id sid tid token lemma pos work_ynzjaxwrf5adfpxrtap5gsrpvu 1 1 Two two CD work_ynzjaxwrf5adfpxrtap5gsrpvu 1 2 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 1 3 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 1 4 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 1 5 One one CD work_ynzjaxwrf5adfpxrtap5gsrpvu 1 6 : : : work_ynzjaxwrf5adfpxrtap5gsrpvu 1 7 Activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 1 8 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 1 9 Inactivation Inactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 10 at at IN work_ynzjaxwrf5adfpxrtap5gsrpvu 1 11 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 1 12 Intracellular Intracellular NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 13 Gate Gate NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 14 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 1 15 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 1 16 Kv Kv NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 17 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 18 Sunday Sunday NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 1 20 February February NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 21 16 16 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 1 22 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 1 23 2014 2014 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 1 24 15a 15a NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 1 25 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 1 26 X X NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 1 27 were be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 1 28 transfected transfecte VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 1 29 into into IN work_ynzjaxwrf5adfpxrtap5gsrpvu 1 30 CHO CHO NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 1 31 cells cell NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 1 32 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 2 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 2 2 CHO CHO NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 2 3 transfectants transfectant NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 2 4 were be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 2 5 char- char- JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 2 6 acterized acterize VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 2 7 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 2 8 FACS FACS NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 2 9 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 2 10 then then RB work_ynzjaxwrf5adfpxrtap5gsrpvu 2 11 scaled scale VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 2 12 up up RP work_ynzjaxwrf5adfpxrtap5gsrpvu 2 13 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 2 14 KinExA kinexa JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 2 15 binding bind VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 2 16 studies study NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 2 17 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 3 1 KinExA KinExA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 3 2 has have VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 3 3 been be VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 4 used use VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 5 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 3 6 measure measure VB work_ynzjaxwrf5adfpxrtap5gsrpvu 3 7 binding bind VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 3 8 affinity affinity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 9 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 10 Adnectin Adnectin NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 3 11 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 3 12 A A NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 3 13 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 14 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 3 15 cell cell NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 16 surface surface NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 17 ex- ex- XX work_ynzjaxwrf5adfpxrtap5gsrpvu 3 18 pressed press VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 3 19 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 20 X X NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 3 21 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 3 22 measure measure VB work_ynzjaxwrf5adfpxrtap5gsrpvu 3 23 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 3 24 effect effect NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 25 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 26 avidity avidity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 27 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 28 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 3 29 multivalent multivalent NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 30 adnectin adnectin NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 3 31 binding bind VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 3 32 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 33 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 3 34 clusters cluster NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 3 35 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 4 1 As as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 2 controls control NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 4 3 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 4 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 4 5 functional functional JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 4 6 activity activity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 7 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 8 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 4 9 Adnectin Adnectin NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 4 10 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 4 11 A A NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 4 12 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 4 13 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 4 14 affinity affinity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 15 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 16 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 4 17 monovalent monovalent JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 4 18 interaction interaction NN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 4 20 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 4 21 same same JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 4 22 KinExa KinExa NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 4 23 assay assay NN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 24 was be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 4 25 used use VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 26 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 4 27 substituting substitute VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 4 28 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 4 29 soluble soluble JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 4 30 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 31 X x NN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 32 extracellular extracellular JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 4 33 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 34 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 4 35 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 4 36 transfected transfected JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 4 37 CHO CHO NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 4 38 cells cell NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 4 39 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 5 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 5 2 binding bind VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 5 3 avidity avidity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 4 measured measure VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 5 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 6 KinExA KinExA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 5 7 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 8 CHO CHO NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 5 9 expressed express VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 5 10 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 11 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 5 12 14 14 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 5 13 pM pm NN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 14 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 15 both both DT work_ynzjaxwrf5adfpxrtap5gsrpvu 5 16 species specie NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 5 17 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 18 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 5 19 X. X. NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 6 1 However however RB work_ynzjaxwrf5adfpxrtap5gsrpvu 6 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 6 3 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 6 4 affinity affinity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 5 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 6 Adnectin Adnectin NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 6 7 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 6 8 A A NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 6 9 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 10 monovalent monovalent NN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 11 soluble soluble JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 6 12 Receptor Receptor NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 6 13 X X NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 6 14 was be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 6 15 quite quite RB work_ynzjaxwrf5adfpxrtap5gsrpvu 6 16 different different JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 6 17 between between IN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 18 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 6 19 species specie NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 6 20 suggesting suggest VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 6 21 that that DT work_ynzjaxwrf5adfpxrtap5gsrpvu 6 22 avidity avidity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 23 due due JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 6 24 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 25 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 26 clustering cluster VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 6 27 equilizes equilize VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 6 28 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 6 29 functional functional JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 6 30 avidity avidity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 31 at at IN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 32 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 6 33 cell cell NN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 34 surface surface NN work_ynzjaxwrf5adfpxrtap5gsrpvu 6 35 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 7 1 Platform platform NN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 2 : : : work_ynzjaxwrf5adfpxrtap5gsrpvu 7 3 Voltage voltage NN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 4 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 7 5 gated gate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 6 K K NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 7 Channels Channels NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 8 : : : work_ynzjaxwrf5adfpxrtap5gsrpvu 7 9 Activation/ activation/ ADD work_ynzjaxwrf5adfpxrtap5gsrpvu 7 10 Inactivation Inactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 11 Mechanisms Mechanisms NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 7 12 92-Plat 92-Plat NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 13 A A NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 14 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 7 15 Type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 16 Kv4 kv4 NN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 17 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 18 Closed closed JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 7 19 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 7 20 State State NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 21 Inactivation Inactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 22 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 7 23 Modulated modulate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 24 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 25 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 7 26 Tetramerization Tetramerization NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 27 Domain Domain NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 28 Interacting interact VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 7 29 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 30 Auxilary Auxilary NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 31 KChIP4a KChIP4a NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 32 Yi Yi NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 33 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 7 34 Quan Quan NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 35 Tang1 tang1 NN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 36 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 7 37 Fan Fan NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 38 Yang2 yang2 NN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 39 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 7 40 Jingheng Jingheng NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 41 Zhou1 Zhou1 VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 7 42 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 7 43 Jie Jie NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 44 Zheng2 Zheng2 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 45 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 7 46 KeWei KeWei NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 7 47 Wang1 wang1 NN work_ynzjaxwrf5adfpxrtap5gsrpvu 7 48 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 8 1 1Peking 1Peking NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 2 University University NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 3 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 8 4 Beijing Beijing NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 5 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 8 6 China China NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 7 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 8 8 2University 2University NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 9 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 8 10 California California NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 11 at at IN work_ynzjaxwrf5adfpxrtap5gsrpvu 8 12 Davis Davis NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 8 14 Davis Davis NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 15 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 8 16 CA CA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 17 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 8 18 USA USA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 8 19 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 9 1 A a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 9 2 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 9 3 type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 4 Kv4 Kv4 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 9 5 potassium potassium NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 6 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 9 7 undergo undergo VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 9 8 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 9 9 conformational conformational JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 9 10 change change NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 11 towards towards IN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 12 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 9 13 non non JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 9 14 - - JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 9 15 conductive conductive JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 9 16 state state NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 17 at at IN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 18 negative negative JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 9 19 membrane membrane NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 20 potentials potential NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 9 21 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 9 22 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 9 23 dynamic dynamic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 9 24 process process NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 25 known know VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 26 as as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 27 closed closed JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 9 28 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 9 29 state state NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 30 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 9 31 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 9 32 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 9 33 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 9 34 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 10 1 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 10 2 causes cause VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 10 3 inhibition inhibition NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 4 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 5 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 10 6 ac- ac- DT work_ynzjaxwrf5adfpxrtap5gsrpvu 10 7 tivity tivity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 8 without without IN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 9 prerequisite prerequisite NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 10 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 11 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 12 opening opening NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 10 14 thus thus RB work_ynzjaxwrf5adfpxrtap5gsrpvu 10 15 providing provide VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 10 16 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 10 17 dynamic dynamic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 10 18 regu- regu- JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 10 19 lation lation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 20 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 21 neuronal neuronal JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 10 22 excitability excitability NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 23 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 10 24 dendritic dendritic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 10 25 signal signal NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 26 integration integration NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 27 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 10 28 synaptic synaptic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 10 29 plasticity plasticity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 10 30 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 11 1 However however RB work_ynzjaxwrf5adfpxrtap5gsrpvu 11 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 11 3 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 11 4 structural structural JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 11 5 determinants determinant NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 11 6 underlying underlie VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 11 7 Kv4 kv4 PRP$ work_ynzjaxwrf5adfpxrtap5gsrpvu 11 8 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 11 9 remain remain VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 11 10 largely largely RB work_ynzjaxwrf5adfpxrtap5gsrpvu 11 11 unknown unknown JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 11 12 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 12 1 We -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 12 2 have have VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 12 3 recently recently RB work_ynzjaxwrf5adfpxrtap5gsrpvu 12 4 demonstrated demonstrate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 12 5 that that IN work_ynzjaxwrf5adfpxrtap5gsrpvu 12 6 auxiliary auxiliary JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 12 7 KChIP4a KChIP4a NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 12 8 sub- sub- DT work_ynzjaxwrf5adfpxrtap5gsrpvu 12 9 unit unit NN work_ynzjaxwrf5adfpxrtap5gsrpvu 12 10 contains contain VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 12 11 an an DT work_ynzjaxwrf5adfpxrtap5gsrpvu 12 12 N n CD work_ynzjaxwrf5adfpxrtap5gsrpvu 12 13 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 12 14 terminal terminal NN work_ynzjaxwrf5adfpxrtap5gsrpvu 12 15 Kv4 kv4 NN work_ynzjaxwrf5adfpxrtap5gsrpvu 12 16 inhibitory inhibitory JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 12 17 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 12 18 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 12 19 KID KID NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 12 20 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 12 21 that that WDT work_ynzjaxwrf5adfpxrtap5gsrpvu 12 22 directly directly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 12 23 interacts interact VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 12 24 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 12 25 Kv4.3 Kv4.3 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 12 26 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 12 27 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 12 28 enhance enhance VB work_ynzjaxwrf5adfpxrtap5gsrpvu 12 29 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 12 30 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 13 1 In in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 2 this this DT work_ynzjaxwrf5adfpxrtap5gsrpvu 13 3 study study NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 4 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 13 5 we -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 13 6 utilized utilize VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 13 7 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 13 8 FRET FRET NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 13 9 two- two- NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 10 hybrid hybrid JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 13 11 mapping mapping NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 12 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 13 13 BiFC bifc NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 14 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 13 15 based base VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 16 screening screening NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 17 combined combine VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 18 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 19 electrophysiology electrophysiology NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 20 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 13 21 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 13 22 identified identify VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 13 23 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 13 24 intracellular intracellular JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 13 25 tetramerization tetramerization NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 26 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 13 27 T1 T1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 13 28 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 13 29 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 30 that that WDT work_ynzjaxwrf5adfpxrtap5gsrpvu 13 31 functions function VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 13 32 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 13 33 suppress suppress VB work_ynzjaxwrf5adfpxrtap5gsrpvu 13 34 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 13 35 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 13 36 serves serve VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 13 37 as as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 38 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 13 39 receptor receptor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 40 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 41 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 13 42 binding binding NN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 43 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 13 44 KID KID NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 13 45 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 14 1 Disrupting Disrupting NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 14 2 Kv4.3 Kv4.3 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 14 3 T1-T1 T1-T1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 14 4 interaction interaction NN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 5 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 6 mutating mutate VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 14 7 C110A c110a CD work_ynzjaxwrf5adfpxrtap5gsrpvu 14 8 within within IN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 9 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 14 10 C3H1 C3H1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 14 11 motif motif NN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 12 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 13 T1 t1 NN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 14 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 15 facilitated facilitate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 16 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 14 17 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 14 18 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 14 19 ablated ablate VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 14 20 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 14 21 KID KID NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 14 22 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 14 23 mediated mediate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 24 enhancement enhancement NN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 25 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 14 26 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 14 27 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 15 1 Furthermore furthermore RB work_ynzjaxwrf5adfpxrtap5gsrpvu 15 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 15 3 replacing replace VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 15 4 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 15 5 characteristic characteristic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 15 6 C3H1 C3H1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 7 motif motif NN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 8 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 9 Kv4.3 Kv4.3 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 10 T1 T1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 11 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 12 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 13 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 15 14 T1 T1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 15 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 16 from from IN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 17 Kv1.4 Kv1.4 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 18 without without IN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 19 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 15 20 C3H1 C3H1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 21 motif motif NN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 22 or or CC work_ynzjaxwrf5adfpxrtap5gsrpvu 15 23 Kv2.1 Kv2.1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 24 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 25 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 15 26 C3H1 C3H1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 27 motif motif NN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 28 resulted result VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 15 29 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 30 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 15 31 functioning function VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 15 32 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 33 enhanced enhanced JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 15 34 or or CC work_ynzjaxwrf5adfpxrtap5gsrpvu 15 35 suppressed suppress VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 15 36 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 15 37 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 15 38 respectively respectively RB work_ynzjaxwrf5adfpxrtap5gsrpvu 15 39 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 16 1 Taken take VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 2 together together RB work_ynzjaxwrf5adfpxrtap5gsrpvu 16 3 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 16 4 our -PRON- PRP$ work_ynzjaxwrf5adfpxrtap5gsrpvu 16 5 findings finding NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 16 6 reveal reveal VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 7 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 16 8 novel novel JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 16 9 role role NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 10 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 11 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 16 12 T1 T1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 13 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 14 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 15 suppressing suppress VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 16 16 Kv4 kv4 PRP$ work_ynzjaxwrf5adfpxrtap5gsrpvu 16 17 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 18 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 19 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 16 20 C3H1 C3H1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 21 motif motif NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 22 functioning function VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 16 23 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 16 24 stabilize stabilize VB work_ynzjaxwrf5adfpxrtap5gsrpvu 16 25 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 16 26 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 27 activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 28 gate gate NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 29 ; ; : work_ynzjaxwrf5adfpxrtap5gsrpvu 16 30 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 16 31 KChIP4a KChIP4a NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 32 KID KID NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 33 directly directly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 16 34 interacts interact VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 16 35 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 36 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 16 37 T1 T1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 38 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 39 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 16 40 relieve relieve VB work_ynzjaxwrf5adfpxrtap5gsrpvu 16 41 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 16 42 stabilization stabilization NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 43 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 16 44 leading lead VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 16 45 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 46 facilitation facilitation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 47 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 48 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 49 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 16 50 inhibition inhibition NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 51 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 52 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 16 53 function function NN work_ynzjaxwrf5adfpxrtap5gsrpvu 16 54 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 17 1 93-Plat 93-plat CD work_ynzjaxwrf5adfpxrtap5gsrpvu 17 2 Two two CD work_ynzjaxwrf5adfpxrtap5gsrpvu 17 3 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 17 4 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 17 5 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 17 6 One one CD work_ynzjaxwrf5adfpxrtap5gsrpvu 17 7 : : : work_ynzjaxwrf5adfpxrtap5gsrpvu 17 8 Activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 17 9 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 17 10 Inactivation Inactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 11 at at IN work_ynzjaxwrf5adfpxrtap5gsrpvu 17 12 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 17 13 Intracellular Intracellular NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 14 Gate Gate NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 15 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 17 16 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 17 17 Kv Kv NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 18 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 19 Manuel Manuel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 20 Covarrubias1 Covarrubias1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 21 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 17 22 Jeffrey Jeffrey NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 23 D. D. NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 24 Fineberg2 Fineberg2 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 17 25 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 18 1 1 1 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 18 2 Neuroscience Neuroscience NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 3 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 4 Jefferson Jefferson NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 5 Medical Medical NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 6 College College NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 7 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 18 8 Thomas Thomas NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 9 Jefferson Jefferson NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 10 University University NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 11 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 12 Philadelphia Philadelphia NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 14 PA PA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 15 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 16 USA USA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 17 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 18 2 2 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 18 19 Physiology Physiology NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 20 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 18 21 Molecular Molecular NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 22 Biophysics Biophysics NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 18 23 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 24 Jefferson Jefferson NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 25 Medical Medical NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 26 College College NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 27 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 18 28 Thomas Thomas NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 29 Jefferson Jefferson NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 30 University University NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 31 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 32 Philadelphia Philadelphia NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 33 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 34 PA PA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 35 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 18 36 USA USA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 18 37 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 19 1 N n CD work_ynzjaxwrf5adfpxrtap5gsrpvu 19 2 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 19 3 type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 4 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 19 5 P p NN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 6 / / SYM work_ynzjaxwrf5adfpxrtap5gsrpvu 19 7 C c NN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 8 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 19 9 type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 10 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 11 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 19 12 firmly firmly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 19 13 established establish VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 14 mechanisms mechanism NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 19 15 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 16 inac- inac- $ work_ynzjaxwrf5adfpxrtap5gsrpvu 19 17 tivation tivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 18 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 19 voltage voltage NN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 20 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 19 21 gated gate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 19 22 Kþ Kþ NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 19 23 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 19 24 Kv Kv NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 19 25 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 19 26 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 19 27 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 20 1 However however RB work_ynzjaxwrf5adfpxrtap5gsrpvu 20 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 20 3 Kv4.x Kv4.x NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 4 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 5 com- com- NN work_ynzjaxwrf5adfpxrtap5gsrpvu 20 6 plexes plexe NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 20 7 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 20 8 which which WDT work_ynzjaxwrf5adfpxrtap5gsrpvu 20 9 undergo undergo VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 10 fast fast JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 20 11 preferential preferential JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 20 12 closed closed JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 20 13 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 20 14 state state NN work_ynzjaxwrf5adfpxrtap5gsrpvu 20 15 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 20 16 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 20 17 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 18 ; ; : work_ynzjaxwrf5adfpxrtap5gsrpvu 20 19 Fineberg Fineberg NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 20 et et NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 21 al al NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 22 . . NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 23 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 20 24 2012 2012 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 20 25 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 20 26 JGP JGP NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 20 27 140.5:513 140.5:513 NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 20 28 - - SYM work_ynzjaxwrf5adfpxrtap5gsrpvu 20 29 527 527 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 20 30 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 20 31 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 20 32 appear appear VB work_ynzjaxwrf5adfpxrtap5gsrpvu 20 33 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 20 34 use use VB work_ynzjaxwrf5adfpxrtap5gsrpvu 20 35 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 20 36 distinct distinct JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 20 37 but but CC work_ynzjaxwrf5adfpxrtap5gsrpvu 20 38 un- un- JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 20 39 known known JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 20 40 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 20 41 mechanism mechanism NN work_ynzjaxwrf5adfpxrtap5gsrpvu 20 42 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 21 1 Previously previously RB work_ynzjaxwrf5adfpxrtap5gsrpvu 21 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 21 3 we -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 21 4 hypothesized hypothesize VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 21 5 that that IN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 6 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 21 7 weak weak JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 21 8 interaction interaction NN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 9 between between IN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 10 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 21 11 voltage voltage NN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 12 sensing sensing NN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 13 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 14 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 21 15 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 21 16 intracellular intracellular JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 21 17 activa- activa- NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 21 18 tion tion NN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 19 gate gate NN work_ynzjaxwrf5adfpxrtap5gsrpvu 21 20 underlies underlie VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 21 21 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 21 22 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 21 23 Bähring Bähring NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 21 24 & & CC work_ynzjaxwrf5adfpxrtap5gsrpvu 21 25 Covarrubias Covarrubias NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 21 26 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 21 27 2011 2011 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 21 28 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 21 29 J J NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 21 30 Physiol Physiol NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 21 31 589:461- 589:461- CD work_ynzjaxwrf5adfpxrtap5gsrpvu 21 32 79 79 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 21 33 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 21 34 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 22 1 Thus thus RB work_ynzjaxwrf5adfpxrtap5gsrpvu 22 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 22 3 CSI CSI NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 22 4 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 22 5 essentially essentially RB work_ynzjaxwrf5adfpxrtap5gsrpvu 22 6 governed govern VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 22 7 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 22 8 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 22 9 intracellular intracellular JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 22 10 activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 22 11 gate gate NN work_ynzjaxwrf5adfpxrtap5gsrpvu 22 12 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 22 13 which which WDT work_ynzjaxwrf5adfpxrtap5gsrpvu 22 14 fails fail VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 22 15 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 22 16 open open VB work_ynzjaxwrf5adfpxrtap5gsrpvu 22 17 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 22 18 adopts adopt VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 22 19 an an DT work_ynzjaxwrf5adfpxrtap5gsrpvu 22 20 inactivated inactivated JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 22 21 conformation conformation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 22 22 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 23 1 To to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 23 2 directly directly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 23 3 test test VB work_ynzjaxwrf5adfpxrtap5gsrpvu 23 4 this this DT work_ynzjaxwrf5adfpxrtap5gsrpvu 23 5 hypothesis hypothesis NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 6 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 23 7 we -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 23 8 investigated investigate VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 23 9 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 23 10 heterologously heterologously RB work_ynzjaxwrf5adfpxrtap5gsrpvu 23 11 expressed express VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 12 Kv4.1 Kv4.1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 23 13 ternary ternary JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 23 14 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 15 complex complex NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 16 including include VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 23 17 accessory accessory NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 18 subunits subunit NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 23 19 KChIP1 KChIP1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 23 20 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 23 21 DPP6 DPP6 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 23 22 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 23 23 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 23 24 ex- ex- RB work_ynzjaxwrf5adfpxrtap5gsrpvu 23 25 ploited ploite VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 23 26 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 23 27 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 23 28 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 23 29 trap trap NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 30 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 23 31 door door NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 32 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 23 33 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 23 34 paradigm paradigm NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 35 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 36 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 23 37 activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 38 gate gate NN work_ynzjaxwrf5adfpxrtap5gsrpvu 23 39 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 24 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 24 2 results result NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 24 3 show show VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 24 4 that that IN work_ynzjaxwrf5adfpxrtap5gsrpvu 24 5 Kv4.1 Kv4.1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 24 6 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 24 7 traps trap NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 24 8 intracellularly intracellularly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 24 9 applied apply VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 24 10 quaternary quaternary NN work_ynzjaxwrf5adfpxrtap5gsrpvu 24 11 ammonium ammonium NN work_ynzjaxwrf5adfpxrtap5gsrpvu 24 12 blockers blocker NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 24 13 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 24 14 bTBuA bTBuA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 24 15 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 24 16 TBuA TBuA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 24 17 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 24 18 inside inside IN work_ynzjaxwrf5adfpxrtap5gsrpvu 24 19 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 24 20 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 24 21 ’s ’s POS work_ynzjaxwrf5adfpxrtap5gsrpvu 24 22 pore pore NN work_ynzjaxwrf5adfpxrtap5gsrpvu 24 23 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 25 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 25 2 trapped trap VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 25 3 blockers blocker NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 25 4 can can MD work_ynzjaxwrf5adfpxrtap5gsrpvu 25 5 only only RB work_ynzjaxwrf5adfpxrtap5gsrpvu 25 6 escape escape VB work_ynzjaxwrf5adfpxrtap5gsrpvu 25 7 if if IN work_ynzjaxwrf5adfpxrtap5gsrpvu 25 8 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 25 9 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 25 10 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 25 11 opened open VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 25 12 again again RB work_ynzjaxwrf5adfpxrtap5gsrpvu 25 13 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 25 14 subsequent subsequent JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 25 15 depolariza- depolariza- JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 25 16 tions tion NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 25 17 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 26 1 By by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 26 2 contrast contrast NN work_ynzjaxwrf5adfpxrtap5gsrpvu 26 3 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 26 4 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 26 5 can can MD work_ynzjaxwrf5adfpxrtap5gsrpvu 26 6 not not RB work_ynzjaxwrf5adfpxrtap5gsrpvu 26 7 trap trap VB work_ynzjaxwrf5adfpxrtap5gsrpvu 26 8 TEA TEA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 26 9 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 26 10 whose whose WP$ work_ynzjaxwrf5adfpxrtap5gsrpvu 26 11 binding bind VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 26 12 kinetics kinetic NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 26 13 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 26 14 faster fast JJR work_ynzjaxwrf5adfpxrtap5gsrpvu 26 15 than than IN work_ynzjaxwrf5adfpxrtap5gsrpvu 26 16 that that DT work_ynzjaxwrf5adfpxrtap5gsrpvu 26 17 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 26 18 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 26 19 gating gating NN work_ynzjaxwrf5adfpxrtap5gsrpvu 26 20 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 27 1 Moreover moreover RB work_ynzjaxwrf5adfpxrtap5gsrpvu 27 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 27 3 under under IN work_ynzjaxwrf5adfpxrtap5gsrpvu 27 4 identical identical JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 27 5 conditions condition NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 27 6 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 27 7 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 27 8 Shaker Shaker NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 27 9 Kv Kv NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 27 10 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 27 11 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 27 12 ShB ShB NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 27 13 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 27 14 T449 T449 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 27 15 K k NN work_ynzjaxwrf5adfpxrtap5gsrpvu 27 16 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 27 17 known know VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 27 18 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 27 19 exhibit exhibit VB work_ynzjaxwrf5adfpxrtap5gsrpvu 27 20 fast fast JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 27 21 P p NN work_ynzjaxwrf5adfpxrtap5gsrpvu 27 22 / / SYM work_ynzjaxwrf5adfpxrtap5gsrpvu 27 23 C C NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 27 24 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 27 25 type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 27 26 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 27 27 can can MD work_ynzjaxwrf5adfpxrtap5gsrpvu 27 28 not not RB work_ynzjaxwrf5adfpxrtap5gsrpvu 27 29 trap trap VB work_ynzjaxwrf5adfpxrtap5gsrpvu 27 30 bTBuA. bTBuA. . work_ynzjaxwrf5adfpxrtap5gsrpvu 28 1 These these DT work_ynzjaxwrf5adfpxrtap5gsrpvu 28 2 findings finding NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 28 3 conclusively conclusively RB work_ynzjaxwrf5adfpxrtap5gsrpvu 28 4 suggest suggest VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 28 5 that that IN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 6 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 28 7 intracellular intracellular JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 28 8 activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 9 gate gate NN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 10 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 11 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 28 12 Kv4.1 Kv4.1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 28 13 ternary ternary JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 28 14 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 28 15 complex complex NN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 16 plays play VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 28 17 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 28 18 novel novel JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 28 19 dual dual JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 28 20 role role NN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 21 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 28 22 controlling control VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 28 23 both both DT work_ynzjaxwrf5adfpxrtap5gsrpvu 28 24 activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 25 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 28 26 inactivation inactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 28 27 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 29 1 Supported support VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 29 2 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 29 3 part part NN work_ynzjaxwrf5adfpxrtap5gsrpvu 29 4 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 29 5 NIH NIH NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 29 6 grant grant NN work_ynzjaxwrf5adfpxrtap5gsrpvu 29 7 R01 R01 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 29 8 NS032337 NS032337 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 29 9 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 29 10 MC MC NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 29 11 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 29 12 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 30 1 94-Plat 94-Plat NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 2 Development Development NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 3 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 30 4 Validation Validation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 5 Studies Studies NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 30 6 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 30 7 Universal Universal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 8 Pharmacophore Pharmacophore NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 9 Models Models NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 30 10 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 30 11 hERG herg NN work_ynzjaxwrf5adfpxrtap5gsrpvu 30 12 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 13 Openers Openers NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 30 14 Serdar Serdar NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 15 Durdagi1,2 durdagi1,2 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 30 16 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 30 17 Matthew Matthew NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 18 Patterson2 Patterson2 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 30 20 Sergei Sergei NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 21 Y. Y. NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 22 Noskov2 Noskov2 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 30 23 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 31 1 1Department 1department CD work_ynzjaxwrf5adfpxrtap5gsrpvu 31 2 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 31 3 Biophysics Biophysics NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 31 4 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 5 Bahcesehir Bahcesehir NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 6 University University NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 7 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 8 Faculty Faculty NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 9 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 31 10 Medicine Medicine NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 11 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 12 Istanbul Istanbul NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 14 Turkey Turkey NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 15 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 16 2 2 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 31 17 Biological Biological NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 18 Sciences Sciences NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 31 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 20 Institute Institute NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 21 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 31 22 Biocomplexity Biocomplexity NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 23 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 31 24 Informatics Informatics NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 25 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 26 University University NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 27 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 31 28 Calgary Calgary NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 29 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 30 Calgary Calgary NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 31 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 32 AB AB NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 33 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 31 34 Canada Canada NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 31 35 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 32 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 32 2 intra intra JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 32 3 - - JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 32 4 cavitary cavitary JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 32 5 drug drug NN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 6 blockade blockade NN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 7 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 8 hERG hERG NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 32 9 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 32 10 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 32 11 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 32 12 common common JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 32 13 off off IN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 14 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 32 15 target target NN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 16 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 17 many many JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 32 18 drugs drug NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 32 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 32 20 have have VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 32 21 been be VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 22 extensively extensively RB work_ynzjaxwrf5adfpxrtap5gsrpvu 32 23 studied study VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 32 24 both both CC work_ynzjaxwrf5adfpxrtap5gsrpvu 32 25 experimentally experimentally RB work_ynzjaxwrf5adfpxrtap5gsrpvu 32 26 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 32 27 theoreti- theoreti- JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 32 28 cally cally RB work_ynzjaxwrf5adfpxrtap5gsrpvu 32 29 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 33 1 Structurally structurally RB work_ynzjaxwrf5adfpxrtap5gsrpvu 33 2 diverse diverse JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 3 ligands ligand VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 4 inadvertent inadvertent JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 5 blockade blockade NN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 6 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 7 rapid rapid JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 8 component component NN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 9 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 10 delayed delay VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 11 rectifying rectify VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 33 12 Kþ Kþ NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 33 13 currents current NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 33 14 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 33 15 potentially potentially RB work_ynzjaxwrf5adfpxrtap5gsrpvu 33 16 pro pro JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 17 - - JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 18 arrhythmic arrhythmic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 19 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 33 20 may may MD work_ynzjaxwrf5adfpxrtap5gsrpvu 33 21 lead lead VB work_ynzjaxwrf5adfpxrtap5gsrpvu 33 22 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 23 drug drug NN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 24 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 33 25 induced induce VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 26 long long JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 33 27 QT QT NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 33 28 syndrome syndrome NN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 29 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 33 30 LQTS lqts NN work_ynzjaxwrf5adfpxrtap5gsrpvu 33 31 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 34 1 There there EX work_ynzjaxwrf5adfpxrtap5gsrpvu 34 2 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 34 3 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 34 4 number number NN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 5 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 6 natural natural JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 34 7 strategies strategy NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 34 8 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 9 rational rational JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 34 10 drug drug NN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 11 design design NN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 12 ; ; : work_ynzjaxwrf5adfpxrtap5gsrpvu 34 13 one one CD work_ynzjaxwrf5adfpxrtap5gsrpvu 34 14 dubbed dub VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 34 15 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 34 16 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 34 17 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 34 18 passive passive JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 34 19 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 34 20 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 34 21 approach approach NN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 22 avoids avoid NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 34 23 block block NN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 24 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 25 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 34 26 whereas whereas IN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 27 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 34 28 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 34 29 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 34 30 proactive proactive JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 34 31 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 34 32 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 34 33 strategy strategy NN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 34 designs design VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 34 35 treatments treatment NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 34 36 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 34 37 acti- acti- VB work_ynzjaxwrf5adfpxrtap5gsrpvu 34 38 vate vate VB work_ynzjaxwrf5adfpxrtap5gsrpvu 34 39 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 34 40 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 34 41 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 35 1 While while IN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 2 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 35 3 ‘ ' `` work_ynzjaxwrf5adfpxrtap5gsrpvu 35 4 passive passive JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 35 5 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 35 6 ’ ' '' work_ynzjaxwrf5adfpxrtap5gsrpvu 35 7 approach approach NN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 8 has have VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 35 9 been be VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 10 developed develop VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 11 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 12 decades decade NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 35 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 35 14 studies study NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 35 15 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 16 structural structural JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 35 17 mechanisms mechanism NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 35 18 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 19 hERG hERG NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 35 20 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 35 21 activation activation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 35 22 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 23 small small JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 35 24 mole- mole- NN work_ynzjaxwrf5adfpxrtap5gsrpvu 35 25 cules cule NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 35 26 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 35 27 truly truly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 35 28 novel novel JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 35 29 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 36 1 Accordingly accordingly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 36 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 36 3 design design NN work_ynzjaxwrf5adfpxrtap5gsrpvu 36 4 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 36 5 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 36 6 hERG herg NN work_ynzjaxwrf5adfpxrtap5gsrpvu 36 7 openers opener NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 36 8 or or CC work_ynzjaxwrf5adfpxrtap5gsrpvu 36 9 current current JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 36 10 ac- ac- JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 36 11 tivators tivator NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 36 12 may may MD work_ynzjaxwrf5adfpxrtap5gsrpvu 36 13 offer offer VB work_ynzjaxwrf5adfpxrtap5gsrpvu 36 14 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 36 15 momentum momentum NN work_ynzjaxwrf5adfpxrtap5gsrpvu 36 16 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 36 17 modern modern JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 36 18 anti anti JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 36 19 - - JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 36 20 arrhythmia arrhythmia JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 36 21 drug drug NN work_ynzjaxwrf5adfpxrtap5gsrpvu 36 22 development development NN work_ynzjaxwrf5adfpxrtap5gsrpvu 36 23 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 37 1 Significant significant JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 37 2 number number NN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 3 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 4 small small JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 37 5 molecules molecule NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 37 6 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 7 capacity capacity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 8 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 9 hERG herg NN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 10 activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 11 was be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 37 12 identified identify VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 13 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 14 mandatory mandatory JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 37 15 hERG herg NN work_ynzjaxwrf5adfpxrtap5gsrpvu 37 16 screens screen NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 37 17 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 38 1 To to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 38 2 establish establish VB work_ynzjaxwrf5adfpxrtap5gsrpvu 38 3 possible possible JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 38 4 correlation correlation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 5 be- be- NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 6 tween tween NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 7 activators activator NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 38 8 structure structure NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 9 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 38 10 reactivity reactivity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 11 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 38 12 we -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 38 13 attempted attempt VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 38 14 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 38 15 construct construct VB work_ynzjaxwrf5adfpxrtap5gsrpvu 38 16 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 38 17 universal universal JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 38 18 pharmacophore pharmacophore NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 19 model model NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 20 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 21 hERG herg NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 22 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 38 23 openers opener NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 38 24 using use VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 38 25 PHASE PHASE NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 38 26 protocol protocol NN work_ynzjaxwrf5adfpxrtap5gsrpvu 38 27 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 39 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 39 2 biochemical biochemical JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 39 3 data data NN work_ynzjaxwrf5adfpxrtap5gsrpvu 39 4 on on IN work_ynzjaxwrf5adfpxrtap5gsrpvu 39 5 38 38 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 39 6 Kþ Kþ NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 39 7 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 39 8 activators activator NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 39 9 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 39 10 used use VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 39 11 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 39 12 training training NN work_ynzjaxwrf5adfpxrtap5gsrpvu 39 13 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 39 14 test test NN work_ynzjaxwrf5adfpxrtap5gsrpvu 39 15 sets set NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 39 16 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 40 1 These these DT work_ynzjaxwrf5adfpxrtap5gsrpvu 40 2 compounds compound NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 40 3 span span VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 40 4 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 40 5 wide wide JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 40 6 range range NN work_ynzjaxwrf5adfpxrtap5gsrpvu 40 7 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 40 8 structurally structurally RB work_ynzjaxwrf5adfpxrtap5gsrpvu 40 9 different different JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 40 10 chemotypes chemotype NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 40 11 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 40 12 ~10 ~10 NFP work_ynzjaxwrf5adfpxrtap5gsrpvu 40 13 ^ ^ NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 40 14 5-fold 5-fold CD work_ynzjaxwrf5adfpxrtap5gsrpvu 40 15 variances variance NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 40 16 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 40 17 binding bind VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 40 18 affinity affinity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 40 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 40 20 which which WDT work_ynzjaxwrf5adfpxrtap5gsrpvu 40 21 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 40 22 sufficient sufficient JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 40 23 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 40 24 statistically statistically RB work_ynzjaxwrf5adfpxrtap5gsrpvu 40 25 sound sound JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 40 26 model model NN work_ynzjaxwrf5adfpxrtap5gsrpvu 40 27 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 41 1 A a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 41 2 developed developed JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 3 five five CD work_ynzjaxwrf5adfpxrtap5gsrpvu 41 4 sites site NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 41 5 AAHHR AAHHR NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 41 6 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 41 7 A a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 41 8 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 41 9 hydrogen hydrogen NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 10 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 41 11 bond bond NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 12 accepting accepting NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 41 14 H h NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 15 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 41 16 hydrophobic hydrophobic NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 17 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 41 18 R r NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 41 20 aromatic aromatic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 21 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 41 22 pharmacophore pharmacophore NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 23 model model NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 24 has have VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 25 showed show VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 26 reasonable reasonable JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 27 high high JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 28 statistical statistical JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 29 results result NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 41 30 compared compare VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 31 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 32 other other JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 33 constructed construct VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 34 models model NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 41 35 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 41 36 was be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 41 37 selected select VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 38 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 39 steric steric JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 40 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 41 41 electrostatic electrostatic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 41 42 contour contour NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 43 maps map NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 41 44 analysis analysis NN work_ynzjaxwrf5adfpxrtap5gsrpvu 41 45 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 42 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 42 2 predictive predictive JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 42 3 power power NN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 4 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 5 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 42 6 model model NN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 7 was be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 42 8 also also RB work_ynzjaxwrf5adfpxrtap5gsrpvu 42 9 tested test VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 10 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 11 6 6 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 42 12 external external JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 42 13 test test NN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 14 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 42 15 set set NN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 16 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 42 17 as as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 42 18 true true JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 42 19 unknowns unknown NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 42 20 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 42 21 compounds compound NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 42 22 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 43 1 Pharmacophore pharmacophore NN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 2 model model NN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 3 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 43 4 also also RB work_ynzjaxwrf5adfpxrtap5gsrpvu 43 5 combined combine VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 6 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 7 previously previously RB work_ynzjaxwrf5adfpxrtap5gsrpvu 43 8 developed develop VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 9 receptor- receptor- NN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 10 based base VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 11 homology homology NN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 12 model model NN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 13 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 14 hERG hERG NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 43 15 K K NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 43 16 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 43 17 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 43 18 novel novel JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 43 19 activators activator NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 43 20 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 43 21 generated generate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 22 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 43 23 screened screen VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 43 24 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 44 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 44 2 developed develop VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 3 ligand ligand NN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 4 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 44 5 based base VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 6 models model NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 44 7 may may MD work_ynzjaxwrf5adfpxrtap5gsrpvu 44 8 serve serve VB work_ynzjaxwrf5adfpxrtap5gsrpvu 44 9 as as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 10 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 44 11 basis basis NN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 12 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 13 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 44 14 synthesis synthesis NN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 15 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 16 novel novel JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 44 17 potential potential JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 44 18 therapeutic therapeutic JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 44 19 hERG herg NN work_ynzjaxwrf5adfpxrtap5gsrpvu 44 20 activators activator NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 44 21 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 45 1 95-Plat 95-Plat NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 2 N N NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 3 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 45 4 Terminal Terminal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 5 Regulation Regulation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 6 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 45 7 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 8 KD KD NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 9 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 10 Deactivation Deactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 11 Steven Steven NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 12 J. J. NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 13 Thomson Thomson NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 14 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 45 15 Angela Angela NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 16 Hansen Hansen NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 17 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 45 18 Michael Michael NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 19 C. C. NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 20 Sanguinetti Sanguinetti NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 45 21 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 46 1 Nora Nora NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 2 Eccles Eccles NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 3 Harrison Harrison NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 4 Cardiovascular Cardiovascular NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 5 Research Research NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 6 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 46 7 Training Training NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 8 Institute Institute NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 9 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 46 10 University University NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 11 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 46 12 Utah Utah NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 46 14 Salt Salt NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 15 Lake Lake NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 16 City City NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 17 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 46 18 UT UT NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 19 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 46 20 USA USA NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 46 21 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 47 1 Slow slow JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 2 deactivation deactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 3 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 4 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 47 5 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 47 6 Kv Kv NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 47 7 11.1 11.1 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 47 8 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 47 9 potassium potassium NN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 10 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 47 11 maintains maintain VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 12 IKr IKr NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 47 13 dur- dur- NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 47 14 ing e VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 47 15 final final JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 16 repolarization repolarization NN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 17 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 18 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 47 19 cardiac cardiac JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 20 action action NN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 21 potential potential NN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 22 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 47 23 opposes oppose VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 24 asynchro- asynchro- JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 25 nous nous JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 26 early early JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 47 27 depolarization depolarization NN work_ynzjaxwrf5adfpxrtap5gsrpvu 47 28 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 48 1 Inherited inherit VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 2 point point NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 3 mutations mutation NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 48 4 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 5 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 48 6 that that WDT work_ynzjaxwrf5adfpxrtap5gsrpvu 48 7 accelerate accelerate VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 48 8 deactivation deactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 9 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 10 IKr IKr NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 48 11 cause cause VB work_ynzjaxwrf5adfpxrtap5gsrpvu 48 12 long long JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 48 13 QT QT NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 48 14 syndrome syndrome NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 15 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 48 16 LQTS lqts NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 17 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 48 18 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 48 19 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 48 20 disorder disorder NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 21 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 22 ventricular ventricular JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 48 23 repolarization repolarization NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 24 that that WDT work_ynzjaxwrf5adfpxrtap5gsrpvu 48 25 increases increase VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 48 26 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 48 27 risk risk NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 28 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 29 lethal lethal JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 48 30 cardiac cardiac JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 48 31 arrhythmia arrhythmia NN work_ynzjaxwrf5adfpxrtap5gsrpvu 48 32 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 49 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 49 2 intracellular intracellular JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 49 3 N n NN work_ynzjaxwrf5adfpxrtap5gsrpvu 49 4 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 49 5 terminal terminal NN work_ynzjaxwrf5adfpxrtap5gsrpvu 49 6 domain domain NN work_ynzjaxwrf5adfpxrtap5gsrpvu 49 7 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 49 8 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 49 9 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 49 10 known know VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 49 11 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 49 12 be be VB work_ynzjaxwrf5adfpxrtap5gsrpvu 49 13 essential essential JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 49 14 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 49 15 slow slow JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 49 16 deactivation deactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 49 17 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 50 1 Deletion deletion NN work_ynzjaxwrf5adfpxrtap5gsrpvu 50 2 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 50 3 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 50 4 entire entire JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 50 5 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 50 6 ~350 ~350 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 50 7 residues residue NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 50 8 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 50 9 or or CC work_ynzjaxwrf5adfpxrtap5gsrpvu 50 10 just just RB work_ynzjaxwrf5adfpxrtap5gsrpvu 50 11 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 50 12 initial initial JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 50 13 16 16 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 50 14 residues residue NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 50 15 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 50 16 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 50 17 N N NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 50 18 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 50 19 terminus terminus NN work_ynzjaxwrf5adfpxrtap5gsrpvu 50 20 accelerates accelerate VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 50 21 deactivation deactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 50 22 10-fold 10-fold CD work_ynzjaxwrf5adfpxrtap5gsrpvu 50 23 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 51 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 51 2 same same JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 51 3 effect effect NN work_ynzjaxwrf5adfpxrtap5gsrpvu 51 4 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 51 5 achieved achieve VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 51 6 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 51 7 neutralization neutralization NN work_ynzjaxwrf5adfpxrtap5gsrpvu 51 8 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 51 9 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 51 10 charged charge VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 51 11 residues residue NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 51 12 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 51 13 Arg4 Arg4 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 51 14 or or CC work_ynzjaxwrf5adfpxrtap5gsrpvu 51 15 Arg5 Arg5 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 51 16 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 52 1 How how WRB work_ynzjaxwrf5adfpxrtap5gsrpvu 52 2 many many JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 52 3 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 52 4 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 52 5 4 4 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 52 6 N N NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 52 7 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 52 8 termini termini NN work_ynzjaxwrf5adfpxrtap5gsrpvu 52 9 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 52 10 required require VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 52 11 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 52 12 slow slow VB work_ynzjaxwrf5adfpxrtap5gsrpvu 52 13 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 52 14 deactivation deactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 52 15 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 52 16 unknown unknown JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 52 17 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 53 1 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 53 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 53 3 like like IN work_ynzjaxwrf5adfpxrtap5gsrpvu 53 4 other other JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 53 5 Kv Kv NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 53 6 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 53 7 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 53 8 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 53 9 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 53 10 homotetramer homotetramer NN work_ynzjaxwrf5adfpxrtap5gsrpvu 53 11 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 54 1 By by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 2 repeatedly repeatedly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 54 3 linking link VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 54 4 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 54 5 C c NN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 6 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 54 7 terminal terminal NN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 8 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 9 one one CD work_ynzjaxwrf5adfpxrtap5gsrpvu 54 10 subunit subunit NN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 11 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 12 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 54 13 N n NN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 14 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 54 15 terminal terminal NN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 16 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 17 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 54 18 next next JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 54 19 subunit subunit NN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 20 we -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 54 21 constructed construct VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 54 22 concatenated concatenate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 54 23 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 54 24 tetramers tetramer NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 54 25 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 55 1 A a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 55 2 variety variety NN work_ynzjaxwrf5adfpxrtap5gsrpvu 55 3 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 55 4 homomeric homomeric JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 55 5 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 55 6 heteromeric heteromeric NN work_ynzjaxwrf5adfpxrtap5gsrpvu 55 7 concatenated concatenate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 55 8 tetramers tetramer NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 55 9 were be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 55 10 characterized characterize VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 55 11 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 55 12 i.e. i.e. FW work_ynzjaxwrf5adfpxrtap5gsrpvu 55 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 55 14 WTn WTn NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 55 15 / / SYM work_ynzjaxwrf5adfpxrtap5gsrpvu 55 16 R4A R4A NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 55 17 : : : work_ynzjaxwrf5adfpxrtap5gsrpvu 55 18 R5A(4-n R5A(4-n NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 55 19 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 55 20 ; ; : work_ynzjaxwrf5adfpxrtap5gsrpvu 55 21 where where WRB work_ynzjaxwrf5adfpxrtap5gsrpvu 55 22 n n NN work_ynzjaxwrf5adfpxrtap5gsrpvu 55 23 = = SYM work_ynzjaxwrf5adfpxrtap5gsrpvu 55 24 1 1 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 55 25 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 55 26 4 4 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 55 27 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 55 28 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 56 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 56 2 concatenated concatenated JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 56 3 channel channel NN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 4 containing contain VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 56 5 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 56 6 single single JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 56 7 R4A r4a NN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 8 / / SYM work_ynzjaxwrf5adfpxrtap5gsrpvu 56 9 R5A R5A NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 56 10 subunit subunit NN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 11 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 56 12 3 3 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 56 13 wild wild JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 56 14 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 56 15 type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 16 subunits subunit NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 56 17 deactivated deactivate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 18 as as RB work_ynzjaxwrf5adfpxrtap5gsrpvu 56 19 fast fast RB work_ynzjaxwrf5adfpxrtap5gsrpvu 56 20 as as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 21 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 56 22 concatenated concatenate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 23 channel channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 56 24 con- con- NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 56 25 taining taine VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 56 26 only only RB work_ynzjaxwrf5adfpxrtap5gsrpvu 56 27 R4A r4a NN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 28 / / SYM work_ynzjaxwrf5adfpxrtap5gsrpvu 56 29 R5A r5a IN work_ynzjaxwrf5adfpxrtap5gsrpvu 56 30 subunits subunit NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 56 31 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 57 1 The the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 57 2 LQTS lqts NN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 3 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 57 4 associated associate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 5 mutation mutation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 6 R56Q R56Q NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 57 7 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 57 8 located locate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 9 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 10 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 57 11 N n NN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 12 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 57 13 terminal terminal NN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 14 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 15 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 57 16 was be VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 57 17 also also RB work_ynzjaxwrf5adfpxrtap5gsrpvu 57 18 studied study VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 57 19 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 58 1 Again again RB work_ynzjaxwrf5adfpxrtap5gsrpvu 58 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 58 3 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 58 4 concatenated concatenated JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 58 5 tetramer tetramer NN work_ynzjaxwrf5adfpxrtap5gsrpvu 58 6 containing contain VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 58 7 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 58 8 single single JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 58 9 mutant mutant NN work_ynzjaxwrf5adfpxrtap5gsrpvu 58 10 subunit subunit NN work_ynzjaxwrf5adfpxrtap5gsrpvu 58 11 deactivated deactivate VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 58 12 as as RB work_ynzjaxwrf5adfpxrtap5gsrpvu 58 13 fast fast RB work_ynzjaxwrf5adfpxrtap5gsrpvu 58 14 as as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 58 15 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 58 16 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 58 17 R56Q r56q NN work_ynzjaxwrf5adfpxrtap5gsrpvu 58 18 mutations mutation NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 58 19 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 58 20 all all DT work_ynzjaxwrf5adfpxrtap5gsrpvu 58 21 four four CD work_ynzjaxwrf5adfpxrtap5gsrpvu 58 22 subunits subunit NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 58 23 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 59 1 Our -PRON- PRP$ work_ynzjaxwrf5adfpxrtap5gsrpvu 59 2 results result NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 59 3 show show VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 59 4 that that IN work_ynzjaxwrf5adfpxrtap5gsrpvu 59 5 all all DT work_ynzjaxwrf5adfpxrtap5gsrpvu 59 6 4 4 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 59 7 N N NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 59 8 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 59 9 termini termini NN work_ynzjaxwrf5adfpxrtap5gsrpvu 59 10 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 59 11 required require VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 59 12 to to TO work_ynzjaxwrf5adfpxrtap5gsrpvu 59 13 mediate mediate VB work_ynzjaxwrf5adfpxrtap5gsrpvu 59 14 slow slow JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 59 15 deactivation deactivation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 59 16 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 59 17 wild wild JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 59 18 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 59 19 type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 59 20 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 59 21 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 59 22 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 60 1 96-Plat 96-plat CD work_ynzjaxwrf5adfpxrtap5gsrpvu 60 2 Lipid Lipid NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 3 Affinity Affinity NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 4 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 60 5 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 60 6 Voltage Voltage NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 7 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 60 8 Gated Gated NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 9 Potassium Potassium NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 10 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 11 KvAP KvAP NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 12 Elise Elise NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 13 Faure1 Faure1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 14 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 60 15 Christine Christine NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 16 Thompson2 Thompson2 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 17 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 60 18 Rikard Rikard NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 60 19 Blunck1,2 blunck1,2 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 60 20 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 61 1 1 1 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 61 2 Physiology Physiology NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 3 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 4 Université Université NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 5 de de IN work_ynzjaxwrf5adfpxrtap5gsrpvu 61 6 Montréal Montréal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 7 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 8 GÉPROM GÉPROM NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 9 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 10 Montréal Montréal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 11 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 12 QC QC NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 13 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 14 Canada Canada NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 15 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 16 2 2 CD work_ynzjaxwrf5adfpxrtap5gsrpvu 61 17 Physique Physique NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 18 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 19 Université Université NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 20 de de IN work_ynzjaxwrf5adfpxrtap5gsrpvu 61 21 Montréal Montréal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 22 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 23 GÉPROM GÉPROM NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 24 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 25 Montréal Montréal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 26 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 27 QC QC NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 28 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 61 29 Canada Canada NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 61 30 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 62 1 Voltage voltage NN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 2 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 62 3 gated gate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 4 potassium potassium NN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 5 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 62 6 ( ( -LRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 62 7 KV KV NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 62 8 ) ) -RRB- work_ynzjaxwrf5adfpxrtap5gsrpvu 62 9 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 62 10 formed form VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 11 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 12 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 62 13 central central JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 62 14 conducting conduct VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 62 15 pore pore NN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 16 surrounded surround VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 17 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 18 four four CD work_ynzjaxwrf5adfpxrtap5gsrpvu 62 19 voltage voltage NN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 20 sensor sensor NN work_ynzjaxwrf5adfpxrtap5gsrpvu 62 21 domains domain NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 62 22 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 63 1 Functional functional JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 63 2 studies study NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 63 3 have have VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 63 4 re- re- RB work_ynzjaxwrf5adfpxrtap5gsrpvu 63 5 vealed veale VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 6 that that IN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 7 biophysical biophysical JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 63 8 properties property NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 63 9 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 10 lipid lipid NN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 11 molecules molecule NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 63 12 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 13 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 63 14 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 63 15 environ- environ- NN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 16 ment ment JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 63 17 can can MD work_ynzjaxwrf5adfpxrtap5gsrpvu 63 18 have have VB work_ynzjaxwrf5adfpxrtap5gsrpvu 63 19 strong strong JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 63 20 effects effect NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 63 21 on on IN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 22 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 63 23 activity activity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 24 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 63 25 KV KV NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 63 26 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 63 27 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 64 1 Here here RB work_ynzjaxwrf5adfpxrtap5gsrpvu 64 2 , , , work_ynzjaxwrf5adfpxrtap5gsrpvu 64 3 we -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 64 4 investigated investigate VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 64 5 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 64 6 influence influence NN work_ynzjaxwrf5adfpxrtap5gsrpvu 64 7 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 64 8 different different JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 64 9 lipids lipid NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 64 10 as as RB work_ynzjaxwrf5adfpxrtap5gsrpvu 64 11 well well RB work_ynzjaxwrf5adfpxrtap5gsrpvu 64 12 as as IN work_ynzjaxwrf5adfpxrtap5gsrpvu 64 13 their -PRON- PRP$ work_ynzjaxwrf5adfpxrtap5gsrpvu 64 14 affinity affinity NN work_ynzjaxwrf5adfpxrtap5gsrpvu 64 15 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 64 16 KvAP kvap NN work_ynzjaxwrf5adfpxrtap5gsrpvu 64 17 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 64 18 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 65 1 We -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 65 2 carried carry VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 65 3 out out RP work_ynzjaxwrf5adfpxrtap5gsrpvu 65 4 electrophysiology electrophysiology NN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 5 measurements measurement NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 65 6 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 7 fusing fuse VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 65 8 vesicles vesicle NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 65 9 containing contain VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 65 10 purified purify VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 11 channels channel NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 65 12 into into IN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 13 planar planar JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 65 14 lipid lipid NN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 15 bilayers bilayer NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 65 16 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 17 varied varied JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 65 18 lipid lipid NN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 19 compo- compo- NN work_ynzjaxwrf5adfpxrtap5gsrpvu 65 20 sitions sition NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 65 21 . . . work_ynzjaxwrf5adfpxrtap5gsrpvu 66 1 We -PRON- PRP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 2 found find VBD work_ynzjaxwrf5adfpxrtap5gsrpvu 66 3 that that IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 4 KvAP kvap NN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 5 properties property NNS work_ynzjaxwrf5adfpxrtap5gsrpvu 66 6 are be VBP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 7 mainly mainly RB work_ynzjaxwrf5adfpxrtap5gsrpvu 66 8 determined determine VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 9 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 10 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 66 11 lipid lipid NN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 12 A A NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 13 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 66 14 Type type NN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 15 Kv4 kv4 NN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 16 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 17 Closed closed JJ work_ynzjaxwrf5adfpxrtap5gsrpvu 66 18 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 66 19 State State NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 20 Inactivation Inactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 21 is be VBZ work_ynzjaxwrf5adfpxrtap5gsrpvu 66 22 Modulated modulate VBN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 23 by by IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 24 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 66 25 Tetramerization Tetramerization NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 26 Domain Domain NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 27 Interacting interact VBG work_ynzjaxwrf5adfpxrtap5gsrpvu 66 28 with with IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 29 Auxilary Auxilary NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 30 KChIP4a KChIP4a NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 31 Two Two NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 32 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 66 33 in in IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 34 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 66 35 One one CD work_ynzjaxwrf5adfpxrtap5gsrpvu 66 36 : : : work_ynzjaxwrf5adfpxrtap5gsrpvu 66 37 Activation activation NN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 38 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 66 39 Inactivation Inactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 40 at at IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 41 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 66 42 Intracellular Intracellular NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 43 Gate Gate NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 44 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 45 a a DT work_ynzjaxwrf5adfpxrtap5gsrpvu 66 46 Kv Kv NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 47 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 48 Development Development NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 49 and and CC work_ynzjaxwrf5adfpxrtap5gsrpvu 66 50 Validation Validation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 51 Studies Studies NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 66 52 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 53 Universal Universal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 54 Pharmacophore Pharmacophore NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 55 Models Models NNPS work_ynzjaxwrf5adfpxrtap5gsrpvu 66 56 for for IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 57 hERG herg NN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 58 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 59 Openers Openers NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 60 N N NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 61 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 66 62 Terminal Terminal NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 63 Regulation Regulation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 64 of of IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 65 hERG1 hERG1 NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 66 K+ K+ NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 67 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 68 Deactivation Deactivation NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 69 Lipid Lipid NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 70 Affinity Affinity NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 71 to to IN work_ynzjaxwrf5adfpxrtap5gsrpvu 66 72 the the DT work_ynzjaxwrf5adfpxrtap5gsrpvu 66 73 Voltage Voltage NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 74 - - HYPH work_ynzjaxwrf5adfpxrtap5gsrpvu 66 75 Gated Gated NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 76 Potassium Potassium NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 77 Channel Channel NNP work_ynzjaxwrf5adfpxrtap5gsrpvu 66 78 KvAP kvap NN