id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_wxh4ufsvcnaotk63e3xldmrm6m	Trevor Baybutt	105 A third-generation human GUCY2C-targeted CAR-T cell for colorectal cancer immunotherapy	2020	2	.pdf	application/pdf	2101	299	64	105 A third-generation human GUCY2C-targeted CAR-T cell for colorectal cancer immunotherapy 104 BCMA-TARGETING CAR-T CELLS EXPANDED IN IL-15 Background Chimeric antigen receptor-T (CAR-T) cells that target B cell maturation antigen (BCMA-CARs) have emerged vivo efficacy and persistence of BCMA-CARs.1 The development of unfavourable differentiation or T cell dysfunction, such as exhaustion and senescence, during the ex vivo expansion of the BCMA-CARs could be limiting their therapeutic CAR-T CELL FOR COLORECTAL CANCER receptor (CAR)-T cell directed towards the extracellular that human GUCY2C CAR-T cells can selectively kill GUCY2C-expressing colorectal cancer cells in vitro and produce inflammatory cytokines in response to antigenic CAR-T cells can selectively target GUCY2C-expressing cancer We hypothesize that GUCY2C-directed CAR-T cells 106 INCREASING AMPK ACTIVITY IN HUMAN T CELLS whose activity increases in memory cells, is a key regulator of human T cells, which significantly increased AMPK activity Abstract 106 Figure 1 AMPK-transduced T cells increase expression	./cache/work_wxh4ufsvcnaotk63e3xldmrm6m.pdf	./txt/work_wxh4ufsvcnaotk63e3xldmrm6m.txt