id sid tid token lemma pos work_vr5p4ez5gjhl3gquctrvk746ua 1 1 Computational Computational NNP work_vr5p4ez5gjhl3gquctrvk746ua 1 2 Study Study NNP work_vr5p4ez5gjhl3gquctrvk746ua 1 3 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 1 4 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 1 5 Prokaryotic Prokaryotic NNP work_vr5p4ez5gjhl3gquctrvk746ua 1 6 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 1 7 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 1 8 136a 136a NNPS work_vr5p4ez5gjhl3gquctrvk746ua 1 9 Sunday Sunday NNP work_vr5p4ez5gjhl3gquctrvk746ua 1 10 , , , work_vr5p4ez5gjhl3gquctrvk746ua 1 11 February February NNP work_vr5p4ez5gjhl3gquctrvk746ua 1 12 3 3 CD work_vr5p4ez5gjhl3gquctrvk746ua 1 13 , , , work_vr5p4ez5gjhl3gquctrvk746ua 1 14 2013 2013 CD work_vr5p4ez5gjhl3gquctrvk746ua 1 15 stabilized stabilize VBD work_vr5p4ez5gjhl3gquctrvk746ua 1 16 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 1 17 surrounding surround VBG work_vr5p4ez5gjhl3gquctrvk746ua 1 18 hydrophobic hydrophobic JJ work_vr5p4ez5gjhl3gquctrvk746ua 1 19 residues residue NNS work_vr5p4ez5gjhl3gquctrvk746ua 1 20 . . . work_vr5p4ez5gjhl3gquctrvk746ua 2 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 2 2 propose propose VBP work_vr5p4ez5gjhl3gquctrvk746ua 2 3 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 2 4 mutations mutation NNS work_vr5p4ez5gjhl3gquctrvk746ua 2 5 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 2 6 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 2 7 asparagines asparagine NNS work_vr5p4ez5gjhl3gquctrvk746ua 2 8 affect affect VBP work_vr5p4ez5gjhl3gquctrvk746ua 2 9 activation activation NN work_vr5p4ez5gjhl3gquctrvk746ua 2 10 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 2 11 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 2 12 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 2 13 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 2 14 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 2 15 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 2 16 drug drug NN work_vr5p4ez5gjhl3gquctrvk746ua 2 17 action action NN work_vr5p4ez5gjhl3gquctrvk746ua 2 18 through through IN work_vr5p4ez5gjhl3gquctrvk746ua 2 19 destabilizing destabilize VBG work_vr5p4ez5gjhl3gquctrvk746ua 2 20 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 2 21 open open JJ work_vr5p4ez5gjhl3gquctrvk746ua 2 22 state state NN work_vr5p4ez5gjhl3gquctrvk746ua 2 23 . . . work_vr5p4ez5gjhl3gquctrvk746ua 3 1 Diversity diversity NN work_vr5p4ez5gjhl3gquctrvk746ua 3 2 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 3 3 H h NN work_vr5p4ez5gjhl3gquctrvk746ua 3 4 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 3 5 bonding bond VBG work_vr5p4ez5gjhl3gquctrvk746ua 3 6 partners partner NNS work_vr5p4ez5gjhl3gquctrvk746ua 3 7 explains explain VBZ work_vr5p4ez5gjhl3gquctrvk746ua 3 8 different different JJ work_vr5p4ez5gjhl3gquctrvk746ua 3 9 effects effect NNS work_vr5p4ez5gjhl3gquctrvk746ua 3 10 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 3 11 mutations mutation NNS work_vr5p4ez5gjhl3gquctrvk746ua 3 12 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 3 13 individual individual JJ work_vr5p4ez5gjhl3gquctrvk746ua 3 14 asparagines asparagine NNS work_vr5p4ez5gjhl3gquctrvk746ua 3 15 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 3 16 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 3 17 channel channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 3 18 activa- activa- NNP work_vr5p4ez5gjhl3gquctrvk746ua 3 19 tion tion NNP work_vr5p4ez5gjhl3gquctrvk746ua 3 20 , , , work_vr5p4ez5gjhl3gquctrvk746ua 3 21 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 3 22 , , , work_vr5p4ez5gjhl3gquctrvk746ua 3 23 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 3 24 drug drug NN work_vr5p4ez5gjhl3gquctrvk746ua 3 25 sensitivity sensitivity NN work_vr5p4ez5gjhl3gquctrvk746ua 3 26 . . . work_vr5p4ez5gjhl3gquctrvk746ua 4 1 Supported support VBN work_vr5p4ez5gjhl3gquctrvk746ua 4 2 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 4 3 NSERC NSERC NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 4 grant grant VBP work_vr5p4ez5gjhl3gquctrvk746ua 4 5 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 4 6 BSZ BSZ NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 7 , , , work_vr5p4ez5gjhl3gquctrvk746ua 4 8 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 4 9 RAS RAS NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 10 program program NN work_vr5p4ez5gjhl3gquctrvk746ua 4 11 ‘ ' `` work_vr5p4ez5gjhl3gquctrvk746ua 4 12 ‘ ' `` work_vr5p4ez5gjhl3gquctrvk746ua 4 13 Molecular Molecular NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 14 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 4 15 Cell Cell NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 16 Biology Biology NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 17 ’ ' '' work_vr5p4ez5gjhl3gquctrvk746ua 4 18 ’ ' '' work_vr5p4ez5gjhl3gquctrvk746ua 4 19 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 4 20 DBT DBT NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 21 , , , work_vr5p4ez5gjhl3gquctrvk746ua 4 22 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 4 23 CIHR cihr NN work_vr5p4ez5gjhl3gquctrvk746ua 4 24 award award NN work_vr5p4ez5gjhl3gquctrvk746ua 4 25 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 4 26 IB IB NNP work_vr5p4ez5gjhl3gquctrvk746ua 4 27 . . . work_vr5p4ez5gjhl3gquctrvk746ua 5 1 695-Pos 695-Pos NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 2 Board Board NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 3 B464 B464 NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 4 Binding bind VBG work_vr5p4ez5gjhl3gquctrvk746ua 5 5 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 5 6 Isoflurane Isoflurane NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 7 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 5 8 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 5 9 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 10 Voltage Voltage NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 11 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 5 12 Gated Gated NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 13 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 14 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 15 : : : work_vr5p4ez5gjhl3gquctrvk746ua 5 16 Structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 5 17 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 5 18 Accessibility Accessibility NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 19 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 5 20 Distinct Distinct NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 21 Interaction Interaction NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 22 Sites Sites NNPS work_vr5p4ez5gjhl3gquctrvk746ua 5 23 Srinivasa Srinivasa NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 24 G. G. NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 25 Raju1 Raju1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 26 , , , work_vr5p4ez5gjhl3gquctrvk746ua 5 27 Vincenzo Vincenzo NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 28 Carnevale1 Carnevale1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 29 , , , work_vr5p4ez5gjhl3gquctrvk746ua 5 30 David David NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 31 N. N. NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 32 Lebard2 Lebard2 NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 33 , , , work_vr5p4ez5gjhl3gquctrvk746ua 5 34 Annika Annika NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 35 F. F. NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 36 Barber3 Barber3 NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 37 , , , work_vr5p4ez5gjhl3gquctrvk746ua 5 38 Michael Michael NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 39 L. L. NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 40 Klein1 Klein1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 5 41 . . . work_vr5p4ez5gjhl3gquctrvk746ua 6 1 1Temple 1Temple NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 2 University University NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 3 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 4 Philadelphia Philadelphia NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 5 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 6 PA PA NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 7 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 8 USA USA NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 9 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 10 2Yeshiva 2Yeshiva NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 11 University University NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 12 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 13 New New NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 14 York York NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 15 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 16 NY NY NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 17 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 18 USA USA NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 19 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 20 3 3 CD work_vr5p4ez5gjhl3gquctrvk746ua 6 21 Thomas Thomas NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 22 Jefferson Jefferson NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 23 University University NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 24 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 25 Philadelphia Philadelphia NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 26 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 27 PA PA NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 28 , , , work_vr5p4ez5gjhl3gquctrvk746ua 6 29 USA USA NNP work_vr5p4ez5gjhl3gquctrvk746ua 6 30 . . . work_vr5p4ez5gjhl3gquctrvk746ua 7 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 7 2 most most RBS work_vr5p4ez5gjhl3gquctrvk746ua 7 3 likely likely JJ work_vr5p4ez5gjhl3gquctrvk746ua 7 4 targets target NNS work_vr5p4ez5gjhl3gquctrvk746ua 7 5 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 7 6 volatile volatile JJ work_vr5p4ez5gjhl3gquctrvk746ua 7 7 anesthetics anesthetic NNS work_vr5p4ez5gjhl3gquctrvk746ua 7 8 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 7 9 VA VA NNP work_vr5p4ez5gjhl3gquctrvk746ua 7 10 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 7 11 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 7 12 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 7 13 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 7 14 . . . work_vr5p4ez5gjhl3gquctrvk746ua 8 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 8 2 mechanism mechanism NN work_vr5p4ez5gjhl3gquctrvk746ua 8 3 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 8 4 volatile volatile JJ work_vr5p4ez5gjhl3gquctrvk746ua 8 5 anesthetic anesthetic JJ work_vr5p4ez5gjhl3gquctrvk746ua 8 6 action action NN work_vr5p4ez5gjhl3gquctrvk746ua 8 7 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 8 8 not not RB work_vr5p4ez5gjhl3gquctrvk746ua 8 9 completely completely RB work_vr5p4ez5gjhl3gquctrvk746ua 8 10 understood understand VBN work_vr5p4ez5gjhl3gquctrvk746ua 8 11 . . . work_vr5p4ez5gjhl3gquctrvk746ua 9 1 Identify- Identify- NNP work_vr5p4ez5gjhl3gquctrvk746ua 9 2 ing e VBG work_vr5p4ez5gjhl3gquctrvk746ua 9 3 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 9 4 molecular molecular JJ work_vr5p4ez5gjhl3gquctrvk746ua 9 5 pathway pathway NN work_vr5p4ez5gjhl3gquctrvk746ua 9 6 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 9 7 drug drug NN work_vr5p4ez5gjhl3gquctrvk746ua 9 8 binding binding NN work_vr5p4ez5gjhl3gquctrvk746ua 9 9 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 9 10 crucial crucial JJ work_vr5p4ez5gjhl3gquctrvk746ua 9 11 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 9 12 understand understand VB work_vr5p4ez5gjhl3gquctrvk746ua 9 13 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 9 14 effect effect NN work_vr5p4ez5gjhl3gquctrvk746ua 9 15 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 9 16 VA VA NNP work_vr5p4ez5gjhl3gquctrvk746ua 9 17 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 9 18 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 9 19 gated gate VBN work_vr5p4ez5gjhl3gquctrvk746ua 9 20 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 9 21 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 9 22 . . . work_vr5p4ez5gjhl3gquctrvk746ua 10 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 10 2 use use VBP work_vr5p4ez5gjhl3gquctrvk746ua 10 3 Molecular Molecular NNP work_vr5p4ez5gjhl3gquctrvk746ua 10 4 Dynamics Dynamics NNPS work_vr5p4ez5gjhl3gquctrvk746ua 10 5 simula- simula- NN work_vr5p4ez5gjhl3gquctrvk746ua 10 6 tions tion NNS work_vr5p4ez5gjhl3gquctrvk746ua 10 7 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 10 8 identify identify VB work_vr5p4ez5gjhl3gquctrvk746ua 10 9 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 10 10 binding bind VBG work_vr5p4ez5gjhl3gquctrvk746ua 10 11 sites site NNS work_vr5p4ez5gjhl3gquctrvk746ua 10 12 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 10 13 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 10 14 hydrophobic hydrophobic NNP work_vr5p4ez5gjhl3gquctrvk746ua 10 15 general general JJ work_vr5p4ez5gjhl3gquctrvk746ua 10 16 anesthetic anesthetic NNP work_vr5p4ez5gjhl3gquctrvk746ua 10 17 isoflur- isoflur- NNP work_vr5p4ez5gjhl3gquctrvk746ua 10 18 ane ane NNP work_vr5p4ez5gjhl3gquctrvk746ua 10 19 , , , work_vr5p4ez5gjhl3gquctrvk746ua 10 20 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 10 21 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 10 22 gated gate VBN work_vr5p4ez5gjhl3gquctrvk746ua 10 23 bacterial bacterial JJ work_vr5p4ez5gjhl3gquctrvk746ua 10 24 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 10 25 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 10 26 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 10 27 . . . work_vr5p4ez5gjhl3gquctrvk746ua 11 1 Apart apart RB work_vr5p4ez5gjhl3gquctrvk746ua 11 2 from from IN work_vr5p4ez5gjhl3gquctrvk746ua 11 3 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 11 4 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 11 5 sensing sensing NN work_vr5p4ez5gjhl3gquctrvk746ua 11 6 domain domain NN work_vr5p4ez5gjhl3gquctrvk746ua 11 7 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 11 8 S1-S4 S1-S4 NNP work_vr5p4ez5gjhl3gquctrvk746ua 11 9 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 11 10 , , , work_vr5p4ez5gjhl3gquctrvk746ua 11 11 linker linker NN work_vr5p4ez5gjhl3gquctrvk746ua 11 12 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 11 13 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 11 14 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 11 15 domain domain NN work_vr5p4ez5gjhl3gquctrvk746ua 11 16 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 11 17 S5-S6 s5-s6 NN work_vr5p4ez5gjhl3gquctrvk746ua 11 18 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 11 19 , , , work_vr5p4ez5gjhl3gquctrvk746ua 11 20 bacterial bacterial JJ work_vr5p4ez5gjhl3gquctrvk746ua 11 21 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 11 22 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 11 23 also also RB work_vr5p4ez5gjhl3gquctrvk746ua 11 24 have have VBP work_vr5p4ez5gjhl3gquctrvk746ua 11 25 fenestrations fenestration NNS work_vr5p4ez5gjhl3gquctrvk746ua 11 26 , , , work_vr5p4ez5gjhl3gquctrvk746ua 11 27 which which WDT work_vr5p4ez5gjhl3gquctrvk746ua 11 28 provide provide VBP work_vr5p4ez5gjhl3gquctrvk746ua 11 29 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 11 30 hydrophobic hydrophobic JJ work_vr5p4ez5gjhl3gquctrvk746ua 11 31 tunnel tunnel NN work_vr5p4ez5gjhl3gquctrvk746ua 11 32 through through IN work_vr5p4ez5gjhl3gquctrvk746ua 11 33 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 11 34 lipid lipid NN work_vr5p4ez5gjhl3gquctrvk746ua 11 35 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 11 36 embedded embed VBN work_vr5p4ez5gjhl3gquctrvk746ua 11 37 portion portion NN work_vr5p4ez5gjhl3gquctrvk746ua 11 38 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 11 39 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 11 40 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 11 41 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 11 42 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 11 43 central central JJ work_vr5p4ez5gjhl3gquctrvk746ua 11 44 cavity cavity NN work_vr5p4ez5gjhl3gquctrvk746ua 11 45 , , , work_vr5p4ez5gjhl3gquctrvk746ua 11 46 where where WRB work_vr5p4ez5gjhl3gquctrvk746ua 11 47 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 11 48 known know VBN work_vr5p4ez5gjhl3gquctrvk746ua 11 49 local local JJ work_vr5p4ez5gjhl3gquctrvk746ua 11 50 anesthetic anesthetic JJ work_vr5p4ez5gjhl3gquctrvk746ua 11 51 site site NN work_vr5p4ez5gjhl3gquctrvk746ua 11 52 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 11 53 located locate VBN work_vr5p4ez5gjhl3gquctrvk746ua 11 54 . . . work_vr5p4ez5gjhl3gquctrvk746ua 12 1 Unbiased unbiased JJ work_vr5p4ez5gjhl3gquctrvk746ua 12 2 ‘ ' `` work_vr5p4ez5gjhl3gquctrvk746ua 12 3 ‘ ' `` work_vr5p4ez5gjhl3gquctrvk746ua 12 4 flooding flooding NN work_vr5p4ez5gjhl3gquctrvk746ua 12 5 ’ ' '' work_vr5p4ez5gjhl3gquctrvk746ua 12 6 ’ ' '' work_vr5p4ez5gjhl3gquctrvk746ua 12 7 simulations simulation NNS work_vr5p4ez5gjhl3gquctrvk746ua 12 8 were be VBD work_vr5p4ez5gjhl3gquctrvk746ua 12 9 performed perform VBN work_vr5p4ez5gjhl3gquctrvk746ua 12 10 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 12 11 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 12 12 activated activate VBN work_vr5p4ez5gjhl3gquctrvk746ua 12 13 open open JJ work_vr5p4ez5gjhl3gquctrvk746ua 12 14 confirmation confirmation NN work_vr5p4ez5gjhl3gquctrvk746ua 12 15 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 12 16 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 12 17 . . . work_vr5p4ez5gjhl3gquctrvk746ua 13 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 13 2 per- per- RB work_vr5p4ez5gjhl3gquctrvk746ua 13 3 formed form VBD work_vr5p4ez5gjhl3gquctrvk746ua 13 4 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 13 5 cluster cluster NN work_vr5p4ez5gjhl3gquctrvk746ua 13 6 analysis analysis NN work_vr5p4ez5gjhl3gquctrvk746ua 13 7 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 13 8 identify identify VB work_vr5p4ez5gjhl3gquctrvk746ua 13 9 all all PDT work_vr5p4ez5gjhl3gquctrvk746ua 13 10 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 13 11 possible possible JJ work_vr5p4ez5gjhl3gquctrvk746ua 13 12 binding bind VBG work_vr5p4ez5gjhl3gquctrvk746ua 13 13 sites site NNS work_vr5p4ez5gjhl3gquctrvk746ua 13 14 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 13 15 isoflurane isoflurane NNP work_vr5p4ez5gjhl3gquctrvk746ua 13 16 . . . work_vr5p4ez5gjhl3gquctrvk746ua 14 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 14 2 three three CD work_vr5p4ez5gjhl3gquctrvk746ua 14 3 most most RBS work_vr5p4ez5gjhl3gquctrvk746ua 14 4 important important JJ work_vr5p4ez5gjhl3gquctrvk746ua 14 5 ones one NNS work_vr5p4ez5gjhl3gquctrvk746ua 14 6 among among IN work_vr5p4ez5gjhl3gquctrvk746ua 14 7 them -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 14 8 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 14 9 : : : work_vr5p4ez5gjhl3gquctrvk746ua 14 10 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 14 11 region region NN work_vr5p4ez5gjhl3gquctrvk746ua 14 12 near near IN work_vr5p4ez5gjhl3gquctrvk746ua 14 13 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 14 14 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 14 15 filter filter NN work_vr5p4ez5gjhl3gquctrvk746ua 14 16 , , , work_vr5p4ez5gjhl3gquctrvk746ua 14 17 called call VBD work_vr5p4ez5gjhl3gquctrvk746ua 14 18 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 14 19 extracellular extracellular NNP work_vr5p4ez5gjhl3gquctrvk746ua 14 20 site site NN work_vr5p4ez5gjhl3gquctrvk746ua 14 21 , , , work_vr5p4ez5gjhl3gquctrvk746ua 14 22 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 14 23 region region NN work_vr5p4ez5gjhl3gquctrvk746ua 14 24 near near IN work_vr5p4ez5gjhl3gquctrvk746ua 14 25 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 14 26 S4-S5 S4-S5 NNP work_vr5p4ez5gjhl3gquctrvk746ua 14 27 linker linker NN work_vr5p4ez5gjhl3gquctrvk746ua 14 28 , , , work_vr5p4ez5gjhl3gquctrvk746ua 14 29 called call VBD work_vr5p4ez5gjhl3gquctrvk746ua 14 30 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 14 31 linker linker NN work_vr5p4ez5gjhl3gquctrvk746ua 14 32 site site NN work_vr5p4ez5gjhl3gquctrvk746ua 14 33 , , , work_vr5p4ez5gjhl3gquctrvk746ua 14 34 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 14 35 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 14 36 region region NN work_vr5p4ez5gjhl3gquctrvk746ua 14 37 within within IN work_vr5p4ez5gjhl3gquctrvk746ua 14 38 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 14 39 cavity cavity NN work_vr5p4ez5gjhl3gquctrvk746ua 14 40 , , , work_vr5p4ez5gjhl3gquctrvk746ua 14 41 called call VBD work_vr5p4ez5gjhl3gquctrvk746ua 14 42 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 14 43 cavity cavity NN work_vr5p4ez5gjhl3gquctrvk746ua 14 44 site site NN work_vr5p4ez5gjhl3gquctrvk746ua 14 45 . . . work_vr5p4ez5gjhl3gquctrvk746ua 15 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 15 2 most most RBS work_vr5p4ez5gjhl3gquctrvk746ua 15 3 important important JJ work_vr5p4ez5gjhl3gquctrvk746ua 15 4 observation observation NN work_vr5p4ez5gjhl3gquctrvk746ua 15 5 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 15 6 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 15 7 isoflurane isoflurane NNP work_vr5p4ez5gjhl3gquctrvk746ua 15 8 enters enter VBZ work_vr5p4ez5gjhl3gquctrvk746ua 15 9 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 15 10 central central JJ work_vr5p4ez5gjhl3gquctrvk746ua 15 11 cavity cavity NN work_vr5p4ez5gjhl3gquctrvk746ua 15 12 through through IN work_vr5p4ez5gjhl3gquctrvk746ua 15 13 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 15 14 fenestrations fenestration NNS work_vr5p4ez5gjhl3gquctrvk746ua 15 15 . . . work_vr5p4ez5gjhl3gquctrvk746ua 16 1 Free free JJ work_vr5p4ez5gjhl3gquctrvk746ua 16 2 energy energy NN work_vr5p4ez5gjhl3gquctrvk746ua 16 3 perturbation perturbation NN work_vr5p4ez5gjhl3gquctrvk746ua 16 4 method method NN work_vr5p4ez5gjhl3gquctrvk746ua 16 5 was be VBD work_vr5p4ez5gjhl3gquctrvk746ua 16 6 employed employ VBN work_vr5p4ez5gjhl3gquctrvk746ua 16 7 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 16 8 calculate calculate VB work_vr5p4ez5gjhl3gquctrvk746ua 16 9 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 16 10 binding bind VBG work_vr5p4ez5gjhl3gquctrvk746ua 16 11 affinities affinity NNS work_vr5p4ez5gjhl3gquctrvk746ua 16 12 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 16 13 isoflurane isoflurane NN work_vr5p4ez5gjhl3gquctrvk746ua 16 14 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 16 15 each each DT work_vr5p4ez5gjhl3gquctrvk746ua 16 16 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 16 17 these these DT work_vr5p4ez5gjhl3gquctrvk746ua 16 18 sites site NNS work_vr5p4ez5gjhl3gquctrvk746ua 16 19 . . . work_vr5p4ez5gjhl3gquctrvk746ua 17 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 17 2 also also RB work_vr5p4ez5gjhl3gquctrvk746ua 17 3 studied study VBD work_vr5p4ez5gjhl3gquctrvk746ua 17 4 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 17 5 interactions interaction NNS work_vr5p4ez5gjhl3gquctrvk746ua 17 6 between between IN work_vr5p4ez5gjhl3gquctrvk746ua 17 7 isoflurane isoflurane NNP work_vr5p4ez5gjhl3gquctrvk746ua 17 8 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 17 9 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 17 10 amino amino JJ work_vr5p4ez5gjhl3gquctrvk746ua 17 11 acids acid NNS work_vr5p4ez5gjhl3gquctrvk746ua 17 12 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 17 13 these these DT work_vr5p4ez5gjhl3gquctrvk746ua 17 14 three three CD work_vr5p4ez5gjhl3gquctrvk746ua 17 15 binding bind VBG work_vr5p4ez5gjhl3gquctrvk746ua 17 16 sites site NNS work_vr5p4ez5gjhl3gquctrvk746ua 17 17 . . . work_vr5p4ez5gjhl3gquctrvk746ua 18 1 696-Pos 696-Pos NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 2 Board Board NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 3 B465 B465 NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 4 A A NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 5 Key Key NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 6 Gating Gating NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 7 Charge Charge NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 8 Interaction Interaction NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 9 Required require VBN work_vr5p4ez5gjhl3gquctrvk746ua 18 10 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 18 11 Slow Slow NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 12 Inactivation Inactivation NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 13 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 18 14 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 18 15 Navab Navab NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 16 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 17 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 18 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 19 Tamer Tamer NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 20 M. M. NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 21 Gamal Gamal NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 22 El El NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 23 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 18 24 Din Din NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 25 , , , work_vr5p4ez5gjhl3gquctrvk746ua 18 26 Todd Todd NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 27 Scheuer Scheuer NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 28 , , , work_vr5p4ez5gjhl3gquctrvk746ua 18 29 William William NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 30 A. a. NN work_vr5p4ez5gjhl3gquctrvk746ua 18 31 Catterall Catterall NNP work_vr5p4ez5gjhl3gquctrvk746ua 18 32 . . . work_vr5p4ez5gjhl3gquctrvk746ua 19 1 University University NNP work_vr5p4ez5gjhl3gquctrvk746ua 19 2 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 19 3 Washington Washington NNP work_vr5p4ez5gjhl3gquctrvk746ua 19 4 , , , work_vr5p4ez5gjhl3gquctrvk746ua 19 5 Seattle Seattle NNP work_vr5p4ez5gjhl3gquctrvk746ua 19 6 , , , work_vr5p4ez5gjhl3gquctrvk746ua 19 7 WA WA NNP work_vr5p4ez5gjhl3gquctrvk746ua 19 8 , , , work_vr5p4ez5gjhl3gquctrvk746ua 19 9 USA USA NNP work_vr5p4ez5gjhl3gquctrvk746ua 19 10 . . . work_vr5p4ez5gjhl3gquctrvk746ua 20 1 Bacterial bacterial JJ work_vr5p4ez5gjhl3gquctrvk746ua 20 2 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 20 3 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 20 4 gated gate VBN work_vr5p4ez5gjhl3gquctrvk746ua 20 5 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 20 6 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 20 7 Nav Nav NNP work_vr5p4ez5gjhl3gquctrvk746ua 20 8 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 20 9 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 20 10 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 20 11 considered consider VBN work_vr5p4ez5gjhl3gquctrvk746ua 20 12 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 20 13 ideal ideal JJ work_vr5p4ez5gjhl3gquctrvk746ua 20 14 model model NN work_vr5p4ez5gjhl3gquctrvk746ua 20 15 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 20 16 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 20 17 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 20 18 function function NN work_vr5p4ez5gjhl3gquctrvk746ua 20 19 studies study NNS work_vr5p4ez5gjhl3gquctrvk746ua 20 20 . . . work_vr5p4ez5gjhl3gquctrvk746ua 21 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 21 2 elucidation elucidation NN work_vr5p4ez5gjhl3gquctrvk746ua 21 3 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 21 4 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 21 5 crystal crystal NN work_vr5p4ez5gjhl3gquctrvk746ua 21 6 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 21 7 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 21 8 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 21 9 bacterial bacterial JJ work_vr5p4ez5gjhl3gquctrvk746ua 21 10 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 21 11 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 21 12 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 21 13 Payandeh Payandeh NNP work_vr5p4ez5gjhl3gquctrvk746ua 21 14 et et NNP work_vr5p4ez5gjhl3gquctrvk746ua 21 15 al al NNP work_vr5p4ez5gjhl3gquctrvk746ua 21 16 . . NNP work_vr5p4ez5gjhl3gquctrvk746ua 21 17 , , , work_vr5p4ez5gjhl3gquctrvk746ua 21 18 Nature Nature NNP work_vr5p4ez5gjhl3gquctrvk746ua 21 19 486 486 CD work_vr5p4ez5gjhl3gquctrvk746ua 21 20 , , , work_vr5p4ez5gjhl3gquctrvk746ua 21 21 135 135 CD work_vr5p4ez5gjhl3gquctrvk746ua 21 22 - - SYM work_vr5p4ez5gjhl3gquctrvk746ua 21 23 139 139 CD work_vr5p4ez5gjhl3gquctrvk746ua 21 24 , , , work_vr5p4ez5gjhl3gquctrvk746ua 21 25 2011 2011 CD work_vr5p4ez5gjhl3gquctrvk746ua 21 26 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 21 27 opened open VBD work_vr5p4ez5gjhl3gquctrvk746ua 21 28 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 21 29 avenue avenue NN work_vr5p4ez5gjhl3gquctrvk746ua 21 30 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 21 31 understand understand VB work_vr5p4ez5gjhl3gquctrvk746ua 21 32 electrical electrical JJ work_vr5p4ez5gjhl3gquctrvk746ua 21 33 signaling signaling NN work_vr5p4ez5gjhl3gquctrvk746ua 21 34 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 21 35 excitable excitable JJ work_vr5p4ez5gjhl3gquctrvk746ua 21 36 cells cell NNS work_vr5p4ez5gjhl3gquctrvk746ua 21 37 at at IN work_vr5p4ez5gjhl3gquctrvk746ua 21 38 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 21 39 structural structural JJ work_vr5p4ez5gjhl3gquctrvk746ua 21 40 level level NN work_vr5p4ez5gjhl3gquctrvk746ua 21 41 . . . work_vr5p4ez5gjhl3gquctrvk746ua 22 1 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 22 2 expressed express VBD work_vr5p4ez5gjhl3gquctrvk746ua 22 3 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 22 4 Hi5 hi5 NN work_vr5p4ez5gjhl3gquctrvk746ua 22 5 insect insect JJ work_vr5p4ez5gjhl3gquctrvk746ua 22 6 cells cell NNS work_vr5p4ez5gjhl3gquctrvk746ua 22 7 as as IN work_vr5p4ez5gjhl3gquctrvk746ua 22 8 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 22 9 structural structural JJ work_vr5p4ez5gjhl3gquctrvk746ua 22 10 studies study NNS work_vr5p4ez5gjhl3gquctrvk746ua 22 11 has have VBZ work_vr5p4ez5gjhl3gquctrvk746ua 22 12 unusually unusually RB work_vr5p4ez5gjhl3gquctrvk746ua 22 13 negative negative JJ work_vr5p4ez5gjhl3gquctrvk746ua 22 14 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 22 15 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 22 16 dependent dependent JJ work_vr5p4ez5gjhl3gquctrvk746ua 22 17 activation activation NN work_vr5p4ez5gjhl3gquctrvk746ua 22 18 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 22 19 Va Va NNP work_vr5p4ez5gjhl3gquctrvk746ua 22 20 ~ ~ NNP work_vr5p4ez5gjhl3gquctrvk746ua 22 21 130 130 CD work_vr5p4ez5gjhl3gquctrvk746ua 22 22 mV mV NNP work_vr5p4ez5gjhl3gquctrvk746ua 22 23 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 22 24 . . . work_vr5p4ez5gjhl3gquctrvk746ua 23 1 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 23 2 also also RB work_vr5p4ez5gjhl3gquctrvk746ua 23 3 has have VBZ work_vr5p4ez5gjhl3gquctrvk746ua 23 4 three three CD work_vr5p4ez5gjhl3gquctrvk746ua 23 5 phases phase NNS work_vr5p4ez5gjhl3gquctrvk746ua 23 6 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 23 7 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 23 8 , , , work_vr5p4ez5gjhl3gquctrvk746ua 23 9 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 23 10 biphasic biphasic NN work_vr5p4ez5gjhl3gquctrvk746ua 23 11 early early JJ work_vr5p4ez5gjhl3gquctrvk746ua 23 12 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 23 13 process process NN work_vr5p4ez5gjhl3gquctrvk746ua 23 14 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 23 15 t1~103 t1~103 NNP work_vr5p4ez5gjhl3gquctrvk746ua 23 16 ms ms NNP work_vr5p4ez5gjhl3gquctrvk746ua 23 17 , , , work_vr5p4ez5gjhl3gquctrvk746ua 23 18 t2~3.8 t2~3.8 NNP work_vr5p4ez5gjhl3gquctrvk746ua 23 19 s s NNP work_vr5p4ez5gjhl3gquctrvk746ua 23 20 , , , work_vr5p4ez5gjhl3gquctrvk746ua 23 21 at at IN work_vr5p4ez5gjhl3gquctrvk746ua 23 22 � � NNP work_vr5p4ez5gjhl3gquctrvk746ua 23 23 180 180 CD work_vr5p4ez5gjhl3gquctrvk746ua 23 24 mV mv NN work_vr5p4ez5gjhl3gquctrvk746ua 23 25 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 23 26 followed follow VBN work_vr5p4ez5gjhl3gquctrvk746ua 23 27 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 23 28 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 23 29 unusually unusually RB work_vr5p4ez5gjhl3gquctrvk746ua 23 30 strong strong JJ work_vr5p4ez5gjhl3gquctrvk746ua 23 31 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 23 32 use use JJ work_vr5p4ez5gjhl3gquctrvk746ua 23 33 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 23 34 dependent dependent JJ work_vr5p4ez5gjhl3gquctrvk746ua 23 35 slow slow JJ work_vr5p4ez5gjhl3gquctrvk746ua 23 36 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 23 37 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 23 38 process process NN work_vr5p4ez5gjhl3gquctrvk746ua 23 39 . . . work_vr5p4ez5gjhl3gquctrvk746ua 24 1 To to TO work_vr5p4ez5gjhl3gquctrvk746ua 24 2 search search VB work_vr5p4ez5gjhl3gquctrvk746ua 24 3 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 24 4 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 24 5 molecular molecular JJ work_vr5p4ez5gjhl3gquctrvk746ua 24 6 basis basis NN work_vr5p4ez5gjhl3gquctrvk746ua 24 7 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 24 8 negative negative JJ work_vr5p4ez5gjhl3gquctrvk746ua 24 9 activation activation NN work_vr5p4ez5gjhl3gquctrvk746ua 24 10 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 24 11 slow slow JJ work_vr5p4ez5gjhl3gquctrvk746ua 24 12 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 24 13 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 24 14 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 24 15 , , , work_vr5p4ez5gjhl3gquctrvk746ua 24 16 we -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 24 17 mutated mutate VBD work_vr5p4ez5gjhl3gquctrvk746ua 24 18 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 24 19 outer- outer- JJ work_vr5p4ez5gjhl3gquctrvk746ua 24 20 most most RBS work_vr5p4ez5gjhl3gquctrvk746ua 24 21 gating gating JJ work_vr5p4ez5gjhl3gquctrvk746ua 24 22 charge charge NN work_vr5p4ez5gjhl3gquctrvk746ua 24 23 partner partner NN work_vr5p4ez5gjhl3gquctrvk746ua 24 24 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 24 25 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 24 26 S2 s2 NN work_vr5p4ez5gjhl3gquctrvk746ua 24 27 segment segment NN work_vr5p4ez5gjhl3gquctrvk746ua 24 28 , , , work_vr5p4ez5gjhl3gquctrvk746ua 24 29 Asn49 Asn49 NNP work_vr5p4ez5gjhl3gquctrvk746ua 24 30 , , , work_vr5p4ez5gjhl3gquctrvk746ua 24 31 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 24 32 Lys Lys NNP work_vr5p4ez5gjhl3gquctrvk746ua 24 33 . . . work_vr5p4ez5gjhl3gquctrvk746ua 25 1 This this DT work_vr5p4ez5gjhl3gquctrvk746ua 25 2 mutation mutation NN work_vr5p4ez5gjhl3gquctrvk746ua 25 3 shifted shift VBD work_vr5p4ez5gjhl3gquctrvk746ua 25 4 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 25 5 activation activation NN work_vr5p4ez5gjhl3gquctrvk746ua 25 6 curve curve NN work_vr5p4ez5gjhl3gquctrvk746ua 25 7 ~ ~ NFP work_vr5p4ez5gjhl3gquctrvk746ua 25 8 75 75 CD work_vr5p4ez5gjhl3gquctrvk746ua 25 9 mV mv $ work_vr5p4ez5gjhl3gquctrvk746ua 25 10 toward toward IN work_vr5p4ez5gjhl3gquctrvk746ua 25 11 more more JJR work_vr5p4ez5gjhl3gquctrvk746ua 25 12 positive positive JJ work_vr5p4ez5gjhl3gquctrvk746ua 25 13 potentials potential NNS work_vr5p4ez5gjhl3gquctrvk746ua 25 14 . . . work_vr5p4ez5gjhl3gquctrvk746ua 26 1 Surpris- Surpris- NNP work_vr5p4ez5gjhl3gquctrvk746ua 26 2 ingly ingly RB work_vr5p4ez5gjhl3gquctrvk746ua 26 3 , , , work_vr5p4ez5gjhl3gquctrvk746ua 26 4 it -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 26 5 also also RB work_vr5p4ez5gjhl3gquctrvk746ua 26 6 completely completely RB work_vr5p4ez5gjhl3gquctrvk746ua 26 7 abolished abolish VBD work_vr5p4ez5gjhl3gquctrvk746ua 26 8 use use NN work_vr5p4ez5gjhl3gquctrvk746ua 26 9 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 26 10 dependent dependent JJ work_vr5p4ez5gjhl3gquctrvk746ua 26 11 slow slow JJ work_vr5p4ez5gjhl3gquctrvk746ua 26 12 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 26 13 . . . work_vr5p4ez5gjhl3gquctrvk746ua 27 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 27 2 showed show VBD work_vr5p4ez5gjhl3gquctrvk746ua 27 3 previously previously RB work_vr5p4ez5gjhl3gquctrvk746ua 27 4 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 27 5 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 27 6 equivalent equivalent JJ work_vr5p4ez5gjhl3gquctrvk746ua 27 7 residue residue NN work_vr5p4ez5gjhl3gquctrvk746ua 27 8 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 27 9 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 27 10 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 27 11 Asp60 Asp60 NNP work_vr5p4ez5gjhl3gquctrvk746ua 27 12 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 27 13 interacts interact VBZ work_vr5p4ez5gjhl3gquctrvk746ua 27 14 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 27 15 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 27 16 R3 r3 JJ work_vr5p4ez5gjhl3gquctrvk746ua 27 17 gating gate VBG work_vr5p4ez5gjhl3gquctrvk746ua 27 18 charge charge NN work_vr5p4ez5gjhl3gquctrvk746ua 27 19 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 27 20 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 27 21 S4 s4 NN work_vr5p4ez5gjhl3gquctrvk746ua 27 22 segment segment NN work_vr5p4ez5gjhl3gquctrvk746ua 27 23 during during IN work_vr5p4ez5gjhl3gquctrvk746ua 27 24 activation activation NN work_vr5p4ez5gjhl3gquctrvk746ua 27 25 using use VBG work_vr5p4ez5gjhl3gquctrvk746ua 27 26 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 27 27 disul- disul- NN work_vr5p4ez5gjhl3gquctrvk746ua 27 28 fide fide JJ work_vr5p4ez5gjhl3gquctrvk746ua 27 29 locking locking NN work_vr5p4ez5gjhl3gquctrvk746ua 27 30 method method NN work_vr5p4ez5gjhl3gquctrvk746ua 27 31 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 27 32 DeCaen DeCaen NNP work_vr5p4ez5gjhl3gquctrvk746ua 27 33 et et NNP work_vr5p4ez5gjhl3gquctrvk746ua 27 34 al al NNP work_vr5p4ez5gjhl3gquctrvk746ua 27 35 , , , work_vr5p4ez5gjhl3gquctrvk746ua 27 36 PNAS PNAS NNP work_vr5p4ez5gjhl3gquctrvk746ua 27 37 2008 2008 CD work_vr5p4ez5gjhl3gquctrvk746ua 27 38 105 105 CD work_vr5p4ez5gjhl3gquctrvk746ua 27 39 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 27 40 39 39 CD work_vr5p4ez5gjhl3gquctrvk746ua 27 41 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 27 42 15142 15142 CD work_vr5p4ez5gjhl3gquctrvk746ua 27 43 - - SYM work_vr5p4ez5gjhl3gquctrvk746ua 27 44 15147 15147 CD work_vr5p4ez5gjhl3gquctrvk746ua 27 45 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 27 46 . . . work_vr5p4ez5gjhl3gquctrvk746ua 28 1 To to TO work_vr5p4ez5gjhl3gquctrvk746ua 28 2 test test VB work_vr5p4ez5gjhl3gquctrvk746ua 28 3 whether whether IN work_vr5p4ez5gjhl3gquctrvk746ua 28 4 this this DT work_vr5p4ez5gjhl3gquctrvk746ua 28 5 interaction interaction NN work_vr5p4ez5gjhl3gquctrvk746ua 28 6 between between IN work_vr5p4ez5gjhl3gquctrvk746ua 28 7 R3 R3 NNP work_vr5p4ez5gjhl3gquctrvk746ua 28 8 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 28 9 N49 N49 NNP work_vr5p4ez5gjhl3gquctrvk746ua 28 10 was be VBD work_vr5p4ez5gjhl3gquctrvk746ua 28 11 critical critical JJ work_vr5p4ez5gjhl3gquctrvk746ua 28 12 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 28 13 slow slow JJ work_vr5p4ez5gjhl3gquctrvk746ua 28 14 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 28 15 , , , work_vr5p4ez5gjhl3gquctrvk746ua 28 16 we -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 28 17 mutated mutate VBD work_vr5p4ez5gjhl3gquctrvk746ua 28 18 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 28 19 R3 r3 NN work_vr5p4ez5gjhl3gquctrvk746ua 28 20 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 28 21 Cys Cys NNP work_vr5p4ez5gjhl3gquctrvk746ua 28 22 . . . work_vr5p4ez5gjhl3gquctrvk746ua 29 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 29 2 resulting result VBG work_vr5p4ez5gjhl3gquctrvk746ua 29 3 mutant mutant JJ work_vr5p4ez5gjhl3gquctrvk746ua 29 4 NavAb_R3C navab_r3c NN work_vr5p4ez5gjhl3gquctrvk746ua 29 5 also also RB work_vr5p4ez5gjhl3gquctrvk746ua 29 6 had have VBD work_vr5p4ez5gjhl3gquctrvk746ua 29 7 positively positively RB work_vr5p4ez5gjhl3gquctrvk746ua 29 8 shifted shift VBN work_vr5p4ez5gjhl3gquctrvk746ua 29 9 channel channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 29 10 activation activation NNP work_vr5p4ez5gjhl3gquctrvk746ua 29 11 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 29 12 þ75 þ75 NN work_vr5p4ez5gjhl3gquctrvk746ua 29 13 mV mV NNP work_vr5p4ez5gjhl3gquctrvk746ua 29 14 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 29 15 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 29 16 no no DT work_vr5p4ez5gjhl3gquctrvk746ua 29 17 use use NN work_vr5p4ez5gjhl3gquctrvk746ua 29 18 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 29 19 dependent dependent JJ work_vr5p4ez5gjhl3gquctrvk746ua 29 20 slow slow JJ work_vr5p4ez5gjhl3gquctrvk746ua 29 21 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 29 22 . . . work_vr5p4ez5gjhl3gquctrvk746ua 30 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 30 2 fact fact NN work_vr5p4ez5gjhl3gquctrvk746ua 30 3 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 30 4 these these DT work_vr5p4ez5gjhl3gquctrvk746ua 30 5 reciprocal reciprocal JJ work_vr5p4ez5gjhl3gquctrvk746ua 30 6 mutations mutation NNS work_vr5p4ez5gjhl3gquctrvk746ua 30 7 have have VBP work_vr5p4ez5gjhl3gquctrvk746ua 30 8 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 30 9 same same JJ work_vr5p4ez5gjhl3gquctrvk746ua 30 10 functional functional JJ work_vr5p4ez5gjhl3gquctrvk746ua 30 11 effects effect NNS work_vr5p4ez5gjhl3gquctrvk746ua 30 12 suggests suggest VBZ work_vr5p4ez5gjhl3gquctrvk746ua 30 13 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 30 14 interaction interaction NN work_vr5p4ez5gjhl3gquctrvk746ua 30 15 between between IN work_vr5p4ez5gjhl3gquctrvk746ua 30 16 R3 r3 NN work_vr5p4ez5gjhl3gquctrvk746ua 30 17 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 30 18 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 30 19 S4 s4 NN work_vr5p4ez5gjhl3gquctrvk746ua 30 20 segment segment NN work_vr5p4ez5gjhl3gquctrvk746ua 30 21 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 30 22 N49 N49 NNP work_vr5p4ez5gjhl3gquctrvk746ua 30 23 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 30 24 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 30 25 S2 s2 NN work_vr5p4ez5gjhl3gquctrvk746ua 30 26 segment segment NN work_vr5p4ez5gjhl3gquctrvk746ua 30 27 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 30 28 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 30 29 important important JJ work_vr5p4ez5gjhl3gquctrvk746ua 30 30 link link NN work_vr5p4ez5gjhl3gquctrvk746ua 30 31 that that WDT work_vr5p4ez5gjhl3gquctrvk746ua 30 32 stabilizes stabilize VBZ work_vr5p4ez5gjhl3gquctrvk746ua 30 33 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 30 34 activated activated JJ work_vr5p4ez5gjhl3gquctrvk746ua 30 35 state state NN work_vr5p4ez5gjhl3gquctrvk746ua 30 36 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 30 37 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 30 38 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 30 39 sensor sensor NN work_vr5p4ez5gjhl3gquctrvk746ua 30 40 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 30 41 triggers trigger VBZ work_vr5p4ez5gjhl3gquctrvk746ua 30 42 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 30 43 slow slow JJ work_vr5p4ez5gjhl3gquctrvk746ua 30 44 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 30 45 process process NN work_vr5p4ez5gjhl3gquctrvk746ua 30 46 . . . work_vr5p4ez5gjhl3gquctrvk746ua 31 1 697-Pos 697-Pos NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 2 Board Board NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 3 B466 B466 NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 4 Computational Computational NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 5 Study Study NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 6 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 31 7 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 31 8 Prokaryotic Prokaryotic NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 9 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 10 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 11 Karen Karen NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 12 M. M. NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 13 Callahan Callahan NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 14 , , , work_vr5p4ez5gjhl3gquctrvk746ua 31 15 Benoit Benoit NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 16 Roux Roux NNP work_vr5p4ez5gjhl3gquctrvk746ua 31 17 . . . work_vr5p4ez5gjhl3gquctrvk746ua 32 1 University University NNP work_vr5p4ez5gjhl3gquctrvk746ua 32 2 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 32 3 Chicago Chicago NNP work_vr5p4ez5gjhl3gquctrvk746ua 32 4 , , , work_vr5p4ez5gjhl3gquctrvk746ua 32 5 Chicago Chicago NNP work_vr5p4ez5gjhl3gquctrvk746ua 32 6 , , , work_vr5p4ez5gjhl3gquctrvk746ua 32 7 IL IL NNP work_vr5p4ez5gjhl3gquctrvk746ua 32 8 , , , work_vr5p4ez5gjhl3gquctrvk746ua 32 9 USA USA NNP work_vr5p4ez5gjhl3gquctrvk746ua 32 10 . . . work_vr5p4ez5gjhl3gquctrvk746ua 33 1 Ion ion VB work_vr5p4ez5gjhl3gquctrvk746ua 33 2 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 33 3 selective selective JJ work_vr5p4ez5gjhl3gquctrvk746ua 33 4 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 33 5 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 33 6 gated gate VBN work_vr5p4ez5gjhl3gquctrvk746ua 33 7 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 33 8 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 33 9 allow allow VBP work_vr5p4ez5gjhl3gquctrvk746ua 33 10 ions ion NNS work_vr5p4ez5gjhl3gquctrvk746ua 33 11 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 33 12 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 33 13 specific specific JJ work_vr5p4ez5gjhl3gquctrvk746ua 33 14 element element NN work_vr5p4ez5gjhl3gquctrvk746ua 33 15 or or CC work_vr5p4ez5gjhl3gquctrvk746ua 33 16 set set NN work_vr5p4ez5gjhl3gquctrvk746ua 33 17 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 33 18 elements element NNS work_vr5p4ez5gjhl3gquctrvk746ua 33 19 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 33 20 pass pass VB work_vr5p4ez5gjhl3gquctrvk746ua 33 21 , , , work_vr5p4ez5gjhl3gquctrvk746ua 33 22 but but CC work_vr5p4ez5gjhl3gquctrvk746ua 33 23 exclude exclude VB work_vr5p4ez5gjhl3gquctrvk746ua 33 24 other other JJ work_vr5p4ez5gjhl3gquctrvk746ua 33 25 ions ion NNS work_vr5p4ez5gjhl3gquctrvk746ua 33 26 . . . work_vr5p4ez5gjhl3gquctrvk746ua 34 1 Recently recently RB work_vr5p4ez5gjhl3gquctrvk746ua 34 2 , , , work_vr5p4ez5gjhl3gquctrvk746ua 34 3 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 34 4 crystal crystal NN work_vr5p4ez5gjhl3gquctrvk746ua 34 5 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 34 6 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 34 7 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 8 was be VBD work_vr5p4ez5gjhl3gquctrvk746ua 34 9 published publish VBN work_vr5p4ez5gjhl3gquctrvk746ua 34 10 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 34 11 Payandeh Payandeh NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 12 et et NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 13 al al NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 14 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 34 15 2011 2011 CD work_vr5p4ez5gjhl3gquctrvk746ua 34 16 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 34 17 Nature nature NN work_vr5p4ez5gjhl3gquctrvk746ua 34 18 475 475 CD work_vr5p4ez5gjhl3gquctrvk746ua 34 19 , , , work_vr5p4ez5gjhl3gquctrvk746ua 34 20 353 353 CD work_vr5p4ez5gjhl3gquctrvk746ua 34 21 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 34 22 , , , work_vr5p4ez5gjhl3gquctrvk746ua 34 23 giving give VBG work_vr5p4ez5gjhl3gquctrvk746ua 34 24 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 34 25 un- un- JJ work_vr5p4ez5gjhl3gquctrvk746ua 34 26 ambiguous ambiguous JJ work_vr5p4ez5gjhl3gquctrvk746ua 34 27 picture picture NN work_vr5p4ez5gjhl3gquctrvk746ua 34 28 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 34 29 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 34 30 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 34 31 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 34 32 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 34 33 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 34 34 channel channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 35 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 34 36 filter filter NN work_vr5p4ez5gjhl3gquctrvk746ua 34 37 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 34 38 SF SF NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 39 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 34 40 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 34 41 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 34 42 prokaryote prokaryote NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 43 Arcobacter Arcobacter NNP work_vr5p4ez5gjhl3gquctrvk746ua 34 44 butzleri butzleri NN work_vr5p4ez5gjhl3gquctrvk746ua 34 45 . . . work_vr5p4ez5gjhl3gquctrvk746ua 35 1 The the DT work_vr5p4ez5gjhl3gquctrvk746ua 35 2 filter filter NN work_vr5p4ez5gjhl3gquctrvk746ua 35 3 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 35 4 much much RB work_vr5p4ez5gjhl3gquctrvk746ua 35 5 wider wide JJR work_vr5p4ez5gjhl3gquctrvk746ua 35 6 than than IN work_vr5p4ez5gjhl3gquctrvk746ua 35 7 that that DT work_vr5p4ez5gjhl3gquctrvk746ua 35 8 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 35 9 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 35 10 narrow narrow JJ work_vr5p4ez5gjhl3gquctrvk746ua 35 11 , , , work_vr5p4ez5gjhl3gquctrvk746ua 35 12 carbonyl carbonyl NN work_vr5p4ez5gjhl3gquctrvk746ua 35 13 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 35 14 lined line VBN work_vr5p4ez5gjhl3gquctrvk746ua 35 15 potassium potassium NN work_vr5p4ez5gjhl3gquctrvk746ua 35 16 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 35 17 , , , work_vr5p4ez5gjhl3gquctrvk746ua 35 18 allowing allow VBG work_vr5p4ez5gjhl3gquctrvk746ua 35 19 ions ion NNS work_vr5p4ez5gjhl3gquctrvk746ua 35 20 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 35 21 penetrate penetrate VB work_vr5p4ez5gjhl3gquctrvk746ua 35 22 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 35 23 minimal minimal JJ work_vr5p4ez5gjhl3gquctrvk746ua 35 24 dehydration dehydration NN work_vr5p4ez5gjhl3gquctrvk746ua 35 25 , , , work_vr5p4ez5gjhl3gquctrvk746ua 35 26 multiple multiple JJ work_vr5p4ez5gjhl3gquctrvk746ua 35 27 pathways pathway NNS work_vr5p4ez5gjhl3gquctrvk746ua 35 28 , , , work_vr5p4ez5gjhl3gquctrvk746ua 35 29 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 35 30 even even RB work_vr5p4ez5gjhl3gquctrvk746ua 35 31 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 35 32 pass pass VB work_vr5p4ez5gjhl3gquctrvk746ua 35 33 each each DT work_vr5p4ez5gjhl3gquctrvk746ua 35 34 other other JJ work_vr5p4ez5gjhl3gquctrvk746ua 35 35 . . . work_vr5p4ez5gjhl3gquctrvk746ua 36 1 Previous previous JJ work_vr5p4ez5gjhl3gquctrvk746ua 36 2 computational computational JJ work_vr5p4ez5gjhl3gquctrvk746ua 36 3 studies study NNS work_vr5p4ez5gjhl3gquctrvk746ua 36 4 have have VBP work_vr5p4ez5gjhl3gquctrvk746ua 36 5 attempted attempt VBN work_vr5p4ez5gjhl3gquctrvk746ua 36 6 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 36 7 explain explain VB work_vr5p4ez5gjhl3gquctrvk746ua 36 8 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 36 9 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 36 10 , , , work_vr5p4ez5gjhl3gquctrvk746ua 36 11 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 36 12 claimed claim VBD work_vr5p4ez5gjhl3gquctrvk746ua 36 13 consensus consensus NN work_vr5p4ez5gjhl3gquctrvk746ua 36 14 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 36 15 Corry Corry NNP work_vr5p4ez5gjhl3gquctrvk746ua 36 16 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 36 17 Thomas Thomas NNP work_vr5p4ez5gjhl3gquctrvk746ua 36 18 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 36 19 2011 2011 CD work_vr5p4ez5gjhl3gquctrvk746ua 36 20 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 36 21 JACS JACS NNP work_vr5p4ez5gjhl3gquctrvk746ua 36 22 134 134 CD work_vr5p4ez5gjhl3gquctrvk746ua 36 23 , , , work_vr5p4ez5gjhl3gquctrvk746ua 36 24 1840 1840 CD work_vr5p4ez5gjhl3gquctrvk746ua 36 25 , , , work_vr5p4ez5gjhl3gquctrvk746ua 36 26 Furini Furini NNP work_vr5p4ez5gjhl3gquctrvk746ua 36 27 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 36 28 Domene Domene NNP work_vr5p4ez5gjhl3gquctrvk746ua 36 29 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 36 30 2012 2012 CD work_vr5p4ez5gjhl3gquctrvk746ua 36 31 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 36 32 PLOS PLOS NNP work_vr5p4ez5gjhl3gquctrvk746ua 36 33 8 8 CD work_vr5p4ez5gjhl3gquctrvk746ua 36 34 , , , work_vr5p4ez5gjhl3gquctrvk746ua 36 35 e1002476 e1002476 NNP work_vr5p4ez5gjhl3gquctrvk746ua 36 36 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 36 37 . . . work_vr5p4ez5gjhl3gquctrvk746ua 37 1 Experimental experimental JJ work_vr5p4ez5gjhl3gquctrvk746ua 37 2 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 37 3 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 37 4 determina- determina- IN work_vr5p4ez5gjhl3gquctrvk746ua 37 5 tion tion NN work_vr5p4ez5gjhl3gquctrvk746ua 37 6 from from IN work_vr5p4ez5gjhl3gquctrvk746ua 37 7 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 37 8 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 37 9 only only JJ work_vr5p4ez5gjhl3gquctrvk746ua 37 10 constructs construct NNS work_vr5p4ez5gjhl3gquctrvk746ua 37 11 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 37 12 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 37 13 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 37 14 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 37 15 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 37 16 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 37 17 same same JJ work_vr5p4ez5gjhl3gquctrvk746ua 37 18 SF SF NNP work_vr5p4ez5gjhl3gquctrvk746ua 37 19 sequence sequence NN work_vr5p4ez5gjhl3gquctrvk746ua 37 20 shows show VBZ work_vr5p4ez5gjhl3gquctrvk746ua 37 21 stronger strong JJR work_vr5p4ez5gjhl3gquctrvk746ua 37 22 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 37 23 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 37 24 from from IN work_vr5p4ez5gjhl3gquctrvk746ua 37 25 reversal reversal NN work_vr5p4ez5gjhl3gquctrvk746ua 37 26 potential potential NN work_vr5p4ez5gjhl3gquctrvk746ua 37 27 than than IN work_vr5p4ez5gjhl3gquctrvk746ua 37 28 from from IN work_vr5p4ez5gjhl3gquctrvk746ua 37 29 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 37 30 ratio ratio NN work_vr5p4ez5gjhl3gquctrvk746ua 37 31 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 37 32 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 37 33 fluxes flux NNS work_vr5p4ez5gjhl3gquctrvk746ua 37 34 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 37 35 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 37 36 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 37 37 potassium potassium NN work_vr5p4ez5gjhl3gquctrvk746ua 37 38 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 37 39 Shaya Shaya NNP work_vr5p4ez5gjhl3gquctrvk746ua 37 40 et et NNP work_vr5p4ez5gjhl3gquctrvk746ua 37 41 al al NNP work_vr5p4ez5gjhl3gquctrvk746ua 37 42 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 37 43 2011 2011 CD work_vr5p4ez5gjhl3gquctrvk746ua 37 44 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 37 45 PNAS pnas NN work_vr5p4ez5gjhl3gquctrvk746ua 37 46 108 108 CD work_vr5p4ez5gjhl3gquctrvk746ua 37 47 , , , work_vr5p4ez5gjhl3gquctrvk746ua 37 48 12313 12313 CD work_vr5p4ez5gjhl3gquctrvk746ua 37 49 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 37 50 , , , work_vr5p4ez5gjhl3gquctrvk746ua 37 51 but but CC work_vr5p4ez5gjhl3gquctrvk746ua 37 52 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 37 53 , , , work_vr5p4ez5gjhl3gquctrvk746ua 37 54 Na Na NNP work_vr5p4ez5gjhl3gquctrvk746ua 37 55 þ þ NNP work_vr5p4ez5gjhl3gquctrvk746ua 37 56 / / SYM work_vr5p4ez5gjhl3gquctrvk746ua 37 57 Kþ Kþ NNP work_vr5p4ez5gjhl3gquctrvk746ua 37 58 , , , work_vr5p4ez5gjhl3gquctrvk746ua 37 59 was be VBD work_vr5p4ez5gjhl3gquctrvk746ua 37 60 still still RB work_vr5p4ez5gjhl3gquctrvk746ua 37 61 less less JJR work_vr5p4ez5gjhl3gquctrvk746ua 37 62 than than IN work_vr5p4ez5gjhl3gquctrvk746ua 37 63 five five CD work_vr5p4ez5gjhl3gquctrvk746ua 37 64 . . . work_vr5p4ez5gjhl3gquctrvk746ua 38 1 Simulations simulation NNS work_vr5p4ez5gjhl3gquctrvk746ua 38 2 based base VBN work_vr5p4ez5gjhl3gquctrvk746ua 38 3 upon upon IN work_vr5p4ez5gjhl3gquctrvk746ua 38 4 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 38 5 closed closed JJ work_vr5p4ez5gjhl3gquctrvk746ua 38 6 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 38 7 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 38 8 crystal crystal NN work_vr5p4ez5gjhl3gquctrvk746ua 38 9 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 38 10 could could MD work_vr5p4ez5gjhl3gquctrvk746ua 38 11 not not RB work_vr5p4ez5gjhl3gquctrvk746ua 38 12 determine determine VB work_vr5p4ez5gjhl3gquctrvk746ua 38 13 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 38 14 directly directly RB work_vr5p4ez5gjhl3gquctrvk746ua 38 15 from from IN work_vr5p4ez5gjhl3gquctrvk746ua 38 16 con- con- NNP work_vr5p4ez5gjhl3gquctrvk746ua 38 17 duction duction NN work_vr5p4ez5gjhl3gquctrvk746ua 38 18 . . . work_vr5p4ez5gjhl3gquctrvk746ua 39 1 To to TO work_vr5p4ez5gjhl3gquctrvk746ua 39 2 investigate investigate VB work_vr5p4ez5gjhl3gquctrvk746ua 39 3 this this DT work_vr5p4ez5gjhl3gquctrvk746ua 39 4 issue issue NN work_vr5p4ez5gjhl3gquctrvk746ua 39 5 , , , work_vr5p4ez5gjhl3gquctrvk746ua 39 6 we -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 39 7 first first RB work_vr5p4ez5gjhl3gquctrvk746ua 39 8 calculated calculate VBD work_vr5p4ez5gjhl3gquctrvk746ua 39 9 multi multi JJ work_vr5p4ez5gjhl3gquctrvk746ua 39 10 - - JJ work_vr5p4ez5gjhl3gquctrvk746ua 39 11 ion ion JJ work_vr5p4ez5gjhl3gquctrvk746ua 39 12 potentials potential NNS work_vr5p4ez5gjhl3gquctrvk746ua 39 13 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 39 14 mean mean JJ work_vr5p4ez5gjhl3gquctrvk746ua 39 15 force force NN work_vr5p4ez5gjhl3gquctrvk746ua 39 16 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 39 17 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 39 18 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 39 19 filter filter NN work_vr5p4ez5gjhl3gquctrvk746ua 39 20 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 39 21 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 39 22 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 39 23 domain domain NN work_vr5p4ez5gjhl3gquctrvk746ua 39 24 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 39 25 only only RB work_vr5p4ez5gjhl3gquctrvk746ua 39 26 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 39 27 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 39 28 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 39 29 ex- ex- NN work_vr5p4ez5gjhl3gquctrvk746ua 39 30 tended tended JJ work_vr5p4ez5gjhl3gquctrvk746ua 39 31 equilibration equilibration NN work_vr5p4ez5gjhl3gquctrvk746ua 39 32 period period NN work_vr5p4ez5gjhl3gquctrvk746ua 39 33 , , , work_vr5p4ez5gjhl3gquctrvk746ua 39 34 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 39 35 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 39 36 replica replica NNP work_vr5p4ez5gjhl3gquctrvk746ua 39 37 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 39 38 exchange exchange NN work_vr5p4ez5gjhl3gquctrvk746ua 39 39 molecular molecular NNP work_vr5p4ez5gjhl3gquctrvk746ua 39 40 dynamics dynamic NNS work_vr5p4ez5gjhl3gquctrvk746ua 39 41 scheme scheme NN work_vr5p4ez5gjhl3gquctrvk746ua 39 42 , , , work_vr5p4ez5gjhl3gquctrvk746ua 39 43 which which WDT work_vr5p4ez5gjhl3gquctrvk746ua 39 44 allows allow VBZ work_vr5p4ez5gjhl3gquctrvk746ua 39 45 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 39 46 improved improve VBN work_vr5p4ez5gjhl3gquctrvk746ua 39 47 sampling sampling NN work_vr5p4ez5gjhl3gquctrvk746ua 39 48 . . . work_vr5p4ez5gjhl3gquctrvk746ua 40 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 40 2 then then RB work_vr5p4ez5gjhl3gquctrvk746ua 40 3 explored explore VBD work_vr5p4ez5gjhl3gquctrvk746ua 40 4 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 40 5 non- non- NNP work_vr5p4ez5gjhl3gquctrvk746ua 40 6 equilibrium equilibrium NNP work_vr5p4ez5gjhl3gquctrvk746ua 40 7 conduction conduction NNP work_vr5p4ez5gjhl3gquctrvk746ua 40 8 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 40 9 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 40 10 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 40 11 potassium potassium NN work_vr5p4ez5gjhl3gquctrvk746ua 40 12 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 40 13 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 40 14 presence presence NN work_vr5p4ez5gjhl3gquctrvk746ua 40 15 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 40 16 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 40 17 applied apply VBN work_vr5p4ez5gjhl3gquctrvk746ua 40 18 electric electric JJ work_vr5p4ez5gjhl3gquctrvk746ua 40 19 field field NN work_vr5p4ez5gjhl3gquctrvk746ua 40 20 through through IN work_vr5p4ez5gjhl3gquctrvk746ua 40 21 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 40 22 model model NN work_vr5p4ez5gjhl3gquctrvk746ua 40 23 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 40 24 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 40 25 truncated truncate VBD work_vr5p4ez5gjhl3gquctrvk746ua 40 26 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 40 27 mimic mimic VB work_vr5p4ez5gjhl3gquctrvk746ua 40 28 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 40 29 conformation conformation NN work_vr5p4ez5gjhl3gquctrvk746ua 40 30 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 40 31 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 40 32 open open JJ work_vr5p4ez5gjhl3gquctrvk746ua 40 33 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 40 34 . . . work_vr5p4ez5gjhl3gquctrvk746ua 41 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 41 2 also also RB work_vr5p4ez5gjhl3gquctrvk746ua 41 3 present present VBP work_vr5p4ez5gjhl3gquctrvk746ua 41 4 multi multi JJ work_vr5p4ez5gjhl3gquctrvk746ua 41 5 - - JJ work_vr5p4ez5gjhl3gquctrvk746ua 41 6 ion ion JJ work_vr5p4ez5gjhl3gquctrvk746ua 41 7 pmf pmf NN work_vr5p4ez5gjhl3gquctrvk746ua 41 8 calculations calculation NNS work_vr5p4ez5gjhl3gquctrvk746ua 41 9 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 41 10 illustrate illustrate VB work_vr5p4ez5gjhl3gquctrvk746ua 41 11 similarities similarity NNS work_vr5p4ez5gjhl3gquctrvk746ua 41 12 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 41 13 differences difference NNS work_vr5p4ez5gjhl3gquctrvk746ua 41 14 between between IN work_vr5p4ez5gjhl3gquctrvk746ua 41 15 this this DT work_vr5p4ez5gjhl3gquctrvk746ua 41 16 model model NN work_vr5p4ez5gjhl3gquctrvk746ua 41 17 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 41 18 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 41 19 intact intact JJ work_vr5p4ez5gjhl3gquctrvk746ua 41 20 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 41 21 . . . work_vr5p4ez5gjhl3gquctrvk746ua 42 1 When when WRB work_vr5p4ez5gjhl3gquctrvk746ua 42 2 taken take VBN work_vr5p4ez5gjhl3gquctrvk746ua 42 3 together together RB work_vr5p4ez5gjhl3gquctrvk746ua 42 4 , , , work_vr5p4ez5gjhl3gquctrvk746ua 42 5 these these DT work_vr5p4ez5gjhl3gquctrvk746ua 42 6 two two CD work_vr5p4ez5gjhl3gquctrvk746ua 42 7 methods method NNS work_vr5p4ez5gjhl3gquctrvk746ua 42 8 provide provide VBP work_vr5p4ez5gjhl3gquctrvk746ua 42 9 complementary complementary JJ work_vr5p4ez5gjhl3gquctrvk746ua 42 10 views view NNS work_vr5p4ez5gjhl3gquctrvk746ua 42 11 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 42 12 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 42 13 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 42 14 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 42 15 conduction conduction NN work_vr5p4ez5gjhl3gquctrvk746ua 42 16 based base VBN work_vr5p4ez5gjhl3gquctrvk746ua 42 17 upon upon IN work_vr5p4ez5gjhl3gquctrvk746ua 42 18 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 42 19 conformation conformation NN work_vr5p4ez5gjhl3gquctrvk746ua 42 20 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 42 21 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 42 22 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 42 23 crystal crystal NN work_vr5p4ez5gjhl3gquctrvk746ua 42 24 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 42 25 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 42 26 Payandeh Payandeh NNP work_vr5p4ez5gjhl3gquctrvk746ua 42 27 et et NNP work_vr5p4ez5gjhl3gquctrvk746ua 42 28 al al NNP work_vr5p4ez5gjhl3gquctrvk746ua 42 29 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 42 30 2011 2011 CD work_vr5p4ez5gjhl3gquctrvk746ua 42 31 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 42 32 . . . work_vr5p4ez5gjhl3gquctrvk746ua 43 1 698-Pos 698-Pos NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 2 Board Board NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 3 B467 B467 NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 4 Volatile Volatile NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 5 General General NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 6 Anesthetic Anesthetic NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 7 Interactions Interactions NNPS work_vr5p4ez5gjhl3gquctrvk746ua 43 8 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 43 9 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 43 10 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 11 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 12 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 13 Annika Annika NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 14 F. F. NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 15 Barber1 Barber1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 16 , , , work_vr5p4ez5gjhl3gquctrvk746ua 43 17 Srinivas Srinivas NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 18 G. G. NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 19 Raju2 Raju2 NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 20 , , , work_vr5p4ez5gjhl3gquctrvk746ua 43 21 David David NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 22 Lebard2 Lebard2 NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 23 , , , work_vr5p4ez5gjhl3gquctrvk746ua 43 24 Vincenzo Vincenzo NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 25 Carnevale2 Carnevale2 NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 26 , , , work_vr5p4ez5gjhl3gquctrvk746ua 43 27 Michael Michael NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 28 L. L. NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 29 Klein2 Klein2 NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 30 , , , work_vr5p4ez5gjhl3gquctrvk746ua 43 31 Manuel Manuel NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 32 Covarrubias1 Covarrubias1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 43 33 . . . work_vr5p4ez5gjhl3gquctrvk746ua 44 1 1 1 CD work_vr5p4ez5gjhl3gquctrvk746ua 44 2 Thomas Thomas NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 3 Jefferson Jefferson NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 4 University University NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 5 , , , work_vr5p4ez5gjhl3gquctrvk746ua 44 6 Philadelphia Philadelphia NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 7 , , , work_vr5p4ez5gjhl3gquctrvk746ua 44 8 PA PA NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 9 , , , work_vr5p4ez5gjhl3gquctrvk746ua 44 10 USA USA NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 11 , , , work_vr5p4ez5gjhl3gquctrvk746ua 44 12 2 2 CD work_vr5p4ez5gjhl3gquctrvk746ua 44 13 Temple Temple NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 14 University University NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 15 , , , work_vr5p4ez5gjhl3gquctrvk746ua 44 16 Philadelphia Philadelphia NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 17 , , , work_vr5p4ez5gjhl3gquctrvk746ua 44 18 PA PA NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 19 , , , work_vr5p4ez5gjhl3gquctrvk746ua 44 20 USA USA NNP work_vr5p4ez5gjhl3gquctrvk746ua 44 21 . . . work_vr5p4ez5gjhl3gquctrvk746ua 45 1 General General NNP work_vr5p4ez5gjhl3gquctrvk746ua 45 2 anesthesia anesthesia NNP work_vr5p4ez5gjhl3gquctrvk746ua 45 3 results result VBZ work_vr5p4ez5gjhl3gquctrvk746ua 45 4 from from IN work_vr5p4ez5gjhl3gquctrvk746ua 45 5 complex complex JJ work_vr5p4ez5gjhl3gquctrvk746ua 45 6 interactions interaction NNS work_vr5p4ez5gjhl3gquctrvk746ua 45 7 involving involve VBG work_vr5p4ez5gjhl3gquctrvk746ua 45 8 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 45 9 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 45 10 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 45 11 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 45 12 brain brain NN work_vr5p4ez5gjhl3gquctrvk746ua 45 13 . . . work_vr5p4ez5gjhl3gquctrvk746ua 46 1 Voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 46 2 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 46 3 gated gate VBN work_vr5p4ez5gjhl3gquctrvk746ua 46 4 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 46 5 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 46 6 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 46 7 modulated modulate VBN work_vr5p4ez5gjhl3gquctrvk746ua 46 8 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 46 9 halogenated halogenate VBN work_vr5p4ez5gjhl3gquctrvk746ua 46 10 inhaled inhale VBN work_vr5p4ez5gjhl3gquctrvk746ua 46 11 general general JJ work_vr5p4ez5gjhl3gquctrvk746ua 46 12 anesthetics anesthetic NNS work_vr5p4ez5gjhl3gquctrvk746ua 46 13 , , , work_vr5p4ez5gjhl3gquctrvk746ua 46 14 however however RB work_vr5p4ez5gjhl3gquctrvk746ua 46 15 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 46 16 drug drug NN work_vr5p4ez5gjhl3gquctrvk746ua 46 17 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 46 18 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 46 19 interactions interaction NNS work_vr5p4ez5gjhl3gquctrvk746ua 46 20 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 46 21 generally generally RB work_vr5p4ez5gjhl3gquctrvk746ua 46 22 believed believe VBN work_vr5p4ez5gjhl3gquctrvk746ua 46 23 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 46 24 be be VB work_vr5p4ez5gjhl3gquctrvk746ua 46 25 non non JJ work_vr5p4ez5gjhl3gquctrvk746ua 46 26 - - JJ work_vr5p4ez5gjhl3gquctrvk746ua 46 27 specific specific JJ work_vr5p4ez5gjhl3gquctrvk746ua 46 28 making make VBG work_vr5p4ez5gjhl3gquctrvk746ua 46 29 it -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 46 30 difficult difficult JJ work_vr5p4ez5gjhl3gquctrvk746ua 46 31 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 46 32 investigate investigate VB work_vr5p4ez5gjhl3gquctrvk746ua 46 33 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 46 34 molecular molecular JJ work_vr5p4ez5gjhl3gquctrvk746ua 46 35 mechanisms mechanism NNS work_vr5p4ez5gjhl3gquctrvk746ua 46 36 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 46 37 anesthetic anesthetic JJ work_vr5p4ez5gjhl3gquctrvk746ua 46 38 action action NN work_vr5p4ez5gjhl3gquctrvk746ua 46 39 . . . work_vr5p4ez5gjhl3gquctrvk746ua 47 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 47 2 find find VBP work_vr5p4ez5gjhl3gquctrvk746ua 47 3 , , , work_vr5p4ez5gjhl3gquctrvk746ua 47 4 however however RB work_vr5p4ez5gjhl3gquctrvk746ua 47 5 , , , work_vr5p4ez5gjhl3gquctrvk746ua 47 6 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 47 7 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 47 8 bacterial bacterial JJ work_vr5p4ez5gjhl3gquctrvk746ua 47 9 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 47 10 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 47 11 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 47 12 exhibits exhibit VBZ work_vr5p4ez5gjhl3gquctrvk746ua 47 13 differential differential JJ work_vr5p4ez5gjhl3gquctrvk746ua 47 14 regulation regulation NN work_vr5p4ez5gjhl3gquctrvk746ua 47 15 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 47 16 different different JJ work_vr5p4ez5gjhl3gquctrvk746ua 47 17 general general JJ work_vr5p4ez5gjhl3gquctrvk746ua 47 18 anes- anes- NNP work_vr5p4ez5gjhl3gquctrvk746ua 47 19 thetics thetics NNP work_vr5p4ez5gjhl3gquctrvk746ua 47 20 , , , work_vr5p4ez5gjhl3gquctrvk746ua 47 21 suggesting suggest VBG work_vr5p4ez5gjhl3gquctrvk746ua 47 22 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 47 23 there there EX work_vr5p4ez5gjhl3gquctrvk746ua 47 24 may may MD work_vr5p4ez5gjhl3gquctrvk746ua 47 25 be be VB work_vr5p4ez5gjhl3gquctrvk746ua 47 26 specific specific JJ work_vr5p4ez5gjhl3gquctrvk746ua 47 27 interactions interaction NNS work_vr5p4ez5gjhl3gquctrvk746ua 47 28 . . . work_vr5p4ez5gjhl3gquctrvk746ua 48 1 Molecular molecular JJ work_vr5p4ez5gjhl3gquctrvk746ua 48 2 dynamics dynamic NNS work_vr5p4ez5gjhl3gquctrvk746ua 48 3 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 48 4 MD MD NNP work_vr5p4ez5gjhl3gquctrvk746ua 48 5 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 48 6 simulations simulation NNS work_vr5p4ez5gjhl3gquctrvk746ua 48 7 have have VBP work_vr5p4ez5gjhl3gquctrvk746ua 48 8 identified identify VBN work_vr5p4ez5gjhl3gquctrvk746ua 48 9 several several JJ work_vr5p4ez5gjhl3gquctrvk746ua 48 10 possible possible JJ work_vr5p4ez5gjhl3gquctrvk746ua 48 11 binding bind VBG work_vr5p4ez5gjhl3gquctrvk746ua 48 12 sites site NNS work_vr5p4ez5gjhl3gquctrvk746ua 48 13 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 48 14 isoflurane isoflurane NNP work_vr5p4ez5gjhl3gquctrvk746ua 48 15 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 48 16 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 48 17 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 48 18 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 48 19 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 48 20 . . . work_vr5p4ez5gjhl3gquctrvk746ua 49 1 Here here RB work_vr5p4ez5gjhl3gquctrvk746ua 49 2 , , , work_vr5p4ez5gjhl3gquctrvk746ua 49 3 we -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 49 4 have have VBP work_vr5p4ez5gjhl3gquctrvk746ua 49 5 characterized characterize VBN work_vr5p4ez5gjhl3gquctrvk746ua 49 6 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 49 7 affinity affinity NN work_vr5p4ez5gjhl3gquctrvk746ua 49 8 , , , work_vr5p4ez5gjhl3gquctrvk746ua 49 9 occu- occu- NN work_vr5p4ez5gjhl3gquctrvk746ua 49 10 pancy pancy NN work_vr5p4ez5gjhl3gquctrvk746ua 49 11 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 49 12 hydrogen hydrogen NN work_vr5p4ez5gjhl3gquctrvk746ua 49 13 bonding bonding NN work_vr5p4ez5gjhl3gquctrvk746ua 49 14 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 49 15 these these DT work_vr5p4ez5gjhl3gquctrvk746ua 49 16 sites site NNS work_vr5p4ez5gjhl3gquctrvk746ua 49 17 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 49 18 identified identify VBN work_vr5p4ez5gjhl3gquctrvk746ua 49 19 key key JJ work_vr5p4ez5gjhl3gquctrvk746ua 49 20 interactions interaction NNS work_vr5p4ez5gjhl3gquctrvk746ua 49 21 . . . work_vr5p4ez5gjhl3gquctrvk746ua 50 1 In in IN work_vr5p4ez5gjhl3gquctrvk746ua 50 2 addition addition NN work_vr5p4ez5gjhl3gquctrvk746ua 50 3 , , , work_vr5p4ez5gjhl3gquctrvk746ua 50 4 experimental experimental JJ work_vr5p4ez5gjhl3gquctrvk746ua 50 5 evidence evidence NN work_vr5p4ez5gjhl3gquctrvk746ua 50 6 suggests suggest VBZ work_vr5p4ez5gjhl3gquctrvk746ua 50 7 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 50 8 both both DT work_vr5p4ez5gjhl3gquctrvk746ua 50 9 isoflurane isoflurane JJ work_vr5p4ez5gjhl3gquctrvk746ua 50 10 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 50 11 sevoflurane sevoflurane NN work_vr5p4ez5gjhl3gquctrvk746ua 50 12 have have VBP work_vr5p4ez5gjhl3gquctrvk746ua 50 13 dual dual JJ work_vr5p4ez5gjhl3gquctrvk746ua 50 14 actions action NNS work_vr5p4ez5gjhl3gquctrvk746ua 50 15 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 50 16 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 50 17 , , , work_vr5p4ez5gjhl3gquctrvk746ua 50 18 possibly possibly RB work_vr5p4ez5gjhl3gquctrvk746ua 50 19 involving involve VBG work_vr5p4ez5gjhl3gquctrvk746ua 50 20 action action NN work_vr5p4ez5gjhl3gquctrvk746ua 50 21 at at IN work_vr5p4ez5gjhl3gquctrvk746ua 50 22 two two CD work_vr5p4ez5gjhl3gquctrvk746ua 50 23 different different JJ work_vr5p4ez5gjhl3gquctrvk746ua 50 24 sites site NNS work_vr5p4ez5gjhl3gquctrvk746ua 50 25 . . . work_vr5p4ez5gjhl3gquctrvk746ua 51 1 Consistent consistent JJ work_vr5p4ez5gjhl3gquctrvk746ua 51 2 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 51 3 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 51 4 block block NN work_vr5p4ez5gjhl3gquctrvk746ua 51 5 , , , work_vr5p4ez5gjhl3gquctrvk746ua 51 6 sevoflurane sevoflurane NNP work_vr5p4ez5gjhl3gquctrvk746ua 51 7 accelerates accelerate VBZ work_vr5p4ez5gjhl3gquctrvk746ua 51 8 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 51 9 decay decay NN work_vr5p4ez5gjhl3gquctrvk746ua 51 10 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 51 11 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 51 12 current current JJ work_vr5p4ez5gjhl3gquctrvk746ua 51 13 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 51 14 20 20 CD work_vr5p4ez5gjhl3gquctrvk746ua 51 15 % % NN work_vr5p4ez5gjhl3gquctrvk746ua 51 16 faster fast JJR work_vr5p4ez5gjhl3gquctrvk746ua 51 17 at at IN work_vr5p4ez5gjhl3gquctrvk746ua 51 18 0.4 0.4 CD work_vr5p4ez5gjhl3gquctrvk746ua 51 19 mM mM NNP work_vr5p4ez5gjhl3gquctrvk746ua 51 20 sevoflurane sevoflurane NN work_vr5p4ez5gjhl3gquctrvk746ua 51 21 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 51 22 but but CC work_vr5p4ez5gjhl3gquctrvk746ua 51 23 , , , work_vr5p4ez5gjhl3gquctrvk746ua 51 24 at at IN work_vr5p4ez5gjhl3gquctrvk746ua 51 25 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 51 26 same same JJ work_vr5p4ez5gjhl3gquctrvk746ua 51 27 time time NN work_vr5p4ez5gjhl3gquctrvk746ua 51 28 , , , work_vr5p4ez5gjhl3gquctrvk746ua 51 29 increases increase VBZ work_vr5p4ez5gjhl3gquctrvk746ua 51 30 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 51 31 peak peak NN work_vr5p4ez5gjhl3gquctrvk746ua 51 32 current current NN work_vr5p4ez5gjhl3gquctrvk746ua 51 33 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 51 34 10 10 CD work_vr5p4ez5gjhl3gquctrvk746ua 51 35 % % NN work_vr5p4ez5gjhl3gquctrvk746ua 51 36 increase increase NN work_vr5p4ez5gjhl3gquctrvk746ua 51 37 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 51 38 0.4 0.4 CD work_vr5p4ez5gjhl3gquctrvk746ua 51 39 mM mm NN work_vr5p4ez5gjhl3gquctrvk746ua 51 40 sevoflurane sevoflurane NN work_vr5p4ez5gjhl3gquctrvk746ua 51 41 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 51 42 , , , work_vr5p4ez5gjhl3gquctrvk746ua 51 43 which which WDT work_vr5p4ez5gjhl3gquctrvk746ua 51 44 argues argue VBZ work_vr5p4ez5gjhl3gquctrvk746ua 51 45 against against IN work_vr5p4ez5gjhl3gquctrvk746ua 51 46 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 51 47 blocking blocking NN work_vr5p4ez5gjhl3gquctrvk746ua 51 48 mechanism mechanism NN work_vr5p4ez5gjhl3gquctrvk746ua 51 49 . . . work_vr5p4ez5gjhl3gquctrvk746ua 52 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 52 2 hypothesize hypothesize VBP work_vr5p4ez5gjhl3gquctrvk746ua 52 3 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 52 4 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 52 5 additional additional JJ work_vr5p4ez5gjhl3gquctrvk746ua 52 6 mechanism mechanism NN work_vr5p4ez5gjhl3gquctrvk746ua 52 7 involving involve VBG work_vr5p4ez5gjhl3gquctrvk746ua 52 8 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 52 9 distinct distinct JJ work_vr5p4ez5gjhl3gquctrvk746ua 52 10 site site NN work_vr5p4ez5gjhl3gquctrvk746ua 52 11 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 52 12 necessary necessary JJ work_vr5p4ez5gjhl3gquctrvk746ua 52 13 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 52 14 explain explain VB work_vr5p4ez5gjhl3gquctrvk746ua 52 15 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 52 16 latter latter JJ work_vr5p4ez5gjhl3gquctrvk746ua 52 17 effect effect NN work_vr5p4ez5gjhl3gquctrvk746ua 52 18 . . . work_vr5p4ez5gjhl3gquctrvk746ua 53 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 53 2 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 53 3 currently currently RB work_vr5p4ez5gjhl3gquctrvk746ua 53 4 employ- employ- VBG work_vr5p4ez5gjhl3gquctrvk746ua 53 5 ing ing NNP work_vr5p4ez5gjhl3gquctrvk746ua 53 6 MD MD NNP work_vr5p4ez5gjhl3gquctrvk746ua 53 7 simulation simulation NN work_vr5p4ez5gjhl3gquctrvk746ua 53 8 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 53 9 structural structural JJ work_vr5p4ez5gjhl3gquctrvk746ua 53 10 modeling modeling NN work_vr5p4ez5gjhl3gquctrvk746ua 53 11 combined combine VBN work_vr5p4ez5gjhl3gquctrvk746ua 53 12 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 53 13 mutagenesis mutagenesis NN work_vr5p4ez5gjhl3gquctrvk746ua 53 14 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 53 15 electrophysiology electrophysiology NN work_vr5p4ez5gjhl3gquctrvk746ua 53 16 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 53 17 test test VB work_vr5p4ez5gjhl3gquctrvk746ua 53 18 this this DT work_vr5p4ez5gjhl3gquctrvk746ua 53 19 two two CD work_vr5p4ez5gjhl3gquctrvk746ua 53 20 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 53 21 site site NN work_vr5p4ez5gjhl3gquctrvk746ua 53 22 hypothesis hypothesis NN work_vr5p4ez5gjhl3gquctrvk746ua 53 23 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 53 24 investigate investigate VB work_vr5p4ez5gjhl3gquctrvk746ua 53 25 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 53 26 molecular molecular JJ work_vr5p4ez5gjhl3gquctrvk746ua 53 27 mechanisms mechanism NNS work_vr5p4ez5gjhl3gquctrvk746ua 53 28 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 53 29 these these DT work_vr5p4ez5gjhl3gquctrvk746ua 53 30 opposing oppose VBG work_vr5p4ez5gjhl3gquctrvk746ua 53 31 effects effect NNS work_vr5p4ez5gjhl3gquctrvk746ua 53 32 . . . work_vr5p4ez5gjhl3gquctrvk746ua 54 1 Supported support VBN work_vr5p4ez5gjhl3gquctrvk746ua 54 2 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 54 3 NINDS NINDS NNP work_vr5p4ez5gjhl3gquctrvk746ua 54 4 F31 F31 NNP work_vr5p4ez5gjhl3gquctrvk746ua 54 5 NS077689 NS077689 NNP work_vr5p4ez5gjhl3gquctrvk746ua 54 6 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 54 7 AFB AFB NNP work_vr5p4ez5gjhl3gquctrvk746ua 54 8 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 54 9 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 54 10 NIGMS NIGMS NNP work_vr5p4ez5gjhl3gquctrvk746ua 54 11 P01 P01 NNP work_vr5p4ez5gjhl3gquctrvk746ua 54 12 GM0558 gm0558 NN work_vr5p4ez5gjhl3gquctrvk746ua 54 13 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 54 14 MLK MLK NNP work_vr5p4ez5gjhl3gquctrvk746ua 54 15 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 54 16 . . . work_vr5p4ez5gjhl3gquctrvk746ua 55 1 699-Pos 699-Pos NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 2 Board Board NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 3 B468 B468 NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 4 Polymodal Polymodal NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 5 , , , work_vr5p4ez5gjhl3gquctrvk746ua 55 6 High High NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 7 Affinity Affinity NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 8 Actions Actions NNPS work_vr5p4ez5gjhl3gquctrvk746ua 55 9 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 55 10 m m NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 11 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 55 12 Conotoxins Conotoxins NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 13 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 55 14 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 55 15 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 16 Voltage- Voltage- NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 17 Gated Gated NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 18 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 19 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 20 Rocio Rocio NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 21 K. K. NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 22 Finol Finol NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 23 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 55 24 Urdaneta1 Urdaneta1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 25 , , , work_vr5p4ez5gjhl3gquctrvk746ua 55 26 Robert Robert NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 27 Glavica1 Glavica1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 28 , , , work_vr5p4ez5gjhl3gquctrvk746ua 55 29 Jeff Jeff NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 30 R. R. NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 31 McArthur2 McArthur2 NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 32 , , , work_vr5p4ez5gjhl3gquctrvk746ua 55 33 Robert Robert NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 34 J. J. NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 35 French1 French1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 55 36 . . . work_vr5p4ez5gjhl3gquctrvk746ua 56 1 1University 1university CD work_vr5p4ez5gjhl3gquctrvk746ua 56 2 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 56 3 Calgary Calgary NNP work_vr5p4ez5gjhl3gquctrvk746ua 56 4 , , , work_vr5p4ez5gjhl3gquctrvk746ua 56 5 Calgary Calgary NNP work_vr5p4ez5gjhl3gquctrvk746ua 56 6 , , , work_vr5p4ez5gjhl3gquctrvk746ua 56 7 AB AB NNP work_vr5p4ez5gjhl3gquctrvk746ua 56 8 , , , work_vr5p4ez5gjhl3gquctrvk746ua 56 9 Canada Canada NNP work_vr5p4ez5gjhl3gquctrvk746ua 56 10 , , , work_vr5p4ez5gjhl3gquctrvk746ua 56 11 2RMIT 2rmit CD work_vr5p4ez5gjhl3gquctrvk746ua 56 12 , , , work_vr5p4ez5gjhl3gquctrvk746ua 56 13 Melbourne Melbourne NNP work_vr5p4ez5gjhl3gquctrvk746ua 56 14 , , , work_vr5p4ez5gjhl3gquctrvk746ua 56 15 Australia Australia NNP work_vr5p4ez5gjhl3gquctrvk746ua 56 16 . . . work_vr5p4ez5gjhl3gquctrvk746ua 57 1 m m LS work_vr5p4ez5gjhl3gquctrvk746ua 57 2 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 57 3 Conotoxins Conotoxins NNP work_vr5p4ez5gjhl3gquctrvk746ua 57 4 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 57 5 mCTXs mctxs NN work_vr5p4ez5gjhl3gquctrvk746ua 57 6 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 57 7 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 57 8 potent potent JJ work_vr5p4ez5gjhl3gquctrvk746ua 57 9 blockers blocker NNS work_vr5p4ez5gjhl3gquctrvk746ua 57 10 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 57 11 eukaryotic eukaryotic JJ work_vr5p4ez5gjhl3gquctrvk746ua 57 12 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 57 13 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 57 14 , , , work_vr5p4ez5gjhl3gquctrvk746ua 57 15 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 57 16 individual individual JJ work_vr5p4ez5gjhl3gquctrvk746ua 57 17 members member NNS work_vr5p4ez5gjhl3gquctrvk746ua 57 18 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 57 19 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 57 20 mCTX mctx NN work_vr5p4ez5gjhl3gquctrvk746ua 57 21 family family NN work_vr5p4ez5gjhl3gquctrvk746ua 57 22 are be VBP work_vr5p4ez5gjhl3gquctrvk746ua 57 23 highly highly RB work_vr5p4ez5gjhl3gquctrvk746ua 57 24 specific specific JJ work_vr5p4ez5gjhl3gquctrvk746ua 57 25 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 57 26 particular particular JJ work_vr5p4ez5gjhl3gquctrvk746ua 57 27 Nav1 Nav1 NNP work_vr5p4ez5gjhl3gquctrvk746ua 57 28 isoforms isoform NNS work_vr5p4ez5gjhl3gquctrvk746ua 57 29 . . . work_vr5p4ez5gjhl3gquctrvk746ua 58 1 We -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 58 2 have have VBP work_vr5p4ez5gjhl3gquctrvk746ua 58 3 begun begin VBN work_vr5p4ez5gjhl3gquctrvk746ua 58 4 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 58 5 explore explore VB work_vr5p4ez5gjhl3gquctrvk746ua 58 6 mCTX mctx NN work_vr5p4ez5gjhl3gquctrvk746ua 58 7 interactions interaction NNS work_vr5p4ez5gjhl3gquctrvk746ua 58 8 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 58 9 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 58 10 , , , work_vr5p4ez5gjhl3gquctrvk746ua 58 11 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 58 12 pro- pro- NN work_vr5p4ez5gjhl3gquctrvk746ua 58 13 karyotic karyotic JJ work_vr5p4ez5gjhl3gquctrvk746ua 58 14 Nav Nav NNP work_vr5p4ez5gjhl3gquctrvk746ua 58 15 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 58 16 closely closely RB work_vr5p4ez5gjhl3gquctrvk746ua 58 17 related relate VBN work_vr5p4ez5gjhl3gquctrvk746ua 58 18 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 58 19 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 58 20 , , , work_vr5p4ez5gjhl3gquctrvk746ua 58 21 whose whose WP$ work_vr5p4ez5gjhl3gquctrvk746ua 58 22 crystal crystal NN work_vr5p4ez5gjhl3gquctrvk746ua 58 23 structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 58 24 was be VBD work_vr5p4ez5gjhl3gquctrvk746ua 58 25 re- re- RB work_vr5p4ez5gjhl3gquctrvk746ua 58 26 cently cently RB work_vr5p4ez5gjhl3gquctrvk746ua 58 27 determined determine VBN work_vr5p4ez5gjhl3gquctrvk746ua 58 28 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 58 29 Payandeh Payandeh NNP work_vr5p4ez5gjhl3gquctrvk746ua 58 30 et et NNP work_vr5p4ez5gjhl3gquctrvk746ua 58 31 al al NNP work_vr5p4ez5gjhl3gquctrvk746ua 58 32 , , , work_vr5p4ez5gjhl3gquctrvk746ua 58 33 2011 2011 CD work_vr5p4ez5gjhl3gquctrvk746ua 58 34 , , , work_vr5p4ez5gjhl3gquctrvk746ua 58 35 Nature Nature NNP work_vr5p4ez5gjhl3gquctrvk746ua 58 36 475:353 475:353 CD work_vr5p4ez5gjhl3gquctrvk746ua 58 37 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 58 38 . . . work_vr5p4ez5gjhl3gquctrvk746ua 59 1 Our -PRON- PRP$ work_vr5p4ez5gjhl3gquctrvk746ua 59 2 data datum NNS work_vr5p4ez5gjhl3gquctrvk746ua 59 3 reveal reveal VBP work_vr5p4ez5gjhl3gquctrvk746ua 59 4 actions action NNS work_vr5p4ez5gjhl3gquctrvk746ua 59 5 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 59 6 both both DT work_vr5p4ez5gjhl3gquctrvk746ua 59 7 ion ion NN work_vr5p4ez5gjhl3gquctrvk746ua 59 8 conduction conduction NN work_vr5p4ez5gjhl3gquctrvk746ua 59 9 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 59 10 gating gate VBG work_vr5p4ez5gjhl3gquctrvk746ua 59 11 , , , work_vr5p4ez5gjhl3gquctrvk746ua 59 12 consistent consistent JJ work_vr5p4ez5gjhl3gquctrvk746ua 59 13 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 59 14 polymodal polymodal JJ work_vr5p4ez5gjhl3gquctrvk746ua 59 15 actions action NNS work_vr5p4ez5gjhl3gquctrvk746ua 59 16 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 59 17 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 59 18 pore pore NN work_vr5p4ez5gjhl3gquctrvk746ua 59 19 domain domain NN work_vr5p4ez5gjhl3gquctrvk746ua 59 20 . . . work_vr5p4ez5gjhl3gquctrvk746ua 60 1 Under under IN work_vr5p4ez5gjhl3gquctrvk746ua 60 2 voltage voltage NN work_vr5p4ez5gjhl3gquctrvk746ua 60 3 clamp clamp NN work_vr5p4ez5gjhl3gquctrvk746ua 60 4 , , , work_vr5p4ez5gjhl3gquctrvk746ua 60 5 whole whole JJ work_vr5p4ez5gjhl3gquctrvk746ua 60 6 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 60 7 cell cell NN work_vr5p4ez5gjhl3gquctrvk746ua 60 8 currents current NNS work_vr5p4ez5gjhl3gquctrvk746ua 60 9 from from IN work_vr5p4ez5gjhl3gquctrvk746ua 60 10 NaChBac NaChBac NNP work_vr5p4ez5gjhl3gquctrvk746ua 60 11 expressed express VBN work_vr5p4ez5gjhl3gquctrvk746ua 60 12 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 60 13 tsA-201 tsa-201 IN work_vr5p4ez5gjhl3gquctrvk746ua 60 14 cells cell NNS work_vr5p4ez5gjhl3gquctrvk746ua 60 15 were be VBD work_vr5p4ez5gjhl3gquctrvk746ua 60 16 reduced reduce VBN work_vr5p4ez5gjhl3gquctrvk746ua 60 17 , , , work_vr5p4ez5gjhl3gquctrvk746ua 60 18 up up IN work_vr5p4ez5gjhl3gquctrvk746ua 60 19 to to TO work_vr5p4ez5gjhl3gquctrvk746ua 60 20 nearly nearly RB work_vr5p4ez5gjhl3gquctrvk746ua 60 21 complete complete JJ work_vr5p4ez5gjhl3gquctrvk746ua 60 22 block block NN work_vr5p4ez5gjhl3gquctrvk746ua 60 23 , , , work_vr5p4ez5gjhl3gquctrvk746ua 60 24 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 60 25 concentrations concentration NNS work_vr5p4ez5gjhl3gquctrvk746ua 60 26 in in IN work_vr5p4ez5gjhl3gquctrvk746ua 60 27 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 60 28 pM pm NN work_vr5p4ez5gjhl3gquctrvk746ua 60 29 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 60 30 mM mm NN work_vr5p4ez5gjhl3gquctrvk746ua 60 31 range range NN work_vr5p4ez5gjhl3gquctrvk746ua 60 32 , , , work_vr5p4ez5gjhl3gquctrvk746ua 60 33 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 60 34 wildtype wildtype NN work_vr5p4ez5gjhl3gquctrvk746ua 60 35 toxins toxin NNS work_vr5p4ez5gjhl3gquctrvk746ua 60 36 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 60 37 derivatives derivative NNS work_vr5p4ez5gjhl3gquctrvk746ua 60 38 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 60 39 mCTX mctx NN work_vr5p4ez5gjhl3gquctrvk746ua 60 40 PIIIA PIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 60 41 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 60 42 KIIIA KIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 60 43 . . . work_vr5p4ez5gjhl3gquctrvk746ua 61 1 For for IN work_vr5p4ez5gjhl3gquctrvk746ua 61 2 wildtype wildtype NN work_vr5p4ez5gjhl3gquctrvk746ua 61 3 PIIIA PIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 61 4 , , , work_vr5p4ez5gjhl3gquctrvk746ua 61 5 dose dose NN work_vr5p4ez5gjhl3gquctrvk746ua 61 6 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 61 7 response response NN work_vr5p4ez5gjhl3gquctrvk746ua 61 8 data datum NNS work_vr5p4ez5gjhl3gquctrvk746ua 61 9 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 61 10 0.001 0.001 CD work_vr5p4ez5gjhl3gquctrvk746ua 61 11 - - SYM work_vr5p4ez5gjhl3gquctrvk746ua 61 12 10,000nM 10,000nm CD work_vr5p4ez5gjhl3gquctrvk746ua 61 13 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 61 14 yielded yield VBD work_vr5p4ez5gjhl3gquctrvk746ua 61 15 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 61 16 following follow VBG work_vr5p4ez5gjhl3gquctrvk746ua 61 17 : : : work_vr5p4ez5gjhl3gquctrvk746ua 61 18 IC50=0.005nM IC50=0.005nM NNP work_vr5p4ez5gjhl3gquctrvk746ua 61 19 ; ; : work_vr5p4ez5gjhl3gquctrvk746ua 61 20 maximal maximal JJ work_vr5p4ez5gjhl3gquctrvk746ua 61 21 fraction fraction NN work_vr5p4ez5gjhl3gquctrvk746ua 61 22 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 61 23 current current JJ work_vr5p4ez5gjhl3gquctrvk746ua 61 24 blocked block VBN work_vr5p4ez5gjhl3gquctrvk746ua 61 25 = = SYM work_vr5p4ez5gjhl3gquctrvk746ua 61 26 0.95 0.95 CD work_vr5p4ez5gjhl3gquctrvk746ua 61 27 ; ; : work_vr5p4ez5gjhl3gquctrvk746ua 61 28 Hill Hill NNP work_vr5p4ez5gjhl3gquctrvk746ua 61 29 coefficient coefficient NN work_vr5p4ez5gjhl3gquctrvk746ua 61 30 = = SYM work_vr5p4ez5gjhl3gquctrvk746ua 61 31 0.7 0.7 CD work_vr5p4ez5gjhl3gquctrvk746ua 61 32 . . . work_vr5p4ez5gjhl3gquctrvk746ua 62 1 Chen Chen NNP work_vr5p4ez5gjhl3gquctrvk746ua 62 2 & & CC work_vr5p4ez5gjhl3gquctrvk746ua 62 3 Chung Chung NNP work_vr5p4ez5gjhl3gquctrvk746ua 62 4 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 62 5 2012 2012 CD work_vr5p4ez5gjhl3gquctrvk746ua 62 6 , , , work_vr5p4ez5gjhl3gquctrvk746ua 62 7 Biophys Biophys NNP work_vr5p4ez5gjhl3gquctrvk746ua 62 8 . . . work_vr5p4ez5gjhl3gquctrvk746ua 63 1 J. J. NNP work_vr5p4ez5gjhl3gquctrvk746ua 64 1 102:483 102:483 LS work_vr5p4ez5gjhl3gquctrvk746ua 64 2 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 64 3 predicted predict VBD work_vr5p4ez5gjhl3gquctrvk746ua 64 4 an an DT work_vr5p4ez5gjhl3gquctrvk746ua 64 5 IC50 IC50 NNP work_vr5p4ez5gjhl3gquctrvk746ua 64 6 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 64 7 0.1nM 0.1nm ADD work_vr5p4ez5gjhl3gquctrvk746ua 64 8 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 64 9 PIIIA PIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 64 10 when when WRB work_vr5p4ez5gjhl3gquctrvk746ua 64 11 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 64 12 NavAb NavAb NNP work_vr5p4ez5gjhl3gquctrvk746ua 64 13 channel channel NN work_vr5p4ez5gjhl3gquctrvk746ua 64 14 is be VBZ work_vr5p4ez5gjhl3gquctrvk746ua 64 15 occupied occupy VBN work_vr5p4ez5gjhl3gquctrvk746ua 64 16 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 64 17 2 2 CD work_vr5p4ez5gjhl3gquctrvk746ua 64 18 sodium sodium NN work_vr5p4ez5gjhl3gquctrvk746ua 64 19 ions ion NNS work_vr5p4ez5gjhl3gquctrvk746ua 64 20 . . . work_vr5p4ez5gjhl3gquctrvk746ua 65 1 Even even RB work_vr5p4ez5gjhl3gquctrvk746ua 65 2 at at IN work_vr5p4ez5gjhl3gquctrvk746ua 65 3 very very RB work_vr5p4ez5gjhl3gquctrvk746ua 65 4 low low JJ work_vr5p4ez5gjhl3gquctrvk746ua 65 5 [ [ -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 65 6 PIIIA PIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 65 7 ] ] -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 65 8 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 65 9 1pM 1pm CD work_vr5p4ez5gjhl3gquctrvk746ua 65 10 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 65 11 , , , work_vr5p4ez5gjhl3gquctrvk746ua 65 12 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 65 13 unblocked unblocked JJ work_vr5p4ez5gjhl3gquctrvk746ua 65 14 currents current NNS work_vr5p4ez5gjhl3gquctrvk746ua 65 15 showed show VBD work_vr5p4ez5gjhl3gquctrvk746ua 65 16 increasing increase VBG work_vr5p4ez5gjhl3gquctrvk746ua 65 17 rates rate NNS work_vr5p4ez5gjhl3gquctrvk746ua 65 18 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 65 19 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 65 20 as as IN work_vr5p4ez5gjhl3gquctrvk746ua 65 21 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 65 22 peptides peptide NNS work_vr5p4ez5gjhl3gquctrvk746ua 65 23 were be VBD work_vr5p4ez5gjhl3gquctrvk746ua 65 24 washed wash VBN work_vr5p4ez5gjhl3gquctrvk746ua 65 25 in in RP work_vr5p4ez5gjhl3gquctrvk746ua 65 26 , , , work_vr5p4ez5gjhl3gquctrvk746ua 65 27 suggesting suggest VBG work_vr5p4ez5gjhl3gquctrvk746ua 65 28 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 65 29 gating gate VBG work_vr5p4ez5gjhl3gquctrvk746ua 65 30 mod- mod- NN work_vr5p4ez5gjhl3gquctrvk746ua 65 31 ulation ulation NN work_vr5p4ez5gjhl3gquctrvk746ua 65 32 , , , work_vr5p4ez5gjhl3gquctrvk746ua 65 33 that that DT work_vr5p4ez5gjhl3gquctrvk746ua 65 34 was be VBD work_vr5p4ez5gjhl3gquctrvk746ua 65 35 not not RB work_vr5p4ez5gjhl3gquctrvk746ua 65 36 tightly tightly RB work_vr5p4ez5gjhl3gquctrvk746ua 65 37 associated associate VBN work_vr5p4ez5gjhl3gquctrvk746ua 65 38 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 65 39 pore pore NNP work_vr5p4ez5gjhl3gquctrvk746ua 65 40 block block NN work_vr5p4ez5gjhl3gquctrvk746ua 65 41 . . . work_vr5p4ez5gjhl3gquctrvk746ua 66 1 For for IN work_vr5p4ez5gjhl3gquctrvk746ua 66 2 mCTX mctx NN work_vr5p4ez5gjhl3gquctrvk746ua 66 3 PIIIA PIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 66 4 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 66 5 0.1nM 0.1nm ADD work_vr5p4ez5gjhl3gquctrvk746ua 66 6 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 66 7 , , , work_vr5p4ez5gjhl3gquctrvk746ua 66 8 or or CC work_vr5p4ez5gjhl3gquctrvk746ua 66 9 KIIIA KIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 66 10 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 66 11 30nM 30nm CD work_vr5p4ez5gjhl3gquctrvk746ua 66 12 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 66 13 , , , work_vr5p4ez5gjhl3gquctrvk746ua 66 14 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 66 15 accelerated accelerate VBN work_vr5p4ez5gjhl3gquctrvk746ua 66 16 by by IN work_vr5p4ez5gjhl3gquctrvk746ua 66 17 ~10-fold ~10-fold NNP work_vr5p4ez5gjhl3gquctrvk746ua 66 18 . . . work_vr5p4ez5gjhl3gquctrvk746ua 67 1 Substitution substitution NN work_vr5p4ez5gjhl3gquctrvk746ua 67 2 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 67 3 key key JJ work_vr5p4ez5gjhl3gquctrvk746ua 67 4 basic basic JJ work_vr5p4ez5gjhl3gquctrvk746ua 67 5 residues residue NNS work_vr5p4ez5gjhl3gquctrvk746ua 67 6 ( ( -LRB- work_vr5p4ez5gjhl3gquctrvk746ua 67 7 PIIIA PIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 67 8 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 67 9 R14A R14A NNP work_vr5p4ez5gjhl3gquctrvk746ua 67 10 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 67 11 KIIIA KIIIA NNP work_vr5p4ez5gjhl3gquctrvk746ua 67 12 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 67 13 K7A K7A NNP work_vr5p4ez5gjhl3gquctrvk746ua 67 14 ) ) -RRB- work_vr5p4ez5gjhl3gquctrvk746ua 67 15 reduced reduce VBN work_vr5p4ez5gjhl3gquctrvk746ua 67 16 blocking block VBG work_vr5p4ez5gjhl3gquctrvk746ua 67 17 potency potency NN work_vr5p4ez5gjhl3gquctrvk746ua 67 18 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 67 19 decreased decrease VBD work_vr5p4ez5gjhl3gquctrvk746ua 67 20 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 67 21 speeding speeding NN work_vr5p4ez5gjhl3gquctrvk746ua 67 22 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 67 23 inactivation inactivation NN work_vr5p4ez5gjhl3gquctrvk746ua 67 24 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 67 25 less less JJR work_vr5p4ez5gjhl3gquctrvk746ua 67 26 than than IN work_vr5p4ez5gjhl3gquctrvk746ua 67 27 2-fold 2-fold CD work_vr5p4ez5gjhl3gquctrvk746ua 67 28 . . . work_vr5p4ez5gjhl3gquctrvk746ua 68 1 Given give VBN work_vr5p4ez5gjhl3gquctrvk746ua 68 2 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 68 3 remarkably remarkably RB work_vr5p4ez5gjhl3gquctrvk746ua 68 4 high high JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 5 selectivity selectivity NN work_vr5p4ez5gjhl3gquctrvk746ua 68 6 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 68 7 affinity affinity NN work_vr5p4ez5gjhl3gquctrvk746ua 68 8 that that WDT work_vr5p4ez5gjhl3gquctrvk746ua 68 9 mCTXs mctx VBG work_vr5p4ez5gjhl3gquctrvk746ua 68 10 show show NN work_vr5p4ez5gjhl3gquctrvk746ua 68 11 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 68 12 certain certain JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 13 eukaryotic eukaryotic JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 14 Nav Nav NNP work_vr5p4ez5gjhl3gquctrvk746ua 68 15 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 68 16 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 68 17 highly highly RB work_vr5p4ez5gjhl3gquctrvk746ua 68 18 asymmetric asymmetric JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 19 pores pore NNS work_vr5p4ez5gjhl3gquctrvk746ua 68 20 , , , work_vr5p4ez5gjhl3gquctrvk746ua 68 21 it -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 68 22 may may MD work_vr5p4ez5gjhl3gquctrvk746ua 68 23 seem seem VB work_vr5p4ez5gjhl3gquctrvk746ua 68 24 surprising surprising JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 25 that that IN work_vr5p4ez5gjhl3gquctrvk746ua 68 26 they -PRON- PRP work_vr5p4ez5gjhl3gquctrvk746ua 68 27 bind bind VBP work_vr5p4ez5gjhl3gquctrvk746ua 68 28 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 68 29 symmetric symmetric JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 30 bacterial bacterial JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 31 Nav Nav NNP work_vr5p4ez5gjhl3gquctrvk746ua 68 32 channels channel NNS work_vr5p4ez5gjhl3gquctrvk746ua 68 33 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 68 34 such such JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 35 high high JJ work_vr5p4ez5gjhl3gquctrvk746ua 68 36 affinity affinity NN work_vr5p4ez5gjhl3gquctrvk746ua 68 37 . . . work_vr5p4ez5gjhl3gquctrvk746ua 69 1 Binding bind VBG work_vr5p4ez5gjhl3gquctrvk746ua 69 2 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 69 3 Isoflurane Isoflurane NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 4 to to IN work_vr5p4ez5gjhl3gquctrvk746ua 69 5 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 69 6 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 7 Voltage Voltage NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 8 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 69 9 Gated Gated NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 10 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 11 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 12 : : : work_vr5p4ez5gjhl3gquctrvk746ua 69 13 Structure structure NN work_vr5p4ez5gjhl3gquctrvk746ua 69 14 and and CC work_vr5p4ez5gjhl3gquctrvk746ua 69 15 Accessibility Accessibility NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 16 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 69 17 Distinct Distinct NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 18 Interaction Interaction NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 19 Sites Sites NNPS work_vr5p4ez5gjhl3gquctrvk746ua 69 20 A a DT work_vr5p4ez5gjhl3gquctrvk746ua 69 21 Key key JJ work_vr5p4ez5gjhl3gquctrvk746ua 69 22 Gating Gating NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 23 Charge Charge NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 24 Interaction Interaction NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 25 Required require VBN work_vr5p4ez5gjhl3gquctrvk746ua 69 26 for for IN work_vr5p4ez5gjhl3gquctrvk746ua 69 27 Slow Slow NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 28 Inactivation Inactivation NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 29 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 69 30 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 69 31 Navab Navab NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 32 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 33 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 34 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 35 Computational Computational NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 36 Study Study NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 37 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 69 38 the the DT work_vr5p4ez5gjhl3gquctrvk746ua 69 39 Prokaryotic Prokaryotic NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 40 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 41 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 42 Volatile Volatile NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 43 General General NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 44 Anesthetic Anesthetic NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 45 Interactions Interactions NNPS work_vr5p4ez5gjhl3gquctrvk746ua 69 46 with with IN work_vr5p4ez5gjhl3gquctrvk746ua 69 47 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 69 48 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 49 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 50 Channel Channel NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 51 Polymodal Polymodal NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 52 , , , work_vr5p4ez5gjhl3gquctrvk746ua 69 53 High High NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 54 Affinity Affinity NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 55 Actions Actions NNPS work_vr5p4ez5gjhl3gquctrvk746ua 69 56 of of IN work_vr5p4ez5gjhl3gquctrvk746ua 69 57 μ μ NN work_vr5p4ez5gjhl3gquctrvk746ua 69 58 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 69 59 Conotoxins Conotoxins NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 60 on on IN work_vr5p4ez5gjhl3gquctrvk746ua 69 61 a a DT work_vr5p4ez5gjhl3gquctrvk746ua 69 62 Bacterial Bacterial NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 63 Voltage Voltage NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 64 - - HYPH work_vr5p4ez5gjhl3gquctrvk746ua 69 65 Gated Gated NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 66 Sodium Sodium NNP work_vr5p4ez5gjhl3gquctrvk746ua 69 67 Channel Channel NNP