id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_tlzzi4yogbajbdxgzyx3vltsmu	S. Linder	Picropodophyllotoxin or Podophyllotoxin Does Not Induce Cell Death via Insulin-like Growth Factor-I Receptor	2007	2	.pdf	application/pdf	867	90	56	inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. this notion is that PPT-resistant cells are resistant to PPP (3). between IGF-IR expression and sensitivity to PPT/PPP was reported Eleven cell types expressing IGF-IR were found sensitive to PPP, and three cell types lacking IGF-IR expression were resistant in vitro C. Shoshan reexamined PPT/PPP effects on IGFIR–deficient R� cells, which were reported resistant to 15 Amol/L ( from Dr. Girnita, Department of Oncology-Pathology, Karolinska Both cell types were equally sensitive; PPP reduced viability of Both drugs induced sub-G1 debris in R� cells, indicative of cell death (PPT, 64% of total counts; PPP, 56%; controls, 6%). Gupta reexamined PPT/PPP effects on HepG2 cells, which were reported resistant to >15 Amol/L PPT/PPP (1). PPT and PPP induce loss of viability and cell death in IGF-IR–deficient Stig Linder, Maria C. Access the most recent version of this article at:	./cache/work_tlzzi4yogbajbdxgzyx3vltsmu.pdf	./txt/work_tlzzi4yogbajbdxgzyx3vltsmu.txt