêts à Cuba; Jefferson, pour sa part, Donc, c''est dans les commentaires, à caractère privé, de Jefferson sur la Jefferson dans les années suivantes voir Ingo Schwarz, « Alexander von Humboldt''s Visit Thomas Jefferson and Alexander von Humboldt », Virginia Magazine of History and et les différents intérêts des États-Unis envers la France et Saint-Domingue ainsi que sur work_zxiop7hzvvbk3pg5uha447xlmu Bell, Jr., associatelibrarian of the American Philosophical Society Library,and I embarked on the project of preparing a guide for the • T h e author is manuscripts librarian of the Library of the American Philosophical Society, 105 South Fifth Street, Philadelphia 6, Pa. His paper was read before volume 1 of the Transactions of the American Philosophical Society, Held in Philadelphia, For Promoting Useful Knowledge (Philadelphia, William and Thomas Bradford, 1771). library so that a special committee was formed "to collect information respecting the past and present state of this country," for One of the major fields of the library, stemming from the interest of such men as Thomas Jefferson and Peter Stephen Du Ponceau, is its collection of manuscripts relating to the American 6 "Report of the Special Committee on the Future Policy of the Library," in American Philosophical Society, Year Book, 1941, p. 7 The American Philosophical Society Library Bulletin was published for 17 years,